diff --git a/src/cmap/connection.ts b/src/cmap/connection.ts
index ce62f9a7da..e235c6e239 100644
--- a/src/cmap/connection.ts
+++ b/src/cmap/connection.ts
@@ -22,7 +22,6 @@ import {
 import {
   MongoCompatibilityError,
   MONGODB_ERROR_CODES,
-  MongoMissingDependencyError,
   MongoNetworkError,
   MongoNetworkTimeoutError,
   MongoOperationTimeoutError,
@@ -868,11 +867,7 @@ export class CryptoConnection extends Connection {
   ): Promise<Document> {
     const { autoEncrypter } = this;
     if (!autoEncrypter) {
-      // TODO(NODE-6065): throw a MongoRuntimeError in Node V7
-      // @ts-expect-error No cause provided because there is no underlying error.
-      throw new MongoMissingDependencyError('No AutoEncrypter available for encryption', {
-        dependencyName: 'n/a'
-      });
+      throw new MongoRuntimeError('No AutoEncrypter available for encryption');
     }
 
     const serverWireVersion = maxWireVersion(this);
diff --git a/test/unit/cmap/connection.test.ts b/test/unit/cmap/connection.test.ts
index fcd15a5dd3..bab1422a89 100644
--- a/test/unit/cmap/connection.test.ts
+++ b/test/unit/cmap/connection.test.ts
@@ -6,10 +6,17 @@ import * as sinon from 'sinon';
 import { setTimeout } from 'timers/promises';
 
 import { connect } from '../../../src/cmap/connect';
-import { Connection, SizedMessageTransform } from '../../../src/cmap/connection';
+import { Connection, CryptoConnection, SizedMessageTransform } from '../../../src/cmap/connection';
 import { MongoNetworkTimeoutError, MongoRuntimeError } from '../../../src/error';
 import { MongoClientAuthProviders } from '../../../src/mongo_client_auth_providers';
-import { isHello, MongoDBCollectionNamespace, ns, promiseWithResolvers } from '../../../src/utils';
+import {
+  HostAddress,
+  isHello,
+  MongoDBCollectionNamespace,
+  MongoDBNamespace,
+  ns,
+  promiseWithResolvers
+} from '../../../src/utils';
 import * as mock from '../../tools/mongodb-mock/index';
 
 const connectionOptionsDefaults = {
@@ -402,3 +409,22 @@ describe('new Connection()', function () {
     });
   });
 });
+
+describe('class CryptoConnection {}', function () {
+  it('CryptoConnection.command() throws if no autoEncrypter is configured', async function () {
+    const connection = new CryptoConnection(new Socket(), {
+      ...connectionOptionsDefaults,
+      hostAddress: HostAddress.fromString('localhost:27017'),
+      authProviders: new MongoClientAuthProviders(),
+      extendedMetadata: Promise.resolve({})
+    });
+
+    const error = await connection
+      .command(MongoDBNamespace.fromString('foo.bar'), {}, {})
+      .catch(e => e);
+
+    expect(error)
+      .to.be.instanceOf(MongoRuntimeError)
+      .to.match(/No AutoEncrypter available for encryption/);
+  });
+});