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Rust implementation


  • Cargo and for package management
  • FFI interface is reusable in other languages
  • Auto-generated C header (cbindgen) and low level bindings (CFFI)
  • Works for PyPy too
  • One wheel per OS (universal)


  • Fewer projects using Rust extensions
  • FFI overhead when calling C code
  • No gradual transition from Python to Rust code
  • Fewer bioinformatics libraries available
  • No NumPy integration
  • Low level abstraction ("what C can represent")

Further reading