diff --git a/clang/lib/Tooling/DependencyScanning/ModuleDepCollector.cpp b/clang/lib/Tooling/DependencyScanning/ModuleDepCollector.cpp
index eb5c50c35428f..94ccbd3351b09 100644
--- a/clang/lib/Tooling/DependencyScanning/ModuleDepCollector.cpp
+++ b/clang/lib/Tooling/DependencyScanning/ModuleDepCollector.cpp
@@ -175,6 +175,9 @@ makeCommonInvocationForModuleBuild(CompilerInvocation CI) {
     CI.getCodeGenOpts().CoverageCompilationDir.clear();
     CI.getCodeGenOpts().CoverageDataFile.clear();
     CI.getCodeGenOpts().CoverageNotesFile.clear();
+    CI.getCodeGenOpts().ProfileInstrumentUsePath.clear();
+    CI.getCodeGenOpts().SampleProfileFile.clear();
+    CI.getCodeGenOpts().ProfileRemappingFile.clear();
   }
 
   // Map output paths that affect behaviour to "-" so their existence is in the
diff --git a/clang/test/ClangScanDeps/Inputs/removed-args/cdb.json.template b/clang/test/ClangScanDeps/Inputs/removed-args/cdb.json.template
index 7ae3c88aedd8d..ca56799cd08ea 100644
--- a/clang/test/ClangScanDeps/Inputs/removed-args/cdb.json.template
+++ b/clang/test/ClangScanDeps/Inputs/removed-args/cdb.json.template
@@ -1,7 +1,7 @@
 [
   {
     "directory": "DIR",
-    "command": "clang -fsyntax-only DIR/tu.c -fmodules -fimplicit-module-maps -fmodules-validate-once-per-build-session -fbuild-session-file=DIR/build-session -fmodules-prune-interval=123 -fmodules-prune-after=123 -fmodules-cache-path=DIR/cache -include DIR/header.h -grecord-command-line -fdebug-compilation-dir=DIR/debug -fcoverage-compilation-dir=DIR/coverage -ftest-coverage -o DIR/tu.o -serialize-diagnostics DIR/tu.diag -MT tu -MD -MF DIR/tu.d",
+    "command": "clang -fsyntax-only DIR/tu.c -fmodules -fimplicit-module-maps -fmodules-validate-once-per-build-session -fbuild-session-file=DIR/build-session -fmodules-prune-interval=123 -fmodules-prune-after=123 -fmodules-cache-path=DIR/cache -include DIR/header.h -grecord-command-line -fdebug-compilation-dir=DIR/debug -fcoverage-compilation-dir=DIR/coverage -ftest-coverage -fprofile-instr-use=DIR/tu.profdata -o DIR/tu.o -serialize-diagnostics DIR/tu.diag -MT tu -MD -MF DIR/tu.d",
     "file": "DIR/tu.c"
   }
 ]
diff --git a/clang/test/ClangScanDeps/removed-args.c b/clang/test/ClangScanDeps/removed-args.c
index 9a4ef25838e46..f49e4ead82f7b 100644
--- a/clang/test/ClangScanDeps/removed-args.c
+++ b/clang/test/ClangScanDeps/removed-args.c
@@ -9,6 +9,8 @@
 // RUN: rm -rf %t && mkdir %t
 // RUN: cp %S/Inputs/removed-args/* %t
 // RUN: touch %t/build-session
+// RUN: touch %t/tu.proftext
+// RUN: llvm-profdata merge %t/tu.proftext -o %t/tu.profdata
 
 // RUN: sed "s|DIR|%/t|g" %S/Inputs/removed-args/cdb.json.template > %t/cdb.json
 // RUN: clang-scan-deps -compilation-database %t/cdb.json -format experimental-full > %t/result.json
@@ -25,6 +27,7 @@
 // CHECK-NOT:          "-fcoverage-compilation-dir="
 // CHECK-NOT:          "-coverage-notes-file
 // CHECK-NOT:          "-coverage-data-file
+// CHECK-NOT:          "-fprofile-instrument-use-path
 // CHECK-NOT:          "-dwarf-debug-flags"
 // CHECK-NOT:          "-main-file-name"
 // CHECK-NOT:          "-include"
@@ -50,6 +53,7 @@
 // CHECK-NOT:          "-fcoverage-compilation-dir=
 // CHECK-NOT:          "-coverage-notes-file
 // CHECK-NOT:          "-coverage-data-file
+// CHECK-NOT:          "-fprofile-instrument-use-path
 // CHECK-NOT:          "-dwarf-debug-flags"
 // CHECK-NOT:          "-main-file-name"
 // CHECK-NOT:          "-include"