diff --git a/clang/lib/Driver/ToolChains/Linux.cpp b/clang/lib/Driver/ToolChains/Linux.cpp
index 7df49c787c8e4e..222c351016a798 100644
--- a/clang/lib/Driver/ToolChains/Linux.cpp
+++ b/clang/lib/Driver/ToolChains/Linux.cpp
@@ -840,6 +840,7 @@ SanitizerMask Linux::getSupportedSanitizers() const {
                          getTriple().getArch() == llvm::Triple::thumb ||
                          getTriple().getArch() == llvm::Triple::armeb ||
                          getTriple().getArch() == llvm::Triple::thumbeb;
+  const bool IsSystemZ = getTriple().getArch() == llvm::Triple::systemz;
   SanitizerMask Res = ToolChain::getSupportedSanitizers();
   Res |= SanitizerKind::Address;
   Res |= SanitizerKind::PointerCompare;
@@ -852,7 +853,8 @@ SanitizerMask Linux::getSupportedSanitizers() const {
   Res |= SanitizerKind::SafeStack;
   if (IsX86_64 || IsMIPS64 || IsAArch64)
     Res |= SanitizerKind::DataFlow;
-  if (IsX86_64 || IsMIPS64 || IsAArch64 || IsX86 || IsArmArch || IsPowerPC64)
+  if (IsX86_64 || IsMIPS64 || IsAArch64 || IsX86 || IsArmArch || IsPowerPC64 ||
+      IsSystemZ)
     Res |= SanitizerKind::Leak;
   if (IsX86_64 || IsMIPS64 || IsAArch64 || IsPowerPC64)
     Res |= SanitizerKind::Thread;
diff --git a/compiler-rt/cmake/config-ix.cmake b/compiler-rt/cmake/config-ix.cmake
index ef62d701dee200..1f3697ff6f6595 100644
--- a/compiler-rt/cmake/config-ix.cmake
+++ b/compiler-rt/cmake/config-ix.cmake
@@ -303,7 +303,7 @@ set(ALL_GWP_ASAN_SUPPORTED_ARCH ${X86} ${X86_64})
 if(APPLE)
   set(ALL_LSAN_SUPPORTED_ARCH ${X86} ${X86_64} ${MIPS64} ${ARM64})
 else()
-  set(ALL_LSAN_SUPPORTED_ARCH ${X86} ${X86_64} ${MIPS64} ${ARM64} ${ARM32} ${PPC64})
+  set(ALL_LSAN_SUPPORTED_ARCH ${X86} ${X86_64} ${MIPS64} ${ARM64} ${ARM32} ${PPC64} ${S390X})
 endif()
 set(ALL_MSAN_SUPPORTED_ARCH ${X86_64} ${MIPS64} ${ARM64} ${PPC64} ${S390X})
 set(ALL_HWASAN_SUPPORTED_ARCH ${X86_64} ${ARM64})
diff --git a/compiler-rt/lib/lsan/lsan_allocator.h b/compiler-rt/lib/lsan/lsan_allocator.h
index bda9d8cdf746dd..17e13cd014ba43 100644
--- a/compiler-rt/lib/lsan/lsan_allocator.h
+++ b/compiler-rt/lib/lsan/lsan_allocator.h
@@ -65,13 +65,16 @@ struct AP32 {
 template <typename AddressSpaceView>
 using PrimaryAllocatorASVT = SizeClassAllocator32<AP32<AddressSpaceView>>;
 using PrimaryAllocator = PrimaryAllocatorASVT<LocalAddressSpaceView>;
-#elif defined(__x86_64__) || defined(__powerpc64__)
+#elif defined(__x86_64__) || defined(__powerpc64__) || defined(__s390x__)
 # if SANITIZER_FUCHSIA
 const uptr kAllocatorSpace = ~(uptr)0;
 const uptr kAllocatorSize  =  0x40000000000ULL;  // 4T.
 # elif defined(__powerpc64__)
 const uptr kAllocatorSpace = 0xa0000000000ULL;
 const uptr kAllocatorSize  = 0x20000000000ULL;  // 2T.
+#elif defined(__s390x__)
+const uptr kAllocatorSpace = 0x40000000000ULL;
+const uptr kAllocatorSize = 0x40000000000ULL;  // 4T.
 # else
 const uptr kAllocatorSpace = 0x600000000000ULL;
 const uptr kAllocatorSize  = 0x40000000000ULL;  // 4T.
diff --git a/compiler-rt/lib/lsan/lsan_common.h b/compiler-rt/lib/lsan/lsan_common.h
index 6252d52c19781c..3434beede82890 100644
--- a/compiler-rt/lib/lsan/lsan_common.h
+++ b/compiler-rt/lib/lsan/lsan_common.h
@@ -29,10 +29,10 @@
 // To enable LeakSanitizer on a new architecture, one needs to implement the
 // internal_clone function as well as (probably) adjust the TLS machinery for
 // the new architecture inside the sanitizer library.
