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<?xml version="1.0"?>
<!DOCTYPE rdf:RDF [
<!ENTITY GO "http://purl.org/obo/owl/GO#" >
<!ENTITY bfo "http://www.ifomis.org/bfo/1.1#" >
<!ENTITY owl "http://www.w3.org/2002/07/owl#" >
<!ENTITY obo "http://purl.obolibrary.org/obo/" >
<!ENTITY UBERON "http://purl.org/obo/owl/UBERON#" >
<!ENTITY OBO_REL "http://purl.org/obo/owl/OBO_REL#" >
<!ENTITY xsd "http://www.w3.org/2001/XMLSchema#" >
<!ENTITY snap "http://www.ifomis.org/bfo/1.1/snap#" >
<!ENTITY span "http://www.ifomis.org/bfo/1.1/span#" >
<!ENTITY AERO "http://purl.obolibrary.org/obo/AERO/" >
<!ENTITY ro "http://www.obofoundry.org/ro/ro.owl#" >
<!ENTITY rdfs "http://www.w3.org/2000/01/rdf-schema#" >
<!ENTITY rdf "http://www.w3.org/1999/02/22-rdf-syntax-ns#" >
<!ENTITY oboInOwl "http://www.geneontology.org/formats/oboInOwl#" >
]>
<rdf:RDF xmlns="&obo;aero.owl#"
xml:base="&obo;aero.owl"
xmlns:ro="http://www.obofoundry.org/ro/ro.owl#"
xmlns:snap="http://www.ifomis.org/bfo/1.1/snap#"
xmlns:bfo="http://www.ifomis.org/bfo/1.1#"
xmlns:AERO="&obo;AERO/"
xmlns:obo="http://purl.obolibrary.org/obo/"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:UBERON="http://purl.org/obo/owl/UBERON#"
xmlns:GO="http://purl.org/obo/owl/GO#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:OBO_REL="http://purl.org/obo/owl/OBO_REL#"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:span="http://www.ifomis.org/bfo/1.1/span#">
<owl:Ontology rdf:about="&obo;aero.owl">
<owl:versionInfo rdf:datatype="&xsd;string">alpha 0.1 </owl:versionInfo>
<rdfs:comment xml:lang="en">This is a proposed hierarchy to deal with Adverse Events. The initial focus of AERO is to represent specifically adverse events following immunization (AEFIs) according to the Brighton case definitions.
It however aims at being an inclusive resource and allows other types of adverse events to be added as needed by other communities.</rdfs:comment>
<owl:imports rdf:resource="&obo;aero/external-by-hand.owl"/>
<owl:imports rdf:resource="&obo;aero/external.owl"/>
<owl:imports rdf:resource="&obo;aero/externalDerived.owl"/>
<owl:imports rdf:resource="&obo;bfo/2010-05-25/ruttenberg-bfo2.owl"/>
<owl:imports rdf:resource="https://information-artifact-ontology.googlecode.com/svn/releases/2012-01-05/merged/iao-all.owl"/>
</owl:Ontology>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotation properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<owl:AnnotationProperty rdf:about="&owl;versionInfo"/>
<owl:AnnotationProperty rdf:about="&obo;IAO_0000115"/>
<owl:AnnotationProperty rdf:about="&obo;AERO_0000106">
<rdfs:label xml:lang="en">BrightonFormula</rdfs:label>
<obo:IAO_0000112>AngEdGenLoc - angioedema, localized or generalized</obo:IAO_0000112>
<obo:IAO_0000115>An annotation property reflecting the string used by Brighton in their ABC tool to encode the term</obo:IAO_0000115>
<obo:IAO_0000112>SuddOnset = sudden onset</obo:IAO_0000112>
</owl:AnnotationProperty>
<owl:AnnotationProperty rdf:about="&obo;IAO_0000119"/>
<owl:AnnotationProperty rdf:about="&obo;IAO_0000118"/>
<owl:AnnotationProperty rdf:about="&rdfs;label"/>
<owl:AnnotationProperty rdf:about="&rdfs;comment"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Datatypes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Object Properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/AERO_0000125 -->
<owl:ObjectProperty rdf:about="&obo;AERO_0000125">
<rdfs:label xml:lang="en">has component</rdfs:label>
<rdfs:subPropertyOf rdf:resource="&obo;BFO_0000051"/>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/BFO_0000051 -->
<owl:ObjectProperty rdf:about="&obo;BFO_0000051"/>
<!-- http://purl.obolibrary.org/obo/BFO_0000062 -->
<owl:ObjectProperty rdf:about="&obo;BFO_0000062"/>
<!-- http://purl.obolibrary.org/obo/BFO_0000063 -->
<owl:ObjectProperty rdf:about="&obo;BFO_0000063"/>
<!-- http://purl.obolibrary.org/obo/OBI_0000299 -->
<rdf:Description rdf:about="&obo;OBI_0000299">
<rdfs:subPropertyOf rdf:resource="&obo;BFO_0000057"/>
</rdf:Description>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/AERO_0000001 -->
<owl:Class rdf:about="&obo;AERO_0000001">
<rdfs:label xml:lang="en">diagnosis guideline</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;IAO_0000033"/>
<obo:IAO_0000115 xml:lang="en">A directive information entity that specifies how to establish a diagnosis based on clinical findings</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000002 -->
<owl:Class rdf:about="&obo;AERO_0000002">
<rdfs:label xml:lang="en">disorder resulting from an AEFI process</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000005"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;OBI_0000312"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000016"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000005"/>
<rdfs:comment xml:lang="en">MC, 20110120: AR mentioned that the use of is_specified_output is not appropriate, as this would indicate that the adverse event process is a planned process - specified output are things that are specified in the plan to realize a process. Adverse events are not planned process but processual entities, and therefore this should be updated. AR mentioned that BFO will include an appropriate relation.</rdfs:comment>
<rdfs:comment xml:lang="en">MC, 20110120: This class should have a different label for OBO Foundry unique label. &quot;adverse event following immunization&quot; is a term in use by the clinician community, however in the context if the Foundry it may be confusing to associate the word &quot;event&quot; which seem to refer to a process with the hierarchical position under continuant.
