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When using the jQuery plupload version with the Flash runtime in Chrome 10.0.648.133 (77742) with Ubuntu 10.10 (latest updates) a "Page Unresponsive" error is shown after waiting about 10 seconds in the "open file dialog".
The page unresponsive error then asks whether you wish to terminate the browser window or keep waiting.
I do not have Ubuntu here, but it worked on Fedora. Will try to install and test.