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format-version: 1.2
subsetdef: ubprop:upper_level "abstract upper-level terms not directly useful for analysis"
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: LATIN "latin term"
synonymtypedef: PLURAL "plural term"
remark: See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl@buffalo.edu, University at Buffalo.
ontology: cl/cl-basic
property_value: http://purl.org/dc/elements/1.1/license http://creativecommons.org/licenses/by/4.0/
[Term]
id: CL:0000000
name: cell
namespace: cell
def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah]
comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
subset: ubprop:upper_level
xref: CALOHA:TS-2035
xref: FMA:68646
xref: GO:0005623
xref: KUPO:0000002
xref: VHOG:0001533
xref: WBbt:0004017
xref: XAO:0003012
[Term]
id: CL:0000001
name: primary cultured cell
namespace: cell
def: "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." [ReO:mhb]
comment: Covers cells actively being cultured or stored in a quiescent state for future use.
synonym: "primary cell culture cell" EXACT []
synonym: "primary cell line cell" RELATED []
synonym: "unpassaged cultured cell" EXACT []
xref: BTO:0002290
is_a: CL:0000010 ! cultured cell
[Term]
id: CL:0000002
name: obsolete immortal cell line cell
namespace: cell
def: "OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." [ReO:mhb]
comment: Obsoleted in July 2013 and replaced by the CLO 'immortal cell line cell' class, as a result of CLO-OBI-CL alignment efforts.\n\nCovers cells actively being cultured or stored in a quiescent state for future use.
synonym: "continuous cell line cell" EXACT []
synonym: "permanent cell line cell" EXACT []
is_obsolete: true
replaced_by: CLO:0000019
[Term]
id: CL:0000003
name: native cell
namespace: cell
def: "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." [CARO:mah]
comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12).
subset: ubprop:upper_level
synonym: "cell in vivo" NARROW []
xref: CARO:0000013
is_a: CL:0000000 ! cell
[Term]
id: CL:0000004
name: obsolete cell by organism
namespace: cell
def: "OBSOLETE: A classification of cells by the organisms within which they are contained." [FB:ma]
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its species. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034
[Term]
id: CL:0000005
name: fibroblast neural crest derived
namespace: cell
is_a: CL:0000057 ! fibroblast
[Term]
id: CL:0000006
name: neuronal receptor cell
namespace: cell
synonym: "neuronal receptor cell (sensu Animalia)" EXACT []
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000197 ! receptor cell
[Term]
id: CL:0000007
name: early embryonic cell
namespace: cell
def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm]
is_a: CL:0002321 ! embryonic cell
[Term]
id: CL:0000008
name: migratory cranial neural crest cell
namespace: cell
is_a: CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000009
name: obsolete fusiform initial
namespace: cell
alt_id: CL:0000274
def: "Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." [ISBN:0471245208]
comment: replaced_by: PO:0000079
synonym: "xylem initial" RELATED []
synonym: "xylem mother cell" RELATED []
is_obsolete: true
[Term]
id: CL:0000010
name: cultured cell
namespace: cell
def: "A cell in vitro that is or has been maintained or propagated as part of a cell culture." [ReO:mhb]
comment: Note that this class was re-labeled to 'cultured cell' instead of 'cell line cell', as it intent was clarified to cover any cultured cells of multicellular and unicellular organisms. This includes cells actively being cultured, or cells that have been cultured but are stored in a quiescent state for future use. In having been cultured, cells must establish homeostasis and often replicate in a foreign environment. Accomodation of this stress initiates a selection of cells fit for such challenges, wherein necessary adaptive biochemical and.or genetic changes can occur. These changes can set them apart from the in vivo cells from which they derive, and such changes will typically accumulate and change over increasing time in culture.
