diff --git a/llvm/test/Transforms/IndVarSimplify/pointer-loop-guards.ll b/llvm/test/Transforms/IndVarSimplify/pointer-loop-guards.ll
new file mode 100644
index 0000000000000..89b132e981899
--- /dev/null
+++ b/llvm/test/Transforms/IndVarSimplify/pointer-loop-guards.ll
@@ -0,0 +1,50 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py UTC_ARGS: --version 6
+; RUN: opt -p indvars -S %s | FileCheck %s
+
+declare i1 @cond()
+
+define i64 @test_ptr_compare_guard(ptr %start, ptr %end) {
+; CHECK-LABEL: define i64 @test_ptr_compare_guard(
+; CHECK-SAME: ptr [[START:%.*]], ptr [[END:%.*]]) {
+; CHECK-NEXT:  [[ENTRY:.*]]:
+; CHECK-NEXT:    [[C_0:%.*]] = icmp eq ptr [[START]], [[END]]
+; CHECK-NEXT:    br i1 [[C_0]], label %[[EXIT:.*]], label %[[LOOP_HEADER_PREHEADER:.*]]
+; CHECK:       [[LOOP_HEADER_PREHEADER]]:
+; CHECK-NEXT:    br label %[[LOOP_HEADER:.*]]
+; CHECK:       [[LOOP_HEADER]]:
+; CHECK-NEXT:    [[PTR_IV:%.*]] = phi ptr [ [[PTR_IV_NEXT:%.*]], %[[LOOP_LATCH:.*]] ], [ [[START]], %[[LOOP_HEADER_PREHEADER]] ]
+; CHECK-NEXT:    [[I64_IV:%.*]] = phi i64 [ [[I64_IV_NEXT:%.*]], %[[LOOP_LATCH]] ], [ 0, %[[LOOP_HEADER_PREHEADER]] ]
+; CHECK-NEXT:    [[C_1:%.*]] = call i1 @cond()
+; CHECK-NEXT:    br i1 [[C_1]], label %[[LOOP_LATCH]], label %[[EXIT_LOOPEXIT:.*]]
+; CHECK:       [[LOOP_LATCH]]:
+; CHECK-NEXT:    [[PTR_IV_NEXT]] = getelementptr i8, ptr [[PTR_IV]], i64 1
+; CHECK-NEXT:    [[I64_IV_NEXT]] = add i64 [[I64_IV]], 1
+; CHECK-NEXT:    [[C_2:%.*]] = icmp eq ptr [[PTR_IV_NEXT]], [[END]]
+; CHECK-NEXT:    br i1 [[C_2]], label %[[EXIT_LOOPEXIT]], label %[[LOOP_HEADER]]
+; CHECK:       [[EXIT_LOOPEXIT]]:
+; CHECK-NEXT:    [[RES_PH:%.*]] = phi i64 [ 0, %[[LOOP_HEADER]] ], [ [[I64_IV]], %[[LOOP_LATCH]] ]
+; CHECK-NEXT:    br label %[[EXIT]]
+; CHECK:       [[EXIT]]:
+; CHECK-NEXT:    [[RES:%.*]] = phi i64 [ 0, %[[ENTRY]] ], [ [[RES_PH]], %[[EXIT_LOOPEXIT]] ]
+; CHECK-NEXT:    ret i64 [[RES]]
+;
+entry:
+  %c.0 = icmp eq ptr %start, %end
+  br i1 %c.0, label %exit, label %loop.header
+
+loop.header:
+  %ptr.iv = phi ptr [ %start, %entry ], [ %ptr.iv.next, %loop.latch ]
+  %i64.iv = phi i64 [ 0, %entry ], [ %i64.iv.next, %loop.latch ]
+  %c.1 = call i1 @cond()
+  br i1 %c.1, label %loop.latch, label %exit
+
+loop.latch:
+  %ptr.iv.next = getelementptr i8, ptr %ptr.iv, i64 1
+  %i64.iv.next = add i64 %i64.iv, 1
+  %c.2 = icmp eq ptr %ptr.iv.next, %end
+  br i1 %c.2, label %exit, label %loop.header
+
+exit:
+  %res = phi i64 [ 0, %entry ], [ %i64.iv, %loop.latch ], [ 0, %loop.header ]
+  ret i64 %res
+}
diff --git a/llvm/test/Transforms/LoopVectorize/single-early-exit-deref-assumptions.ll b/llvm/test/Transforms/LoopVectorize/single-early-exit-deref-assumptions.ll
index 9349977c69462..b1b3a3feb007a 100644
--- a/llvm/test/Transforms/LoopVectorize/single-early-exit-deref-assumptions.ll
+++ b/llvm/test/Transforms/LoopVectorize/single-early-exit-deref-assumptions.ll
@@ -1,17 +1,17 @@
-; NOTE: Assertions have been autogenerated by utils/update_test_checks.py UTC_ARGS: --check-globals none --version 4
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py UTC_ARGS: --check-globals none --version 6
 ; RUN: opt -S < %s -p loop-vectorize -enable-early-exit-vectorization -force-vector-width=4 | FileCheck %s
 
 define i64 @early_exit_alignment_and_deref_known_via_assumption_with_constant_size(ptr noalias %p1, ptr noalias %p2) nofree nosync {
 ; CHECK-LABEL: define i64 @early_exit_alignment_and_deref_known_via_assumption_with_constant_size(
 ; CHECK-SAME: ptr noalias [[P1:%.*]], ptr noalias [[P2:%.*]]) #[[ATTR0:[0-9]+]] {
-; CHECK-NEXT:  entry:
+; CHECK-NEXT:  [[ENTRY:.*:]]
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[P1]], i64 4), "dereferenceable"(ptr [[P1]], i64 1024) ]
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[P2]], i64 4), "dereferenceable"(ptr [[P2]], i64 1024) ]
-; CHECK-NEXT:    br label [[VECTOR_PH:%.*]]
-; CHECK:       vector.ph:
-; CHECK-NEXT:    br label [[LOOP:%.*]]
-; CHECK:       vector.body:
-; CHECK-NEXT:    [[INDEX1:%.*]] = phi i64 [ 0, [[VECTOR_PH]] ], [ [[INDEX_NEXT3:%.*]], [[LOOP]] ]
+; CHECK-NEXT:    br label %[[VECTOR_PH:.*]]
