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<?xml version="1.0"?>
<rdf:RDF xmlns="http://purl.obolibrary.org/obo/aero.owl#"
xml:base="http://purl.obolibrary.org/obo/aero.owl"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:ro="http://www.obofoundry.org/ro/ro.owl#"
xmlns:snap="http://www.ifomis.org/bfo/1.1/snap#"
xmlns:bfo="http://www.ifomis.org/bfo/1.1#"
xmlns:AERO="http://purl.obolibrary.org/obo/AERO/"
xmlns:obo="http://purl.obolibrary.org/obo/"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:ogms="http://purl.obolibrary.org/obo/ogms/"
xmlns:GO="http://purl.org/obo/owl/GO#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:OBO_REL="http://purl.org/obo/owl/OBO_REL#"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:span="http://www.ifomis.org/bfo/1.1/span#">
<owl:Ontology rdf:about="http://purl.obolibrary.org/obo/aero.owl">
<dc:contributor xml:lang="en">Alan Ruttenberg</dc:contributor>
<dc:contributor xml:lang="en">Melanie Courtot</dc:contributor>
<rdfs:comment xml:lang="en">The Adverse Event Reporting Ontology (AERO) is designed to facilitate the representation of adverse event reports and their evaluation in relation to clinical guidelines written by various authorities. We take a realist approach in which findings in reports are information artifacts and are related to instances or types that represent patient, symptoms, diseases, etc. We intend that use of this ontology will result in data that interoperates well with OBO Foundry ontologies as we directly use terms from OBO ontologies wherever appropriate.
The initial domain for this work are reports of adverse events following immunization (AEFIs). We represent the Brighton case definitions as our guidelines, show how findings can be assessed in terms of Brighton criteria and how diagnoses of adverse events with different levels of certainty can be obtained by use of the OWL reasoner.</rdfs:comment>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/aero/OMRE_AEROImport.owl"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/aero/external-by-hand.owl"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/aero/external.owl"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/aero/externalDerived.owl"/>
</owl:Ontology>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotation properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/AERO_0000106 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/AERO_0000106">
<rdfs:label xml:lang="en">BrightonFormula</rdfs:label>
<obo:IAO_0000112>SuddOnset = sudden onset</obo:IAO_0000112>
<obo:IAO_0000115>An annotation property reflecting the string used by Brighton in their ABC tool to encode the term</obo:IAO_0000115>
<obo:IAO_0000112>AngEdGenLoc - angioedema, localized or generalized</obo:IAO_0000112>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/AERO_0000324 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/AERO_0000324">
<rdfs:label xml:lang="en">PHAC definition</rdfs:label>
<obo:IAO_0000115 xml:lang="en">The definition of the term as formalized in the PHAC user guide, http://www.phac-aspc.gc.ca/im/pdf/AEFI-ug-gu-eng.pdf. Those definitions are often very specific to adverse event following immunization and are intended for reporting personel.</obo:IAO_0000115>
</owl:AnnotationProperty>
<!-- http://purl.obolibrary.org/obo/IAO_0000115 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000118 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000118"/>
<!-- http://purl.obolibrary.org/obo/IAO_0000119 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
<!-- http://www.w3.org/2000/01/rdf-schema#comment -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#comment"/>
<!-- http://www.w3.org/2000/01/rdf-schema#label -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#label"/>
<!-- http://www.w3.org/2002/07/owl#versionInfo -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2002/07/owl#versionInfo"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Object Properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/AERO_0000088 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/AERO_0000088">
<rdfs:label xml:lang="en">found to exhibit</rdfs:label>
<obo:IAO_0000116 xml:lang="en">A funny kind of relation, as there is a sense in which this is really a made up relation so we can speak from a patient centric point of view. Really, the relation is established in the inverse direction - a process in which a patient or information about the patient is assessed leads to a finding about the patient. </obo:IAO_0000116>
<obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
<obo:IAO_0000115 xml:lang="en">if something is &apos;found to exhibit&apos; a clinical finding, then there is a clinical finding &apos;that &apos;is clinical finding about&apos; that something. </obo:IAO_0000115>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/AERO_0000125 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/AERO_0000125">
<rdfs:label xml:lang="en">has component</rdfs:label>
<obo:IAO_0000112 xml:lang="en">a VAERS report has_component MedDRA term 12345</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">indicates the constitutive elements of a document/guideline/specification.</obo:IAO_0000115>
