Our research focuses on simple questions about complex brain traits: where do they occur (in which cell types)? When do they occur (at which developmental stages)? How do they occur (which quantitative traits of cells are affected)? We aim to develop the methods and datasets required to enable these questions to be answered systematically for any trait for which well-powered genetic data is available.
Find causal cell-types underlying complex trait genetics
Rapid standardisation and quality control of GWAS or QTL summary statistics
Continuous integration for R packages. 🔀 Automates testing ✅, documentation website building 📦, & containerised deployment 🐳.
A re-analysis of the [Single-cell transcriptomic analysis of Alzheimer’s disease](https://www.nature.com/articles/s41586-019-1195-2) using a standardised data processing and pseudobulk differential…
Prioritise cell-type-specific gene targets from the Rare Disease Celltyping project.
Continuous integration for R packages. 🔀 Automates testing ✅, documentation website building 📦, & containerised deployment 🐳.
Code, data and results associated with the "Rare diseases cell-typing" project.
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