diff --git a/CHANGES/3332.feature b/CHANGES/3332.feature
new file mode 100644
index 0000000000..be943de910
--- /dev/null
+++ b/CHANGES/3332.feature
@@ -0,0 +1 @@
+Added set_label and delets_label endpoints to allow manipulating individual labels synchronously.
diff --git a/pulpcore/app/serializers/__init__.py b/pulpcore/app/serializers/__init__.py
index 81884f2df6..ae74827ff9 100644
--- a/pulpcore/app/serializers/__init__.py
+++ b/pulpcore/app/serializers/__init__.py
@@ -4,20 +4,22 @@
 
 from .base import (
     AsyncOperationResponseSerializer,
+    DeleteLabelSerializer,
     DetailIdentityField,
     DetailRelatedField,
     DomainUniqueValidator,
     GetOrCreateSerializerMixin,
+    HiddenFieldsMixin,
     IdentityField,
     ModelSerializer,
     NestedIdentityField,
     NestedRelatedField,
     RelatedField,
     RelatedResourceField,
+    SetLabelSerializer,
     TaskGroupOperationResponseSerializer,
     ValidateFieldsMixin,
     validate_unknown_fields,
-    HiddenFieldsMixin,
 )
 from .fields import (
     BaseURLField,
diff --git a/pulpcore/app/serializers/base.py b/pulpcore/app/serializers/base.py
index f842328f12..8e90c5c7f2 100644
--- a/pulpcore/app/serializers/base.py
+++ b/pulpcore/app/serializers/base.py
@@ -504,3 +504,27 @@ class TaskGroupOperationResponseSerializer(serializers.Serializer):
         view_name="task-groups-detail",
         allow_null=False,
     )
+
+
+class DeleteLabelSerializer(serializers.Serializer):
+    """
+    Serializer for synchronously setting a label.
+    """
+
+    label = serializers.SlugField(required=True)
+
+    def validate_label(self, value):
+        if value not in self.context["content_object"].pulp_labels:
+            raise serializers.ValidationError(
+                _("Label '{label}' is not set on the object.").format(label=value)
+            )
+        return value
+
+
+class SetLabelSerializer(serializers.Serializer):
+    """
+    Serializer for synchronously setting a label.
+    """
+
+    label = serializers.SlugField(required=True)
+    value = serializers.CharField(required=True, allow_null=True, allow_blank=True)
diff --git a/pulpcore/app/viewsets/__init__.py b/pulpcore/app/viewsets/__init__.py
index 6d17c93fc8..6f017e6a03 100644
--- a/pulpcore/app/viewsets/__init__.py
+++ b/pulpcore/app/viewsets/__init__.py
@@ -2,6 +2,7 @@
     AsyncCreateMixin,
     AsyncRemoveMixin,
     AsyncUpdateMixin,
+    LabelsMixin,
     NamedModelViewSet,
     RolesMixin,
     NAME_FILTER_OPTIONS,
diff --git a/pulpcore/app/viewsets/base.py b/pulpcore/app/viewsets/base.py
index 017cdcd419..0af78b33fb 100644
--- a/pulpcore/app/viewsets/base.py
+++ b/pulpcore/app/viewsets/base.py
@@ -4,6 +4,7 @@
 
 from django.conf import settings
 from django.db import transaction
+from django.db.models.expressions import RawSQL
 from django.core.exceptions import FieldError, ValidationError
 from django.urls import Resolver404, resolve
 from django.contrib.contenttypes.models import ContentType
@@ -20,7 +21,12 @@
 from pulpcore.app.models.role import GroupRole, UserRole
 from pulpcore.app.response import OperationPostponedResponse
 from pulpcore.app.role_util import get_objects_for_user
-from pulpcore.app.serializers import AsyncOperationResponseSerializer, NestedRoleSerializer
+from pulpcore.app.serializers import (
+    AsyncOperationResponseSerializer,
+    NestedRoleSerializer,
+    DeleteLabelSerializer,
+    SetLabelSerializer,
+)
 from pulpcore.app.util import get_viewset_for_model
 from pulpcore.tasking.tasks import dispatch
 