Proposed OBO Foundry label: disorder resulting from an AEFI</rdfs:comment>
<rdfs:comment xml:lang="en">MC, 20110126: class renamed from &quot;adverse event following immunization continuant&quot; following AR suggestion</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000003 -->
<owl:Class rdf:about="&obo;AERO_0000003">
<rdfs:label xml:lang="en">Brighton case definition</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000001"/>
<obo:IAO_0000115 xml:lang="en">A diagnosis guideline specifying how to establish a diagnosis of adverse event with an associated degree of certainty, as developed by the Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000115>
<rdfs:comment xml:lang="en">MC, 20110126: this should be linked to the different adverse events reported. AR suggests using a new relation to appear in BFO2, maybe &quot;ascription&quot;</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000004 -->
<owl:Class rdf:about="&obo;AERO_0000004">
<rdfs:label>Brighton assessment of generalized convulsive seizure as an adverse event following immunization </rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:oneOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000024"/>
<rdf:Description rdf:about="&obo;AERO_0000036"/>
<rdf:Description rdf:about="&obo;AERO_0000034"/>
<rdf:Description rdf:about="&obo;AERO_0000032"/>
<rdf:Description rdf:about="&obo;AERO_0000033"/>
</owl:oneOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000208"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;IAO_0000136"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000009"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000119>a categorical measurement datum whose instances are used to classify adverse events according to whether or not they have some likelihood of being a seizure and if so, to what degree</obo:IAO_0000119>
<obo:IAO_0000119>PMID:14741144#Generalized convulsive seizure as an adverse event following immunization: case definition and guidelines for data collection, analysis, and presentation.</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000005 -->
<owl:Class rdf:about="&obo;AERO_0000005">
<rdfs:label xml:lang="en">disorder resulting from an adverse event process</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;OGMS_0000045"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000068"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000015"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:comment xml:lang="en">MC, 20110120: AR mentioned that the use of is_specified_output is not appropriate, as this would indicate that the adverse event process is a planned process - specified output are things that are specified in the plan to realize a process. Adverse events are not planned process but processual entities, and therefore this should be updated. AR mentioned that BFO will include an appropriate relation.</rdfs:comment>
<rdfs:comment xml:lang="en">MC, 20110120: This class was initially labeled &quot;adverse event continuant&quot;. After discussion with AR, and due to the fact that the word &quot;event&quot; implicitely refers to a process, we renamed this class.</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000006 -->
<owl:Class rdf:about="&obo;AERO_0000006">
<rdfs:label xml:lang="en">adverse event rash</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000005"/>
<rdf:Description rdf:about="&obo;AERO_0000008"/>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:comment xml:lang="en">MC, 20110120: This class should have a different label for OBO Foundry unique label. &quot;adverse event rash&quot; is a term in use by the clinician community, however in the context if the Foundry it may be confusing to associate the word &quot;event&quot; which seem to refer to a process with the hierarchical position under continuant.
Proposed OBO Foundry label: rash resulting from an adverse event</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000007 -->
<owl:Class rdf:about="&obo;AERO_0000007">
<rdfs:label xml:lang="en">AEFI rash</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000002"/>
<rdf:Description rdf:about="&obo;AERO_0000008"/>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:comment xml:lang="en">MC, 20110120: This class should have a different label for OBO Foundry unique label. &quot;AEFI_rash&quot; is a term in use by the clinician community, however in the context if the Foundry it may be confusing to associate the word &quot;event&quot; which seem to refer to a process with the hierarchical position under continuant.
Proposed OBO Foundry label: rash resulting from an AEFI process</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000008 -->
<owl:Class rdf:about="&obo;AERO_0000008">
<rdfs:label xml:lang="en">rash</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;OGMS_0000045"/>
<obo:IAO_0000115 xml:lang="en">A rash is a change of the skin which affects its color, appearance or texture. </obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">WEB: http://en.wikipedia.org/wiki/Rash</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000009 -->
<owl:Class rdf:about="&obo;AERO_0000009">
<rdfs:label xml:lang="en">adverse event</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000005"/>
<rdf:Description rdf:about="&obo;AERO_0000015"/>
</owl:unionOf>
</owl:Class>
</owl:equivalentClass>
<obo:IAO_0000115 xml:lang="en">An adverse event is an undesirable, unfavorable and unintended medical occurrence presenting in a predetermined time frame following administration of a compound or usage of a device</obo:IAO_0000115>
<rdfs:comment xml:lang="en">I initialy made adverse event a defined class: is_a sign and preceded by administration. However, by doing so, and as the range of preceded by is processual entities, I was implicitely making adverse event a subclass of processual entity, therfore making adverse event rash (a continuant) inconsistent.</rdfs:comment>
<obo:IAO_0000119>ICH Topic E 2 A Clinical Safety Data Management: Definitions and Standards for Expedited Reporting</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000010 -->
<owl:Class rdf:about="&obo;AERO_0000010">
<rdfs:label xml:lang="en">adverse event following immunization</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000002"/>
<rdf:Description rdf:about="&obo;AERO_0000016"/>
</owl:unionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000009"/>
<obo:IAO_0000115>An adverse event is an undesirable, unfavorable and unintended medical occurrence presenting in a predetermined time frame following administration of a vaccine</obo:IAO_0000115>
<obo:IAO_0000119>Adapted from ICH Topic E 2 A Clinical Safety Data Management: Definitions and Standards for Expedited Reporting</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000011 -->
<owl:Class rdf:about="&obo;AERO_0000011">
<rdfs:label xml:lang="en">_manifestations</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;BFO_0000007"/>
<rdfs:comment xml:lang="en">temporary placeholder - to be removed
This class just helps me group some terms during development of the structure</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000012 -->
<owl:Class rdf:about="&obo;AERO_0000012">
<rdfs:label xml:lang="en">Idiopathic thrombocytopenic purpura</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000011"/>