<rdfs:subPropertyOf rdf:resource="http://www.obofoundry.org/ro/ro.owl#has_part"/>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/AERO_0000354 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/AERO_0000354">
<rdfs:label xml:lang="en">involves</rdfs:label>
<rdfs:comment xml:lang="en">20101115, MC: one difiiculty in defining this relation is how to &quot;cut&quot; the chain at the first system involved. Example (from AR): a patient has a stroke in a nexk artery, which causes brain damage. We would still say &quot;stroke involves cardiovascular system&quot; and NOT &quot;stroke involves nervous system&quot;</rdfs:comment>
<obo:IAO_0000115 xml:lang="en">A relation between a clinical finding and the anatomical system or entity in which it takes place, at least partly. </obo:IAO_0000115>
<rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:range rdf:resource="http://www.ifomis.org/bfo/1.1/snap#MaterialEntity"/>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/AERO_0000374 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/AERO_0000374">
<rdfs:label xml:lang="en">is clinical finding about</rdfs:label>
<obo:IAO_0000112 xml:lang="en">A clinician records a finding that the patient has nausea</obo:IAO_0000112>
<obo:IAO_0000115 xml:lang="en">Relates a clinical finding to the patient or part about which the finding was made.</obo:IAO_0000115>
<obo:IAO_0000112 xml:lang="en">a finding is made that the heart has a malfunctioning valve</obo:IAO_0000112>
<owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000088"/>
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:range>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.obofoundry.org/ro/ro.owl#part_of"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000270"/>
</owl:Restriction>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/BFO_0000055 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000055">
<rdfs:label xml:lang="en">realizes</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/BFO_0000068 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000068">
<rdfs:label xml:lang="en">begins to exist during</rdfs:label>
<rdfs:subPropertyOf rdf:resource="http://www.obofoundry.org/ro/ro.owl#participates_in"/>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/BFO_0000083 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000083">
<rdfs:label xml:lang="en">located at</rdfs:label>
</owl:ObjectProperty>
<!-- http://purl.obolibrary.org/obo/OBI_0000294 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000294"/>
<!-- http://purl.obolibrary.org/obo/OBI_0000297 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000297"/>
<!-- http://purl.obolibrary.org/obo/OBI_0000299 -->
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000299">
<rdfs:subPropertyOf rdf:resource="http://www.obofoundry.org/ro/ro.owl#has_participant"/>
</rdf:Description>
<!-- http://purl.obolibrary.org/obo/OBI_0000300 -->
<owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000300"/>
<!-- http://purl.org/obo/owl/OBO_REL#unfolds_in -->
<owl:ObjectProperty rdf:about="http://purl.org/obo/owl/OBO_REL#unfolds_in"/>
<!-- http://www.obofoundry.org/ro/ro.owl#has_part -->
<owl:ObjectProperty rdf:about="http://www.obofoundry.org/ro/ro.owl#has_part"/>
<!-- http://www.obofoundry.org/ro/ro.owl#located_in -->
<owl:ObjectProperty rdf:about="http://www.obofoundry.org/ro/ro.owl#located_in"/>
<!-- http://www.obofoundry.org/ro/ro.owl#preceded_by -->
<owl:ObjectProperty rdf:about="http://www.obofoundry.org/ro/ro.owl#preceded_by"/>
<!-- http://www.obofoundry.org/ro/ro.owl#precedes -->
<owl:ObjectProperty rdf:about="http://www.obofoundry.org/ro/ro.owl#precedes"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/AERO_0000001 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000001">
<rdfs:label xml:lang="en">diagnosis guideline</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000033"/>
<obo:IAO_0000115 xml:lang="en">A directive information entity that specifies how to establish a diagnosis based on clinical findings</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000002 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000002">
<rdfs:label xml:lang="en">disorder resulting from an AEFI process</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000005"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000016"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000005"/>
<rdfs:comment xml:lang="en">MC, 20110120: AR mentioned that the use of is_specified_output is not appropriate, as this would indicate that the adverse event process is a planned process - specified output are things that are specified in the plan to realize a process. Adverse events are not planned process but processual entities, and therefore this should be updated. AR mentioned that BFO will include an appropriate relation.</rdfs:comment>
<rdfs:comment xml:lang="en">MC, 20110120: This class should have a different label for OBO Foundry unique label. &quot;adverse event following immunization&quot; is a term in use by the clinician community, however in the context if the Foundry it may be confusing to associate the word &quot;event&quot; which seem to refer to a process with the hierarchical position under continuant.