@@ -626,3 +632,46 @@ def my_permissions(self, request, pk=None):
             ".".join((app_label, codename)) for codename in request.user.get_all_permissions(obj)
         ]
         return Response({"permissions": permissions})
+
+
+class LabelsMixin:
+    @extend_schema(
+        summary="Set a label",
+        description="Set a single pulp_label on the object to a specific value or null.",
+        responses={
+            200: SetLabelSerializer,
+        },
+    )
+    @action(detail=True, methods=["put"], serializer_class=SetLabelSerializer)
+    def set_label(self, request, pk=None):
+        obj = self.get_object()
+        serializer = SetLabelSerializer(
+            data=request.data, context={"request": request, "content_object": obj}
+        )
+        serializer.is_valid(raise_exception=True)
+        obj._meta.model.objects.filter(pk=obj.pk).update(
+            pulp_labels=RawSQL(
+                "pulp_labels || hstore(%s, %s)",
+                [serializer.validated_data["label"], serializer.validated_data["value"]],
+            )
+        )
+        return Response(serializer.validated_data)
+
+    @extend_schema(
+        summary="Delete a label",
+        description="Delete a single pulp_label on the object.",
+        responses={
+            204: None,
+        },
+    )
+    @action(detail=True, methods=["post"], serializer_class=DeleteLabelSerializer)
+    def delete_label(self, request, pk=None):
+        obj = self.get_object()
+        serializer = DeleteLabelSerializer(
+            data=request.data, context={"request": request, "content_object": obj}
+        )
+        serializer.is_valid(raise_exception=True)
+        obj._meta.model.objects.filter(pk=obj.pk).update(
+            pulp_labels=RawSQL("pulp_labels - %s::text", [serializer.validated_data["label"]])
+        )
+        return Response(status=204)
diff --git a/pulpcore/app/viewsets/publication.py b/pulpcore/app/viewsets/publication.py
index 2431e5396c..087f73df4d 100644
--- a/pulpcore/app/viewsets/publication.py
+++ b/pulpcore/app/viewsets/publication.py
@@ -27,6 +27,7 @@
     AsyncCreateMixin,
     AsyncRemoveMixin,
     AsyncUpdateMixin,
+    LabelsMixin,
     NamedModelViewSet,
     RolesMixin,
 )
@@ -434,6 +435,7 @@ class DistributionViewSet(
     AsyncCreateMixin,
     AsyncRemoveMixin,
     AsyncUpdateMixin,
+    LabelsMixin,
 ):
     """
     Provides read and list methods and also provides asynchronous CUD methods to dispatch tasks
diff --git a/pulpcore/app/viewsets/repository.py b/pulpcore/app/viewsets/repository.py
index 75af664274..c28a5492b7 100644
--- a/pulpcore/app/viewsets/repository.py
+++ b/pulpcore/app/viewsets/repository.py
@@ -30,6 +30,7 @@
 from pulpcore.app.viewsets import (
     AsyncRemoveMixin,
     AsyncUpdateMixin,
+    LabelsMixin,
     NamedModelViewSet,
 )
 from pulpcore.app.viewsets.base import (
@@ -168,7 +169,7 @@ class ImmutableRepositoryViewSet(
     """
 
 
-class RepositoryViewSet(ImmutableRepositoryViewSet, AsyncUpdateMixin):
+class RepositoryViewSet(ImmutableRepositoryViewSet, AsyncUpdateMixin, LabelsMixin):
     """
     A ViewSet for an ordinary repository.
     """
@@ -369,6 +370,7 @@ class RemoteViewSet(
     mixins.ListModelMixin,
     AsyncUpdateMixin,
     AsyncRemoveMixin,
+    LabelsMixin,
 ):
     endpoint_name = "remotes"
     serializer_class = RemoteSerializer
diff --git a/pulpcore/plugin/viewsets/__init__.py b/pulpcore/plugin/viewsets/__init__.py
index 6f00b938d9..0a4c9af9e9 100644
--- a/pulpcore/plugin/viewsets/__init__.py
+++ b/pulpcore/plugin/viewsets/__init__.py
@@ -18,6 +18,7 @@
     ImmutableRepositoryViewSet,
     ImporterViewSet,
     ImportViewSet,
+    LabelsMixin,
     NamedModelViewSet,
     NAME_FILTER_OPTIONS,
     NULLABLE_NUMERIC_FILTER_OPTIONS,