<obo:IAO_0000115 xml:lang="en">Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet count (thrombocytopenia) of no known cause (idiopathic).v</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">http://en.wikipedia.org/wiki/Idiopathic_thrombocytopenic_purpura</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000013 -->
<owl:Class rdf:about="&obo;AERO_0000013">
<rdfs:label xml:lang="en">encephalitis</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000011"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&OBO_REL;stimulates"/>
<owl:someValuesFrom rdf:resource="&GO;GO_0006954"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&OBO_REL;unfolds_in"/>
<owl:someValuesFrom rdf:resource="&UBERON;UBERON_0000955"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">Encephalitis is an inflammation of the brain. It may be caused by a number of different factors. One of the most common causes is direct infection of the brain by a virus or bacterium. Inflammation can also occur as a complication of some other disorder, such as mumps (see mumps entry) or herpes simplex (see herpes infections entry).</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">http://www.faqs.org/health/Sick-V2/Encephalitis-Definition.html</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000014 -->
<owl:Class rdf:about="&obo;AERO_0000014">
<rdfs:label xml:lang="en">motor manifestation</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000011"/>
<obo:IAO_0000115 xml:lang="en">A _manifestation involving the motor system</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000015 -->
<owl:Class rdf:about="&obo;AERO_0000015">
<rdfs:label xml:lang="en">adverse event process</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;BFO_0000007"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000062"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;OBI_0000274"/>
<rdf:Description rdf:about="&obo;OBI_0600007"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<obo:IAO_0000115 xml:lang="en">An adverse event process is a processual entity occurring in a pre determined time frame following administration of a compound or usage of a device</obo:IAO_0000115>
<rdfs:comment xml:lang="en">I included the usage of a device into the definition of adverse event as I am aiming at being inclusive, and cover cases such as those described by MAUDE - Manufacturer and User Facility Device Experience. See for example http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfMAUDE/detail.cfm?mdrfoi__id=1942591 - a patient get fitted with bioprosthetic heart valves and dies within the following 4 months.</rdfs:comment>
<rdfs:comment xml:lang="en">Note that this definition of adverse event doesn&#39;t imply any type of causality between the sign observed and the coumpond administration/device utilization. For our purposes, we consider any type of sign presenting within a specific time frame after the coumpound administration/device utilization to be an adverse event.</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000016 -->
<owl:Class rdf:about="&obo;AERO_0000016">
<rdfs:label xml:lang="en">adverse event following immunization process</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000015"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000062"/>
<owl:someValuesFrom rdf:resource="&obo;VO_0000002"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000015"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000017 -->
<owl:Class rdf:about="&obo;AERO_0000017">
<rdfs:label xml:lang="en">generalized convulsive seizure according to Brighton criteria</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;BFO_0000007"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000051"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000014"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="&OBO_REL;regulates"/>
<owl:someValuesFrom rdf:resource="&GO;GO_0007610"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&OBO_REL;unfolds_in"/>
<owl:someValuesFrom rdf:resource="&UBERON;UBERON_0001016"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000018 -->
<owl:Class rdf:about="&obo;AERO_0000018">
<rdfs:label xml:lang="en">AEFI generalized convulsive seizure according to Brighton guideline</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000009"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000062"/>
<owl:someValuesFrom rdf:resource="&obo;VO_0000002"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty>
<rdf:Description>
<owl:inverseOf rdf:resource="&obo;IAO_0000136"/>
</rdf:Description>
</owl:onProperty>
<owl:someValuesFrom>
<owl:Class>
<owl:oneOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000024"/>
<rdf:Description rdf:about="&obo;AERO_0000032"/>
<rdf:Description rdf:about="&obo;AERO_0000033"/>
</owl:oneOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000021 -->
<owl:Class rdf:about="&obo;AERO_0000021">
<rdfs:label xml:lang="en">seizure level 1 of certainty according to the Brighton criteria</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000051"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000048"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000026"/>
<rdf:Description rdf:about="&obo;AERO_0000029"/>
<rdf:Description rdf:about="&obo;AERO_0000030"/>
<rdf:Description rdf:about="&obo;AERO_0000031"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000017"/>
<rdfs:comment xml:lang="en">MC, 20110126: this needs to be linked to the Brighton guideline defined under directive information entity</rdfs:comment>
<obo:IAO_0000115 xml:lang="en">witnessed sudden loss of consciousness AND generalized,
tonic, clonic, tonic–clonic, or atonic motor manifestations. (atonic In the absence of: hypotonic hyporesponsive episode (as defined by the Brighton Collaboration), syncope, and myoclonic jerks.</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000022 -->
<owl:Class rdf:about="&obo;AERO_0000022">
<rdfs:label xml:lang="en">seizure level 2 of certainty according to the Brighton criteria</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000051"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000047"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000026"/>
<rdf:Description rdf:about="&obo;AERO_0000029"/>
<rdf:Description rdf:about="&obo;AERO_0000030"/>
<rdf:Description rdf:about="&obo;AERO_0000031"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000017"/>
<rdfs:comment xml:lang="en">MC, 20110126: this needs to be linked to the Brighton guideline defined under directive information entity</rdfs:comment>
<obo:IAO_0000115 xml:lang="en">history of unconsciousness AND generalized,
tonic, clonic, tonic–clonic, or atonic motor manifestations. (atonic In the absence of: hypotonic hyporesponsive episode (as defined by the Brighton Collaboration), syncope, and myoclonic jerks.</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000023 -->
<owl:Class rdf:about="&obo;AERO_0000023">
<rdfs:label xml:lang="en">seizure level 3 of certainty according to the Brighton criteria</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000051"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000028"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000051"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000047"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000017"/>
<rdfs:comment xml:lang="en">MC, 20110126: this needs to be linked to the Brighton guideline defined under directive information entity</rdfs:comment>
