diff --git a/mono/utils/mono-threads-coop.c b/mono/utils/mono-threads-coop.c
index 7f2748536830..ed6b1807a3a2 100644
--- a/mono/utils/mono-threads-coop.c
+++ b/mono/utils/mono-threads-coop.c
@@ -288,6 +288,12 @@ mono_threads_exit_gc_safe_region_unbalanced (gpointer cookie, gpointer *stackdat
 	default:
 		g_error ("Unknown thread state");
 	}
+
+	if (info->async_target) {
+		info->async_target (info->user_data);
+		info->async_target = NULL;
+		info->user_data = NULL;
+	}
 }
 
 void
@@ -355,6 +361,12 @@ mono_threads_enter_gc_unsafe_region_unbalanced_with_info (MonoThreadInfo *info,
 		g_error ("Unknown thread state");
 	}
 
+	if (info->async_target) {
+		info->async_target (info->user_data);
+		info->async_target = NULL;
+		info->user_data = NULL;
+	}
+
 	return info;
 }
 
diff --git a/mono/utils/mono-threads.c b/mono/utils/mono-threads.c
index b0e98d43f287..76821d0d3599 100644
--- a/mono/utils/mono-threads.c
+++ b/mono/utils/mono-threads.c
@@ -1005,8 +1005,12 @@ currently used only to deliver exceptions.
 void
 mono_thread_info_setup_async_call (MonoThreadInfo *info, void (*target_func)(void*), void *user_data)
 {
-	/* An async call can only be setup on an async suspended thread */
-	g_assert (mono_thread_info_run_state (info) == STATE_ASYNC_SUSPENDED);
+	if (!mono_threads_is_coop_enabled ()) {
+		/* In non-coop mode, an async call can only be setup on an async suspended thread, but in coop mode, a thread
+		 * may be in blocking state, and will execute the async call when leaving the safepoint, leaving a gc safe
+		 * region or entering a gc unsafe region */
+		g_assert (mono_thread_info_run_state (info) == STATE_ASYNC_SUSPENDED);
+	}
 	/*FIXME this is a bad assert, we probably should do proper locking and fail if one is already set*/
 	g_assert (!info->async_target);
 	info->async_target = target_func;