diff --git a/Lib/dataclasses.py b/Lib/dataclasses.py
index aca60501d0e0f1..8643589077a4a8 100644
--- a/Lib/dataclasses.py
+++ b/Lib/dataclasses.py
@@ -447,7 +447,7 @@ def _field_assign(frozen, name, value, self_name):
     return f'{self_name}.{name}={value}'
 
 
-def _field_init(f, frozen, globals, self_name):
+def _field_init(f, frozen, globals, self_name, slots):
     # Return the text of the line in the body of __init__ that will
     # initialize this field.
 
@@ -487,9 +487,15 @@ def _field_init(f, frozen, globals, self_name):
                 globals[default_name] = f.default
                 value = f.name
         else:
-            # This field does not need initialization.  Signify that
-            # to the caller by returning None.
-            return None
+            # If the class has slots, then initialize this field.
+            if slots and f.default is not MISSING:
+                globals[default_name] = f.default
+                value = default_name
+            else:
+                # This field does not need initialization: reading from it will
+                # just use the class attribute that contains the default.
+                # Signify that to the caller by returning None.
+                return None
 
     # Only test this now, so that we can create variables for the
     # default.  However, return None to signify that we're not going
@@ -521,7 +527,7 @@ def _init_param(f):
 
 
 def _init_fn(fields, std_fields, kw_only_fields, frozen, has_post_init,
-             self_name, globals):
+             self_name, globals, slots):
     # fields contains both real fields and InitVar pseudo-fields.
 
     # Make sure we don't have fields without defaults following fields
@@ -548,7 +554,7 @@ def _init_fn(fields, std_fields, kw_only_fields, frozen, has_post_init,
 
     body_lines = []
     for f in fields:
-        line = _field_init(f, frozen, locals, self_name)
+        line = _field_init(f, frozen, locals, self_name, slots)
         # line is None means that this field doesn't require
         # initialization (it's a pseudo-field).  Just skip it.
         if line:
@@ -1027,6 +1033,7 @@ def _process_class(cls, init, repr, eq, order, unsafe_hash, frozen,
                                     '__dataclass_self__' if 'self' in fields
                                             else 'self',
                                     globals,
+                                    slots,
                           ))
 
     # Get the fields as a list, and include only real fields.  This is
diff --git a/Lib/test/test_dataclasses.py b/Lib/test/test_dataclasses.py
index b00d0484d387ea..bcd004f4ec3aa2 100644
--- a/Lib/test/test_dataclasses.py
+++ b/Lib/test/test_dataclasses.py
@@ -2880,6 +2880,28 @@ def test_frozen_pickle(self):
                 self.assertIsNot(obj, p)
                 self.assertEqual(obj, p)
 
+    def test_slots_with_default_no_init(self):
+        # Originally reported in bpo-44649.
+        @dataclass(slots=True)
+        class A:
+            a: str
+            b: str = field(default='b', init=False)
+
+        obj = A("a")
+        self.assertEqual(obj.a, 'a')
+        self.assertEqual(obj.b, 'b')
+
+    def test_slots_with_default_factory_no_init(self):
+        # Originally reported in bpo-44649.
+        @dataclass(slots=True)
+        class A:
+            a: str
+            b: str = field(default_factory=lambda:'b', init=False)
+
+        obj = A("a")
+        self.assertEqual(obj.a, 'a')
+        self.assertEqual(obj.b, 'b')
+
 class TestDescriptors(unittest.TestCase):
     def test_set_name(self):
         # See bpo-33141.
diff --git a/Misc/NEWS.d/next/Library/2021-11-21-20-50-42.bpo-44649.E8M936.rst b/Misc/NEWS.d/next/Library/2021-11-21-20-50-42.bpo-44649.E8M936.rst
new file mode 100644
index 00000000000000..f6391a915a8210
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2021-11-21-20-50-42.bpo-44649.E8M936.rst
@@ -0,0 +1,2 @@
+Handle dataclass(slots=True) with a field that has default a default value,
+but for which init=False.