<obo:IAO_0000115 xml:lang="en">history of unconsciousness AND other generalized motor manifestations.</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000025 -->
<owl:Class rdf:about="&obo;AERO_0000025">
<rdfs:label xml:lang="en">atonic motor manifestation</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000014"/>
<obo:IAO_0000115 xml:lang="en">A sudden loss of tone in postural muscle, often preceded by a myoclonic jerk and precipitated by hyperventilation</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000026 -->
<owl:Class rdf:about="&obo;AERO_0000026">
<rdfs:label xml:lang="en">generalized atonic motor manifestation</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000025"/>
<rdf:Description rdf:about="&obo;AERO_0000028"/>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000025"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000027 -->
<owl:Class rdf:about="&obo;AERO_0000027">
<rdfs:label xml:lang="en">clonic motor manifestation</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000014"/>
<obo:IAO_0000119 xml:lang="en">Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000119>
<obo:IAO_0000115 xml:lang="en">Sudden, brief (100ms) involuntary contractions of the same muscle groups, regularly repetitive at a frequency of about two to three contractions per second.</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000028 -->
<owl:Class rdf:about="&obo;AERO_0000028">
<rdfs:label xml:lang="en">generalized motor manifestation</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000014"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&OBO_REL;unfolds_in"/>
<owl:allValuesFrom rdf:resource="&obo;AERO_0000050"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<obo:IAO_0000119 xml:lang="en">Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000119>
<obo:IAO_0000115 xml:lang="en">bilateral motor manifestation, more than minimal muscle involvement</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000029 -->
<owl:Class rdf:about="&obo;AERO_0000029">
<rdfs:label xml:lang="en">generalized clonic motor manifestation</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000027"/>
<rdf:Description rdf:about="&obo;AERO_0000028"/>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000030 -->
<owl:Class rdf:about="&obo;AERO_0000030">
<rdfs:label xml:lang="en">generalized tonic motor manifestation</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000028"/>
<rdf:Description rdf:about="&obo;AERO_0000044"/>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000031 -->
<owl:Class rdf:about="&obo;AERO_0000031">
<rdfs:label xml:lang="en">generalized tonic-clonic motor manifestation</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000028"/>
<rdf:Description rdf:about="&obo;AERO_0000044"/>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000035 -->
<owl:Class rdf:about="&obo;AERO_0000035">
<rdfs:label xml:lang="en">hypotonic-hyporesponsive episode</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000011"/>
<obo:IAO_0000118 xml:lang="en">HHE</obo:IAO_0000118>
<obo:IAO_0000115 xml:lang="en">HHE is characterized by sudde onset of reduced muscle tone, hyporesponsiveness (i.e., less responsive than usual to verbal or other sensorial stimuli) and change of skin color (pallor or cyanosis)</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000037 -->
<owl:Class rdf:about="&obo;AERO_0000037">
<rdfs:label>bilateral</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;BFO_0000019"/>
<obo:IAO_0000119>http://www.thefreedictionary.com/bilateral</obo:IAO_0000119>
<obo:IAO_0000115>Affecting or undertaken by two sides equally; binding on both parties</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000038 -->
<owl:Class rdf:about="&obo;AERO_0000038">
<rdfs:label>diagnosing generalized convulsive seizure according to Brighton guidelines</rdfs:label>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000058"/>
<owl:allValuesFrom rdf:resource="&obo;AERO_0000039"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000207"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;OBI_0000299"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000004"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115>performing a diagnosis specified by the Brighton case definition for convulsive seizure as an adverse event following immunization</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000039 -->
<owl:Class rdf:about="&obo;AERO_0000039">
<rdfs:label xml:lang="en">Brighton case definition of generalized convulsive seizure as an adverse event following immunization</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000003"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000059"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000054"/>
<owl:allValuesFrom rdf:resource="&obo;AERO_0000038"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000119>PMID:14741144#Generalized convulsive seizure as an adverse event following immunization: case definition and guidelines for data collection, analysis, and presentation.</obo:IAO_0000119>
<obo:IAO_0000115>A Brighton case definition of generalized convulsive seizure as an adverse event following immunization</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000040 -->
<owl:Class rdf:about="&obo;AERO_0000040">
<rdfs:label xml:lang="en">shaking</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000014"/>
<obo:IAO_0000118 xml:lang="en">quivering</obo:IAO_0000118>
<obo:IAO_0000115 xml:lang="en">repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement</obo:IAO_0000115>
<obo:IAO_0000118 xml:lang="en">shivering</obo:IAO_0000118>
<obo:IAO_0000118 xml:lang="en">trembling</obo:IAO_0000118>
<obo:IAO_0000118 xml:lang="en">tremor</obo:IAO_0000118>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000041 -->
<owl:Class rdf:about="&obo;AERO_0000041">
<rdfs:label xml:lang="en">bilateral shaking</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000040"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&OBO_REL;unfolds_in"/>
<owl:allValuesFrom rdf:resource="&obo;AERO_0000050"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000040"/>
<obo:IAO_0000115 xml:lang="en">A shaking process which unfolds in both sides of an organism</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000042 -->
<owl:Class rdf:about="&obo;AERO_0000042">
<rdfs:label xml:lang="en">syncope</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000014"/>
<rdfs:comment xml:lang="en">MC, 20110126: The Brighton guideline on which this is based needs to be checked.
Email correspondance with Brighton:
[MC] One thing is unclear to me: Level 1 of diagnostic certainty is defined
as &quot;witnessed sudden loss of consciousness AND generalized, tonic,
clonic, tonic–clonic, or atonic motor manifestations.&quot;
A footnote adds: atonic in the absence of: hypotonic hyporesponsive
episode (as defined by the Brighton Collaboration), syncope, and
myoclonic jerks.
If we define syncope as being a loss of consciousness, how can I have
a witnessed sudden loss of consciousness and a generalized atonic
motor manifestation in the absence of syncope?
[Brighton] Thank you for your question. You are right, that there is an overlap between the clinical presentation of an atonic seizure and a Syncope. This is also true for HHE. This is the very reasonf or the footnote to alert the user of the definition to this differential diagnosis.
