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model depot

mrgsolve has a function called modlib() that returns path to a library of precoded models that can be accessed like this

mod <- mread("pk1", modlib())

or more concisely

mod <- modlib("pk1")

depot works just like modlib(), but the models come in a separate package housed here. For example

mod <- depot("gcsf")

Please see the vignettes for the models listed below. More models to come.

Installation

remotes::install_github("mrgsolve/depot", subdir = "pkg")

Models

azithro

Reference Zhao Q, Tensfeldt TG, Chandra R, Mould DR. Population pharmacokinetics of azithromycin and chloroquine in healthy adults and paediatric malaria subjects following oral administration of fixed-dose azithromycin and chloroquine combination tablets. Malar J. 2014 Jan 29;13:36. doi:10.1186/1475-2875-13-36. PubMed PMID: 24472224; PubMed Central PMCID: PMC3909452.

cipro

Reference Sadiq MW, Nielsen EI, Khachman D, Conil JM, Georges B, Houin G, Laffont CM, Karlsson MO, Friberg LE. A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection. J Pharmacokinet Pharmacodyn. 2017 Apr;44(2):69-79. doi: 10.1007/s10928-016-9486-9. Epub 2016 Aug 30. PubMed PMID: 27578330; PubMed Central PMCID: PMC5376394.

gcsf

Reference Krzyzanski W, Wiczling P, Lowe P, Pigeolet E, Fink M, Berghout A, Balser S. Population modeling of filgrastim PK-PD in healthy adults following intravenous and subcutaneous administrations. J Clin Pharmacol. 2010 Sep;50(9 Suppl):101S-112S. doi: 10.1177/0091270010376966. PubMed PMID: 20881223.

sunit

Reference Houk BE, Bello CL, Kang D, Amantea M. A population pharmacokinetic meta-analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients. Clin Cancer Res. 2009 Apr 1;15(7):2497-506. doi: 10.1158/1078-0432.CCR-08-1893. Epub 2009 Mar 3. PubMed PMID: 19258444.

secukinumab

Reference FDA Clin Pharm Review 125504Orig1s000ClinPharmR.pdf

  • Clinical Pharmacology Reviewer: Jie Wang, Ph.D.
  • Pharmcometrics Reviewer: Jee Eun Lee, Ph.D.
  • Pharmacometrics Team Leader: Jeffry Florian, Ph.D.
  • Clinical Pharmacology Team Leader: Yow-Ming Wang, Ph.D.

https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/125504Orig1s000ClinPharmR.pdf

rifampicin

Reference Asaumi R, Toshimoto K, Tobe Y, Hashizume K, Nunoya KI, Imawaka H, Lee W, Sugiyama Y. Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug-Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects. CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):186-196. doi: 10.1002/psp4.12275. Epub 2018 Feb 5. PubMed PMID: 29368402; PubMed Central PMCID: PMC5869557.

moxi

Reference Wicha SG, Haak T, Zink K, Kees F, Kloft C, Kees MG. Population pharmacokinetics and target attainment analysis of moxifloxacin in patients with diabetic foot infections. J Clin Pharmacol. 2015 Jun;55(6):639-46. doi:10.1002/jcph.464. Epub 2015 Feb 13. PubMed PMID: 25600294.

opg

Reference Zierhut ML, Gastonguay MR, Martin SW, Vicini P, Bekker PJ, Holloway D, Leese PT, Peterson MC. Population PK-PD model for Fc-osteoprotegerin in healthy postmenopausal women. J Pharmacokinet Pharmacodyn. 2008 Aug;35(4):379-99. doi: 10.1007/s10928-008-9093-5. Epub 2008 Jul 17. PubMed PMID: 18633695.

epo

Reference Yan X, Lowe PJ, Fink M, Berghout A, Balser S, Krzyzanski W. Population pharmacokinetic and pharmacodynamic model-based comparability assessment of a recombinant human Epoetin Alfa and the Biosimilar HX575. J Clin Pharmacol. 2012 Nov;52(11):1624-44. doi: 10.1177/0091270011421911. Epub 2011 Dec 12. PubMed PMID: 22162538; PubMed Central PMCID: PMC3483448.

pbpk

Note: this is the general PBPK model coded in the Supplementary Data.

Reference Jones H, Rowland-Yeo K. Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development. CPT Pharmacometrics Syst Pharmacol. 2013 Aug 14;2:e63. doi: 10.1038/psp.2013.41. PubMed PMID: 23945604; PubMed Central PMCID: PMC3828005.

TMDD

Reference Peletier LA, Gabrielsson J. Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification. J Pharmacokinet Pharmacodyn. 2012 Oct;39(5):429-51. doi: 10.1007/s10928-012-9260-6. Epub 2012 Aug 1. PMID: 22851162; PMCID: PMC3446204.