Proposed OBO Foundry label: disorder resulting from an AEFI</rdfs:comment>
<rdfs:comment xml:lang="en">MC, 20110126: class renamed from &quot;adverse event following immunization continuant&quot; following AR suggestion</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000003 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000003">
<rdfs:label xml:lang="en">Brighton case definition</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000001"/>
<obo:IAO_0000115 xml:lang="en">A diagnosis guideline specifying how to establish a diagnosis of adverse event with an associated degree of certainty, as developed by the Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000115>
<rdfs:comment xml:lang="en">MC, 20110126: this should be linked to the different adverse events reported. AR suggests using a new relation to appear in BFO2, maybe &quot;ascription&quot;</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000004 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000004">
<rdfs:label>Brighton diagnosis of generalized convulsive seizure as an adverse event following immunization </rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000208"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000009"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000119>PMID:14741144#Generalized convulsive seizure as an adverse event following immunization: case definition and guidelines for data collection, analysis, and presentation.</obo:IAO_0000119>
<rdfs:comment>20121115, MC: originally &quot;a categorical measurement datum whose instances are used to classify adverse events according to whether or not they have some likelihood of being a seizure and if so, to what degree&quot;</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000005 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000005">
<rdfs:label xml:lang="en">disorder resulting from an adverse event process</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OGMS_0000045"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000068"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000015"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:comment xml:lang="en">MC, 20110120: AR mentioned that the use of is_specified_output is not appropriate, as this would indicate that the adverse event process is a planned process - specified output are things that are specified in the plan to realize a process. Adverse events are not planned process but processual entities, and therefore this should be updated. AR mentioned that BFO will include an appropriate relation.</rdfs:comment>
<rdfs:comment xml:lang="en">MC, 20110120: This class was initially labeled &quot;adverse event continuant&quot;. After discussion with AR, and due to the fact that the word &quot;event&quot; implicitely refers to a process, we renamed this class.</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000009 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000009">
<rdfs:label xml:lang="en">adverse event</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000005"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000015"/>
</owl:unionOf>
</owl:Class>
</owl:equivalentClass>
<obo:IAO_0000119>ICH Topic E 2 A Clinical Safety Data Management: Definitions and Standards for Expedited Reporting</obo:IAO_0000119>
<obo:IAO_0000115 xml:lang="en">An adverse event is an undesirable, unfavorable and unintended medical occurrence presenting in a predetermined time frame following administration of a compound or usage of a device</obo:IAO_0000115>
<rdfs:comment xml:lang="en">I initialy made adverse event a defined class: is_a sign and preceded by administration. However, by doing so, and as the range of preceded by is processual entities, I was implicitely making adverse event a subclass of processual entity, therfore making adverse event rash (a continuant) inconsistent.</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000010 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000010">
<rdfs:label xml:lang="en">adverse event following immunization</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000002"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000016"/>
</owl:unionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000009"/>
<obo:IAO_0000119>Adapted from ICH Topic E 2 A Clinical Safety Data Management: Definitions and Standards for Expedited Reporting</obo:IAO_0000119>
<obo:IAO_0000115>An adverse event is an undesirable, unfavorable and unintended medical occurrence presenting in a predetermined time frame following administration of a vaccine</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000011 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000011">
<rdfs:label xml:lang="en">_manifestations</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000101"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000245"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000247"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000254"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000261"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000264"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000285"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000302"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000364"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<rdfs:comment xml:lang="en">temporary placeholder - to be removed
This class just helps me group some terms during development of the structure</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000012 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000012">
<rdfs:label xml:lang="en">AEFI idiopathic thrombocytopenic purpura according to Brighton</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000011"/>
<obo:IAO_0000115 xml:lang="en">Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet count (thrombocytopenia) of no known cause (idiopathic).v</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">http://en.wikipedia.org/wiki/Idiopathic_thrombocytopenic_purpura</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000013 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000013">
<rdfs:label xml:lang="en">AEFI encephalitis according to Brighton</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000011"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000955"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">Encephalitis is an inflammation of the brain. It may be caused by a number of different factors. One of the most common causes is direct infection of the brain by a virus or bacterium. Inflammation can also occur as a complication of some other disorder, such as mumps (see mumps entry) or herpes simplex (see herpes infections entry).</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">http://www.faqs.org/health/Sick-V2/Encephalitis-Definition.html</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000014 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000014">
<rdfs:label xml:lang="en">motor manifestation</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000011"/>
<obo:IAO_0000115 xml:lang="en">A _manifestation involving the motor system</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000015 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000015">
<rdfs:label xml:lang="en">adverse event process</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://www.ifomis.org/bfo/1.1/span#ProcessualEntity"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.obofoundry.org/ro/ro.owl#preceded_by"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000274"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0600007"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<obo:IAO_0000115 xml:lang="en">An adverse event process is a processual entity occurring in a pre determined time frame following administration of a compound or usage of a device</obo:IAO_0000115>
<rdfs:comment xml:lang="en">I included the usage of a device into the definition of adverse event as I am aiming at being inclusive, and cover cases such as those described by MAUDE - Manufacturer and User Facility Device Experience. See for example http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfMAUDE/detail.cfm?mdrfoi__id=1942591 - a patient get fitted with bioprosthetic heart valves and dies within the following 4 months.</rdfs:comment>
<rdfs:comment xml:lang="en">Note that this definition of adverse event doesn&apos;t imply any type of causality between the sign observed and the coumpond administration/device utilization. For our purposes, we consider any type of sign presenting within a specific time frame after the coumpound administration/device utilization to be an adverse event.</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000016 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000016">
