diff --git a/news/2 Fixes/9935.md b/news/2 Fixes/9935.md
new file mode 100644
index 000000000000..d80250f6b9b6
--- /dev/null
+++ b/news/2 Fixes/9935.md	
@@ -0,0 +1 @@
+Switching kernels should disable the run/interrupt/restart buttons.
\ No newline at end of file
diff --git a/src/client/datascience/interactive-common/interactiveBase.ts b/src/client/datascience/interactive-common/interactiveBase.ts
index d59512819fb5..25399406a10d 100644
--- a/src/client/datascience/interactive-common/interactiveBase.ts
+++ b/src/client/datascience/interactive-common/interactiveBase.ts
@@ -1480,7 +1480,12 @@ export abstract class InteractiveBase extends WebViewHost<IInteractiveWindowMapp
         if (!this._notebook) {
             return;
         }
-        await this.commandManager.executeCommand(Commands.SwitchJupyterKernel, this._notebook);
+        try {
+            this.startProgress();
+            await this.commandManager.executeCommand(Commands.SwitchJupyterKernel, this._notebook);
+        } finally {
+            this.stopProgress();
+        }
     }
     private async kernelChangeHandler(kernel: IJupyterKernelSpec | LiveKernelModel) {
         // Check if we are changing to LiveKernelModel
diff --git a/src/datascience-ui/native-editor/nativeCell.tsx b/src/datascience-ui/native-editor/nativeCell.tsx
index a34ce587156c..c6797dc43658 100644
--- a/src/datascience-ui/native-editor/nativeCell.tsx
+++ b/src/datascience-ui/native-editor/nativeCell.tsx
@@ -43,6 +43,7 @@ interface INativeCellBaseProps {
     editorOptions: monacoEditor.editor.IEditorOptions;
     themeMatplotlibPlots: boolean | undefined;
     focusPending: number;
+    busy: boolean;
 }
 
 type INativeCellProps = INativeCellBaseProps & typeof actionCreators;
@@ -567,6 +568,7 @@ export class NativeCell extends React.Component<INativeCellProps> {
                         onClick={runCell}
                         tooltip={getLocString('DataScience.runCell', 'Run cell')}
                         hidden={this.isMarkdownCell()}
+                        disabled={this.props.busy}
                     >
                         <Image baseTheme={this.props.baseTheme} class="image-button-image" image={ImageName.Run} />
                     </ImageButton>
diff --git a/src/datascience-ui/native-editor/nativeEditor.tsx b/src/datascience-ui/native-editor/nativeEditor.tsx
index 622052e7c7d9..f6f83fc375a0 100644
--- a/src/datascience-ui/native-editor/nativeEditor.tsx
+++ b/src/datascience-ui/native-editor/nativeEditor.tsx
@@ -477,6 +477,7 @@ ${buildSettingsCss(this.props.settings)}`}</style>
                         themeMatplotlibPlots={this.props.settings.themeMatplotlibPlots}
                         // Focus pending does not apply to native editor.
                         focusPending={0}
+                        busy={this.props.busy}
                     />
                 </ErrorBoundary>
                 {lastLine}