diff --git a/compiler-rt/cmake/base-config-ix.cmake b/compiler-rt/cmake/base-config-ix.cmake
index 55f322538cc27..45e490481bf9f 100644
--- a/compiler-rt/cmake/base-config-ix.cmake
+++ b/compiler-rt/cmake/base-config-ix.cmake
@@ -148,7 +148,13 @@ macro(test_targets)
         endif()
       endif()
     elseif("${COMPILER_RT_DEFAULT_TARGET_ARCH}" MATCHES "powerpc")
+      # Strip out -nodefaultlibs when calling TEST_BIG_ENDIAN. Configuration
+      # will fail with this option when building with a sanitizer.
+      cmake_push_check_state()
+      string(REPLACE "-nodefaultlibs" "" CMAKE_REQUIRED_FLAGS ${OLD_CMAKE_REQUIRED_FLAGS})
       TEST_BIG_ENDIAN(HOST_IS_BIG_ENDIAN)
+      cmake_pop_check_state()
+
       if(HOST_IS_BIG_ENDIAN)
         test_target_arch(powerpc64 "" "-m64")
       else()