diff --git a/Libraries/Pressability/Pressability.js b/Libraries/Pressability/Pressability.js
index 7f1626239ed8b8..4e8928ec3e9c58 100644
--- a/Libraries/Pressability/Pressability.js
+++ b/Libraries/Pressability/Pressability.js
@@ -628,12 +628,35 @@ export default class Pressability {
         if (onKeyDown != null) {
           onKeyDown(event);
         }
+        // Pressables on macOS should respond to the enter/return and spacebar keys.
+        // The keyDown event triggers a press event as well as the pressIn effect mimicking a native control behavior.
+        if (
+          (event.nativeEvent.key === 'Enter' ||
+            event.nativeEvent.key === ' ') &&
+          event.defaultPrevented !== true
+        ) {
+          const {onPress, onPressIn} = this._config;
+          // $FlowFixMe: PressEvents don't mesh with keyboarding APIs. Keep legacy behavior of passing KeyEvents instead
+          onPressIn && onPressIn(event);
+          // $FlowFixMe: PressEvents don't mesh with keyboarding APIs. Keep legacy behavior of passing KeyEvents instead
+          onPress && onPress(event);
+        }
       },
       onKeyUp: (event: KeyEvent): void => {
         const {onKeyUp} = this._config;
         if (onKeyUp != null) {
           onKeyUp(event);
         }
+        // The keyUp event triggers the pressOut effect.
+        if (
+          (event.nativeEvent.key === 'Enter' ||
+            event.nativeEvent.key === ' ') &&
+          event.defaultPrevented !== true
+        ) {
+          const {onPressOut} = this._config;
+          // $FlowFixMe: PressEvents don't mesh with keyboarding APIs. Keep legacy behavior of passing KeyEvents instead
+          onPressOut && onPressOut(event);
+        }
       },
     };
     // ]TODO(macOS GH#774)
diff --git a/React/Views/RCTView.m b/React/Views/RCTView.m
index 7571f349d97435..02ce4f3a1b0459 100644
--- a/React/Views/RCTView.m
+++ b/React/Views/RCTView.m
@@ -1632,6 +1632,12 @@ - (RCTViewKeyboardEvent*)keyboardEvent:(NSEvent*)event {
   NSArray<NSString *> *validKeys = keyDown ? self.validKeysDown : self.validKeysUp;
   NSString *key = [RCTViewKeyboardEvent keyFromEvent:event];
 
+  // If the view is focusable and the component didn't explicity set the validKeysDown or Up,
+  // allow enter/return and spacebar key events to mimic the behavior of native controls.
+  if (self.focusable && validKeys == nil) {
+    validKeys = @[@"Enter", @" "];
+  }
+
   // Only post events for keys we care about
   if (![validKeys containsObject:key]) {
     return nil;