diff --git a/.gitignore b/.gitignore
index dd140cf0549..c8c6bbe4817 100644
--- a/.gitignore
+++ b/.gitignore
@@ -33,6 +33,12 @@ node_modules
 # Optional REPL history
 .node_repl_history
 
+# No NPM config to pass CFS compliance
+.npmrc
+
+# We use yarn, not npm
+package-lock.json
+
 #React Native
 *AppPackages*
 *BundleArtifacts*
diff --git a/GuardianCustomConfiguration.json b/GuardianCustomConfiguration.json
new file mode 100644
index 00000000000..a13b148c28d
--- /dev/null
+++ b/GuardianCustomConfiguration.json
@@ -0,0 +1,3 @@
+{
+    "Enabled": false,
+}
diff --git a/NuGet.Config b/NuGet.Config
index 37fd926fae7..9bbea8e6786 100644
--- a/NuGet.Config
+++ b/NuGet.Config
@@ -6,9 +6,7 @@
   </packageRestore>
   <packageSources>
     <clear />
-    <add key="Nuget.org" value="https://api.nuget.org/v3/index.json" />
+    <!-- Warning: Do not add/change the NuGet feeds here. To be compliant this repo must only rely on this single ADO feed. -->
+    <add key="react-native" value="https://pkgs.dev.azure.com/ms/react-native/_packaging/react-native-public/nuget/v3/index.json" />
   </packageSources>
-  <disabledPackageSources>
-    <clear />
-  </disabledPackageSources>  
 </configuration>
diff --git a/change/@react-native-windows-cli-81517eff-3586-4693-8d07-0ff6bd9710b0.json b/change/@react-native-windows-cli-81517eff-3586-4693-8d07-0ff6bd9710b0.json
new file mode 100644
index 00000000000..a73cc8a3b3b
--- /dev/null
+++ b/change/@react-native-windows-cli-81517eff-3586-4693-8d07-0ff6bd9710b0.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "[0.68] Compliance: Rename template Nuget.config files to stop triggering multi-feed warnings",
+  "packageName": "@react-native-windows/cli",
+  "email": "jthysell@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/change/react-native-windows-14a87dda-f285-4cd4-8a0f-b5aa9543cb9f.json b/change/react-native-windows-14a87dda-f285-4cd4-8a0f-b5aa9543cb9f.json
new file mode 100644
index 00000000000..01fe610b6b1
--- /dev/null
+++ b/change/react-native-windows-14a87dda-f285-4cd4-8a0f-b5aa9543cb9f.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "[0.68] Fix Secure Supply Chain compliance issues",
+  "packageName": "react-native-windows",
+  "email": "jthysell@microsoft.com",
+  "dependentChangeType": "patch"
+}
\ No newline at end of file
diff --git a/change/react-native-windows-74880bf0-e7b0-4668-9148-3c7fbf28d4a9.json b/change/react-native-windows-74880bf0-e7b0-4668-9148-3c7fbf28d4a9.json
new file mode 100644
index 00000000000..6f6578a53f7
--- /dev/null
+++ b/change/react-native-windows-74880bf0-e7b0-4668-9148-3c7fbf28d4a9.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "[0.68] Compliance: Rename template Nuget.config files to stop triggering multi-feed warnings",
+  "packageName": "react-native-windows",
+  "email": "jthysell@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/packages/@react-native-windows/cli/src/generator-windows/index.ts b/packages/@react-native-windows/cli/src/generator-windows/index.ts
index cfd815a1735..a6c1132d304 100644
--- a/packages/@react-native-windows/cli/src/generator-windows/index.ts
+++ b/packages/@react-native-windows/cli/src/generator-windows/index.ts
@@ -343,7 +343,7 @@ export async function copyProjectTemplateAndReplace(
     const sharedProjMappings = [];
 
     sharedProjMappings.push({
-      from: path.join(sharedPath, projDir, 'NuGet.Config'),
+      from: path.join(sharedPath, projDir, 'NuGet_Config'),
       to: path.join(windowsDir, 'NuGet.Config'),
     });
 