is_a: CL:0000578 ! experimentally modified cell in vitro
[Term]
id: CL:0000011
name: migratory trunk neural crest cell
namespace: cell
is_a: CL:0000333 ! migratory neural crest cell
[Term]
id: CL:0000012
name: obsolete cell by class
namespace: cell
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034
[Term]
id: CL:0000013
name: obsolete dentine secreting cell
namespace: cell
is_obsolete: true
consider: CL:0000140
[Term]
id: CL:0000014
name: germ line stem cell
namespace: cell
synonym: "germline stem cell" EXACT []
is_a: CL:0000034 ! stem cell
is_a: CL:0000039 ! germ line cell
[Term]
id: CL:0000015
name: male germ cell
namespace: cell
xref: FMA:72290
xref: MA:0002765
xref: ncithesaurus:Spermatogenic_Cell
xref: VHOG:0001531
is_a: CL:0000586 ! germ cell
[Term]
id: CL:0000016
name: male germ line stem cell
namespace: cell
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000015 ! male germ cell
[Term]
id: CL:0000017
name: spermatocyte
namespace: cell
def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:A05.360.490.890.880]
xref: BTO:0001275
xref: CALOHA:TS-0951
xref: EMAPA:31484
xref: FBbt:00004936
xref: FMA:84049
xref: WBbt:0006799
is_a: CL:0000015 ! male germ cell
[Term]
id: CL:0000018
name: spermatid
namespace: cell
def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:A05.360.490.890.860]
synonym: "nematoblast" EXACT []
xref: BTO:0001274
xref: CALOHA:TS-0950
xref: EMAPA:31486
xref: FBbt:00004942
xref: FMA:72294
xref: WBbt:0006800
is_a: CL:0000015 ! male germ cell
is_a: CL:0000413 ! haploid cell
[Term]
id: CL:0000019
name: sperm
namespace: cell
def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:A05.360.490.890]
synonym: "sperm cell" EXACT []
synonym: "spermatozoid" EXACT []
synonym: "spermatozoon" EXACT []
xref: BTO:0001277
xref: BTO:0002046
xref: CALOHA:TS-0949
xref: FBbt:00004954
xref: FMA:67338
xref: WBbt:0006798
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000219 ! motile cell
is_a: CL:0000408 ! male gamete
[Term]
id: CL:0000020
name: spermatogonium
namespace: cell
def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:A05.360.490.890.900]
xref: BTO:0000958
xref: CALOHA:TS-2193
xref: EMAPA:31482
xref: FBbt:00004935
xref: FMA:72291
is_a: CL:0000015 ! male germ cell
[Term]
id: CL:0000021
name: female germ cell
namespace: cell
def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446]
xref: MA:0000388
xref: ncithesaurus:Egg
xref: VHOG:0001530
is_a: CL:0000586 ! germ cell
[Term]
id: CL:0000022
name: female germ line stem cell
namespace: cell
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000021 ! female germ cell
[Term]
id: CL:0000023
name: oocyte
namespace: cell
def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544]
synonym: "oogonium" RELATED []
xref: BTO:0000964
xref: CALOHA:TS-0711
xref: FBbt:00004886
xref: FMA:18644
xref: WBbt:0006797
is_a: CL:0000021 ! female germ cell
[Term]
id: CL:0000024
name: oogonial cell
namespace: cell
def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544]
xref: FMA:83673
is_a: CL:0000021 ! female germ cell
[Term]
id: CL:0000025
name: egg cell
namespace: cell
def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544]
synonym: "mature oocyte" EXACT []
synonym: "ovum" EXACT []
xref: BTO:0000369
xref: BTO:0003801
xref: CALOHA:TS-2191
xref: FBbt:00057012
xref: FMA:67343
xref: MA:0000388
is_a: CL:0000675 ! female gamete
[Term]
id: CL:0000026
name: invertebrate nurse cell
namespace: cell
def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [GOC:tfm, PMID:15848391]
synonym: "nurse cell" RELATED []
xref: BTO:0000953
xref: FBbt:00004878
is_a: CL:0000039 ! germ line cell
is_a: CL:0000412 ! polyploid cell
[Term]
id: CL:0000027
name: smooth muscle cell neural crest derived
namespace: cell
is_a: CL:0000192 ! smooth muscle cell
[Term]
id: CL:0000028
name: CNS neuron (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:2000029 ! central nervous system neuron
[Term]
id: CL:0000029
name: neuron neural crest derived
namespace: cell
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000030
name: glioblast
namespace: cell