If you are working on a database and only have the clinical criteria vailable, you may have some false positives for the atonic seizure cases, unless you obtain additional information, e.g. that the Syncope was vasovagal or orthostatic, or arrhythmic, etc.</rdfs:comment>
<obo:IAO_0000119 xml:lang="en">http://en.wikipedia.org/wiki/Syncope_%28medicine%29</obo:IAO_0000119>
<obo:IAO_0000115 xml:lang="en">loss of consciousness, fainting</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000043 -->
<owl:Class rdf:about="&obo;AERO_0000043">
<rdfs:label xml:lang="en">myoclonic jerk</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000014"/>
<obo:IAO_0000115 xml:lang="en">A myoclonic jerk is the brief, involuntary twitching of a muscle or group of muscles. It may be caused either by a sudden muscle contraction, or a sudden lapse of contraction. This happens when a person is on the verge of falling asleep, and suddenly have a sensation or feeling that they are free falling through the air. Contractions are called positive myoclonus; relaxations are called negative myoclonus. When falling asleep, it is common for people to experience a type of myoclonic jerk known as a hypnic jerk. Hiccups are also a kind of myoclonic jerk specifically affecting the diaphragm.</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">http://house.wikia.com/wiki/Myoclonic_jerk</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000044 -->
<owl:Class rdf:about="&obo;AERO_0000044">
<rdfs:label xml:lang="en">tonic motor manifestation</rdfs:label>
<rdfs:label xml:lang="en">tonic-clonic motor manifestation</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000027"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000062"/>
<owl:allValuesFrom rdf:resource="&obo;AERO_0000044"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000044"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000063"/>
<owl:allValuesFrom rdf:resource="&obo;AERO_0000027"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A sequence consisting of a tonic followed by a clonic phase</obo:IAO_0000115>
<obo:IAO_0000115 xml:lang="en">A sustained increase in muscle contraction lasting a few seconds to minutes</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000045 -->
<owl:Class rdf:about="&obo;AERO_0000045">
<rdfs:label xml:lang="en">loss of consciousness</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000014"/>
<obo:IAO_0000115 xml:lang="en">i.e., unreactive to verbal and painful stimuli</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000047 -->
<owl:Class rdf:about="&obo;AERO_0000047">
<rdfs:label xml:lang="en">history of unconsciousness</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000045"/>
<obo:IAO_0000119 xml:lang="en">Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000119>
<rdfs:comment xml:lang="en">MC, 20110126: AR suggest that &quot;history of consciousness is not a process.
definition reads &quot;the sudden loss of consciousness was not observed, but the patient was found unconscious&quot;, so maybe updating the label would be better : &quot;unwitnessed loss of consciousness with history of unconsciousness&quot; would help</rdfs:comment>
<obo:IAO_0000115 xml:lang="en">the sudden loss of consciousness was not observed, but the patient was found unconscious</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000048 -->
<owl:Class rdf:about="&obo;AERO_0000048">
<rdfs:label xml:lang="en">witnessed sudden loss of consciousness</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000047"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000055"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000055"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000119 xml:lang="en">Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000050 -->
<owl:Class rdf:about="&obo;AERO_0000050">
<rdfs:label xml:lang="en">bilateral site</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;BFO_0000029"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000086"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000037"/>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000055 -->
<owl:Class rdf:about="&obo;AERO_0000055">
<rdfs:label xml:lang="en">witness role</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;BFO_0000023"/>
<obo:IAO_0000115 xml:lang="en">A role inhering in a person that is realized when the bearer sees an event and reports what happened</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">adapted from http://golovchenko.org/cgi-bin/wnsearch?q=witness</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000061 -->
<owl:Class rdf:about="&obo;AERO_0000061">
<rdfs:label xml:lang="en">AEFI encephalitis</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000013"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000062"/>
<owl:someValuesFrom rdf:resource="&obo;VO_0000002"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000013"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000062 -->
<owl:Class rdf:about="&obo;AERO_0000062">
<rdfs:label xml:lang="en">AEFI Idiopathic thrombocytopenic purpura</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000012"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000062"/>
<owl:someValuesFrom rdf:resource="&obo;VO_0000002"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000012"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000063 -->
<owl:Class rdf:about="&obo;AERO_0000063">
<rdfs:label xml:lang="en">AEFI: hypotonic-hyporesponsive episode</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000035"/>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000062"/>
<owl:someValuesFrom rdf:resource="&obo;VO_0000002"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000035"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000066 -->
<owl:Class rdf:about="&obo;AERO_0000066">
<rdfs:label xml:lang="en">adverse side effect</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000009"/>
<obo:IAO_0000115 xml:lang="en">side effect is an adverse event of a type that has been determined by a review board to be causally related to the intervention.</obo:IAO_0000115>
<rdfs:comment xml:lang="en">while in some cases the particular may not be actually caused by the intervention, it is an adverse side effect nonetheless.</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000067 -->
<owl:Class rdf:about="&obo;AERO_0000067">
<rdfs:label xml:lang="en">device malfunction</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;BFO_0000007"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;OBI_0000293"/>
<owl:someValuesFrom rdf:resource="&obo;OBI_0000968"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A process in which the device doesn&#39;t perform as expected</obo:IAO_0000115>
<obo:IAO_0000111 xml:lang="en">device malfunction</obo:IAO_0000111>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000068 -->
<owl:Class rdf:about="&obo;AERO_0000068">
<rdfs:label xml:lang="en">adverse event report</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;IAO_0000088"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="&obo;AERO_0000009"/>
<rdf:Description rdf:about="&obo;AERO_0000067"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;OBI_0000312"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000209"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A report as submitted in an adverse event reporting system</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">MC, 20110719: not all adverse event report are about adverse event. See for example cases in MAUDE database that are about potential adverse events such as device malfunctions.</obo:IAO_0000116>
<obo:IAO_0000111 xml:lang="en">adverse event report</obo:IAO_0000111>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000080 -->
