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model depot

mrgsolve has a function called modlib() that returns path to a library of precoded models that can be accessed like this

mod <- mread("pk1", modlib())

or more concisely

mod <- modlib("pk1")

depot works just like modlib(), but the models come in a separate package housed here. For example

mod <- depot("gcsf")

Please see the vignettes for the models listed below. More models to come.


remotes::install_github("mrgsolve/depot", subdir = "pkg")



Reference Zhao Q, Tensfeldt TG, Chandra R, Mould DR. Population pharmacokinetics of azithromycin and chloroquine in healthy adults and paediatric malaria subjects following oral administration of fixed-dose azithromycin and chloroquine combination tablets. Malar J. 2014 Jan 29;13:36. doi:10.1186/1475-2875-13-36. PubMed PMID: 24472224; PubMed Central PMCID: PMC3909452.


Reference Sadiq MW, Nielsen EI, Khachman D, Conil JM, Georges B, Houin G, Laffont CM, Karlsson MO, Friberg LE. A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection. J Pharmacokinet Pharmacodyn. 2017 Apr;44(2):69-79. doi: 10.1007/s10928-016-9486-9. Epub 2016 Aug 30. PubMed PMID: 27578330; PubMed Central PMCID: PMC5376394.


Reference Krzyzanski W, Wiczling P, Lowe P, Pigeolet E, Fink M, Berghout A, Balser S. Population modeling of filgrastim PK-PD in healthy adults following intravenous and subcutaneous administrations. J Clin Pharmacol. 2010 Sep;50(9 Suppl):101S-112S. doi: 10.1177/0091270010376966. PubMed PMID: 20881223.


Reference Houk BE, Bello CL, Kang D, Amantea M. A population pharmacokinetic meta-analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients. Clin Cancer Res. 2009 Apr 1;15(7):2497-506. doi: 10.1158/1078-0432.CCR-08-1893. Epub 2009 Mar 3. PubMed PMID: 19258444.


Reference FDA Clin Pharm Review 125504Orig1s000ClinPharmR.pdf

  • Clinical Pharmacology Reviewer: Jie Wang, Ph.D.
  • Pharmcometrics Reviewer: Jee Eun Lee, Ph.D.
  • Pharmacometrics Team Leader: Jeffry Florian, Ph.D.
  • Clinical Pharmacology Team Leader: Yow-Ming Wang, Ph.D.


Reference Asaumi R, Toshimoto K, Tobe Y, Hashizume K, Nunoya KI, Imawaka H, Lee W, Sugiyama Y. Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug-Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects. CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):186-196. doi: 10.1002/psp4.12275. Epub 2018 Feb 5. PubMed PMID: 29368402; PubMed Central PMCID: PMC5869557.


Reference Wicha SG, Haak T, Zink K, Kees F, Kloft C, Kees MG. Population pharmacokinetics and target attainment analysis of moxifloxacin in patients with diabetic foot infections. J Clin Pharmacol. 2015 Jun;55(6):639-46. doi:10.1002/jcph.464. Epub 2015 Feb 13. PubMed PMID: 25600294.


Reference Zierhut ML, Gastonguay MR, Martin SW, Vicini P, Bekker PJ, Holloway D, Leese PT, Peterson MC. Population PK-PD model for Fc-osteoprotegerin in healthy postmenopausal women. J Pharmacokinet Pharmacodyn. 2008 Aug;35(4):379-99. doi: 10.1007/s10928-008-9093-5. Epub 2008 Jul 17. PubMed PMID: 18633695.


Reference Yan X, Lowe PJ, Fink M, Berghout A, Balser S, Krzyzanski W. Population pharmacokinetic and pharmacodynamic model-based comparability assessment of a recombinant human Epoetin Alfa and the Biosimilar HX575. J Clin Pharmacol. 2012 Nov;52(11):1624-44. doi: 10.1177/0091270011421911. Epub 2011 Dec 12. PubMed PMID: 22162538; PubMed Central PMCID: PMC3483448.


Note: this is the general PBPK model coded in the Supplementary Data.

Reference Jones H, Rowland-Yeo K. Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development. CPT Pharmacometrics Syst Pharmacol. 2013 Aug 14;2:e63. doi: 10.1038/psp.2013.41. PubMed PMID: 23945604; PubMed Central PMCID: PMC3828005.


Reference Peletier LA, Gabrielsson J. Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification. J Pharmacokinet Pharmacodyn. 2012 Oct;39(5):429-51. doi: 10.1007/s10928-012-9260-6. Epub 2012 Aug 1. PMID: 22851162; PMCID: PMC3446204.