xref: FBbt:00005145
is_a: CL:0000055 ! non-terminally differentiated cell
[Term]
id: CL:0000031
name: neuroblast
namespace: cell
def: "A cell that will develop into a neuron often after a migration phase." [http://en.wikipedia.org/wiki/Neuroblast]
xref: BTO:0000930
xref: FBbt:00005146
xref: FMA:70563
is_a: CL:0000047 ! neuronal stem cell
is_a: CL:0000055 ! non-terminally differentiated cell
[Term]
id: CL:0000032
name: neuroplacodal cell
namespace: cell
def: "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." [GOC:tfm, ISBN:0618947256]
synonym: "neural placode cell" EXACT []
is_a: CL:0002321 ! embryonic cell
[Term]
id: CL:0000033
name: apocrine cell
namespace: cell
def: "An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000034
name: stem cell
namespace: cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:A11.872]
xref: CALOHA:TS-2086
xref: FMA:63368
is_a: CL:0011115 ! precursor cell
[Term]
id: CL:0000035
name: single fate stem cell
namespace: cell
def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm]
synonym: "unipotent stem cell" EXACT []
synonym: "unipotential stem cell" EXACT []
xref: FMA:70569
is_a: CL:0000723 ! somatic stem cell
[Term]
id: CL:0000036
name: epithelial fate stem cell
namespace: cell
is_a: CL:0000035 ! single fate stem cell
[Term]
id: CL:0000037
name: hematopoietic stem cell
namespace: cell
def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770]
comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
synonym: "HSC" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:70337
xref: FMA:86475
xref: VHOG:0001485
is_a: CL:0000723 ! somatic stem cell
is_a: CL:0008001 ! hematopoietic precursor cell
[Term]
id: CL:0000038
name: erythroid progenitor cell
namespace: cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
synonym: "BFU-E" RELATED []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
[Term]
id: CL:0000039
name: germ line cell
namespace: cell
def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544]
comment: Originally this term had some plant germ line cell children.
subset: ubprop:upper_level
is_a: CL:0000548 ! animal cell
[Term]
id: CL:0000040
name: monoblast
namespace: cell
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740]
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
synonym: "CFU-M" RELATED []
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
xref: CALOHA:TS-1195
xref: FMA:83553
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 ! monopoietic cell
[Term]
id: CL:0000041
name: mature eosinophil
namespace: cell
def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464]
comment: Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP.
synonym: "mature eosinocyte" EXACT []
synonym: "mature eosinophil leucocyte" EXACT []
synonym: "mature eosinophil leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
is_a: CL:0000771 ! eosinophil
is_a: CL:0002242 ! nucleate cell
[Term]
id: CL:0000042
name: neutrophilic myeloblast
namespace: cell
def: "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." [GOC:add, ISBN:0721601464, PMID:12560239, PMID:15514007]
comment: These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction.
synonym: "neutrophilic granuloblast" RELATED []
is_a: CL:0000834 ! neutrophil progenitor cell
is_a: CL:0000835 ! myeloblast
[Term]
id: CL:0000043
name: mature basophil
namespace: cell
alt_id: CL:0000739
def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030, PMID:19231594, PMID:20837449]
comment: Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4.
synonym: "mature basophil leucocyte" EXACT []
synonym: "mature basophil leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
xref: BTO:0001026
xref: CALOHA:TS-0688
is_a: CL:0000767 ! basophil
is_a: CL:0002242 ! nucleate cell
is_a: CL:0002274 ! histamine secreting cell
[Term]
id: CL:0000045
name: obsolete thymus processed stem cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead.
is_obsolete: true
[Term]
id: CL:0000046
name: obsolete bursa processed stem cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816 or one of its children instead.
