diff --git a/.github/workflows/release-binaries.yml b/.github/workflows/release-binaries.yml
index 3f2eb3a1d8ea8..fadada54d5ed9 100644
--- a/.github/workflows/release-binaries.yml
+++ b/.github/workflows/release-binaries.yml
@@ -132,11 +132,6 @@ jobs:
             arches=arm64
           else
             arches=x86_64
-            # Disable Flang builds on macOS x86_64.  The FortranLower library takes
-            # 2-3 hours to build on macOS, much slower than on Linux.
-            # The long build time causes the release build to time out on x86_64,
-            # so we need to disable flang there.
-            target_cmake_flags="$target_cmake_flags -DLLVM_RELEASE_ENABLE_PROJECTS='clang;lld;lldb;clang-tools-extra;polly;mlir'"
           fi
           target_cmake_flags="$target_cmake_flags -DBOOTSTRAP_BOOTSTRAP_DARWIN_osx_ARCHS=$arches -DBOOTSTRAP_BOOTSTRAP_DARWIN_osx_BUILTIN_ARCHS=$arches"
         fi
diff --git a/clang/cmake/caches/Release.cmake b/clang/cmake/caches/Release.cmake
index 82bfdc0cfd565..25f7970119d07 100644
--- a/clang/cmake/caches/Release.cmake
+++ b/clang/cmake/caches/Release.cmake
@@ -30,12 +30,18 @@ endfunction()
 #
 # cmake -D LLVM_RELEASE_ENABLE_PGO=ON -C Release.cmake
 
-set (DEFAULT_PROJECTS "clang;lld;lldb;clang-tools-extra;polly;mlir;flang")
+set (DEFAULT_PROJECTS "clang;lld;lldb;clang-tools-extra;polly;mlir")
 # bolt only supports ELF, so only enable it for Linux.
 if (${CMAKE_HOST_SYSTEM_NAME} MATCHES "Linux")
   list(APPEND DEFAULT_PROJECTS "bolt")
 endif()
 
+# Don't build flang on Darwin due to:
+# https://github.com/llvm/llvm-project/issues/160546
+if (NOT ${CMAKE_HOST_SYSTEM_NAME} MATCHES "Darwin")
+  list(APPEND DEFAULT_PROJECTS "flang")
+endif()
+
 set (DEFAULT_RUNTIMES "compiler-rt;libcxx")
 if (NOT WIN32)
   list(APPEND DEFAULT_RUNTIMES "libcxxabi" "libunwind")