<rdfs:label xml:lang="en">adverse event following immunization process</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000015"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.obofoundry.org/ro/ro.owl#preceded_by"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/VO_0000002"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000015"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000021 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000021">
<rdfs:label xml:lang="en">seizure level 1 of certainty according to the Brighton criteria</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000048"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000026"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000029"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000030"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000031"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000004"/>
<rdfs:comment xml:lang="en">MC, 20110126: this needs to be linked to the Brighton guideline defined under directive information entity</rdfs:comment>
<obo:IAO_0000115 xml:lang="en">witnessed sudden loss of consciousness AND generalized,
tonic, clonic, tonic–clonic, or atonic motor manifestations. (atonic In the absence of: hypotonic hyporesponsive episode (as defined by the Brighton Collaboration), syncope, and myoclonic jerks.</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000022 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000022">
<rdfs:label xml:lang="en">seizure level 2 of certainty according to the Brighton criteria</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000047"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000026"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000029"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000030"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000031"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000004"/>
<rdfs:comment xml:lang="en">MC, 20110126: this needs to be linked to the Brighton guideline defined under directive information entity</rdfs:comment>
<obo:IAO_0000115 xml:lang="en">history of unconsciousness AND generalized,
tonic, clonic, tonic–clonic, or atonic motor manifestations. (atonic In the absence of: hypotonic hyporesponsive episode (as defined by the Brighton Collaboration), syncope, and myoclonic jerks.</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000023 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000023">
<rdfs:label xml:lang="en">seizure level 3 of certainty according to the Brighton criteria</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000028"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000047"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000004"/>
<rdfs:comment xml:lang="en">MC, 20110126: this needs to be linked to the Brighton guideline defined under directive information entity</rdfs:comment>
<obo:IAO_0000115 xml:lang="en">history of unconsciousness AND other generalized motor manifestations.</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000025 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000025">
<rdfs:label xml:lang="en">atonic motor manifestation finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000014"/>
<obo:IAO_0000115 xml:lang="en">A sudden loss of tone in postural muscle, often preceded by a myoclonic jerk and precipitated by hyperventilation</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000026 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000026">
<rdfs:label xml:lang="en">generalized atonic motor manifestation finding</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000025"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000028"/>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000025"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000027 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000027">
<rdfs:label xml:lang="en">clonic motor manifestation finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000014"/>
<obo:IAO_0000119 xml:lang="en">Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000119>
<obo:IAO_0000115 xml:lang="en">Sudden, brief (100ms) involuntary contractions of the same muscle groups, regularly repetitive at a frequency of about two to three contractions per second.</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000028 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000028">
<rdfs:label xml:lang="en">generalized motor manifestation finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000014"/>
<obo:IAO_0000119 xml:lang="en">Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000119>
<obo:IAO_0000115 xml:lang="en">bilateral motor manifestation, more than minimal muscle involvement</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000029 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000029">
<rdfs:label xml:lang="en">generalized clonic motor manifestation finding</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000027"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000028"/>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000030 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000030">
<rdfs:label xml:lang="en">generalized tonic motor manifestation finding</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000028"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000044"/>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000031 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000031">
<rdfs:label xml:lang="en">generalized tonic-clonic motor manifestation finding</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000027"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000028"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000044"/>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000035 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000035">
<rdfs:label xml:lang="en">AEFI hypotonic-hyporesponsive episode according to Brighton</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000011"/>
<obo:IAO_0000118 xml:lang="en">HHE</obo:IAO_0000118>
<obo:IAO_0000115 xml:lang="en">HHE is characterized by sudde onset of reduced muscle tone, hyporesponsiveness (i.e., less responsive than usual to verbal or other sensorial stimuli) and change of skin color (pallor or cyanosis)</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000038 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000038">
<rdfs:label xml:lang="en">performing a diagnosis of generalized convulsive seizure according to Brighton guidelines</rdfs:label>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000294"/>
<owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000039"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000207"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000004"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115>performing a diagnosis specified by the Brighton case definition for convulsive seizure as an adverse event following immunization</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000039 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000039">
<rdfs:label xml:lang="en">Brighton case definition of generalized convulsive seizure as an adverse event following immunization</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000003"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000297"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000300"/>
<owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000038"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115>A Brighton case definition of generalized convulsive seizure as an adverse event following immunization</obo:IAO_0000115>
<obo:IAO_0000119>PMID:14741144#Generalized convulsive seizure as an adverse event following immunization: case definition and guidelines for data collection, analysis, and presentation.</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000040 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000040">
<rdfs:label xml:lang="en">shaking finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000014"/>
<obo:IAO_0000118 xml:lang="en">quivering</obo:IAO_0000118>
<obo:IAO_0000115 xml:lang="en">repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement</obo:IAO_0000115>
<obo:IAO_0000118 xml:lang="en">shivering</obo:IAO_0000118>
<obo:IAO_0000118 xml:lang="en">trembling</obo:IAO_0000118>
<obo:IAO_0000118 xml:lang="en">tremor</obo:IAO_0000118>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000041 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000041">
<rdfs:label xml:lang="en">bilateral shaking finding</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000040"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.org/obo/owl/OBO_REL#unfolds_in"/>
<owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000050"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000040"/>
<obo:IAO_0000115 xml:lang="en">A shaking process which unfolds in both sides of an organism</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000042 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000042">
<rdfs:label xml:lang="en">syncope finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000014"/>
<rdfs:comment xml:lang="en">MC, 20110126: The Brighton guideline on which this is based needs to be checked.
