diff --git a/llvm/lib/Target/AMDGPU/SIInstrInfo.cpp b/llvm/lib/Target/AMDGPU/SIInstrInfo.cpp
index d4746b559d925..d05d3c6996261 100644
--- a/llvm/lib/Target/AMDGPU/SIInstrInfo.cpp
+++ b/llvm/lib/Target/AMDGPU/SIInstrInfo.cpp
@@ -3651,6 +3651,9 @@ bool SIInstrInfo::areMemAccessesTriviallyDisjoint(const MachineInstr &MIa,
   if (MIa.hasOrderedMemoryRef() || MIb.hasOrderedMemoryRef())
     return false;
 
+  if (isLDSDMA(MIa) || isLDSDMA(MIb))
+    return false;
+
   // TODO: Should we check the address space from the MachineMemOperand? That
   // would allow us to distinguish objects we know don't alias based on the
   // underlying address space, even if it was lowered to a different one,