diff --git a/clang/lib/Format/WhitespaceManager.cpp b/clang/lib/Format/WhitespaceManager.cpp
index cc3cc0f6906cc..ecc696c539226 100644
--- a/clang/lib/Format/WhitespaceManager.cpp
+++ b/clang/lib/Format/WhitespaceManager.cpp
@@ -1295,7 +1295,10 @@ void WhitespaceManager::alignArrayInitializers() {
       bool FoundComplete = false;
       for (unsigned InsideIndex = ChangeIndex + 1; InsideIndex < ChangeEnd;
            ++InsideIndex) {
-        if (Changes[InsideIndex].Tok == C.Tok->MatchingParen) {
+        const auto *Tok = Changes[InsideIndex].Tok;
+        if (Tok->is(tok::pp_define))
+          break;
+        if (Tok == C.Tok->MatchingParen) {
           alignArrayInitializers(ChangeIndex, InsideIndex + 1);
           ChangeIndex = InsideIndex + 1;
           FoundComplete = true;
diff --git a/clang/unittests/Format/FormatTest.cpp b/clang/unittests/Format/FormatTest.cpp
index 8db0500573ec0..760c5a4ce4195 100644
--- a/clang/unittests/Format/FormatTest.cpp
+++ b/clang/unittests/Format/FormatTest.cpp
@@ -22429,6 +22429,19 @@ TEST_F(FormatTest, CatchAlignArrayOfStructuresLeftAlignment) {
                "});",
                Style);
 
+  verifyNoCrash(
+      "PANEL_Ic PANEL_ic[PANEL_IC_NUMBER] =\n"
+      "    {\n"
+      "        {PIC(0),   PIC(0),   PIC(99),  PIC(81),  0}, // Backbox\n"
+      "        {PIC(1),   PIC(83),  PIC(191), PIC(137), 0}, // AK47\n"
+      "\n"
+      "#define PICALL1(a, b, c, d) \\\n"
+      "    { PIC(a), PIC(b), PIC(c), PIC(d), 1 }\n"
+      "\n"
+      "        PICALL1(1, 1, 75, 50),\n"
+      "};",
+      Style);
+
   Style.AlignEscapedNewlines = FormatStyle::ENAS_DontAlign;
   verifyFormat("#define FOO \\\n"
                "  int foo[][2] = { \\\n"