Email correspondance with Brighton:
[MC] One thing is unclear to me: Level 1 of diagnostic certainty is defined
as &quot;witnessed sudden loss of consciousness AND generalized, tonic,
clonic, tonic–clonic, or atonic motor manifestations.&quot;
A footnote adds: atonic in the absence of: hypotonic hyporesponsive
episode (as defined by the Brighton Collaboration), syncope, and
myoclonic jerks.
If we define syncope as being a loss of consciousness, how can I have
a witnessed sudden loss of consciousness and a generalized atonic
motor manifestation in the absence of syncope?
[Brighton] Thank you for your question. You are right, that there is an overlap between the clinical presentation of an atonic seizure and a Syncope. This is also true for HHE. This is the very reasonf or the footnote to alert the user of the definition to this differential diagnosis.
If you are working on a database and only have the clinical criteria vailable, you may have some false positives for the atonic seizure cases, unless you obtain additional information, e.g. that the Syncope was vasovagal or orthostatic, or arrhythmic, etc.</rdfs:comment>
<obo:IAO_0000119 xml:lang="en">http://en.wikipedia.org/wiki/Syncope_%28medicine%29</obo:IAO_0000119>
<obo:IAO_0000115 xml:lang="en">loss of consciousness, fainting</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000043 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000043">
<rdfs:label xml:lang="en">myoclonic jerk finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000014"/>
<obo:IAO_0000115 xml:lang="en">A myoclonic jerk is the brief, involuntary twitching of a muscle or group of muscles. It may be caused either by a sudden muscle contraction, or a sudden lapse of contraction. This happens when a person is on the verge of falling asleep, and suddenly have a sensation or feeling that they are free falling through the air. Contractions are called positive myoclonus; relaxations are called negative myoclonus. When falling asleep, it is common for people to experience a type of myoclonic jerk known as a hypnic jerk. Hiccups are also a kind of myoclonic jerk specifically affecting the diaphragm.</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">http://house.wikia.com/wiki/Myoclonic_jerk</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000044 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000044">
<rdfs:label xml:lang="en">tonic motor manifestation finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000044"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.obofoundry.org/ro/ro.owl#precedes"/>
<owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000027"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A sustained increase in muscle contraction lasting a few seconds to minutes</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000045 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000045">
<rdfs:label xml:lang="en">loss of consciousness finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<obo:AERO_0000324 xml:lang="en">Total suspension of conscious relationship with the outside world demonstrated by the inability to perceive and to respond to verbal, visual, and painful stimulus</obo:AERO_0000324>
<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000047 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000047">
<rdfs:label xml:lang="en">history of unconsciousness</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000045"/>
<obo:IAO_0000119 xml:lang="en">Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000119>
<rdfs:comment xml:lang="en">MC, 20110126: AR suggest that &quot;history of consciousness is not a process.
definition reads &quot;the sudden loss of consciousness was not observed, but the patient was found unconscious&quot;, so maybe updating the label would be better : &quot;unwitnessed loss of consciousness with history of unconsciousness&quot; would help</rdfs:comment>
<obo:IAO_0000115 xml:lang="en">the sudden loss of consciousness was not observed, but the patient was found unconscious</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000048 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000048">
<rdfs:label xml:lang="en">witnessed sudden loss of consciousness finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000047"/>
<obo:IAO_0000119 xml:lang="en">Brighton Collaboration, http://www.brightoncollaboration.org/</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000050 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000050">
<rdfs:label xml:lang="en">bilateral site</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.ifomis.org/bfo/1.1/snap#Site"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000086"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000137"/>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000055 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000055">
<rdfs:label xml:lang="en">witness role</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.ifomis.org/bfo/1.1/snap#Role"/>
<obo:IAO_0000115 xml:lang="en">A role inhering in a person that is realized when the bearer sees an event and reports what happened</obo:IAO_0000115>
<obo:IAO_0000119 xml:lang="en">adapted from http://golovchenko.org/cgi-bin/wnsearch?q=witness</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000066 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000066">
<rdfs:label xml:lang="en">adverse side effect</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000009"/>
<obo:IAO_0000115 xml:lang="en">side effect is an adverse event of a type that has been determined by a review board to be causally related to the intervention.</obo:IAO_0000115>
<rdfs:comment xml:lang="en">while in some cases the particular may not be actually caused by the intervention, it is an adverse side effect nonetheless.</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000067 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000067">
<rdfs:label xml:lang="en">device malfunction</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.ifomis.org/bfo/1.1/span#ProcessualEntity"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000968"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A process in which the device doesn&apos;t perform as expected</obo:IAO_0000115>
<obo:IAO_0000111 xml:lang="en">device malfunction</obo:IAO_0000111>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000068 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000068">
<rdfs:label xml:lang="en">adverse event report</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000088"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000009"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000067"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000209"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">A report as submitted in an adverse event reporting system</obo:IAO_0000115>
<obo:IAO_0000116 xml:lang="en">MC, 20110719: not all adverse event report are about adverse event. See for example cases in MAUDE database that are about potential adverse events such as device malfunctions.</obo:IAO_0000116>
<obo:IAO_0000111 xml:lang="en">adverse event report</obo:IAO_0000111>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000080 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000080">
<rdfs:label xml:lang="en">reporting process</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.ifomis.org/bfo/1.1/span#ProcessualEntity"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000088"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">The process of creating documentation about something and adding it to a system allowing further analysis of the reported entity</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000100 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000100">
<rdfs:label xml:lang="en">sudden onset</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000101"/>
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<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:AERO_0000106>SuddOnset</obo:AERO_0000106>
<obo:IAO_0000119>Anaphylaxis: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine 25 (2007) 5675–5684</obo:IAO_0000119>
<obo:IAO_0000115>The term sudden onsets refers to an event that occurred unexpectedly and without warning leading to a marked change in a subjects previously stable condition</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000101 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000101">
<rdfs:label xml:lang="en">rapid progression</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000123"/>
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<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000301"/>
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<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000358"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000359"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000360"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000363"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000364"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000365"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000368"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000370"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000382"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/OBI_0000075"/>
