diff --git a/llvm/lib/Target/SPIRV/SPIRVAsmPrinter.cpp b/llvm/lib/Target/SPIRV/SPIRVAsmPrinter.cpp
index b765fecbc8de3..56a6168775365 100644
--- a/llvm/lib/Target/SPIRV/SPIRVAsmPrinter.cpp
+++ b/llvm/lib/Target/SPIRV/SPIRVAsmPrinter.cpp
@@ -139,8 +139,8 @@ void SPIRVAsmPrinter::emitEndOfAsmFile(Module &M) {
 // anymore.
 void SPIRVAsmPrinter::cleanUp(Module &M) {
   // Verifier disallows uses of intrinsic global variables.
-  for (StringRef GVName : {"llvm.global_ctors", "llvm.global_dtors",
-                           "llvm.used", "llvm.compiler.used"}) {
+  for (StringRef GVName :
+       {"llvm.global_ctors", "llvm.global_dtors", "llvm.used"}) {
     if (GlobalVariable *GV = M.getNamedGlobal(GVName))
       GV->setName("");
   }
diff --git a/llvm/lib/Target/SPIRV/SPIRVEmitIntrinsics.cpp b/llvm/lib/Target/SPIRV/SPIRVEmitIntrinsics.cpp
index e16c8f0fc302e..c6c618218006a 100644
--- a/llvm/lib/Target/SPIRV/SPIRVEmitIntrinsics.cpp
+++ b/llvm/lib/Target/SPIRV/SPIRVEmitIntrinsics.cpp
@@ -17,6 +17,7 @@
 #include "SPIRVTargetMachine.h"
 #include "SPIRVUtils.h"
 #include "llvm/ADT/DenseSet.h"
+#include "llvm/ADT/StringSet.h"
 #include "llvm/IR/IRBuilder.h"
 #include "llvm/IR/InstIterator.h"
 #include "llvm/IR/InstVisitor.h"
@@ -2028,9 +2029,13 @@ Instruction *SPIRVEmitIntrinsics::visitUnreachableInst(UnreachableInst &I) {
 
 void SPIRVEmitIntrinsics::processGlobalValue(GlobalVariable &GV,
                                              IRBuilder<> &B) {
-  // Skip special artifical variable llvm.global.annotations.
-  if (GV.getName() == "llvm.global.annotations")
+  // Skip special artificial variables.
+  static const StringSet<> ArtificialGlobals{"llvm.global.annotations",
+                                             "llvm.compiler.used"};
+
+  if (ArtificialGlobals.contains(GV.getName()))
     return;
+
   Constant *Init = nullptr;
   if (hasInitializer(&GV)) {
     // Deduce element type and store results in Global Registry.
diff --git a/llvm/test/CodeGen/SPIRV/llvm-compiler-used.ll b/llvm/test/CodeGen/SPIRV/llvm-compiler-used.ll
new file mode 100644
index 0000000000000..ddc2585f2da7e
--- /dev/null
+++ b/llvm/test/CodeGen/SPIRV/llvm-compiler-used.ll
@@ -0,0 +1,19 @@
+; RUN: llc -verify-machineinstrs -mtriple=spirv-unknown-unknown %s -o - | FileCheck %s
+; RUN: %if spirv-tools %{ llc -mtriple=spirv-unknown-unknown %s -o - -filetype=obj | spirv-val %}
+; RUN: llc -verify-machineinstrs -mtriple=spirv-unknown-vulkan %s -o - | FileCheck %s
+; RUN: %if spirv-tools %{ llc -mtriple=spirv-unknown-vulkan %s -o - -filetype=obj | spirv-val %}
+
+; Verify that llvm.compiler.used is not lowered.
+; CHECK: OpName %{{[0-9]+}} "unused"
+; CHECK-NOT: OpName %{{[0-9]+}} "llvm.compiler.used"
+
+; Check that the type of llvm.compiler.used is not emitted too.
+; CHECK-NOT: OpTypeArray
+
+@unused = private addrspace(3) global i32 0
+@llvm.compiler.used = appending addrspace(2) global [1 x ptr addrspace (4)] [ptr addrspace(4) addrspacecast (ptr addrspace(3) @unused to ptr addrspace(4))]
+
+define spir_func void @foo() {
+entry:
+  ret void
+}