+; CHECK:       [[VECTOR_PH]]:
+; CHECK-NEXT:    br label %[[LOOP:.*]]
+; CHECK:       [[LOOP]]:
+; CHECK-NEXT:    [[INDEX1:%.*]] = phi i64 [ 0, %[[VECTOR_PH]] ], [ [[INDEX_NEXT3:%.*]], %[[LOOP]] ]
 ; CHECK-NEXT:    [[TMP0:%.*]] = getelementptr inbounds i8, ptr [[P1]], i64 [[INDEX1]]
 ; CHECK-NEXT:    [[WIDE_LOAD:%.*]] = load <4 x i8>, ptr [[TMP0]], align 1
 ; CHECK-NEXT:    [[TMP2:%.*]] = getelementptr inbounds i8, ptr [[P2]], i64 [[INDEX1]]
@@ -22,31 +22,31 @@ define i64 @early_exit_alignment_and_deref_known_via_assumption_with_constant_si
 ; CHECK-NEXT:    [[TMP5:%.*]] = call i1 @llvm.vector.reduce.or.v4i1(<4 x i1> [[TMP3]])
 ; CHECK-NEXT:    [[TMP6:%.*]] = icmp eq i64 [[INDEX_NEXT3]], 1024
 ; CHECK-NEXT:    [[TMP7:%.*]] = or i1 [[TMP5]], [[TMP6]]
-; CHECK-NEXT:    br i1 [[TMP7]], label [[MIDDLE_SPLIT:%.*]], label [[LOOP]], !llvm.loop [[LOOP0:![0-9]+]]
-; CHECK:       middle.split:
-; CHECK-NEXT:    br i1 [[TMP5]], label [[VECTOR_EARLY_EXIT:%.*]], label [[MIDDLE_BLOCK:%.*]]
-; CHECK:       middle.block:
-; CHECK-NEXT:    br label [[LOOP_END:%.*]]
-; CHECK:       vector.early.exit:
+; CHECK-NEXT:    br i1 [[TMP7]], label %[[MIDDLE_SPLIT:.*]], label %[[LOOP]], !llvm.loop [[LOOP0:![0-9]+]]
+; CHECK:       [[MIDDLE_SPLIT]]:
+; CHECK-NEXT:    br i1 [[TMP5]], label %[[VECTOR_EARLY_EXIT:.*]], label %[[MIDDLE_BLOCK:.*]]
+; CHECK:       [[MIDDLE_BLOCK]]:
+; CHECK-NEXT:    br label %[[LOOP_END:.*]]
+; CHECK:       [[VECTOR_EARLY_EXIT]]:
 ; CHECK-NEXT:    [[TMP8:%.*]] = call i64 @llvm.experimental.cttz.elts.i64.v4i1(<4 x i1> [[TMP4]], i1 true)
 ; CHECK-NEXT:    [[TMP9:%.*]] = add i64 [[INDEX1]], [[TMP8]]
-; CHECK-NEXT:    br label [[LOOP_END]]
-; CHECK:       scalar.ph:
-; CHECK-NEXT:    br label [[LOOP1:%.*]]
-; CHECK:       loop:
-; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ [[INDEX_NEXT:%.*]], [[LOOP_INC:%.*]] ], [ 0, [[SCALAR_PH:%.*]] ]
+; CHECK-NEXT:    br label %[[LOOP_END]]
+; CHECK:       [[SCALAR_PH:.*]]:
+; CHECK-NEXT:    br label %[[LOOP1:.*]]
+; CHECK:       [[LOOP1]]:
+; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ [[INDEX_NEXT:%.*]], %[[LOOP_INC:.*]] ], [ 0, %[[SCALAR_PH]] ]
 ; CHECK-NEXT:    [[ARRAYIDX:%.*]] = getelementptr inbounds i8, ptr [[P1]], i64 [[INDEX]]
 ; CHECK-NEXT:    [[LD1:%.*]] = load i8, ptr [[ARRAYIDX]], align 1
 ; CHECK-NEXT:    [[ARRAYIDX1:%.*]] = getelementptr inbounds i8, ptr [[P2]], i64 [[INDEX]]
 ; CHECK-NEXT:    [[LD2:%.*]] = load i8, ptr [[ARRAYIDX1]], align 1
 ; CHECK-NEXT:    [[CMP3:%.*]] = icmp eq i8 [[LD1]], [[LD2]]
-; CHECK-NEXT:    br i1 [[CMP3]], label [[LOOP_INC]], label [[LOOP_END]]
-; CHECK:       loop.inc:
+; CHECK-NEXT:    br i1 [[CMP3]], label %[[LOOP_INC]], label %[[LOOP_END]]
+; CHECK:       [[LOOP_INC]]:
 ; CHECK-NEXT:    [[INDEX_NEXT]] = add i64 [[INDEX]], 1
 ; CHECK-NEXT:    [[EXITCOND:%.*]] = icmp ne i64 [[INDEX_NEXT]], 1024
-; CHECK-NEXT:    br i1 [[EXITCOND]], label [[LOOP1]], label [[LOOP_END]]
-; CHECK:       loop.end:
-; CHECK-NEXT:    [[RETVAL:%.*]] = phi i64 [ [[INDEX]], [[LOOP1]] ], [ -1, [[LOOP_INC]] ], [ -1, [[MIDDLE_BLOCK]] ], [ [[TMP9]], [[VECTOR_EARLY_EXIT]] ]
+; CHECK-NEXT:    br i1 [[EXITCOND]], label %[[LOOP1]], label %[[LOOP_END]]
+; CHECK:       [[LOOP_END]]:
+; CHECK-NEXT:    [[RETVAL:%.*]] = phi i64 [ [[INDEX]], %[[LOOP1]] ], [ -1, %[[LOOP_INC]] ], [ -1, %[[MIDDLE_BLOCK]] ], [ [[TMP9]], %[[VECTOR_EARLY_EXIT]] ]
 ; CHECK-NEXT:    ret i64 [[RETVAL]]
 ;
 entry:
@@ -76,24 +76,24 @@ loop.end:
 define i64 @early_exit_alignment_and_deref_via_assumption_with_constant_size_too_small(ptr noalias %p1, ptr noalias %p2) nofree nosync {
 ; CHECK-LABEL: define i64 @early_exit_alignment_and_deref_via_assumption_with_constant_size_too_small(
 ; CHECK-SAME: ptr noalias [[P1:%.*]], ptr noalias [[P2:%.*]]) #[[ATTR0]] {
-; CHECK-NEXT:  entry:
+; CHECK-NEXT:  [[ENTRY:.*]]:
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[P1]], i64 4), "dereferenceable"(ptr [[P1]], i64 1024) ]
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[P2]], i64 4), "dereferenceable"(ptr [[P2]], i64 1024) ]
-; CHECK-NEXT:    br label [[LOOP:%.*]]
-; CHECK:       loop:
-; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ [[INDEX_NEXT:%.*]], [[LOOP_INC:%.*]] ], [ 0, [[ENTRY:%.*]] ]
+; CHECK-NEXT:    br label %[[LOOP:.*]]
+; CHECK:       [[LOOP]]:
+; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ [[INDEX_NEXT:%.*]], %[[LOOP_INC:.*]] ], [ 0, %[[ENTRY]] ]
 ; CHECK-NEXT:    [[ARRAYIDX:%.*]] = getelementptr inbounds i8, ptr [[P1]], i64 [[INDEX]]
 ; CHECK-NEXT:    [[LD1:%.*]] = load i8, ptr [[ARRAYIDX]], align 1
 ; CHECK-NEXT:    [[ARRAYIDX1:%.*]] = getelementptr inbounds i8, ptr [[P2]], i64 [[INDEX]]
 ; CHECK-NEXT:    [[LD2:%.*]] = load i8, ptr [[ARRAYIDX1]], align 1
 ; CHECK-NEXT:    [[CMP3:%.*]] = icmp eq i8 [[LD1]], [[LD2]]
-; CHECK-NEXT:    br i1 [[CMP3]], label [[LOOP_INC]], label [[LOOP_END:%.*]]
-; CHECK:       loop.inc:
+; CHECK-NEXT:    br i1 [[CMP3]], label %[[LOOP_INC]], label %[[LOOP_END:.*]]
+; CHECK:       [[LOOP_INC]]:
 ; CHECK-NEXT:    [[INDEX_NEXT]] = add i64 [[INDEX]], 1
 ; CHECK-NEXT:    [[EXITCOND:%.*]] = icmp ne i64 [[INDEX_NEXT]], 1025
-; CHECK-NEXT:    br i1 [[EXITCOND]], label [[LOOP]], label [[LOOP_END]]
-; CHECK:       loop.end:
-; CHECK-NEXT:    [[RETVAL:%.*]] = phi i64 [ [[INDEX]], [[LOOP]] ], [ -1, [[LOOP_INC]] ]
+; CHECK-NEXT:    br i1 [[EXITCOND]], label %[[LOOP]], label %[[LOOP_END]]
+; CHECK:       [[LOOP_END]]:
+; CHECK-NEXT:    [[RETVAL:%.*]] = phi i64 [ [[INDEX]], %[[LOOP]] ], [ -1, %[[LOOP_INC]] ]
 ; CHECK-NEXT:    ret i64 [[RETVAL]]
 ;
 entry:
@@ -123,20 +123,20 @@ loop.end:
 define i64 @early_exit_alignment_and_deref_known_via_assumption_n_not_zero(ptr noalias %p1, ptr noalias %p2, i64 %n) nofree nosync {
 ; CHECK-LABEL: define i64 @early_exit_alignment_and_deref_known_via_assumption_n_not_zero(
 ; CHECK-SAME: ptr noalias [[P1:%.*]], ptr noalias [[P2:%.*]], i64 [[N:%.*]]) #[[ATTR0]] {
-; CHECK-NEXT:  entry:
+; CHECK-NEXT:  [[ENTRY:.*]]:
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[P1]], i64 4), "dereferenceable"(ptr [[P1]], i64 [[N]]) ]
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[P2]], i64 4), "dereferenceable"(ptr [[P2]], i64 [[N]]) ]
 ; CHECK-NEXT:    [[C:%.*]] = icmp ne i64 [[N]], 0
-; CHECK-NEXT:    br i1 [[C]], label [[LOOP_PREHEADER:%.*]], label [[LOOP_END:%.*]]
-; CHECK:       loop.preheader:
+; CHECK-NEXT:    br i1 [[C]], label %[[LOOP_PREHEADER:.*]], label %[[LOOP_END:.*]]
+; CHECK:       [[LOOP_PREHEADER]]:
 ; CHECK-NEXT:    [[MIN_ITERS_CHECK:%.*]] = icmp ult i64 [[N]], 4
-; CHECK-NEXT:    br i1 [[MIN_ITERS_CHECK]], label [[SCALAR_PH:%.*]], label [[VECTOR_PH:%.*]]
-; CHECK:       vector.ph:
+; CHECK-NEXT:    br i1 [[MIN_ITERS_CHECK]], label %[[SCALAR_PH:.*]], label %[[VECTOR_PH:.*]]
+; CHECK:       [[VECTOR_PH]]:
 ; CHECK-NEXT:    [[N_MOD_VF:%.*]] = urem i64 [[N]], 4
 ; CHECK-NEXT:    [[N_VEC:%.*]] = sub i64 [[N]], [[N_MOD_VF]]
-; CHECK-NEXT:    br label [[VECTOR_BODY:%.*]]
-; CHECK:       vector.body:
-; CHECK-NEXT:    [[INDEX1:%.*]] = phi i64 [ 0, [[VECTOR_PH]] ], [ [[INDEX_NEXT3:%.*]], [[VECTOR_BODY]] ]
+; CHECK-NEXT:    br label %[[VECTOR_BODY:.*]]
+; CHECK:       [[VECTOR_BODY]]:
+; CHECK-NEXT:    [[INDEX1:%.*]] = phi i64 [ 0, %[[VECTOR_PH]] ], [ [[INDEX_NEXT3:%.*]], %[[VECTOR_BODY]] ]
 ; CHECK-NEXT:    [[TMP0:%.*]] = getelementptr inbounds i8, ptr [[P1]], i64 [[INDEX1]]
 ; CHECK-NEXT:    [[WIDE_LOAD:%.*]] = load <4 x i8>, ptr [[TMP0]], align 1
 ; CHECK-NEXT:    [[TMP1:%.*]] = getelementptr inbounds i8, ptr [[P2]], i64 [[INDEX1]]
@@ -147,36 +147,36 @@ define i64 @early_exit_alignment_and_deref_known_via_assumption_n_not_zero(ptr n
 ; CHECK-NEXT:    [[TMP4:%.*]] = call i1 @llvm.vector.reduce.or.v4i1(<4 x i1> [[TMP3]])
 ; CHECK-NEXT:    [[TMP5:%.*]] = icmp eq i64 [[INDEX_NEXT3]], [[N_VEC]]
 ; CHECK-NEXT:    [[TMP6:%.*]] = or i1 [[TMP4]], [[TMP5]]
-; CHECK-NEXT:    br i1 [[TMP6]], label [[MIDDLE_SPLIT:%.*]], label [[VECTOR_BODY]], !llvm.loop [[LOOP3:![0-9]+]]
-; CHECK:       middle.split:
-; CHECK-NEXT:    br i1 [[TMP4]], label [[VECTOR_EARLY_EXIT:%.*]], label [[MIDDLE_BLOCK:%.*]]
-; CHECK:       middle.block:
+; CHECK-NEXT:    br i1 [[TMP6]], label %[[MIDDLE_SPLIT:.*]], label %[[VECTOR_BODY]], !llvm.loop [[LOOP3:![0-9]+]]
