diff --git a/python/analysis/auto_generated/vector/qgszonalstatistics.sip.in b/python/analysis/auto_generated/vector/qgszonalstatistics.sip.in
index a5bb2ca20c83..3c32378856d1 100644
--- a/python/analysis/auto_generated/vector/qgszonalstatistics.sip.in
+++ b/python/analysis/auto_generated/vector/qgszonalstatistics.sip.in
@@ -130,7 +130,9 @@ Returns a short, friendly display name for a ``statistic``, suitable for use in
 .. versionadded:: 3.12
 %End
 
-    static QMap<QgsZonalStatistics::Statistic, QVariant> calculateStatistics( QgsRasterInterface *rasterInterface, const QgsGeometry &geometry, double cellSizeX, double cellSizeY, int rasterBand, QgsZonalStatistics::Statistics statistics );
+
+
+    static QMap<int, QVariant> calculateStatisticsInt( QgsRasterInterface *rasterInterface, const QgsGeometry &geometry, double cellSizeX, double cellSizeY, int rasterBand, QgsZonalStatistics::Statistics statistics ) /PyName=calculateStatistics/;
 %Docstring
 Calculates the specified ``statistics`` for the pixels of ``rasterBand``
 in ``rasterInterface`` (a raster layer :py:func:`~QgsZonalStatistics.dataProvider` ) within polygon ``geometry``.
diff --git a/src/analysis/vector/qgszonalstatistics.cpp b/src/analysis/vector/qgszonalstatistics.cpp
index 74ed6e76284d..733aea3dcd70 100644
--- a/src/analysis/vector/qgszonalstatistics.cpp
+++ b/src/analysis/vector/qgszonalstatistics.cpp
@@ -287,6 +287,19 @@ QString QgsZonalStatistics::shortName( QgsZonalStatistics::Statistic statistic )
   return QString();
 }
 
+///@cond PRIVATE
+QMap<int, QVariant> QgsZonalStatistics::calculateStatisticsInt( QgsRasterInterface *rasterInterface, const QgsGeometry &geometry, double cellSizeX, double cellSizeY, int rasterBand, QgsZonalStatistics::Statistics statistics )
+{
+  const auto result { QgsZonalStatistics::calculateStatistics( rasterInterface, geometry, cellSizeX, cellSizeY, rasterBand, statistics ) };
+  QMap<int, QVariant> pyResult;
+  for ( auto it = result.constBegin(); it != result.constEnd(); ++it )
+  {
+    pyResult.insert( it.key(), it.value() );
+  }
+  return pyResult;
+}
+/// @endcond
+
 QMap<QgsZonalStatistics::Statistic, QVariant> QgsZonalStatistics::calculateStatistics( QgsRasterInterface *rasterInterface, const QgsGeometry &geometry, double cellSizeX, double cellSizeY, int rasterBand, QgsZonalStatistics::Statistics statistics )
 {
   QMap<QgsZonalStatistics::Statistic, QVariant> results;
@@ -327,7 +340,7 @@ QMap<QgsZonalStatistics::Statistic, QVariant> QgsZonalStatistics::calculateStati
   }
 
   // calculate the statistics
-  QgsAttributeMap changeAttributeMap;
+
   if ( statistics & QgsZonalStatistics::Count )
     results.insert( QgsZonalStatistics::Count, QVariant( featureStats.count ) );
   if ( statistics & QgsZonalStatistics::Sum )
diff --git a/src/analysis/vector/qgszonalstatistics.h b/src/analysis/vector/qgszonalstatistics.h
index 66df8ad1b1ba..306865b98950 100644
--- a/src/analysis/vector/qgszonalstatistics.h
+++ b/src/analysis/vector/qgszonalstatistics.h
@@ -155,7 +155,23 @@ class ANALYSIS_EXPORT QgsZonalStatistics
      *
      * \since QGIS 3.16
      */
+#ifndef SIP_RUN
     static QMap<QgsZonalStatistics::Statistic, QVariant> calculateStatistics( QgsRasterInterface *rasterInterface, const QgsGeometry &geometry, double cellSizeX, double cellSizeY, int rasterBand, QgsZonalStatistics::Statistics statistics );
+#endif
+
+///@cond PRIVATE
+    // Required to fix https://github.com/qgis/QGIS/issues/43245 (SIP is failing to convert the enum to values)
+
+    /**
+     * Calculates the specified \a statistics for the pixels of \a rasterBand
+     * in \a rasterInterface (a raster layer dataProvider() ) within polygon \a geometry.
+     *
+     * Returns a map of statistic to result value.
+     *
+     * \since QGIS 3.16
+     */
+    static QMap<int, QVariant> calculateStatisticsInt( QgsRasterInterface *rasterInterface, const QgsGeometry &geometry, double cellSizeX, double cellSizeY, int rasterBand, QgsZonalStatistics::Statistics statistics ) SIP_PYNAME( calculateStatistics );
+/// @endcond
 
   private:
     QgsZonalStatistics() = default;
diff --git a/tests/src/python/test_qgszonalstatistics.py b/tests/src/python/test_qgszonalstatistics.py
index 2f59bc9eecb3..fe25265ae735 100644
--- a/tests/src/python/test_qgszonalstatistics.py
+++ b/tests/src/python/test_qgszonalstatistics.py
@@ -11,9 +11,10 @@
 __copyright__ = 'Copyright 2013, The QGIS Project'
 
 import qgis  # NOQA
-
-from qgis.PyQt.QtCore import QDir, QFile
-from qgis.core import QgsVectorLayer, QgsRasterLayer, QgsFeature, QgsFeatureRequest
+import os
+import shutil
+from qgis.PyQt.QtCore import QDir, QFile, QTemporaryDir
+from qgis.core import QgsVectorLayer, QgsRasterLayer, QgsFeature, QgsFeatureRequest, QgsGeometry
 from qgis.analysis import QgsZonalStatistics
 
 from qgis.testing import start_app, unittest
@@ -21,6 +22,8 @@
 
 start_app()
 
+TEST_DATA_DIR = unitTestDataPath()
+
 
 class TestQgsZonalStatistics(unittest.TestCase):
 
@@ -117,6 +120,29 @@ def testStatistics(self):
         myMessage = ('Expected: %f\nGot: %f\n' % (2.0, feat[11]))
         assert feat[11] == 2.0, myMessage
 
+    def test_enum_conversion(self):
+        """Test regression GH #43245"""
+
+        tmp = QTemporaryDir()
+        origin = os.path.join(TEST_DATA_DIR, 'raster', 'band1_byte_ct_epsg4326.tif')
+        dest = os.path.join(tmp.path(), 'band1_byte_ct_epsg4326.tif')
+        shutil.copyfile(origin, dest)
+
+        layer = QgsRasterLayer(dest, 'rast', 'gdal')
+
+        stats = QgsZonalStatistics.calculateStatistics(
+            layer.dataProvider(),
+            QgsGeometry.fromWkt(layer.extent().asWktPolygon()),
+            layer.rasterUnitsPerPixelX(),
+            layer.rasterUnitsPerPixelY(),
+            1,
+            QgsZonalStatistics.Statistic.Max | QgsZonalStatistics.Statistic.Median
+        )
+
+        self.assertEqual(sorted(list(stats.keys())), [QgsZonalStatistics.Statistic.Median, QgsZonalStatistics.Statistic.Max])
+        self.assertEqual(stats[QgsZonalStatistics.Statistic.Median], 142.0)
+        self.assertEqual(stats[QgsZonalStatistics.Statistic.Max], 254.0)
+
 
 if __name__ == '__main__':
     unittest.main()