diff --git a/clang/test/Driver/fsemantic-interposition.c b/clang/test/Driver/fsemantic-interposition.c
index e2713de80f690..0ee0dbb3be347 100644
--- a/clang/test/Driver/fsemantic-interposition.c
+++ b/clang/test/Driver/fsemantic-interposition.c
@@ -1,20 +1,20 @@
-// RUN: %clang -target x86_64 %s -Werror -fpic -fsemantic-interposition -c -### 2>&1 | FileCheck %s
-// RUN: %clang -target x86_64 %s -Werror -fPIC -fsemantic-interposition -c -### 2>&1 | FileCheck %s
+// RUN: %clang --sysroot=%S/Inputs -target x86_64 %s -Werror -fpic -fsemantic-interposition -c -### 2>&1 | FileCheck %s
+// RUN: %clang --sysroot=%S/Inputs -target x86_64 %s -Werror -fPIC -fsemantic-interposition -c -### 2>&1 | FileCheck %s
 // CHECK: "-fsemantic-interposition"
 
 /// No-op for -fno-pic/-fpie.
-// RUN: %clang -target x86_64 %s -Werror -fsemantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NOOP %s
-// RUN: %clang -target x86_64 %s -Werror -fPIE -fsemantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NOOP %s
+// RUN: %clang --sysroot=%S/Inputs -target x86_64 %s -Werror -fsemantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NOOP %s
+// RUN: %clang --sysroot=%S/Inputs -target x86_64 %s -Werror -fPIE -fsemantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NOOP %s
 // NOOP-NOT: "-fsemantic-interposition"
 // NOOP-NOT: "-fno-semantic-interposition"
 
 /// If -fno-semantic-interposition is specified and the target supports local
 /// aliases, neither CC1 option is set.
-// RUN: %clang -target aarch64 %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NO %s
-// RUN: %clang -target riscv32 %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NO %s
-// RUN: %clang -target riscv64 %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NO %s
-// RUN: %clang -target i386 %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NO %s
-// RUN: %clang -target x86_64 %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NO %s
+// RUN: %clang --sysroot=%S/Inputs -target aarch64 %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NO %s
+// RUN: %clang --sysroot=%S/Inputs -target riscv32 %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NO %s
+// RUN: %clang --sysroot=%S/Inputs -target riscv64 %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NO %s
+// RUN: %clang --sysroot=%S/Inputs -target i386 %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NO %s
+// RUN: %clang --sysroot=%S/Inputs -target x86_64 %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=NO %s
 // NO-NOT: "-fsemantic-interposition"
 // NO-NOT: "-fhalf-no-semantic-interposition"
 
@@ -23,8 +23,8 @@
 /// local aliases, use the traditional half-baked behavor: interprocedural
 /// optimizations are allowed but local aliases are not used. If references are
 /// not optimized out, semantic interposition at runtime is possible.
-// RUN: %clang -target ppc64le %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=HALF %s
+// RUN: %clang --sysroot=%S/Inputs -target ppc64le %s -Werror -fPIC -fno-semantic-interposition -c -### 2>&1 | FileCheck --check-prefix=HALF %s
 
-// RUN: %clang -target x86_64 %s -Werror -fPIC -c -### 2>&1 | FileCheck --check-prefix=HALF %s
+// RUN: %clang --sysroot=%S/Inputs -target x86_64 %s -Werror -fPIC -c -### 2>&1 | FileCheck --check-prefix=HALF %s
 //
 // HALF: "-fhalf-no-semantic-interposition"