-#if (SANITIZER_LINUX && !SANITIZER_ANDROID || SANITIZER_MAC) && \
-    (SANITIZER_WORDSIZE == 64) &&                               \
+#if (SANITIZER_LINUX && !SANITIZER_ANDROID || SANITIZER_MAC) &&          \
+    (SANITIZER_WORDSIZE == 64) &&                                        \
     (defined(__x86_64__) || defined(__mips64) || defined(__aarch64__) || \
-     defined(__powerpc64__))
+     defined(__powerpc64__) || defined(__s390x__))
 #define CAN_SANITIZE_LEAKS 1
 #elif defined(__i386__) && \
     (SANITIZER_LINUX && !SANITIZER_ANDROID || SANITIZER_MAC)
diff --git a/compiler-rt/test/lsan/TestCases/stale_stack_leak.cpp b/compiler-rt/test/lsan/TestCases/stale_stack_leak.cpp
index 32627dbc58938d..505e62762629fa 100644
--- a/compiler-rt/test/lsan/TestCases/stale_stack_leak.cpp
+++ b/compiler-rt/test/lsan/TestCases/stale_stack_leak.cpp
@@ -5,7 +5,8 @@
 // RUN: %env_lsan_opts=$LSAN_BASE":exitcode=0" %run %t 2>&1 | FileCheck --check-prefix=CHECK-sanity %s
 //
 // x86 passes parameters through stack that may lead to false negatives
-// UNSUPPORTED: x86,powerpc64,arm
+// The same applies to s390x register save areas.
+// UNSUPPORTED: x86,powerpc64,arm,s390x
 
 #include <stdio.h>
 #include <stdlib.h>
diff --git a/compiler-rt/test/lsan/TestCases/use_registers.cpp b/compiler-rt/test/lsan/TestCases/use_registers.cpp
index edcf1ae1631e8c..63ab282d4340c3 100644
--- a/compiler-rt/test/lsan/TestCases/use_registers.cpp
+++ b/compiler-rt/test/lsan/TestCases/use_registers.cpp
@@ -43,6 +43,10 @@ void *registers_thread_func(void *arg) {
       :
       : "r" (p)
       );
+#elif defined(__s390x__)
+  asm("lgr %%r10, %0"
+      :
+      : "r"(p));
 #else
 #error "Test is not supported on this architecture."
 #endif
diff --git a/compiler-rt/test/lsan/lit.common.cfg.py b/compiler-rt/test/lsan/lit.common.cfg.py
index 208d9f92eeb0c4..6b699b274c637b 100644
--- a/compiler-rt/test/lsan/lit.common.cfg.py
+++ b/compiler-rt/test/lsan/lit.common.cfg.py
@@ -69,8 +69,8 @@ def build_invocation(compile_flags):
 config.substitutions.append( ("%clang_lsan ", build_invocation(clang_lsan_cflags)) )
 config.substitutions.append( ("%clangxx_lsan ", build_invocation(clang_lsan_cxxflags)) )
 
-# LeakSanitizer tests are currently supported on x86-64 Linux, PowerPC64 Linux, arm Linux, mips64 Linux, and x86_64 Darwin.
-supported_linux = config.host_os == 'Linux' and config.host_arch in ['x86_64', 'ppc64', 'ppc64le', 'mips64', 'arm', 'armhf', 'armv7l']
+# LeakSanitizer tests are currently supported on x86-64 Linux, PowerPC64 Linux, arm Linux, mips64 Linux, s390x Linux and x86_64 Darwin.
+supported_linux = config.host_os is 'Linux' and config.host_arch in ['x86_64', 'ppc64', 'ppc64le', 'mips64', 'arm', 'armhf', 'armv7l', 's390x']
 supported_darwin = config.host_os == 'Darwin' and config.target_arch in ['x86_64']
 supported_netbsd = config.host_os == 'NetBSD' and config.target_arch in ['x86_64', 'i386']
 if not (supported_linux or supported_darwin or supported_netbsd):
diff --git a/compiler-rt/test/sanitizer_common/print_address.h b/compiler-rt/test/sanitizer_common/print_address.h
index db2e8341a9d2dd..e7bb1a36897722 100644
--- a/compiler-rt/test/sanitizer_common/print_address.h
+++ b/compiler-rt/test/sanitizer_common/print_address.h
@@ -7,7 +7,8 @@ void print_address(const char *str, int n, ...) {
   va_start(ap, n);
   while (n--) {
     void *p = va_arg(ap, void *);
-#if defined(__x86_64__) || defined(__aarch64__) || defined(__powerpc64__)
+#if defined(__x86_64__) || defined(__aarch64__) || defined(__powerpc64__) || \
+    defined(__s390x__)
     // On FreeBSD, the %p conversion specifier works as 0x%x and thus does not
     // match to the format used in the diagnotic message.
     fprintf(stderr, "0x%012lx ", (unsigned long) p);