diff --git a/multimedia/libheif/Portfile b/multimedia/libheif/Portfile
index 7536f64f1d2e9..fd8ea11071326 100644
--- a/multimedia/libheif/Portfile
+++ b/multimedia/libheif/Portfile
@@ -2,13 +2,14 @@
 
 PortSystem                  1.0
 PortGroup                   github 1.0
+PortGroup                   cmake 1.1
 
-github.setup                strukturag libheif 1.15.2 v
+github.setup                strukturag libheif 1.16.1 v
 revision                    0
 
-checksums                   rmd160  54782c77a0d849aef47eb85ce71b9d527667d9d7 \
-                            sha256  7a4c6077f45180926583e2087571371bdd9cb21b6e6fada85a6fbd544f26a0e2 \
-                            size    1749773
+checksums                   rmd160  3f9cb03118f246cc6516b142208d25252de30fea \
+                            sha256  ac15b54b6d7c315710e156d119b8a1bfc89f29621e99222b2750b1f31c9c3558 \
+                            size    1338412
 
 categories                  multimedia
 license                     LGPL-3+
@@ -18,23 +19,30 @@ long_description            ${name} is {*}${description}.
 
 github.tarball_from         releases
 
-depends_build-append        port:pkgconfig
+depends_build-append \
+                            port:pkgconfig
 
-depends_lib-append          port:dav1d \
-                            path:lib/pkgconfig/gdk-pixbuf-2.0.pc:gdk-pixbuf2 \
+depends_lib-append \
                             port:aom \
-                            path:include/turbojpeg.h:libjpeg-turbo \
+                            port:dav1d \
+                            path:lib/pkgconfig/gdk-pixbuf-2.0.pc:gdk-pixbuf2 \
                             port:libde265 \
+                            path:include/turbojpeg.h:libjpeg-turbo \
                             port:libpng \
                             port:rav1e \
+                            port:svt-av1 \
+                            port:webp \
                             port:x265
 
-compiler.cxx_standard       2011
+configure.args-append \
+                            -DENABLE_PLUGIN_LOADING:BOOL=OFF
 
-configure.args-append       --disable-go
+compiler.cxx_standard       2011
 
 variant tests description {Enable tests} {
-    configure.args-append   --enable-tests
+    configure.args-append \
+                            -DBUILD_TESTING:BOOL=ON \
+                            -DWITH_REDUCED_VISIBILITY:BOOL=OFF
     test.run                yes
 }
 
@@ -43,12 +51,15 @@ platform darwin {
         # TODO: Disable rav1e on 10.6, due to issues with cargo-c; re-enable once fixed
         # See: https://trac.macports.org/ticket/65434
         depends_lib-delete      port:rav1e
-        configure.args-append   --disable-rav1e
+        configure.args-append \
+                                -DWITH_RAV1E:BOOL=OFF
     }
     if {${os.major} < 10 || (${os.major} == 10 && ${build_arch} eq "ppc")} {
         # https://trac.macports.org/ticket/62619
         # aom does not build on 10.6 Rosetta too
         depends_lib-delete      port:aom
-        configure.args-append   --disable-aom
+        configure.args-append \
+                                -DWITH_AOM_DECODER:BOOL=OFF \
+                                -DWITH_AOM_ENCODER:BOOL=OFF
     }
 }