<obo:AERO_0000106>RapidProgr</obo:AERO_0000106>
<obo:IAO_0000119>Anaphylaxis: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine 25 (2007) 5675–5684</obo:IAO_0000119>
<obo:IAO_0000115>The term rapid progression is a conventional clinical term. An exact timeframe sould not be offered since it would have to refer to a wide range of signs and symptoms without a scientific evidence base. Using an arbitrarily restrictive setpoint might bias future data collection unnecessarily.</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000123 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000123">
<rdfs:label xml:lang="en">respiratory distress diagnosis</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000265"/>
<owl:minQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">2</owl:minQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000260"/>
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</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000261"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000262"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000263"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000264"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000208"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000245"/>
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<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000364"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:IAO_0000115>respiratory distress—2 or more of the
following:
• tachypnoea
• increased use of accessory respiratory muscles (sternocleidomastoid, intercostals, etc.)
• recession
• cyanosis
• grunting</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000207 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000207">
<rdfs:label xml:lang="en">performing a diagnosis according to a Brighton case definition</rdfs:label>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
<owl:someValuesFrom>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000294"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000003"/>
</owl:Restriction>
</owl:someValuesFrom>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000988"/>
<rdfs:comment xml:lang="en"></rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000208 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000208">
<rdfs:label xml:lang="en">Brighton diagnosis result</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000210"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000221"/>
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<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000246"/>
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<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000251"/>
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<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000340"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000341"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000357"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000358"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000359"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000360"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000363"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000364"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000365"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000368"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000370"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000382"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/OBI_0000075"/>
<obo:IAO_0000115 xml:lang="en">The diagnosis performed upon review of an adverse event report according to the Brighton case definitions</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000209 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000209">
<rdfs:label xml:lang="en">adverse event reporting process</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000080"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000068"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 xml:lang="en">The process of creating documentation about an adverse event and adding it to a system allowing further analysis of the event</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000210 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000210">
<rdfs:label xml:lang="en">clinical diagnosis of uncompensated shock</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000252"/>
<owl:minQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">3</owl:minQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000253"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000254"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000255"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000256"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000245"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000264"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000302"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:IAO_0000115 xml:lang="en">combination of at least 3 of the following:
- tachycardia
- capillary refill time &gt; 3s
- reduced central pulse volume
- decreased level of consciousness or loss of consciousness</obo:IAO_0000115>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000221 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000221">
<rdfs:label xml:lang="en">dermatologic or mucosal sign</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0012125"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000254"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000264"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000285"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
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<!-- http://purl.obolibrary.org/obo/AERO_0000223 -->
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<!-- http://purl.obolibrary.org/obo/AERO_0000230 -->
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<!-- http://purl.obolibrary.org/obo/AERO_0000244 -->
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<!-- http://purl.obolibrary.org/obo/AERO_0000245 -->
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<!-- http://purl.obolibrary.org/obo/AERO_0000246 -->
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<rdfs:comment xml:lang="en">20130423, MC: in the anaphylaxis case definition, angioedeme can be localized or generalized. There was no need as of today to create specialized subclasses representing those.</rdfs:comment>
<obo:AERO_0000106 xml:lang="en">AngEdGenLoc</obo:AERO_0000106>
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<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
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<!-- http://purl.obolibrary.org/obo/AERO_0000247 -->
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<!-- http://purl.obolibrary.org/obo/AERO_0000248 -->
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<rdfs:label xml:lang="en">_anaphylaxis according to Brighton criteria set of clinical findings</rdfs:label>
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<rdfs:comment xml:lang="en">20120821, MC: placeholder for development</rdfs:comment>
<obo:IAO_0000115>the set of clinical findings that are classified as being relevant for the anaphylaxis diagnosis</obo:IAO_0000115>
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<!-- http://purl.obolibrary.org/obo/AERO_0000250 -->
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<!-- http://purl.obolibrary.org/obo/AERO_0000251 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000251">
<rdfs:label xml:lang="en">measured hypotension finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004535"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000037"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000254"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000264"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:AERO_0000324 xml:lang="en">An abnormally low blood pressure and documented by appropriate measurement. Infants and children: age specific systolic BP of &lt;3-5%percentile or greater than a 30% decrease from that person’s baseline; Adults: systolic BP of &lt;90mm Hg or greater than 30% decrease from that person’s baseline.</obo:AERO_0000324>
<obo:AERO_0000106 xml:lang="en">HypotensMeas</obo:AERO_0000106>
<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000252 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000252">
<rdfs:label xml:lang="en">uncompensated shock sign finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004535"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000261"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000263"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000264"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000285"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000302"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000364"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<owl:disjointUnionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000253"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000254"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000255"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000256"/>
</owl:disjointUnionOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000253 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000253">