<owl:Class rdf:about="&obo;AERO_0000080">
<rdfs:label xml:lang="en">reporting process</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;BFO_0000007"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;OBI_0000299"/>
<owl:someValuesFrom rdf:resource="&obo;IAO_0000088"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">The process of creating documentation about something and adding it to a system allowing further analysis of the reported entity</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000100 -->
<owl:Class rdf:about="&obo;AERO_0000100">
<rdfs:label xml:lang="en">sudden onset</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:IAO_0000115>The term sudden onsets refers to an event that occurred unexpectedly and without warning leading to a marked change in a subjects previously stable condition</obo:IAO_0000115>
<obo:IAO_0000119>Anaphylaxis: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine 25 (2007) 5675–5684</obo:IAO_0000119>
<obo:AERO_0000106>SuddOnset</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000101 -->
<owl:Class rdf:about="&obo;AERO_0000101">
<rdfs:label xml:lang="en">rapid progression</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:IAO_0000115>The term rapid progression is a conventional clinical term. An exact timeframe sould not be offered since it would have to refer to a wide range of signs and symptoms without a scientific evidence base. Using an arbitrarily restrictive setpoint might bias future data collection unnecessarily.</obo:IAO_0000115>
<obo:IAO_0000119>Anaphylaxis: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine 25 (2007) 5675–5684</obo:IAO_0000119>
<obo:AERO_0000106>RapidProgr</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000102 -->
<owl:Class rdf:about="&obo;AERO_0000102">
<rdfs:label xml:lang="en">anaphylaxis</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonDiagnosis"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000103 -->
<owl:Class rdf:about="&obo;AERO_0000103">
<rdfs:label xml:lang="en">generalized urticaria</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:IAO_0000118>hives</obo:IAO_0000118>
<obo:AERO_0000106>UrticariaGen</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000104 -->
<owl:Class rdf:about="&obo;AERO_0000104">
<rdfs:label xml:lang="en">generalized erythema</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:AERO_0000106>ErythemaGen</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000105 -->
<owl:Class rdf:about="&obo;AERO_0000105">
<rdfs:label xml:lang="en">angioedema</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:IAO_0000232>localized or generalized</obo:IAO_0000232>
<obo:AERO_0000106>AngEdGenLoc</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000107 -->
<owl:Class rdf:about="&obo;AERO_0000107">
<rdfs:label xml:lang="en">generalized pruritus</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:AERO_0000106>PruritusGen</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000108 -->
<owl:Class rdf:about="&obo;AERO_0000108">
<rdfs:label xml:lang="en">skin rash</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:AERO_0000106>SkinRash</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000109 -->
<owl:Class rdf:about="&obo;AERO_0000109">
<rdfs:label xml:lang="en">measured hypotension</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:AERO_0000106>HypotensMeas</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000110 -->
<owl:Class rdf:about="&obo;AERO_0000110">
<rdfs:label xml:lang="en">tachycardia</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000211"/>
<obo:AERO_0000106>TacchyCard</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000111 -->
<owl:Class rdf:about="&obo;AERO_0000111">
<rdfs:label xml:lang="en">capillary refill time &gt; 3s</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000211"/>
<obo:AERO_0000106>CapRefillOver3</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000112 -->
<owl:Class rdf:about="&obo;AERO_0000112">
<rdfs:label xml:lang="en">reduced central pulse volume</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000211"/>
<obo:AERO_0000106>PulseVolRed</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000113 -->
<owl:Class rdf:about="&obo;AERO_0000113">
<rdfs:label xml:lang="en">decreased level of consciousness or loss of consciousness</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000211"/>
<obo:IAO_0000232>should be a union class</obo:IAO_0000232>
<obo:AERO_0000106>ConscDecr</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000114 -->
<owl:Class rdf:about="&obo;AERO_0000114">
<rdfs:label xml:lang="en">bilateral wheeze</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:IAO_0000118>bronchospasm</obo:IAO_0000118>
<obo:AERO_0000106>WheezeBilat</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000115 -->
<owl:Class rdf:about="&obo;AERO_0000115">
<rdfs:label xml:lang="en">stridor</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:AERO_0000106>Stridor</obo:AERO_0000106>
<obo:IAO_0000115>a harsh or vibrating noise when breathing caused by obstruction of the windpipe or larynx.</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000116 -->
<owl:Class rdf:about="&obo;AERO_0000116">
<rdfs:label xml:lang="en">upper airway swelling</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:IAO_0000232>lip, tongue, throat, uvula or larynx</obo:IAO_0000232>
<obo:AERO_0000106>SwellUpAirways</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000117 -->
<owl:Class rdf:about="&obo;AERO_0000117">
<rdfs:label xml:lang="en">tachypnoea</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000124"/>
<owl:disjointWith rdf:resource="&obo;AERO_0000120"/>
<obo:AERO_0000106>TachyPnea</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000118 -->
<owl:Class rdf:about="&obo;AERO_0000118">
<rdfs:label xml:lang="en">increased use of accessory respiratory muscles</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000124"/>
<owl:disjointWith rdf:resource="&obo;AERO_0000120"/>
<obo:AERO_0000106>RespMuscAccIncr</obo:AERO_0000106>
<obo:IAO_0000232>sternocleidomastoid, intercostals, etc</obo:IAO_0000232>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000119 -->
<owl:Class rdf:about="&obo;AERO_0000119">
<rdfs:label xml:lang="en">recession</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000124"/>
<owl:disjointWith rdf:resource="&obo;AERO_0000120"/>
<obo:AERO_0000106>Recess</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000120 -->
<owl:Class rdf:about="&obo;AERO_0000120">
<rdfs:label xml:lang="en">cyanosis</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000124"/>
<owl:disjointWith rdf:resource="&obo;AERO_0000121"/>
<obo:AERO_0000106>Cyanosis</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000121 -->
<owl:Class rdf:about="&obo;AERO_0000121">
<rdfs:label xml:lang="en">grunting</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000124"/>
<obo:AERO_0000106>Grunting</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000123 -->
<owl:Class rdf:about="&obo;AERO_0000123">
<rdfs:label xml:lang="en">respiratory distress</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000124"/>
<owl:minQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">2</owl:minQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000117"/>
<owl:maxQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000118"/>
<owl:maxQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000119"/>
<owl:maxQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000120"/>
<owl:maxQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000121"/>
<owl:maxQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonMidLevelTerms"/>
<obo:IAO_0000115>respiratory distress—2 or more of the
following:
• tachypnoea
• increased use of accessory respiratory muscles (sternocleidomastoid, intercostals, etc.)