+; CHECK:       [[MIDDLE_SPLIT]]:
+; CHECK-NEXT:    br i1 [[TMP4]], label %[[VECTOR_EARLY_EXIT:.*]], label %[[MIDDLE_BLOCK:.*]]
+; CHECK:       [[MIDDLE_BLOCK]]:
 ; CHECK-NEXT:    [[CMP_N:%.*]] = icmp eq i64 [[N]], [[N_VEC]]
-; CHECK-NEXT:    br i1 [[CMP_N]], label [[LOOP_END_LOOPEXIT:%.*]], label [[SCALAR_PH]]
-; CHECK:       vector.early.exit:
+; CHECK-NEXT:    br i1 [[CMP_N]], label %[[LOOP_END_LOOPEXIT:.*]], label %[[SCALAR_PH]]
+; CHECK:       [[VECTOR_EARLY_EXIT]]:
 ; CHECK-NEXT:    [[TMP7:%.*]] = call i64 @llvm.experimental.cttz.elts.i64.v4i1(<4 x i1> [[TMP2]], i1 true)
 ; CHECK-NEXT:    [[TMP8:%.*]] = add i64 [[INDEX1]], [[TMP7]]
-; CHECK-NEXT:    br label [[LOOP_END_LOOPEXIT]]
-; CHECK:       scalar.ph:
-; CHECK-NEXT:    [[BC_RESUME_VAL:%.*]] = phi i64 [ [[N_VEC]], [[MIDDLE_BLOCK]] ], [ 0, [[LOOP_PREHEADER]] ]
-; CHECK-NEXT:    br label [[LOOP:%.*]]
-; CHECK:       loop:
-; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ [[INDEX_NEXT:%.*]], [[LOOP_INC:%.*]] ], [ [[BC_RESUME_VAL]], [[SCALAR_PH]] ]
+; CHECK-NEXT:    br label %[[LOOP_END_LOOPEXIT]]
+; CHECK:       [[SCALAR_PH]]:
+; CHECK-NEXT:    [[BC_RESUME_VAL:%.*]] = phi i64 [ [[N_VEC]], %[[MIDDLE_BLOCK]] ], [ 0, %[[LOOP_PREHEADER]] ]
+; CHECK-NEXT:    br label %[[LOOP:.*]]
+; CHECK:       [[LOOP]]:
+; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ [[INDEX_NEXT:%.*]], %[[LOOP_INC:.*]] ], [ [[BC_RESUME_VAL]], %[[SCALAR_PH]] ]
 ; CHECK-NEXT:    [[ARRAYIDX:%.*]] = getelementptr inbounds i8, ptr [[P1]], i64 [[INDEX]]
 ; CHECK-NEXT:    [[LD1:%.*]] = load i8, ptr [[ARRAYIDX]], align 1
 ; CHECK-NEXT:    [[ARRAYIDX1:%.*]] = getelementptr inbounds i8, ptr [[P2]], i64 [[INDEX]]
 ; CHECK-NEXT:    [[LD2:%.*]] = load i8, ptr [[ARRAYIDX1]], align 1
 ; CHECK-NEXT:    [[CMP3:%.*]] = icmp eq i8 [[LD1]], [[LD2]]
-; CHECK-NEXT:    br i1 [[CMP3]], label [[LOOP_INC]], label [[LOOP_END_LOOPEXIT]]
-; CHECK:       loop.inc:
+; CHECK-NEXT:    br i1 [[CMP3]], label %[[LOOP_INC]], label %[[LOOP_END_LOOPEXIT]]
+; CHECK:       [[LOOP_INC]]:
 ; CHECK-NEXT:    [[INDEX_NEXT]] = add i64 [[INDEX]], 1
 ; CHECK-NEXT:    [[EXITCOND:%.*]] = icmp ne i64 [[INDEX_NEXT]], [[N]]
-; CHECK-NEXT:    br i1 [[EXITCOND]], label [[LOOP]], label [[LOOP_END_LOOPEXIT]], !llvm.loop [[LOOP4:![0-9]+]]
-; CHECK:       loop.end.loopexit:
-; CHECK-NEXT:    [[RETVAL_PH:%.*]] = phi i64 [ -1, [[LOOP_INC]] ], [ [[INDEX]], [[LOOP]] ], [ -1, [[MIDDLE_BLOCK]] ], [ [[TMP8]], [[VECTOR_EARLY_EXIT]] ]
-; CHECK-NEXT:    br label [[LOOP_END]]
-; CHECK:       loop.end:
-; CHECK-NEXT:    [[RETVAL:%.*]] = phi i64 [ 0, [[ENTRY:%.*]] ], [ [[RETVAL_PH]], [[LOOP_END_LOOPEXIT]] ]
+; CHECK-NEXT:    br i1 [[EXITCOND]], label %[[LOOP]], label %[[LOOP_END_LOOPEXIT]], !llvm.loop [[LOOP4:![0-9]+]]
+; CHECK:       [[LOOP_END_LOOPEXIT]]:
+; CHECK-NEXT:    [[RETVAL_PH:%.*]] = phi i64 [ -1, %[[LOOP_INC]] ], [ [[INDEX]], %[[LOOP]] ], [ -1, %[[MIDDLE_BLOCK]] ], [ [[TMP8]], %[[VECTOR_EARLY_EXIT]] ]
+; CHECK-NEXT:    br label %[[LOOP_END]]
+; CHECK:       [[LOOP_END]]:
+; CHECK-NEXT:    [[RETVAL:%.*]] = phi i64 [ 0, %[[ENTRY]] ], [ [[RETVAL_PH]], %[[LOOP_END_LOOPEXIT]] ]
 ; CHECK-NEXT:    ret i64 [[RETVAL]]
 ;
 entry:
@@ -207,24 +207,24 @@ loop.end:
 define i64 @early_exit_alignment_and_deref_known_via_assumption_n_may_be_zero(ptr noalias %p1, ptr noalias %p2, i64 %n) nofree nosync {
 ; CHECK-LABEL: define i64 @early_exit_alignment_and_deref_known_via_assumption_n_may_be_zero(
 ; CHECK-SAME: ptr noalias [[P1:%.*]], ptr noalias [[P2:%.*]], i64 [[N:%.*]]) #[[ATTR0]] {
-; CHECK-NEXT:  entry:
+; CHECK-NEXT:  [[ENTRY:.*]]:
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[P1]], i64 4), "dereferenceable"(ptr [[P1]], i64 [[N]]) ]
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[P2]], i64 4), "dereferenceable"(ptr [[P2]], i64 [[N]]) ]
-; CHECK-NEXT:    br label [[LOOP:%.*]]
-; CHECK:       loop:
-; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ [[INDEX_NEXT:%.*]], [[LOOP_INC:%.*]] ], [ 0, [[ENTRY:%.*]] ]
+; CHECK-NEXT:    br label %[[LOOP:.*]]
+; CHECK:       [[LOOP]]:
+; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ [[INDEX_NEXT:%.*]], %[[LOOP_INC:.*]] ], [ 0, %[[ENTRY]] ]