<rdfs:label xml:lang="en">tachycardia finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004535"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000044"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000254"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:AERO_0000324 xml:lang="en">A heart rate that is abnormally high for age and circumstance (In beats per minute: &lt;1year old: &gt;160; 1 – 2 yrs: &gt;150; 2-5 yrs: &gt;140; 5-12 yrs: &gt;120; &gt;12 yrs: &gt;100)</obo:AERO_0000324>
<obo:IAO_0000119 xml:lang="en">Citation for norms is Don &amp; Roberton; Physical examination; in Practical Pediatrics 2007; 6th ed</obo:IAO_0000119>
<obo:AERO_0000106 xml:lang="en">TachyCard</obo:AERO_0000106>
<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000254 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000254">
<rdfs:label xml:lang="en">capillary refill time &gt; 3s finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004535"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000021"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000255"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000258"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000259"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000260"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000261"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000262"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000263"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000264"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000265"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000276"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000281"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000285"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000290"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000293"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000299"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000301"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000302"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000341"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000357"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000358"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000359"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000360"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000363"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000364"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000365"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000368"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000370"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000382"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/OBI_0000075"/>
<obo:AERO_0000106 xml:lang="en">CapRefillOver3</obo:AERO_0000106>
<obo:AERO_0000324 xml:lang="en">Capillary refill time is the time required for the normal skin colour to reappear after a blanching pressure is applied. It is usually performed by pressing on the nail bed to cause blanching and then counting the time it takes for the blood to return to the tissue, indicated by a pink colour returning to the nail. Normally it is &lt;3 seconds.</obo:AERO_0000324>
<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000255 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000255">
<rdfs:label xml:lang="en">reduced central pulse volume finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004535"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000263"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000264"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000302"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:AERO_0000106 xml:lang="en">PulseVolRed</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000256 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000256">
<rdfs:label xml:lang="en">decreased level of consciousness or loss of consciousness finding</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000045"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000372"/>
</owl:unionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004535"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:comment xml:lang="en">loss of counsciousness is a subclass of decreased consciousness, so saying &quot;is about some decreased level of consciousness&quot; I cover all cases</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000257 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000257">
<rdfs:label xml:lang="en">bilateral wheeze finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000360"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000114"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:AERO_0000106 xml:lang="en">WheezeBilat</obo:AERO_0000106>
<obo:IAO_0000118 xml:lang="en">bronchospasm finding</obo:IAO_0000118>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000258 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000258">
<rdfs:label xml:lang="en">stridor finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001004"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000042"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000263"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:AERO_0000324 xml:lang="en">A harsh and continuous sound made on breathing in.</obo:AERO_0000324>
<obo:AERO_0000106 xml:lang="en">Stridor</obo:AERO_0000106>
<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000259 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000259">
<rdfs:label xml:lang="en">upper airway swelling finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001004"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000116"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000263"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:AERO_0000106 xml:lang="en">SwellUpAirways</obo:AERO_0000106>
<obo:IAO_0000232 xml:lang="en">lip, tongue, throat, uvula or larynx</obo:IAO_0000232>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000260 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000260">
<rdfs:label xml:lang="en">tachypnoea finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000045"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001004"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000263"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:IAO_0000119 xml:lang="en">Citation for norms is Don &amp; Roberton; Physical examination; in Practical Pediatrics 2007; 6th ed</obo:IAO_0000119>
<obo:AERO_0000324 xml:lang="en">Rapid breathing which is abnormally high for age and circumstance rapid breathing whichis abnormally high for age and circumstance (&lt;1yr: &gt;60; 1-2 yrs: &gt;40; 2-5 yrs: &gt;35; 5-12 yrs: &gt;30: &gt;12 yrs: &gt;16)</obo:AERO_0000324>
<obo:AERO_0000106 xml:lang="en">TachyPnea</obo:AERO_0000106>
<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
<obo:IAO_0000118 xml:lang="en">tachypnea finding</obo:IAO_0000118>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000261 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000261">
<rdfs:label xml:lang="en">increased use of accessory respiratory muscles finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001004"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000031"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000264"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000276"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000277"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000279"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000293"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:AERO_0000106 xml:lang="en">RespMuscAccIncr</obo:AERO_0000106>
<obo:IAO_0000232 xml:lang="en">sternocleidomastoid, intercostals, etc</obo:IAO_0000232>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000262 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000262">
<rdfs:label xml:lang="en">recession finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000355"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001004"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000264"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:AERO_0000106 xml:lang="en">Recess</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000263 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000263">
<rdfs:label xml:lang="en">cyanosis finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001004"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000023"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000277"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000290"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000301"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000304"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000358"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000359"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000360"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000363"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000370"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000382"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:AERO_0000324 xml:lang="en">A dark bluish or purplish discolouration of the skin and mucous membrane due to lack of oxygen in the blood.</obo:AERO_0000324>
<obo:AERO_0000106>Cyanosis</obo:AERO_0000106>
