diff --git a/python/py-setuptools/Portfile b/python/py-setuptools/Portfile
index f099bf514d087..83430ad109798 100644
--- a/python/py-setuptools/Portfile
+++ b/python/py-setuptools/Portfile
@@ -4,7 +4,7 @@ PortSystem          1.0
 PortGroup           python 1.0
 
 name                py-setuptools
-version             46.1.3
+version             46.3.1
 categories-append   devel
 # License status is murky. The current maintainer decided to relicense as
 # MIT, but he doesn't appear to have obtained the permission of previous
@@ -25,9 +25,9 @@ supported_archs     noarch
 homepage            https://pypi.org/project/setuptools/
 use_zip             yes
 
-checksums           md5 562328cde5a33564c0ebf16699a27b65 \
-                    rmd160 c57944be049b4030f9bc57b16507a2fb34ddaa82 \
-                    sha256 795e0475ba6cd7fa082b1ee6e90d552209995627a2a227a47c6ea93282f4bfb1
+checksums           md5 2e959769c9e10d63b30807fe00a2424c \
+                    rmd160 d57b50b985c97292b507c20892c9fe1fab125eec \
+                    sha256 1c22cd6aae116930efec56de05347ee89ca43b1f1c09c147984e7e7c4a133c85
 
 python.versions     26 27 33 34 35 36 37 38
 python.link_binaries no