is_obsolete: true
[Term]
id: CL:0000047
name: neuronal stem cell
namespace: cell
def: "Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors." [GOC:tfm, http://en.wikipedia.org/wiki/Neural_stem_cell, MESH:D058953, PMID:15247488]
synonym: "neural stem cell" EXACT []
synonym: "NSC" EXACT []
xref: BTO:0002881
xref: CALOHA:TS-2360
xref: FMA:86684
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002319 ! neural cell
[Term]
id: CL:0000048
name: multi fate stem cell
namespace: cell
def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add]
synonym: "multi-fate stem cell" EXACT []
synonym: "multifate stem cell" EXACT []
synonym: "multipotent cell" EXACT []
synonym: "multipotent stem cell" EXACT []
xref: FMA:84789
is_a: CL:0000034 ! stem cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000049
name: common myeloid progenitor
namespace: cell
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
synonym: "CFU-GEMM" RELATED [ISBN:0878932437]
synonym: "CFU-S" RELATED [ISBN:0878932437]
synonym: "CMP" EXACT [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437]
xref: BTO:0004730
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
[Term]
id: CL:0000050
name: megakaryocyte-erythroid progenitor cell
namespace: cell
def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566]
comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.
synonym: "CFU-EM" EXACT []
synonym: "CFU-MegE" EXACT []
synonym: "colony forming unit erythroid megakaryocyte" EXACT []
synonym: "Meg/E progenitor" EXACT []
synonym: "megakaryocyte/erythrocyte progenitor" EXACT []
synonym: "megakaryocyte/erythroid progenitor cell" EXACT []
synonym: "MEP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
is_a: CL:0011115 ! precursor cell
[Term]
id: CL:0000051
name: common lymphoid progenitor
namespace: cell
alt_id: CL:0000044
def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251]
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
synonym: "CLP" EXACT []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
synonym: "ELP" RELATED []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
is_a: CL:0011115 ! precursor cell
[Term]
id: CL:0000052
name: totipotent stem cell
namespace: cell
def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm]
synonym: "totipotential stem cell" EXACT []
xref: FMA:84790
is_a: CL:0000723 ! somatic stem cell
[Term]
id: CL:0000054
name: bone matrix secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000055
name: non-terminally differentiated cell
namespace: cell
def: "A precursor cell with a limited number of potential fates." [SANBI:mhl]
comment: define using PATO mulit-potent or oligopotent?
synonym: "blast cell" EXACT []
xref: BTO:0000125
xref: FMA:84782
is_a: CL:0011115 ! precursor cell
[Term]
id: CL:0000056
name: myoblast
namespace: cell
def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:A11.635, PMID:21849021]
xref: BTO:0000222
xref: CALOHA:TS-0650
xref: FBbt:00005083
xref: FMA:70335
xref: VHOG:0001529
is_a: CL:0000680 ! muscle precursor cell
[Term]
id: CL:0000057
name: fibroblast
namespace: cell
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:A11.329.228, MESH:D005347]
comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.
xref: BTO:0000452
xref: CALOHA:TS-0362
xref: FMA:63877
xref: VHOG:0001482
is_a: CL:0002320 ! connective tissue cell
[Term]
id: CL:0000058
name: chondroblast
namespace: cell
def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256]
synonym: "chrondoplast" EXACT []
xref: BTO:0003607
xref: FMA:66783
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell
[Term]
id: CL:0000059
name: ameloblast
namespace: cell
alt_id: CL:0000053
alt_id: CL:0000139
def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [GO_REF:0000034, GOC:tfm, MESH:A11.436.107]
comment: non-encoded relationship from VSAO produces VSAO:0000066
synonym: "amelocyte" EXACT []
synonym: "enamel secreting cell" EXACT []
xref: BTO:0001663
xref: FMA:70576
is_a: CL:0000146 ! simple columnar epithelial cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0002077 ! ecto-epithelial cell
[Term]
id: CL:0000060
name: odontoblast
namespace: cell
def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [GO_REF:0000034, ISBN:0618947256]
comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin.