<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000264 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000264">
<rdfs:label xml:lang="en">grunting finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000029"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001004"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000276"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000277"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000279"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000285"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000299"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000302"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000303"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000304"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000307"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000309"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000310"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000340"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000357"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000363"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000364"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000365"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000368"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/OBI_0000075"/>
<obo:AERO_0000324 xml:lang="en">A sudden and short noise with each breath when breathing out.</obo:AERO_0000324>
<obo:AERO_0000106 xml:lang="en">Grunting</obo:AERO_0000106>
<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000265 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000265">
<rdfs:label xml:lang="en">respiratory distress sign finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000285"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000302"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000364"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<owl:disjointUnionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000260"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000261"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000262"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000263"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000264"/>
</owl:disjointUnionOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000267 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000267">
<rdfs:label xml:lang="en">Brighton diagnosis of anaphylaxis as an adverse event following immunization</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000208"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000269 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000269">
<rdfs:label xml:lang="en">Level 1 of certainty of anaphylaxis according to Brighton</rdfs:label>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/AERO_0000244"/>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:someValuesFrom>
<owl:Class>
<owl:unionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000249"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000250"/>
</owl:unionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000267"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000270 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000270">
<rdfs:label xml:lang="en">patient</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.ifomis.org/bfo/1.1/snap#MaterialEntity"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000272 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000272">
<rdfs:label xml:lang="en">generalized prickle sensation finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000365"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0012125"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000271"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:AERO_0000106 xml:lang="en">PrickleSens</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000274 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000274">
<rdfs:label xml:lang="en">localized injection site urticaria finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000370"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000383"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0012125"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:AERO_0000324 xml:lang="en">Localized redness of superficial layers of skin that is itchy, raised, sharply demarcated and transient (that is skin changes at any location are usually present for less than 12 hours).</obo:AERO_0000324>
<obo:AERO_0000106 xml:lang="en">UrticariaLOC</obo:AERO_0000106>
<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000276 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000276">
<rdfs:label xml:lang="en">red and itchy eyes finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000285"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<obo:AERO_0000106 xml:lang="en">EyeRedItch</obo:AERO_0000106>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000277 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000277">
<rdfs:label xml:lang="en">reduced peripheral circulation finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004535"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000285"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000302"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000364"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<owl:disjointUnionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000253"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000256"/>
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/AERO_0000278"/>
</owl:disjointUnionOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000278 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000278">
<rdfs:label xml:lang="en">capillary refill time &gt; 3s finding without hypotension</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000254"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004535"/>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000279 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000279">
<rdfs:label xml:lang="en">reduced peripheral circulation diagnosis</rdfs:label>
<owl:equivalentClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000304"/>
<owl:equivalentClass>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000277"/>
<owl:minQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">2</owl:minQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000253"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000256"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000125"/>
<owl:onClass rdf:resource="http://purl.obolibrary.org/obo/AERO_0000278"/>
<owl:maxQualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:maxQualifiedCardinality>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0004535"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000285"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000302"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000347"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000364"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000366"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
<rdfs:comment>The reduced peripheral circulation diagnosis is the minor cardiovascular criterion for anaphylaxis according to Brighton. The diagnosis is established by observing the combination of at least 2 reduced peripheral circulation findings, but at most one of each type.</rdfs:comment>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000281 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000281">
<rdfs:label xml:lang="en">generalized pruritus without skin rash finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000367"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0012125"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000220"/>
</owl:Restriction>
</rdfs:subClassOf>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000295"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000297"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000356"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000361"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000372"/>
<owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/AERO_0000414"/>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000283 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000283">
<rdfs:label xml:lang="en">persistent dry cough finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/AERO_0000355"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000027"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:AERO_0000106 xml:lang="en">CoughPersisDry</obo:AERO_0000106>
<obo:AERO_0000324 xml:lang="en">Rapid expulsion of air from the lungs to clear the lung airways and not accompanied by expectoration (a non-productive cough).</obo:AERO_0000324>
<obo:IAO_0000119 xml:lang="en">Vaccine 28 (2010) 4487-4498</obo:IAO_0000119>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/AERO_0000285 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/AERO_0000285">
<rdfs:label xml:lang="en">hoarse voice finding</rdfs:label>
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000014"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/AERO_0000354"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001004"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/ogms/OMRE_0000030"/>
</owl