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I have Box A z-index layered higher than Box B. Because of some other effects, this is a necessity. Also, because of their layering, Box A visually casts a shadow onto Box B. In normal CSS3, this isn't an issue.
However, when PIE is applied, the VML created by the box-shadow on Box A overlaps all of Box B, which means nothing in Box B is clickable.
Has this issue of VML obscuring mouse interaction been addressed, in cases where the CSS3 effects extend outside of the box?
Logged as issue #98
Short answer: I don't know of any way to prevent this.