diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7e0895192..4bc3d557b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -14,12 +14,14 @@ and this project adheres to [Semantic Versioning](http://semver.org/spec/v2.0.0.
 * Merged in [nf-core/tools](https://github.com/nf-core/tools) release V1.6 template changes  
 
 ### `Fixed`
+* [#152](https://github.com/nf-core/eager/pull/152) - DamageProfiler errors [won't crash entire pipeline anymore](https://github.com/nf-core/eager/issues/171)
+* [#176](https://github.com/nf-core/eager/pull/176) - Increase runtime for DamageProfiler on [large reference genomes](https://github.com/nf-core/eager/issues/173)
 * [#172](https://github.com/nf-core/eager/pull/152) - DamageProfiler errors [won't crash entire pipeline anymore](https://github.com/nf-core/eager/issues/171)
 * [#174](https://github.com/nf-core/eager/pull/190) - Publish DeDup files [properly](https://github.com/nf-core/eager/issues/183) 
 
 ### `Dependencies`
 
-* Added DeDup v0.12.4 (json support)
+* Added DeDup v0.12.5 (json support)
 * Added mtnucratio v0.5 (json support)
 * Updated Picard 2.18.27 -> 2.19.0
 * Updated GATK 4.1.0.0 -> 4.1.1.1
diff --git a/conf/base.config b/conf/base.config
index 11b585c68..afde5594b 100644
--- a/conf/base.config
+++ b/conf/base.config
@@ -23,14 +23,15 @@ process {
     memory = { check_max( 2.GB, 'memory' ) }
     cache = false
   }
-  
   withName:convertBam {
     cpus = { check_max(8 * task.attempt, 'cpus') }
   }
   withName:makeSeqDict {
     memory = { check_max( 16.GB * task.attempt, 'memory' ) }
   }
-
+  withname:makeBWAIndex {
+    time = params.large_ref ? '12.h' : { check_max(8.h * task.attempt, 'time') }
+  }
   withName:bwa {
     memory = { check_max( 16.GB * task.attempt, 'memory' ) }
     cpus = { check_max(8 * task.attempt, 'cpus') }
@@ -63,6 +64,7 @@ process {
 
   withName: damageprofiler {
     errorStrategy = 'ignore'
+    params.large_ref ? "time = { check_max(8.h * task.attempt, 'time') }" : "time = { check_max(2.h * task.attempt, 'time') }"
   }
 
   withName: extract_unmapped_reads {