diff --git a/lib/_http_agent.js b/lib/_http_agent.js
index e1cfa6d7fc9d17..48bdf98088931f 100644
--- a/lib/_http_agent.js
+++ b/lib/_http_agent.js
@@ -40,10 +40,18 @@ const { async_id_symbol } = require('internal/async_hooks').symbols;
 // ClientRequest.onSocket(). The Agent is now *strictly*
 // concerned with managing a connection pool.
 
+const kReusedHandle = Symbol('kReusedHandle');
 class ReusedHandle {
   constructor(type, handle) {
     this.type = type;
     this.handle = handle;
+    // We need keep the resource object alive from this object, because
+    // domains rely on GC of the resource object for lifetime tracking.
+    // TODO(addaleax): This should really apply to all uses of
+    // AsyncWrap::AsyncReset() when the resource is not the AsyncWrap object
+    // itself. However, HTTPClientAsyncResource and HTTPServerAsyncResource
+    // hold on to other objects, inhibiting GC.
+    handle[kReusedHandle] = this;
   }
 }
 
diff --git a/test/parallel/test-http-agent-domain-reused-gc.js b/test/parallel/test-http-agent-domain-reused-gc.js
new file mode 100644
index 00000000000000..9470b23b472662
--- /dev/null
+++ b/test/parallel/test-http-agent-domain-reused-gc.js
@@ -0,0 +1,98 @@
+// Flags: --expose-gc --expose-internals
+'use strict';
+const common = require('../common');
+const http = require('http');
+const async_hooks = require('async_hooks');
+const makeDuplexPair = require('../common/duplexpair');
+
+// Regression test for https://github.com/nodejs/node/issues/30122
+// When a domain is attached to an http Agent’s ReusedHandle object, that
+// domain should be kept alive through the ReusedHandle and that in turn
+// through the actual underlying handle.
+
+// Consistency check: There is a ReusedHandle being used, and it emits events.
+// We also use this async hook to manually trigger GC just before the domain’s
+// own `before` hook runs, in order to reproduce the bug above (the ReusedHandle
+// being collected and the domain with it while the handle is still alive).
+const checkInitCalled = common.mustCall();
+const checkBeforeCalled = common.mustCallAtLeast();
+let reusedHandleId;
+async_hooks.createHook({
+  init(id, type, triggerId, resource) {
+    if (resource.constructor.name === 'ReusedHandle') {
+      reusedHandleId = id;
+      checkInitCalled();
+    }
+  },
+  before(id) {
+    if (id === reusedHandleId) {
+      global.gc();
+      checkBeforeCalled();
+    }
+  }
+}).enable();
+
+// We use a DuplexPair rather than TLS sockets to keep the domain from being
+// attached to too many objects that use strong references (timers, the network
+// socket handle, etc.) and wrap the client side in a JSStreamSocket so we don’t
+// have to implement the whole _handle API ourselves.
+const { serverSide, clientSide } = makeDuplexPair();
+const JSStreamSocket = require('internal/js_stream_socket');
+const wrappedClientSide = new JSStreamSocket(clientSide);
+
+// Consistency check: We use asyncReset exactly once.
+wrappedClientSide._handle.asyncReset =
+  common.mustCall(wrappedClientSide._handle.asyncReset);
+
+// Dummy server implementation, could be any server for this test...
+const server = http.createServer(common.mustCall((req, res) => {
+  res.writeHead(200, {
+    'Content-Type': 'text/plain'
+  });
+  res.end('Hello, world!');
+}, 2));
+server.emit('connection', serverSide);
+
+// HTTP Agent that only returns the fake connection.
+class TestAgent extends http.Agent {
+  createConnection = common.mustCall(() => wrappedClientSide)
+}
+const agent = new TestAgent({ keepAlive: true, maxSockets: 1 });
+
+function makeRequest(cb) {
+  const req = http.request({ agent }, common.mustCall((res) => {
+    res.resume();
+    res.on('end', cb);
+  }));
+  req.end('');
+}
+
+// The actual test starts here:
+
+const domain = require('domain');
+// Create the domain in question and a dummy “noDomain” domain that we use to
+// avoid attaching new async resources to the original domain.
+const d = domain.create();
+const noDomain = domain.create();
+
+d.run(common.mustCall(() => {
+  // Create a first request only so that we can get a “re-used” socket later.
+  makeRequest(common.mustCall(() => {
+    // Schedule the second request.
+    setImmediate(common.mustCall(() => {
+      makeRequest(common.mustCall(() => {
+        // The `setImmediate()` is run inside of `noDomain` so that it doesn’t
+        // keep the actual target domain alive unnecessarily.
+        noDomain.run(common.mustCall(() => {
+          setImmediate(common.mustCall(() => {
+            // This emits an async event on the reused socket, so it should
+            // run the domain’s `before` hooks.
+            // This should *not* throw an error because the domain was garbage
+            // collected too early.
+            serverSide.end();
+          }));
+        }));
+      }));
+    }));
+  }));
+}));