diff --git a/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp b/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
index 965a72d3a6500d..ceeddda05fd9a7 100644
--- a/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
@@ -1599,7 +1599,7 @@ Instruction *InstCombinerImpl::foldVectorBinop(BinaryOperator &Inst) {
   Constant *C;
   if (match(&Inst,
             m_c_BinOp(m_OneUse(m_Shuffle(m_Value(V1), m_Undef(), m_Mask(Mask))),
-                      m_Constant(C))) &&
+                      m_Constant(C))) && !isa<ConstantExpr>(C) &&
       cast<FixedVectorType>(V1->getType())->getNumElements() <= NumElts) {
     assert(Inst.getType()->getScalarType() == V1->getType()->getScalarType() &&
            "Shuffle should not change scalar type");
diff --git a/llvm/test/Transforms/InstCombine/vec_shuffle.ll b/llvm/test/Transforms/InstCombine/vec_shuffle.ll
index e7e55b07b7cd10..3f3431c5d9045b 100644
--- a/llvm/test/Transforms/InstCombine/vec_shuffle.ll
+++ b/llvm/test/Transforms/InstCombine/vec_shuffle.ll
@@ -1745,3 +1745,18 @@ define <4 x i32> @splat_assoc_add_mul(<4 x i32> %x, <4 x i32> %y) {
   %r = mul <4 x i32> %splatx, %a
   ret <4 x i32> %r
 }
+
+
+; Do not crash on constant expressions.
+
+define <4 x i32> @PR46872(<4 x i32> %x) {
+; CHECK-LABEL: @PR46872(
+; CHECK-NEXT:    [[S:%.*]] = shufflevector <4 x i32> [[X:%.*]], <4 x i32> undef, <4 x i32> <i32 undef, i32 0, i32 1, i32 1>
+; CHECK-NEXT:    [[A:%.*]] = and <4 x i32> [[S]], bitcast (<2 x i64> <i64 ptrtoint (<4 x i32> (<4 x i32>)* @PR46872 to i64), i64 ptrtoint (<4 x i32> (<4 x i32>)* @PR46872 to i64)> to <4 x i32>)
+; CHECK-NEXT:    ret <4 x i32> [[A]]
+;
+  %s = shufflevector <4 x i32> %x, <4 x i32> undef, <4 x i32> <i32 undef, i32 0, i32 1, i32 1>
+  %a = and <4 x i32> %s, bitcast (<2 x i64> <i64 ptrtoint (<4 x i32> (<4 x i32>)* @PR46872 to i64), i64 ptrtoint (<4 x i32> (<4 x i32>)* @PR46872 to i64)> to <4 x i32>)
+  ret <4 x i32> %a
+}
+