diff --git a/llvm/lib/Target/AMDGPU/GCNSubtarget.h b/llvm/lib/Target/AMDGPU/GCNSubtarget.h
index e567176e658b3..34eb8b2266311 100644
--- a/llvm/lib/Target/AMDGPU/GCNSubtarget.h
+++ b/llvm/lib/Target/AMDGPU/GCNSubtarget.h
@@ -1868,6 +1868,12 @@ class GCNSubtarget final : public AMDGPUGenSubtargetInfo,
     return GFX1250Insts && getGeneration() == GFX12;
   }
 
+  // src_flat_scratch_hi cannot be used as a source in SALU producing a 64-bit
+  // result.
+  bool hasFlatScratchHiInB64InstHazard() const {
+    return GFX1250Insts && getGeneration() == GFX12;
+  }
+
   /// \returns true if the subtarget supports clusters of workgroups.
   bool hasClusters() const { return HasClusters; }
 
diff --git a/llvm/lib/Target/AMDGPU/SIInstrInfo.cpp b/llvm/lib/Target/AMDGPU/SIInstrInfo.cpp
index da019b6e476df..50860a9a8e4c1 100644
--- a/llvm/lib/Target/AMDGPU/SIInstrInfo.cpp
+++ b/llvm/lib/Target/AMDGPU/SIInstrInfo.cpp
@@ -6256,6 +6256,17 @@ bool SIInstrInfo::isLegalRegOperand(const MachineInstr &MI, unsigned OpIdx,
       (int)OpIdx == AMDGPU::getNamedOperandIdx(Opc, AMDGPU::OpName::src0) &&
       RI.isSGPRReg(MRI, MO.getReg()))
     return false;
+
+  if (ST.hasFlatScratchHiInB64InstHazard() &&
+      MO.getReg() == AMDGPU::SRC_FLAT_SCRATCH_BASE_HI && isSALU(MI)) {
+    if (const MachineOperand *Dst = getNamedOperand(MI, AMDGPU::OpName::sdst)) {
+      if (AMDGPU::getRegBitWidth(*MRI.getRegClass(Dst->getReg())) == 64)
+        return false;
+    }
+    if (Opc == AMDGPU::S_BITCMP0_B64 || Opc == AMDGPU::S_BITCMP1_B64)
+      return false;
+  }
+
   return true;
 }
 
diff --git a/llvm/test/CodeGen/AMDGPU/hazard-gfx1250-flat-scr-hi.mir b/llvm/test/CodeGen/AMDGPU/hazard-gfx1250-flat-scr-hi.mir
new file mode 100644
index 0000000000000..e661b6859e09d
--- /dev/null
+++ b/llvm/test/CodeGen/AMDGPU/hazard-gfx1250-flat-scr-hi.mir
@@ -0,0 +1,145 @@
+# NOTE: Assertions have been autogenerated by utils/update_mir_test_checks.py UTC_ARGS: --version 6
+# RUN: llc -mtriple=amdgcn -mcpu=gfx1250 -run-pass si-fold-operands %s -o - | FileCheck -check-prefix=GCN %s
+
+---
+name:            s_ashr_i64
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_ashr_i64
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: [[S_ASHR_I64_:%[0-9]+]]:sreg_64 = S_ASHR_I64 undef %2:sreg_64, [[COPY]], implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    %2:sreg_64 = S_ASHR_I64 undef %1:sreg_64, %0, implicit-def $scc
+...
+
+---
+name:            s_lshl_b64
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_lshl_b64
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: [[S_LSHL_B64_:%[0-9]+]]:sreg_64 = S_LSHL_B64 undef %2:sreg_64, [[COPY]], implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    %2:sreg_64 = S_LSHL_B64 undef %1:sreg_64, %0, implicit-def $scc
+...
+
+---
+name:            s_lshr_b64
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_lshr_b64
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: [[S_LSHR_B64_:%[0-9]+]]:sreg_64 = S_LSHR_B64 undef %2:sreg_64, [[COPY]], implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    %2:sreg_64 = S_LSHR_B64 undef %1:sreg_64, %0, implicit-def $scc
+...
+
+---
+name:            s_bfe_i64
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_bfe_i64
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: [[S_BFE_I64_:%[0-9]+]]:sreg_64 = S_BFE_I64 undef %2:sreg_64, [[COPY]], implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    %2:sreg_64 = S_BFE_I64 undef %1:sreg_64, %0, implicit-def $scc
+...
+
+---
+name:            s_bfe_u64
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_bfe_u64
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: [[S_BFE_U64_:%[0-9]+]]:sreg_64 = S_BFE_U64 undef %2:sreg_64, [[COPY]], implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    %2:sreg_64 = S_BFE_U64 undef %1:sreg_64, %0, implicit-def $scc
+...
+
+---
+name:            s_bfm_b64
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_bfm_b64
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: [[S_BFM_B64_:%[0-9]+]]:sreg_64 = S_BFM_B64 [[COPY]], 1, implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    %1:sreg_64 = S_BFM_B64 %0, 1, implicit-def $scc
+...
+
+---
+name:            s_bitcmp0_b64
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_bitcmp0_b64
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: S_BITCMP0_B64 undef %1:sreg_64, [[COPY]], implicit undef $scc, implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    S_BITCMP0_B64 undef %1:sreg_64, %0, implicit undef $scc, implicit-def $scc
+...
+
+---
+name:            s_bitcmp1_b64
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_bitcmp1_b64
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: S_BITCMP1_B64 undef %1:sreg_64, [[COPY]], implicit undef $scc, implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    S_BITCMP1_B64 undef %1:sreg_64, %0, implicit undef $scc, implicit-def $scc
+...
+
+---
+name:            s_bitreplicate_b64_b32
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_bitreplicate_b64_b32
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: [[S_BITREPLICATE_B64_B32_:%[0-9]+]]:sreg_64 = S_BITREPLICATE_B64_B32 [[COPY]], implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    %2:sreg_64 = S_BITREPLICATE_B64_B32 %0, implicit-def $scc
+...
+
+---
+name:            s_bitset0_b64
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_bitset0_b64
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: [[S_BITSET0_B64_:%[0-9]+]]:sreg_64 = S_BITSET0_B64 [[COPY]], undef [[S_BITSET0_B64_]], implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    %1:sreg_64 = S_BITSET0_B64 %0, undef %1:sreg_64, implicit-def $scc
+...
+
+---
+name:            s_bitset1_b64
+tracksRegLiveness: true
+body:             |
+  bb.0:
+
+    ; GCN-LABEL: name: s_bitset1_b64
+    ; GCN: [[COPY:%[0-9]+]]:sreg_32 = COPY $src_flat_scratch_base_hi
+    ; GCN-NEXT: [[S_BITSET1_B64_:%[0-9]+]]:sreg_64 = S_BITSET1_B64 [[COPY]], undef [[S_BITSET1_B64_]], implicit-def $scc
+    %0:sreg_32 = COPY $src_flat_scratch_base_hi
+    %1:sreg_64 = S_BITSET1_B64 %0, undef %1:sreg_64, implicit-def $scc
+...