 ; CHECK-NEXT:    [[ARRAYIDX:%.*]] = getelementptr inbounds i8, ptr [[P1]], i64 [[INDEX]]
 ; CHECK-NEXT:    [[LD1:%.*]] = load i8, ptr [[ARRAYIDX]], align 1
 ; CHECK-NEXT:    [[ARRAYIDX1:%.*]] = getelementptr inbounds i8, ptr [[P2]], i64 [[INDEX]]
 ; CHECK-NEXT:    [[LD2:%.*]] = load i8, ptr [[ARRAYIDX1]], align 1
 ; CHECK-NEXT:    [[CMP3:%.*]] = icmp eq i8 [[LD1]], [[LD2]]
-; CHECK-NEXT:    br i1 [[CMP3]], label [[LOOP_INC]], label [[LOOP_END:%.*]]
-; CHECK:       loop.inc:
+; CHECK-NEXT:    br i1 [[CMP3]], label %[[LOOP_INC]], label %[[LOOP_END:.*]]
+; CHECK:       [[LOOP_INC]]:
 ; CHECK-NEXT:    [[INDEX_NEXT]] = add i64 [[INDEX]], 1
 ; CHECK-NEXT:    [[EXITCOND:%.*]] = icmp ne i64 [[INDEX_NEXT]], [[N]]
-; CHECK-NEXT:    br i1 [[EXITCOND]], label [[LOOP]], label [[LOOP_END]]
-; CHECK:       loop.end:
-; CHECK-NEXT:    [[RETVAL:%.*]] = phi i64 [ [[INDEX]], [[LOOP]] ], [ -1, [[LOOP_INC]] ]
+; CHECK-NEXT:    br i1 [[EXITCOND]], label %[[LOOP]], label %[[LOOP_END]]
+; CHECK:       [[LOOP_END]]:
+; CHECK-NEXT:    [[RETVAL:%.*]] = phi i64 [ [[INDEX]], %[[LOOP]] ], [ -1, %[[LOOP_INC]] ]
 ; CHECK-NEXT:    ret i64 [[RETVAL]]
 ;
 entry:
@@ -254,32 +254,32 @@ loop.end:
 define i64 @early_exit_alignment_and_deref_known_via_assumption_n_not_zero_i16(ptr noalias %p1, ptr noalias %p2, i32 %n) nofree nosync {
 ; CHECK-LABEL: define i64 @early_exit_alignment_and_deref_known_via_assumption_n_not_zero_i16(
 ; CHECK-SAME: ptr noalias [[P1:%.*]], ptr noalias [[P2:%.*]], i32 [[N:%.*]]) #[[ATTR0]] {
-; CHECK-NEXT:  entry:
+; CHECK-NEXT:  [[ENTRY:.*]]:
 ; CHECK-NEXT:    [[N_EXT:%.*]] = zext i32 [[N]] to i64
 ; CHECK-NEXT:    [[N_SCALED:%.*]] = shl nuw nsw i64 [[N_EXT]], 1
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[P1]], i64 4), "dereferenceable"(ptr [[P1]], i64 [[N_SCALED]]) ]
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[P2]], i64 4), "dereferenceable"(ptr [[P2]], i64 [[N_SCALED]]) ]
 ; CHECK-NEXT:    [[C:%.*]] = icmp ne i64 [[N_EXT]], 0
-; CHECK-NEXT:    br i1 [[C]], label [[LOOP_PREHEADER:%.*]], label [[LOOP_END:%.*]]
-; CHECK:       loop.preheader:
-; CHECK-NEXT:    br label [[LOOP:%.*]]
-; CHECK:       loop:
-; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ [[INDEX_NEXT:%.*]], [[LOOP_INC:%.*]] ], [ 0, [[LOOP_PREHEADER]] ]
+; CHECK-NEXT:    br i1 [[C]], label %[[LOOP_PREHEADER:.*]], label %[[LOOP_END:.*]]
+; CHECK:       [[LOOP_PREHEADER]]:
+; CHECK-NEXT:    br label %[[LOOP:.*]]
+; CHECK:       [[LOOP]]:
+; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ [[INDEX_NEXT:%.*]], %[[LOOP_INC:.*]] ], [ 0, %[[LOOP_PREHEADER]] ]
 ; CHECK-NEXT:    [[ARRAYIDX:%.*]] = getelementptr inbounds i8, ptr [[P1]], i64 [[INDEX]]
 ; CHECK-NEXT:    [[LD1:%.*]] = load i8, ptr [[ARRAYIDX]], align 1
 ; CHECK-NEXT:    [[ARRAYIDX1:%.*]] = getelementptr inbounds i8, ptr [[P2]], i64 [[INDEX]]
 ; CHECK-NEXT:    [[LD2:%.*]] = load i8, ptr [[ARRAYIDX1]], align 1
 ; CHECK-NEXT:    [[CMP3:%.*]] = icmp eq i8 [[LD1]], [[LD2]]
-; CHECK-NEXT:    br i1 [[CMP3]], label [[LOOP_INC]], label [[LOOP_END_LOOPEXIT:%.*]]
-; CHECK:       loop.inc:
+; CHECK-NEXT:    br i1 [[CMP3]], label %[[LOOP_INC]], label %[[LOOP_END_LOOPEXIT:.*]]
+; CHECK:       [[LOOP_INC]]:
 ; CHECK-NEXT:    [[INDEX_NEXT]] = add i64 [[INDEX]], 1
 ; CHECK-NEXT:    [[EXITCOND:%.*]] = icmp ne i64 [[INDEX_NEXT]], [[N_EXT]]
-; CHECK-NEXT:    br i1 [[EXITCOND]], label [[LOOP]], label [[LOOP_END_LOOPEXIT]]
-; CHECK:       loop.end.loopexit:
-; CHECK-NEXT:    [[RETVAL_PH:%.*]] = phi i64 [ -1, [[LOOP_INC]] ], [ [[INDEX]], [[LOOP]] ]
-; CHECK-NEXT:    br label [[LOOP_END]]
-; CHECK:       loop.end:
-; CHECK-NEXT:    [[RETVAL:%.*]] = phi i64 [ 0, [[ENTRY:%.*]] ], [ [[RETVAL_PH]], [[LOOP_END_LOOPEXIT]] ]
+; CHECK-NEXT:    br i1 [[EXITCOND]], label %[[LOOP]], label %[[LOOP_END_LOOPEXIT]]
+; CHECK:       [[LOOP_END_LOOPEXIT]]:
+; CHECK-NEXT:    [[RETVAL_PH:%.*]] = phi i64 [ -1, %[[LOOP_INC]] ], [ [[INDEX]], %[[LOOP]] ]
+; CHECK-NEXT:    br label %[[LOOP_END]]
+; CHECK:       [[LOOP_END]]:
+; CHECK-NEXT:    [[RETVAL:%.*]] = phi i64 [ 0, %[[ENTRY]] ], [ [[RETVAL_PH]], %[[LOOP_END_LOOPEXIT]] ]