• recession
• cyanosis
• grunting</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000124 -->
<owl:Class rdf:about="&obo;AERO_0000124">
<rdfs:label xml:lang="en">respiratory distress sign</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:IAO_0000232>a helper class which allows us to define a qualified cardinality restriction for respiratory distress such as used in the case definition of anaphylaxis.Respiratory distress is defined as having at least 2 respiratory distress signs</obo:IAO_0000232>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000200 -->
<owl:Class rdf:about="&obo;AERO_0000200">
<rdfs:label xml:lang="en">infected abscess</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;OGMS_0000045"/>
<obo:IAO_0000115 xml:lang="en">A localized collection of pus in a cavity formed by the disintegration of tissue, usually caused by microorganisms that invade the tissues.</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">PHAC user guide, http://www.phac-aspc.gc.ca/im/pdf/AEFI-ug-gu-eng.pdf</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000201 -->
<owl:Class rdf:about="&obo;AERO_0000201">
<rdfs:label xml:lang="en">sterile abscess</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;OGMS_0000045"/>
<obo:IAO_0000115 xml:lang="en">An abscess whose contents are not caused by pyogenic bacteria.</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">PHAC user guide, http://www.phac-aspc.gc.ca/im/pdf/AEFI-ug-gu-eng.pdf</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000202 -->
<owl:Class rdf:about="&obo;AERO_0000202">
<rdfs:label xml:lang="en">cellulitis</rdfs:label>
<rdfs:subClassOf rdf:resource="&GO;GO_0006954"/>
<obo:IAO_0000115 xml:lang="en">A diffuse inflammatory process within solid tissues, characterized by edema, redness, pain, and interference with function, usually caused by infection with streptococci, staphylococci, or similar organisms.</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">PHAC user guide, http://www.phac-aspc.gc.ca/im/pdf/AEFI-ug-gu-eng.pdf</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000203 -->
<owl:Class rdf:about="&obo;AERO_0000203">
<rdfs:label xml:lang="en">nodule</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;OGMS_0000045"/>
<obo:IAO_0000115 xml:lang="en">A firm, small mass of tissue at the injection site with discrete or well demarcated borders in the absence of abscess formation, erythema and warmth.</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">PHAC user guide, http://www.phac-aspc.gc.ca/im/pdf/AEFI-ug-gu-eng.pdf</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000204 -->
<owl:Class rdf:about="&obo;AERO_0000204">
<rdfs:label xml:lang="en">lymphadenitis</rdfs:label>
<rdfs:subClassOf rdf:resource="&GO;GO_0006954"/>
<obo:IAO_0000115 xml:lang="en">Inflammation of one or more lymph nodes, usually caused by a primary focus of infection elsewhere in the body.</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">PHAC user guide, http://www.phac-aspc.gc.ca/im/pdf/AEFI-ug-gu-eng.pdf</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000205 -->
<owl:Class rdf:about="&obo;AERO_0000205">
<rdfs:label xml:lang="en">erythema</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000008"/>
<obo:IAO_0000115 xml:lang="en">Abnormal redness of the skin.</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">PHAC user guide, http://www.phac-aspc.gc.ca/im/pdf/AEFI-ug-gu-eng.pdf</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000206 -->
<owl:Class rdf:about="&obo;AERO_0000206">
<rdfs:label xml:lang="en">induration</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;OGMS_0000045"/>
<obo:IAO_0000119 xml:lang="en">PHAC user guide, http://www.phac-aspc.gc.ca/im/pdf/AEFI-ug-gu-eng.pdf</obo:IAO_0000119>
<obo:IAO_0000115 xml:lang="en">Palpable thickening, firmness or hardening of soft tissue that is assessed by a health care provider</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000207 -->
<owl:Class rdf:about="&obo;AERO_0000207">
<rdfs:label xml:lang="en">performing a diagnosis according to a Brighton case definition</rdfs:label>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;BFO_0000058"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000003"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;OBI_0000988"/>
<rdfs:comment xml:lang="en"></rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000208 -->
<owl:Class rdf:about="&obo;AERO_0000208">
<rdfs:label xml:lang="en">Brighton assessment</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;OBI_0000938"/>
<obo:IAO_0000115 xml:lang="en">The assessment performed upon review of an adverse event report according to the Brighton case definitions</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000209 -->
<owl:Class rdf:about="&obo;AERO_0000209">
<rdfs:label xml:lang="en">adverse event reporting process</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO_0000080"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;OBI_0000299"/>
<owl:someValuesFrom rdf:resource="&obo;AERO_0000068"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">The process of creating documentation about an adverse event and adding it to a system allowing further analysis of the event</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000210 -->
<owl:Class rdf:about="&obo;AERO_0000210">
<rdfs:label xml:lang="en">clinical diagnosis of uncompensated shock</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000211"/>
<owl:minQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">2</owl:minQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000110"/>
<owl:maxQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000111"/>
<owl:maxQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000112"/>