diff --git a/packages/e2e-test-app/.npmrc b/packages/e2e-test-app/.npmrc
deleted file mode 100644
index 9cf9495031e..00000000000
--- a/packages/e2e-test-app/.npmrc
+++ /dev/null
@@ -1 +0,0 @@
-package-lock=false
\ No newline at end of file
diff --git a/packages/e2e-test-app/windows/NuGet.Config b/packages/e2e-test-app/windows/NuGet.Config
deleted file mode 100644
index e5dd43a0afa..00000000000
--- a/packages/e2e-test-app/windows/NuGet.Config
+++ /dev/null
@@ -1,14 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<configuration>
-  <config>
-    <add key="repositoryPath" value="packages" />
-  </config>
-  <packageSources>
-    <clear />
-    <add key="react-native" value="https://pkgs.dev.azure.com/ms/react-native/_packaging/react-native-public/nuget/v3/index.json" />
-    <add key="Nuget.org" value="https://api.nuget.org/v3/index.json" />
-  </packageSources>
-  <disabledPackageSources>
-    <clear />
-  </disabledPackageSources>  
-</configuration>
diff --git a/packages/integration-test-app/windows/NuGet.Config b/packages/integration-test-app/windows/NuGet.Config
deleted file mode 100644
index e5dd43a0afa..00000000000
--- a/packages/integration-test-app/windows/NuGet.Config
+++ /dev/null
@@ -1,14 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<configuration>
-  <config>
-    <add key="repositoryPath" value="packages" />
-  </config>
-  <packageSources>
-    <clear />
-    <add key="react-native" value="https://pkgs.dev.azure.com/ms/react-native/_packaging/react-native-public/nuget/v3/index.json" />
-    <add key="Nuget.org" value="https://api.nuget.org/v3/index.json" />
-  </packageSources>
-  <disabledPackageSources>
-    <clear />
-  </disabledPackageSources>  
-</configuration>
diff --git a/packages/playground/windows/NuGet.Config b/packages/playground/windows/NuGet.Config
deleted file mode 100644
index b0fe52ba03f..00000000000
--- a/packages/playground/windows/NuGet.Config
+++ /dev/null
@@ -1,13 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<configuration>
-  <config>
-    <add key="repositoryPath" value="packages" />
-  </config>
-  <packageSources>
-    <clear />
-    <add key="Nuget.org" value="https://api.nuget.org/v3/index.json" />
-  </packageSources>
-  <disabledPackageSources>
-    <clear />
-  </disabledPackageSources>  
-</configuration>
diff --git a/packages/sample-apps/.npmrc b/packages/sample-apps/.npmrc
deleted file mode 100644
index 9cf9495031e..00000000000
--- a/packages/sample-apps/.npmrc
+++ /dev/null
@@ -1 +0,0 @@
-package-lock=false
\ No newline at end of file
diff --git a/packages/sample-apps/windows/NuGet.Config b/packages/sample-apps/windows/NuGet.Config
deleted file mode 100644
index e5dd43a0afa..00000000000
--- a/packages/sample-apps/windows/NuGet.Config
+++ /dev/null
@@ -1,14 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<configuration>
-  <config>
-    <add key="repositoryPath" value="packages" />
-  </config>
-  <packageSources>
-    <clear />
-    <add key="react-native" value="https://pkgs.dev.azure.com/ms/react-native/_packaging/react-native-public/nuget/v3/index.json" />
-    <add key="Nuget.org" value="https://api.nuget.org/v3/index.json" />
-  </packageSources>
-  <disabledPackageSources>
-    <clear />
-  </disabledPackageSources>  
-</configuration>
diff --git a/vnext/.npmrc b/vnext/.npmrc
deleted file mode 100644
index 9cf9495031e..00000000000
--- a/vnext/.npmrc
+++ /dev/null
@@ -1 +0,0 @@
-package-lock=false
\ No newline at end of file
diff --git a/vnext/NuGet.Config b/vnext/NuGet.Config
deleted file mode 100644
index e5dd43a0afa..00000000000
--- a/vnext/NuGet.Config
+++ /dev/null
@@ -1,14 +0,0 @@
-<?xml version="1.0" encoding="utf-8"?>
-<configuration>
-  <config>
-    <add key="repositoryPath" value="packages" />
-  </config>
-  <packageSources>
-    <clear />
-    <add key="react-native" value="https://pkgs.dev.azure.com/ms/react-native/_packaging/react-native-public/nuget/v3/index.json" />
-    <add key="Nuget.org" value="https://api.nuget.org/v3/index.json" />
-  </packageSources>
-  <disabledPackageSources>
-    <clear />
-  </disabledPackageSources>  
-</configuration>
diff --git a/vnext/template/shared-app/proj/NuGet.Config b/vnext/template/shared-app/proj/NuGet_Config
similarity index 100%
rename from vnext/template/shared-app/proj/NuGet.Config
rename to vnext/template/shared-app/proj/NuGet_Config
diff --git a/vnext/template/shared-lib/proj/NuGet.Config b/vnext/template/shared-lib/proj/NuGet_Config
similarity index 100%
rename from vnext/template/shared-lib/proj/NuGet.Config
rename to vnext/template/shared-lib/proj/NuGet_Config