diff --git a/cypress/e2e/40-manual-partial-execution.cy.ts b/cypress/e2e/40-manual-partial-execution.cy.ts
new file mode 100644
index 0000000000000..5fe31b56ad137
--- /dev/null
+++ b/cypress/e2e/40-manual-partial-execution.cy.ts
@@ -0,0 +1,28 @@
+import { NDV, WorkflowPage } from '../pages';
+
+const canvas = new WorkflowPage();
+const ndv = new NDV();
+
+describe('Manual partial execution', () => {
+	it('should execute parent nodes with no run data only once', () => {
+		canvas.actions.visit();
+
+		cy.fixture('manual-partial-execution.json').then((data) => {
+			cy.get('body').paste(JSON.stringify(data));
+		});
+
+		canvas.actions.zoomToFit();
+
+		canvas.actions.openNode('Edit Fields');
+
+		cy.get('button').contains('Test step').click(); // create run data
+		cy.get('button').contains('Test step').click(); // use run data
+
+		ndv.actions.close();
+
+		canvas.actions.openNode('Webhook1');
+
+		ndv.getters.nodeRunSuccessIndicator().should('exist');
+		ndv.getters.outputRunSelector().should('not.exist'); // single run
+	});
+});
diff --git a/cypress/fixtures/manual-partial-execution.json b/cypress/fixtures/manual-partial-execution.json
new file mode 100644
index 0000000000000..9e43cd525bef0
--- /dev/null
+++ b/cypress/fixtures/manual-partial-execution.json
@@ -0,0 +1,107 @@
+{
+  "meta": {
+    "templateCredsSetupCompleted": true
+  },
+  "nodes": [
+    {
+      "parameters": {
+        "options": {}
+      },
+      "id": "f4467143-fdb9-46fa-8020-6417cc5eea7d",
+      "name": "Edit Fields",
+      "type": "n8n-nodes-base.set",
+      "typeVersion": 3.3,
+      "position": [
+        1140,
+        260
+      ]
+    },
+    {
+      "parameters": {
+        "path": "30ff316d-405f-4288-a0ac-e713546c9d4e",
+        "options": {}
+      },
+      "id": "4760aafb-5d56-4633-99d3-7a97c576a216",
+      "name": "Webhook1",
+      "type": "n8n-nodes-base.webhook",
+      "typeVersion": 2,
+      "position": [
+        680,
+        340
+      ],
+      "webhookId": "30ff316d-405f-4288-a0ac-e713546c9d4e"
+    },
+    {
+      "parameters": {
+        "articleId": "123",
+        "additionalFields": {}
+      },
+      "id": "8c811eca-8978-44d9-b8f7-ef2c7725784c",
+      "name": "Hacker News",
+      "type": "n8n-nodes-base.hackerNews",
+      "typeVersion": 1,
+      "position": [
+        920,
+        260
+      ]
+    },
+    {
+      "parameters": {
+        "path": "4a3398e4-1388-4e10-9d21-add90b804955",
+        "options": {}
+      },
+      "id": "1c2c2d06-45c9-4712-9fa0-c655bef8d0e5",
+      "name": "Webhook",
+      "type": "n8n-nodes-base.webhook",
+      "typeVersion": 2,
+      "position": [
+        680,
+        180
+      ],
+      "webhookId": "4a3398e4-1388-4e10-9d21-add90b804955"
+    }
+  ],
+  "connections": {
+    "Webhook1": {
+      "main": [
+        [
+          {
+            "node": "Hacker News",
+            "type": "main",
+            "index": 0
+          }
+        ]
+      ]
+    },
+    "Hacker News": {
+      "main": [
+        [
+          {
+            "node": "Edit Fields",
+            "type": "main",
+            "index": 0
+          }
+        ]
+      ]
+    },
+    "Webhook": {
+      "main": [
+        [
+          {
+            "node": "Hacker News",
+            "type": "main",
+            "index": 0
+          }
+        ]
+      ]
+    }
+  },
+  "pinData": {
+    "Webhook": [
+      {
+        "name": "First item",
+        "code": 1
+      }
+    ]
+  }
+}
diff --git a/packages/editor-ui/src/composables/useRunWorkflow.ts b/packages/editor-ui/src/composables/useRunWorkflow.ts
index 9706a57729135..71527e8ed65b1 100644
--- a/packages/editor-ui/src/composables/useRunWorkflow.ts
+++ b/packages/editor-ui/src/composables/useRunWorkflow.ts
@@ -334,7 +334,7 @@ export function useRunWorkflow(useRunWorkflowOpts: { router: ReturnType<typeof u
 		pinData: IPinData | undefined,
 		workflow: Workflow,
 	): { runData: IRunData | undefined; startNodeNames: string[] } {
-		const startNodeNames: string[] = [];
+		const startNodeNames = new Set<string>();
 		let newRunData: IRunData | undefined;
 
 		if (runData !== null && Object.keys(runData).length !== 0) {
@@ -360,7 +360,7 @@ export function useRunWorkflow(useRunWorkflowOpts: { router: ReturnType<typeof u
 						// When we hit a node which has no data we stop and set it
 						// as a start node the execution from and then go on with other
 						// direct input nodes
-						startNodeNames.push(parentNode);
+						startNodeNames.add(parentNode);
 						break;
 					}
 					if (runData[parentNode] && !runData[parentNode]?.[0]?.error) {
@@ -376,7 +376,7 @@ export function useRunWorkflow(useRunWorkflowOpts: { router: ReturnType<typeof u
 			}
 		}
 
-		return { runData: newRunData, startNodeNames };
+		return { runData: newRunData, startNodeNames: [...startNodeNames] };
 	}
 
 	async function stopCurrentExecution() {