diff --git a/lldb/cmake/modules/LLDBConfig.cmake b/lldb/cmake/modules/LLDBConfig.cmake
index 89da2341839bc..9509859344bc5 100644
--- a/lldb/cmake/modules/LLDBConfig.cmake
+++ b/lldb/cmake/modules/LLDBConfig.cmake
@@ -182,16 +182,21 @@ if (LLDB_ENABLE_PYTHON)
 
   # Enable targeting the Python Limited C API.
   set(PYTHON_LIMITED_API_MIN_SWIG_VERSION "4.2")
+  set(AFFECTED_BY_SWIG_BUG SWIG_VERSION VERSION_EQUAL "4.4.0" AND Python3_VERSION VERSION_GREATER_EQUAL "3.13")
   if (SWIG_VERSION VERSION_GREATER_EQUAL PYTHON_LIMITED_API_MIN_SWIG_VERSION
-      AND NOT LLDB_EMBED_PYTHON_HOME)
+      AND NOT LLDB_EMBED_PYTHON_HOME AND NOT AFFECTED_BY_SWIG_BUG)
     set(default_enable_python_limited_api ON)
   else()
     set(default_enable_python_limited_api OFF)
   endif()
+
   option(LLDB_ENABLE_PYTHON_LIMITED_API "Force LLDB to only use the Python Limited API (requires SWIG 4.2 or later)"
     ${default_enable_python_limited_api})
 
   # Diagnose unsupported configurations.
+  if (LLDB_ENABLE_PYTHON_LIMITED_API AND AFFECTED_BY_SWIG_BUG)
+    message(SEND_ERROR "LLDB_ENABLE_PYTHON_LIMITED_API is not compatible with SWIG 4.4.0 and Python 3.13 due to a bug in SWIG: https://github.com/swig/swig/issues/3283")
+  endif()
   if (LLDB_ENABLE_PYTHON_LIMITED_API AND LLDB_EMBED_PYTHON_HOME)
     message(SEND_ERROR "LLDB_ENABLE_PYTHON_LIMITED_API is not compatible with LLDB_EMBED_PYTHON_HOME")
   endif()