diff --git a/enrol/lti/db/upgrade.php b/enrol/lti/db/upgrade.php
index 3b852efc25f41..9a60ac89b378a 100644
--- a/enrol/lti/db/upgrade.php
+++ b/enrol/lti/db/upgrade.php
@@ -459,5 +459,17 @@ function xmldb_enrol_lti_upgrade($oldversion) {
     // Automatically generated Moodle v4.0.0 release upgrade line.
     // Put any upgrade step following this.
 
+    if ($oldversion < 2022041901) {
+        // Disable all orphaned enrolment method instances.
+        $sql = "id IN (SELECT t.enrolid
+                         FROM {enrol_lti_tools} t
+                    LEFT JOIN {context} c ON (t.contextid = c.id)
+                        WHERE c.id IS NULL)";
+        $DB->set_field_select('enrol', 'status', 1, $sql);
+
+        // Lti savepoint reached.
+        upgrade_plugin_savepoint(true, 2022041901, 'enrol', 'lti');
+    }
+
     return true;
 }
diff --git a/enrol/lti/lib.php b/enrol/lti/lib.php
index 684993a20bfe5..f01522cb9e129 100644
--- a/enrol/lti/lib.php
+++ b/enrol/lti/lib.php
@@ -479,3 +479,18 @@ function enrol_lti_get_fontawesome_icon_map() {
         'enrol_lti:enrolinstancewarning' => 'fa-exclamation-circle text-danger',
     ];
 }
+
+/**
+ * Pre-delete course module hook which disables any methods referring to the deleted module, preventing launches and allowing remap.
+ *
+ * @param stdClass $cm The deleted course module record.
+ */
+function enrol_lti_pre_course_module_delete(stdClass $cm) {
+    global $DB;
+    $sql = "id IN (SELECT t.enrolid
+                     FROM {enrol_lti_tools} t
+                     JOIN {context} c ON (t.contextid = c.id)
+                    WHERE c.contextlevel = :contextlevel
+                      AND c.instanceid = :cmid)";
+    $DB->set_field_select('enrol', 'status', ENROL_INSTANCE_DISABLED, $sql, ['contextlevel' => CONTEXT_MODULE, 'cmid' => $cm->id]);
+}
diff --git a/enrol/lti/tests/lib_test.php b/enrol/lti/tests/lib_test.php
index d11e0f826990e..9698d5e818b49 100644
--- a/enrol/lti/tests/lib_test.php
+++ b/enrol/lti/tests/lib_test.php
@@ -216,4 +216,36 @@ public function test_get_user_enrolment_actions() {
         // LTI enrolment has 1 enrol actions for active users -- unenrol.
         $this->assertCount(1, $actions);
     }
+
+    /**
+     * Test the behaviour of an enrolment method when the activity to which it provides access is deleted.
+     *
+     * @covers \enrol_lti_pre_course_module_delete
+     */
+    public function test_course_module_deletion() {
+        // Create two modules and publish them.
+        $course = $this->getDataGenerator()->create_course();
+        $mod = $this->getDataGenerator()->create_module('assign', ['course' => $course->id]);
+        $mod2 = $this->getDataGenerator()->create_module('assign', ['course' => $course->id]);
+        $tooldata = [
+            'cmid' => $mod->cmid,
+            'courseid' => $course->id,
+        ];
+        $tool = $this->getDataGenerator()->create_lti_tool((object)$tooldata);
+        $tooldata['cmid'] = $mod2->cmid;
+        $tool2 = $this->getDataGenerator()->create_lti_tool((object)$tooldata);
+
+        // Verify the instances are both enabled.
+        $modinstance = helper::get_lti_tool($tool->id);
+        $mod2instance = helper::get_lti_tool($tool2->id);
+        $this->assertEquals(ENROL_INSTANCE_ENABLED, $modinstance->status);
+        $this->assertEquals(ENROL_INSTANCE_ENABLED, $mod2instance->status);
+
+        // Delete a module and verify the associated instance is disabled.
+        course_delete_module($mod->cmid);
+        $modinstance = helper::get_lti_tool($tool->id);
+        $mod2instance = helper::get_lti_tool($tool2->id);
+        $this->assertEquals(ENROL_INSTANCE_DISABLED, $modinstance->status);
+        $this->assertEquals(ENROL_INSTANCE_ENABLED, $mod2instance->status);
+    }
 }
diff --git a/enrol/lti/tests/local/ltiadvantage/task/sync_grades_test.php b/enrol/lti/tests/local/ltiadvantage/task/sync_grades_test.php
index e8680a5f238bd..76cabc0184d38 100644
--- a/enrol/lti/tests/local/ltiadvantage/task/sync_grades_test.php
+++ b/enrol/lti/tests/local/ltiadvantage/task/sync_grades_test.php
@@ -419,6 +419,8 @@ public function test_sync_grades_no_service_endpoint() {
      */
     public function test_sync_grades_deleted_context() {
         $this->resetAfterTest();
+        global $DB;
+
         [$course, $resource] = $this->create_test_environment();
         $launchservice = $this->get_tool_launch_service();
 
@@ -427,10 +429,11 @@ public function test_sync_grades_deleted_context() {
         $instructoruser = $this->getDataGenerator()->create_user();
         [$userid] = $launchservice->user_launches_tool($instructoruser, $teachermocklaunch);
 
-        global $CFG;
-        require_once($CFG->dirroot . '/course/lib.php');
+        // Delete the activity, then enable the enrolment method (it is disabled during activity deletion).
         $modcontext = \context::instance_by_id($resource->contextid);
         course_delete_module($modcontext->instanceid);
+        $enrol = ['id' => $resource->enrolid, 'status' => ENROL_INSTANCE_ENABLED];
+        $DB->update_record('enrol', $enrol);
 
         $task = $this->get_task_with_mocked_grade_service();
         $this->expectOutputRegex(
diff --git a/enrol/lti/version.php b/enrol/lti/version.php
index 87b900db4a1a5..f51f117a91127 100644
--- a/enrol/lti/version.php
+++ b/enrol/lti/version.php
@@ -24,7 +24,7 @@
 
 defined('MOODLE_INTERNAL') || die();
 
-$plugin->version = 2022041900; // The current plugin version (Date: YYYYMMDDXX).
+$plugin->version = 2022041901; // The current plugin version (Date: YYYYMMDDXX).
 $plugin->requires = 2022041200; // Requires this Moodle version.
 $plugin->component = 'enrol_lti'; // Full name of the plugin (used for diagnostics).
 $plugin->dependencies = [