 ; CHECK-NEXT:    ret i64 [[RETVAL]]
 ;
 entry:
@@ -312,28 +312,28 @@ loop.end:
 define i64 @early_exit_alignment_and_deref_known_via_assumption_n_not_zero_i16_ptr_iv(ptr %A, i32 noundef %n) nofree nosync {
 ; CHECK-LABEL: define i64 @early_exit_alignment_and_deref_known_via_assumption_n_not_zero_i16_ptr_iv(
 ; CHECK-SAME: ptr [[A:%.*]], i32 noundef [[N:%.*]]) #[[ATTR0]] {
-; CHECK-NEXT:  entry:
+; CHECK-NEXT:  [[ENTRY:.*]]:
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[A]], i64 2) ]
 ; CHECK-NEXT:    [[N_EXT:%.*]] = zext i32 [[N]] to i64
 ; CHECK-NEXT:    [[MUL:%.*]] = shl i64 [[N_EXT]], 1
 ; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "dereferenceable"(ptr [[A]], i64 [[MUL]]) ]
 ; CHECK-NEXT:    [[A_END:%.*]] = getelementptr i8, ptr [[A]], i64 [[MUL]]
 ; CHECK-NEXT:    [[PRE:%.*]] = icmp eq i32 [[N]], 0
-; CHECK-NEXT:    br i1 [[PRE]], label [[EXIT:%.*]], label [[LOOP_HEADER_PREHEADER:%.*]]
-; CHECK:       loop.header.preheader:
+; CHECK-NEXT:    br i1 [[PRE]], label %[[EXIT:.*]], label %[[LOOP_HEADER_PREHEADER:.*]]
+; CHECK:       [[LOOP_HEADER_PREHEADER]]:
 ; CHECK-NEXT:    [[TMP0:%.*]] = add nsw i64 [[MUL]], -2
 ; CHECK-NEXT:    [[TMP1:%.*]] = lshr i64 [[TMP0]], 1
 ; CHECK-NEXT:    [[TMP2:%.*]] = add nuw i64 [[TMP1]], 1
 ; CHECK-NEXT:    [[MIN_ITERS_CHECK:%.*]] = icmp ult i64 [[TMP2]], 4
-; CHECK-NEXT:    br i1 [[MIN_ITERS_CHECK]], label [[SCALAR_PH:%.*]], label [[VECTOR_PH:%.*]]
-; CHECK:       vector.ph:
+; CHECK-NEXT:    br i1 [[MIN_ITERS_CHECK]], label %[[SCALAR_PH:.*]], label %[[VECTOR_PH:.*]]
+; CHECK:       [[VECTOR_PH]]:
 ; CHECK-NEXT:    [[N_MOD_VF:%.*]] = urem i64 [[TMP2]], 4
 ; CHECK-NEXT:    [[N_VEC:%.*]] = sub i64 [[TMP2]], [[N_MOD_VF]]
 ; CHECK-NEXT:    [[TMP3:%.*]] = mul i64 [[N_VEC]], 2
 ; CHECK-NEXT:    [[IV_NEXT1:%.*]] = getelementptr i8, ptr [[A]], i64 [[TMP3]]
-; CHECK-NEXT:    br label [[LOOP_HEADER1:%.*]]
-; CHECK:       vector.body:
-; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ 0, [[VECTOR_PH]] ], [ [[INDEX_NEXT:%.*]], [[LOOP_HEADER1]] ]
+; CHECK-NEXT:    br label %[[LOOP_HEADER1:.*]]
+; CHECK:       [[LOOP_HEADER1]]:
+; CHECK-NEXT:    [[INDEX:%.*]] = phi i64 [ 0, %[[VECTOR_PH]] ], [ [[INDEX_NEXT:%.*]], %[[LOOP_HEADER1]] ]
 ; CHECK-NEXT:    [[OFFSET_IDX:%.*]] = mul i64 [[INDEX]], 2
 ; CHECK-NEXT:    [[NEXT_GEP:%.*]] = getelementptr i8, ptr [[A]], i64 [[OFFSET_IDX]]
 ; CHECK-NEXT:    [[WIDE_LOAD:%.*]] = load <4 x i16>, ptr [[NEXT_GEP]], align 2
@@ -343,35 +343,35 @@ define i64 @early_exit_alignment_and_deref_known_via_assumption_n_not_zero_i16_p
 ; CHECK-NEXT:    [[TMP7:%.*]] = call i1 @llvm.vector.reduce.or.v4i1(<4 x i1> [[TMP6]])
 ; CHECK-NEXT:    [[TMP8:%.*]] = icmp eq i64 [[INDEX_NEXT]], [[N_VEC]]
 ; CHECK-NEXT:    [[TMP9:%.*]] = or i1 [[TMP7]], [[TMP8]]
-; CHECK-NEXT:    br i1 [[TMP9]], label [[MIDDLE_SPLIT:%.*]], label [[LOOP_HEADER1]], !llvm.loop [[LOOP5:![0-9]+]]
-; CHECK:       middle.split:
-; CHECK-NEXT:    br i1 [[TMP7]], label [[VECTOR_EARLY_EXIT:%.*]], label [[LOOP_LATCH1:%.*]]
-; CHECK:       middle.block:
+; CHECK-NEXT:    br i1 [[TMP9]], label %[[MIDDLE_SPLIT:.*]], label %[[LOOP_HEADER1]], !llvm.loop [[LOOP5:![0-9]+]]
+; CHECK:       [[MIDDLE_SPLIT]]:
+; CHECK-NEXT:    br i1 [[TMP7]], label %[[VECTOR_EARLY_EXIT:.*]], label %[[LOOP_LATCH1:.*]]
+; CHECK:       [[LOOP_LATCH1]]:
 ; CHECK-NEXT:    [[CMP_N:%.*]] = icmp eq i64 [[TMP2]], [[N_VEC]]
-; CHECK-NEXT:    br i1 [[CMP_N]], label [[EXIT_LOOPEXIT:%.*]], label [[SCALAR_PH]]
-; CHECK:       vector.early.exit:
+; CHECK-NEXT:    br i1 [[CMP_N]], label %[[EXIT_LOOPEXIT:.*]], label %[[SCALAR_PH]]
+; CHECK:       [[VECTOR_EARLY_EXIT]]:
 ; CHECK-NEXT:    [[TMP10:%.*]] = call i64 @llvm.experimental.cttz.elts.i64.v4i1(<4 x i1> [[TMP5]], i1 true)
 ; CHECK-NEXT:    [[TMP11:%.*]] = add i64 [[INDEX]], [[TMP10]]
 ; CHECK-NEXT:    [[TMP12:%.*]] = mul i64 [[TMP11]], 2
 ; CHECK-NEXT:    [[TMP13:%.*]] = getelementptr i8, ptr [[A]], i64 [[TMP12]]
-; CHECK-NEXT:    br label [[EXIT_LOOPEXIT]]
-; CHECK:       scalar.ph:
-; CHECK-NEXT:    [[IV1:%.*]] = phi ptr [ [[IV_NEXT1]], [[LOOP_LATCH1]] ], [ [[A]], [[LOOP_HEADER_PREHEADER]] ]
