diff --git a/clang/lib/Basic/Targets/OSTargets.h b/clang/lib/Basic/Targets/OSTargets.h
index 756cb7a8bbe3c4..70fac030bc5d83 100644
--- a/clang/lib/Basic/Targets/OSTargets.h
+++ b/clang/lib/Basic/Targets/OSTargets.h
@@ -538,6 +538,7 @@ class LLVM_LIBRARY_VISIBILITY PS4OSTargetInfo : public OSTargetInfo<Target> {
     Builder.defineMacro("__KPRINTF_ATTRIBUTE__");
     DefineStd(Builder, "unix", Opts);
     Builder.defineMacro("__ELF__");
+    Builder.defineMacro("__SCE__");
     Builder.defineMacro("__ORBIS__");
   }
 
diff --git a/clang/test/Preprocessor/init.c b/clang/test/Preprocessor/init.c
index cf0f428d38bb10..9b116dda0ace5f 100644
--- a/clang/test/Preprocessor/init.c
+++ b/clang/test/Preprocessor/init.c
@@ -9599,6 +9599,7 @@
 // PS4:#define __PTRDIFF_TYPE__ long int
 // PS4:#define __PTRDIFF_WIDTH__ 64
 // PS4:#define __REGISTER_PREFIX__
+// PS4:#define __SCE__ 1
 // PS4:#define __SCHAR_MAX__ 127
 // PS4:#define __SHRT_MAX__ 32767
 // PS4:#define __SIG_ATOMIC_MAX__ 2147483647