<owl:maxQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;AERO_0000125"/>
<owl:onClass rdf:resource="&obo;AERO_0000113"/>
<owl:maxQualifiedCardinality rdf:datatype="&xsd;nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonMidLevelTerms"/>
<obo:IAO_0000115 xml:lang="en">combination of at least 3 of the following:
- tachycardia
- capillary refill time &gt; 3s
- reduced central pulse volume
- decreased level of consciousness or loss of consciousness</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000211 -->
<owl:Class rdf:about="&obo;AERO_0000211">
<rdfs:label xml:lang="en">uncompensated shock sign</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;AERO/_BrightonTerms"/>
<obo:IAO_0000115 xml:lang="en">a helper class which allows us to define a qualified cardinality restriction for uncompensated shock such as used in the case definition of anaphylaxis. Clinical diagnosis of uncompensated shock is defined as having at least 3 uncompensated shock signs</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/BFO_0000001 -->
<owl:Class rdf:about="&obo;BFO_0000001"/>
<!-- http://purl.obolibrary.org/obo/BFO_0000002 -->
<rdf:Description rdf:about="&obo;BFO_0000002">
<owl:disjointWith rdf:resource="&obo;BFO_0000003"/>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/BFO_0000003 -->
<rdf:Description rdf:about="&obo;BFO_0000003"/>
<!-- http://purl.obolibrary.org/obo/BFO_0000007 -->
<owl:Class rdf:about="&obo;BFO_0000007"/>
<!-- http://purl.obolibrary.org/obo/BFO_0000019 -->
<owl:Class rdf:about="&obo;BFO_0000019"/>
<!-- http://purl.obolibrary.org/obo/BFO_0000023 -->
<owl:Class rdf:about="&obo;BFO_0000023"/>
<!-- http://purl.obolibrary.org/obo/BFO_0000029 -->
<owl:Class rdf:about="&obo;BFO_0000029"/>
<!-- http://purl.obolibrary.org/obo/BFO_0000040 -->
<owl:Class rdf:about="&obo;BFO_0000040"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000033 -->
<owl:Class rdf:about="&obo;IAO_0000033"/>
<!-- http://purl.obolibrary.org/obo/OBI_0000274 -->
<owl:Class rdf:about="&obo;OBI_0000274"/>
<!-- http://purl.obolibrary.org/obo/OBI_0000938 -->
<owl:Class rdf:about="&obo;OBI_0000938"/>
<!-- http://purl.obolibrary.org/obo/OBI_0000988 -->
<owl:Class rdf:about="&obo;OBI_0000988">
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="&obo;OBI_0000293"/>
<owl:someValuesFrom rdf:resource="&obo;OGMS_0000014"/>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0600007 -->
<owl:Class rdf:about="&obo;OBI_0600007"/>
<!-- http://purl.obolibrary.org/obo/OGMS_0000014 -->
<owl:Class rdf:about="&obo;OGMS_0000014"/>
<!-- http://purl.obolibrary.org/obo/OGMS_0000045 -->
<owl:Class rdf:about="&obo;OGMS_0000045"/>
<!-- http://purl.obolibrary.org/obo/OGMS_0000059 -->
<rdf:Description rdf:about="&obo;OGMS_0000059">
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty>
<rdf:Description>
<owl:inverseOf rdf:resource="&obo;BFO_0000068"/>
</rdf:Description>
</owl:onProperty>
<owl:someValuesFrom rdf:resource="&obo;OGMS_0000045"/>
</owl:Restriction>
</rdfs:subClassOf>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/VO_0000002 -->
<owl:Class rdf:about="&obo;VO_0000002"/>
<!-- http://purl.obolibrary.org/obo/AERO/_BrightonDiagnosis -->
<owl:Class rdf:about="&obo;AERO/_BrightonDiagnosis">
<rdfs:subClassOf rdf:resource="&obo;BFO_0000001"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO/_BrightonMidLevelTerms -->
<owl:Class rdf:about="&obo;AERO/_BrightonMidLevelTerms">
<rdfs:label xml:lang="en">_BrightonMidLevelTerms</rdfs:label>
<rdfs:subClassOf rdf:resource="&obo;BFO_0000001"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO/_BrightonTerms -->
<owl:Class rdf:about="&obo;AERO/_BrightonTerms">
<rdfs:subClassOf rdf:resource="&obo;BFO_0000001"/>
</owl:Class>
<!-- http://purl.org/obo/owl/GO#GO_0001660 -->
<owl:Class rdf:about="&GO;GO_0001660"/>
<!-- http://purl.org/obo/owl/GO#GO_0006954 -->
<owl:Class rdf:about="&GO;GO_0006954"/>
<!-- http://purl.org/obo/owl/GO#GO_0007610 -->
<owl:Class rdf:about="&GO;GO_0007610"/>
<!-- http://purl.org/obo/owl/UBERON#UBERON_0000955 -->
<owl:Class rdf:about="&UBERON;UBERON_0000955"/>
<!-- http://purl.org/obo/owl/UBERON#UBERON_0001016 -->
<owl:Class rdf:about="&UBERON;UBERON_0001016"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Individuals
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/AERO_0000024 -->
<owl:NamedIndividual rdf:about="&obo;AERO_0000024">
<rdf:type rdf:resource="&obo;AERO_0000004"/>
<rdfs:label>Level 1 of certainty of generalized convulsive seizure as an adverse event following immunization</rdfs:label>
</owl:NamedIndividual>
<!-- http://purl.obolibrary.org/obo/AERO_0000032 -->
<owl:NamedIndividual rdf:about="&obo;AERO_0000032">
<rdf:type rdf:resource="&obo;AERO_0000004"/>
<rdfs:label>Level 2 of certainty of generalized convulsive seizure as an adverse event following immunization</rdfs:label>
</owl:NamedIndividual>
<!-- http://purl.obolibrary.org/obo/AERO_0000033 -->
<owl:NamedIndividual rdf:about="&obo;AERO_0000033">
<rdf:type rdf:resource="&obo;AERO_0000004"/>
<rdfs:label>Level 3 of certainty of generalized convulsive seizure as an adverse event following immunization</rdfs:label>
</owl:NamedIndividual>
<!-- http://purl.obolibrary.org/obo/AERO_0000034 -->
<owl:NamedIndividual rdf:about="&obo;AERO_0000034">
<rdf:type rdf:resource="&obo;AERO_0000004"/>
<rdfs:label>Reported generalized convulsive seizure with insufficient evidence to meet the case definition</rdfs:label>
</owl:NamedIndividual>
<!-- http://purl.obolibrary.org/obo/AERO_0000036 -->
<owl:NamedIndividual rdf:about="&obo;AERO_0000036">
<rdf:type rdf:resource="&obo;AERO_0000004"/>
<rdfs:label>not a case of generalized convulsive seizure</rdfs:label>
</owl:NamedIndividual>
</rdf:RDF>
<!-- Generated by the OWL API (version 3.2.3.1824) http://owlapi.sourceforge.net -->