-; CHECK-NEXT:    br label [[LOOP_HEADER:%.*]]
-; CHECK:       loop.header:
-; CHECK-NEXT:    [[IV:%.*]] = phi ptr [ [[IV_NEXT:%.*]], [[LOOP_LATCH:%.*]] ], [ [[IV1]], [[SCALAR_PH]] ]
+; CHECK-NEXT:    br label %[[EXIT_LOOPEXIT]]
+; CHECK:       [[SCALAR_PH]]:
+; CHECK-NEXT:    [[IV1:%.*]] = phi ptr [ [[IV_NEXT1]], %[[LOOP_LATCH1]] ], [ [[A]], %[[LOOP_HEADER_PREHEADER]] ]
+; CHECK-NEXT:    br label %[[LOOP_HEADER:.*]]
+; CHECK:       [[LOOP_HEADER]]:
+; CHECK-NEXT:    [[IV:%.*]] = phi ptr [ [[IV_NEXT:%.*]], %[[LOOP_LATCH:.*]] ], [ [[IV1]], %[[SCALAR_PH]] ]
 ; CHECK-NEXT:    [[L:%.*]] = load i16, ptr [[IV]], align 2
 ; CHECK-NEXT:    [[C_0:%.*]] = icmp eq i16 [[L]], 0
-; CHECK-NEXT:    br i1 [[C_0]], label [[EXIT_LOOPEXIT]], label [[LOOP_LATCH]]
-; CHECK:       loop.latch:
+; CHECK-NEXT:    br i1 [[C_0]], label %[[EXIT_LOOPEXIT]], label %[[LOOP_LATCH]]
+; CHECK:       [[LOOP_LATCH]]:
 ; CHECK-NEXT:    [[IV_NEXT]] = getelementptr inbounds nuw i8, ptr [[IV]], i64 2
 ; CHECK-NEXT:    [[EC:%.*]] = icmp eq ptr [[IV_NEXT]], [[A_END]]
-; CHECK-NEXT:    br i1 [[EC]], label [[EXIT_LOOPEXIT]], label [[LOOP_HEADER]], !llvm.loop [[LOOP6:![0-9]+]]
-; CHECK:       exit.loopexit:
-; CHECK-NEXT:    [[P_PH:%.*]] = phi ptr [ [[A_END]], [[LOOP_LATCH]] ], [ [[IV]], [[LOOP_HEADER]] ], [ [[A_END]], [[LOOP_LATCH1]] ], [ [[TMP13]], [[VECTOR_EARLY_EXIT]] ]
-; CHECK-NEXT:    br label [[EXIT]]
-; CHECK:       exit:
-; CHECK-NEXT:    [[P:%.*]] = phi ptr [ [[A]], [[ENTRY:%.*]] ], [ [[P_PH]], [[EXIT_LOOPEXIT]] ]
+; CHECK-NEXT:    br i1 [[EC]], label %[[EXIT_LOOPEXIT]], label %[[LOOP_HEADER]], !llvm.loop [[LOOP6:![0-9]+]]
+; CHECK:       [[EXIT_LOOPEXIT]]:
+; CHECK-NEXT:    [[P_PH:%.*]] = phi ptr [ [[A_END]], %[[LOOP_LATCH]] ], [ [[IV]], %[[LOOP_HEADER]] ], [ [[A_END]], %[[LOOP_LATCH1]] ], [ [[TMP13]], %[[VECTOR_EARLY_EXIT]] ]
+; CHECK-NEXT:    br label %[[EXIT]]
+; CHECK:       [[EXIT]]:
+; CHECK-NEXT:    [[P:%.*]] = phi ptr [ [[A]], %[[ENTRY]] ], [ [[P_PH]], %[[EXIT_LOOPEXIT]] ]
 ; CHECK-NEXT:    [[RES:%.*]] = ptrtoint ptr [[P]] to i64
 ; CHECK-NEXT:    ret i64 [[RES]]
 ;
@@ -400,3 +400,117 @@ exit:
   %res = ptrtoint ptr %p to i64
   ret i64 %res
 }
+
+; TODO: The existing assumptions should be strong enough to vectorize this.
+define ptr @find_deref_pointer_distance_align_attribute_argument(ptr align 2 %first, ptr align 2 %last) nofree nosync {
+; CHECK-LABEL: define ptr @find_deref_pointer_distance_align_attribute_argument(
+; CHECK-SAME: ptr align 2 [[FIRST:%.*]], ptr align 2 [[LAST:%.*]]) #[[ATTR0]] {
+; CHECK-NEXT:  [[ENTRY:.*]]:
+; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[FIRST]], i64 2) ]
+; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[LAST]], i64 2) ]
+; CHECK-NEXT:    [[LAST_I64:%.*]] = ptrtoint ptr [[LAST]] to i64
+; CHECK-NEXT:    [[FIRST_I64:%.*]] = ptrtoint ptr [[FIRST]] to i64
+; CHECK-NEXT:    [[DISTANCE:%.*]] = sub i64 [[LAST_I64]], [[FIRST_I64]]
+; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "dereferenceable"(ptr [[FIRST]], i64 [[DISTANCE]]) ]
+; CHECK-NEXT:    [[C_0:%.*]] = icmp eq ptr [[FIRST]], [[LAST]]
+; CHECK-NEXT:    br i1 [[C_0]], label %[[EXIT:.*]], label %[[LOOP_HEADER_PREHEADER:.*]]
+; CHECK:       [[LOOP_HEADER_PREHEADER]]:
+; CHECK-NEXT:    br label %[[LOOP_HEADER:.*]]
+; CHECK:       [[LOOP_HEADER]]:
+; CHECK-NEXT:    [[IV:%.*]] = phi ptr [ [[IV_NEXT:%.*]], %[[LOOP_LATCH:.*]] ], [ [[FIRST]], %[[LOOP_HEADER_PREHEADER]] ]
+; CHECK-NEXT:    [[L:%.*]] = load i16, ptr [[IV]], align 2
+; CHECK-NEXT:    [[C_1:%.*]] = icmp eq i16 [[L]], 1
+; CHECK-NEXT:    br i1 [[C_1]], label %[[EXIT_LOOPEXIT:.*]], label %[[LOOP_LATCH]]
+; CHECK:       [[LOOP_LATCH]]:
+; CHECK-NEXT:    [[IV_NEXT]] = getelementptr inbounds nuw i8, ptr [[IV]], i64 2
+; CHECK-NEXT:    [[C_2:%.*]] = icmp eq ptr [[IV_NEXT]], [[LAST]]
+; CHECK-NEXT:    br i1 [[C_2]], label %[[EXIT_LOOPEXIT]], label %[[LOOP_HEADER]]
+; CHECK:       [[EXIT_LOOPEXIT]]:
+; CHECK-NEXT:    [[FIRST_ADDR_0_LCSSA_I_PH:%.*]] = phi ptr [ [[IV_NEXT]], %[[LOOP_LATCH]] ], [ [[IV]], %[[LOOP_HEADER]] ]
+; CHECK-NEXT:    br label %[[EXIT]]
+; CHECK:       [[EXIT]]:
+; CHECK-NEXT:    [[FIRST_ADDR_0_LCSSA_I:%.*]] = phi ptr [ [[FIRST]], %[[ENTRY]] ], [ [[FIRST_ADDR_0_LCSSA_I_PH]], %[[EXIT_LOOPEXIT]] ]
+; CHECK-NEXT:    ret ptr [[FIRST_ADDR_0_LCSSA_I]]
+;
+entry:
+  call void @llvm.assume(i1 true) [ "align"(ptr %first, i64 2) ]
+  call void @llvm.assume(i1 true) [ "align"(ptr %last, i64 2) ]
+  %last.i64 = ptrtoint ptr %last to i64
+  %first.i64 = ptrtoint ptr %first to i64
+  %distance = sub i64 %last.i64, %first.i64
+  call void @llvm.assume(i1 true) [ "dereferenceable"(ptr %first, i64 %distance) ]
+  %c.0 = icmp eq ptr %first, %last
+  br i1 %c.0, label %exit, label %loop.header
+
+loop.header:
+  %iv = phi ptr [ %first, %entry ], [ %iv.next, %loop.latch ]
+  %l = load i16, ptr %iv, align 2
+  %c.1 = icmp eq i16 %l, 1
+  br i1 %c.1, label %exit, label %loop.latch
+
+loop.latch:
+  %iv.next = getelementptr inbounds nuw i8, ptr %iv, i64 2
+  %c.2 = icmp eq ptr %iv.next, %last
+  br i1 %c.2, label %exit, label %loop.header
+
+exit:
+  %first.addr.0.lcssa.i = phi ptr [ %first, %entry ], [ %iv, %loop.header ], [ %iv.next, %loop.latch ]
+  ret ptr %first.addr.0.lcssa.i
+}
+
+; TODO: The existing assumptions should be strong enough to vectorize this.
+define ptr @find_deref_pointer_distance_align_assumption(ptr %first, ptr %last) nofree nosync {
+; CHECK-LABEL: define ptr @find_deref_pointer_distance_align_assumption(
+; CHECK-SAME: ptr [[FIRST:%.*]], ptr [[LAST:%.*]]) #[[ATTR0]] {
+; CHECK-NEXT:  [[ENTRY:.*]]:
+; CHECK-NEXT:    [[LAST_I64:%.*]] = ptrtoint ptr [[LAST]] to i64
+; CHECK-NEXT:    [[FIRST_I64:%.*]] = ptrtoint ptr [[FIRST]] to i64
+; CHECK-NEXT:    [[DISTANCE:%.*]] = sub i64 [[LAST_I64]], [[FIRST_I64]]
+; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[FIRST]], i64 2) ]
+; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "align"(ptr [[LAST]], i64 2) ]
+; CHECK-NEXT:    call void @llvm.assume(i1 true) [ "dereferenceable"(ptr [[FIRST]], i64 [[DISTANCE]]) ]
+; CHECK-NEXT:    [[C_0:%.*]] = icmp eq ptr [[FIRST]], [[LAST]]
+; CHECK-NEXT:    br i1 [[C_0]], label %[[EXIT:.*]], label %[[LOOP_HEADER_PREHEADER:.*]]
+; CHECK:       [[LOOP_HEADER_PREHEADER]]:
+; CHECK-NEXT:    br label %[[LOOP_HEADER:.*]]
+; CHECK:       [[LOOP_HEADER]]:
+; CHECK-NEXT:    [[IV:%.*]] = phi ptr [ [[IV_NEXT:%.*]], %[[LOOP_LATCH:.*]] ], [ [[FIRST]], %[[LOOP_HEADER_PREHEADER]] ]
+; CHECK-NEXT:    [[L:%.*]] = load i16, ptr [[IV]], align 2
+; CHECK-NEXT:    [[C_1:%.*]] = icmp eq i16 [[L]], 1
+; CHECK-NEXT:    br i1 [[C_1]], label %[[EXIT_LOOPEXIT:.*]], label %[[LOOP_LATCH]]
+; CHECK:       [[LOOP_LATCH]]:
+; CHECK-NEXT:    [[IV_NEXT]] = getelementptr inbounds nuw i8, ptr [[IV]], i64 2
+; CHECK-NEXT:    [[C_2:%.*]] = icmp eq ptr [[IV_NEXT]], [[LAST]]
+; CHECK-NEXT:    br i1 [[C_2]], label %[[EXIT_LOOPEXIT]], label %[[LOOP_HEADER]]
+; CHECK:       [[EXIT_LOOPEXIT]]:
+; CHECK-NEXT:    [[FIRST_ADDR_0_LCSSA_I_PH:%.*]] = phi ptr [ [[IV_NEXT]], %[[LOOP_LATCH]] ], [ [[IV]], %[[LOOP_HEADER]] ]
+; CHECK-NEXT:    br label %[[EXIT]]
+; CHECK:       [[EXIT]]:
+; CHECK-NEXT:    [[FIRST_ADDR_0_LCSSA_I:%.*]] = phi ptr [ [[FIRST]], %[[ENTRY]] ], [ [[FIRST_ADDR_0_LCSSA_I_PH]], %[[EXIT_LOOPEXIT]] ]
+; CHECK-NEXT:    ret ptr [[FIRST_ADDR_0_LCSSA_I]]
+;
+entry:
+  %last.i64 = ptrtoint ptr %last to i64
+  %first.i64 = ptrtoint ptr %first to i64
+  %distance = sub i64 %last.i64, %first.i64
+  call void @llvm.assume(i1 true) [ "align"(ptr %first, i64 2) ]
+  call void @llvm.assume(i1 true) [ "align"(ptr %last, i64 2) ]
+  call void @llvm.assume(i1 true) [ "dereferenceable"(ptr %first, i64 %distance) ]
+  %c.0 = icmp eq ptr %first, %last
+  br i1 %c.0, label %exit, label %loop.header
+
+loop.header:
+  %iv = phi ptr [ %first, %entry ], [ %iv.next, %loop.latch ]
+  %l = load i16, ptr %iv, align 2
+  %c.1 = icmp eq i16 %l, 1
+  br i1 %c.1, label %exit, label %loop.latch
+
+loop.latch:
+  %iv.next = getelementptr inbounds nuw i8, ptr %iv, i64 2
+  %c.2 = icmp eq ptr %iv.next, %last
+  br i1 %c.2, label %exit, label %loop.header
+
+exit:
+  %first.addr.0.lcssa.i = phi ptr [ %first, %entry ], [ %iv, %loop.header ], [ %iv.next, %loop.latch ]
+  ret ptr %first.addr.0.lcssa.i
+}