diff --git a/llvm/lib/CodeGen/GlobalISel/InlineAsmLowering.cpp b/llvm/lib/CodeGen/GlobalISel/InlineAsmLowering.cpp
index 2ce1d414e7550f..1e2a82615da8cb 100644
--- a/llvm/lib/CodeGen/GlobalISel/InlineAsmLowering.cpp
+++ b/llvm/lib/CodeGen/GlobalISel/InlineAsmLowering.cpp
@@ -455,19 +455,23 @@ bool InlineAsmLowering::lowerInlineAsm(
         unsigned DefRegIdx = InstFlagIdx + 1;
         Register Def = Inst->getOperand(DefRegIdx).getReg();
 
-        // Copy input to new vreg with same reg class as Def
-        const TargetRegisterClass *RC = MRI->getRegClass(Def);
         ArrayRef<Register> SrcRegs = GetOrCreateVRegs(*OpInfo.CallOperandVal);
         assert(SrcRegs.size() == 1 && "Single register is expected here");
-        Register Tmp = MRI->createVirtualRegister(RC);
-        if (!buildAnyextOrCopy(Tmp, SrcRegs[0], MIRBuilder))
-          return false;
 
-        // Add Flag and input register operand (Tmp) to Inst. Tie Tmp to Def.
+        // When Def is physreg: use given input.
+        Register In = SrcRegs[0];
+        // When Def is vreg: copy input to new vreg with same reg class as Def.
+        if (Def.isVirtual()) {
+          In = MRI->createVirtualRegister(MRI->getRegClass(Def));
+          if (!buildAnyextOrCopy(In, SrcRegs[0], MIRBuilder))
+            return false;
+        }
+
+        // Add Flag and input register operand (In) to Inst. Tie In to Def.
         unsigned UseFlag = InlineAsm::getFlagWord(InlineAsm::Kind_RegUse, 1);
         unsigned Flag = InlineAsm::getFlagWordForMatchingOp(UseFlag, DefIdx);
         Inst.addImm(Flag);
-        Inst.addReg(Tmp);
+        Inst.addReg(In);
         Inst->tieOperands(DefRegIdx, Inst->getNumOperands() - 1);
         break;
       }
diff --git a/llvm/test/CodeGen/AArch64/GlobalISel/irtranslator-inline-asm.ll b/llvm/test/CodeGen/AArch64/GlobalISel/irtranslator-inline-asm.ll
index f8b23ef84721e9..bfe96827dfe3c2 100644
--- a/llvm/test/CodeGen/AArch64/GlobalISel/irtranslator-inline-asm.ll
+++ b/llvm/test/CodeGen/AArch64/GlobalISel/irtranslator-inline-asm.ll
@@ -243,3 +243,15 @@ define i16 @test_anyext_input_with_matching_constraint() {
   %1 = call i16 asm sideeffect "", "=r,0"(i16 1)
   ret i16 %1
 }
+
+define i64 @test_input_with_matching_constraint_to_physical_register() {
+  ; CHECK-LABEL: name: test_input_with_matching_constraint_to_physical_register
+  ; CHECK: bb.1 (%ir-block.0):
+  ; CHECK:   [[C:%[0-9]+]]:_(s64) = G_CONSTANT i64 0
+  ; CHECK:   INLINEASM &"", 0 /* attdialect */, 10 /* regdef */, implicit-def $x2, 2147483657 /* reguse tiedto:$0 */, [[C]](tied-def 3)(s64)
+  ; CHECK:   [[COPY:%[0-9]+]]:_(s64) = COPY $x2
+  ; CHECK:   $x0 = COPY [[COPY]](s64)
+  ; CHECK:   RET_ReallyLR implicit $x0
+  %1 = tail call i64 asm "", "={x2},0"(i64 0)
+  ret i64 %1
+}