xref: BTO:0001769
xref: CALOHA:TS-0696
xref: FMA:62999
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
[Term]
id: CL:0000061
name: cementoblast
namespace: cell
alt_id: CL:0000859
def: "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell." [GO_REF:0000034, ISBN:0781733901]
comment: Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth.
synonym: "cementum secreting cell" EXACT []
xref: CALOHA:TS-1164
xref: FMA:63002
is_a: CL:0000062 ! osteoblast
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000062
name: osteoblast
namespace: cell
def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [GO_REF:0000034, MESH:A11.329.629]
comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020
xref: BTO:0001593
xref: CALOHA:TS-0720
xref: FMA:66780
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell
[Term]
id: CL:0000063
name: obsolete cell by histology
namespace: cell
def: "OBSOLETE: A classification of cells by their microscopic appearance." [FB:ma, GOC:tfm]
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its microscopic appearance. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034
[Term]
id: CL:0000064
name: ciliated cell
namespace: cell
def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm]
xref: VHOG:0001532
xref: XAO:0000031
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000065
name: ependymal cell
namespace: cell
def: "A neurectoderm derived cell that lines the neural lumen." [GOC:tfm, JB:jb, PMID:9550134]
synonym: "ependymocyte" EXACT []
xref: BTO:0001724
xref: FMA:70550
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
[Term]
id: CL:0000066
name: epithelial cell
namespace: cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:A11.436]
synonym: "epitheliocyte" EXACT []
xref: BTO:0000414
xref: CALOHA:TS-2026
xref: CARO:0000077
xref: FBbt:00000124
xref: FMA:66768
xref: WBbt:0003672
is_a: CL:0000548 ! animal cell
[Term]
id: CL:0000067
name: ciliated epithelial cell
namespace: cell
def: "An epithelial cell that has a cillia." [GOC:tfm]
xref: FMA:70605
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
[Term]
id: CL:0000068
name: duct epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000069
name: branched duct epithelial cell
namespace: cell
is_a: CL:0000068 ! duct epithelial cell
[Term]
id: CL:0000070
name: obsolete epithelial cell of gland
namespace: cell
is_obsolete: true
[Term]
id: CL:0000071
name: blood vessel endothelial cell
namespace: cell
def: "An endothelial cell that lines the vasculature." [GOC:tfm]
synonym: "cuboidal endothelial cell of vascular tree" EXACT []
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002139 ! endothelial cell of vascular tree
[Term]
id: CL:0000072
name: non-branched duct epithelial cell
namespace: cell
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
[Term]
id: CL:0000073
name: barrier epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000074
name: obsolete epithem cell
namespace: cell
def: "Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." [ISBN:0471245208, PMID:12662305]
comment: replaced_by: PO:0000066
is_obsolete: true
[Term]
id: CL:0000075
name: columnar/cuboidal epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000076
name: squamous epithelial cell
namespace: cell
xref: CALOHA:TS-1249
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0000077
name: mesothelial cell
namespace: cell
def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544]
synonym: "mesotheliocyte" EXACT []
xref: FMA:66773
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
[Term]
id: CL:0000078
name: peridermal cell
namespace: cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000079
name: stratified epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000080
name: circulating cell
namespace: cell
def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000081
name: blood cell
namespace: cell
def: "A cell found predominately in the blood." [GOC:add, GOC:tfm]
xref: FMA:62844
is_a: CL:0000988 ! hematopoietic cell
[Term]
id: CL:0000082
name: epithelial cell of lung
namespace: cell
synonym: "lung epithelial cell" EXACT []
xref: BTO:0004299
is_a: CL:0000066 ! epithelial cell
[Term]
id: CL:0000083
name: epithelial cell of pancreas
namespace: cell
def: "An epithelial cell of the pancreas." [GOC:tfm]
synonym: "pancreas epithelial cell" EXACT []
synonym: "pancreatic epithelial cell" EXACT []
xref: BTO:0000028
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000084
name: T cell
namespace: cell
alt_id: CL:0000804
alt_id: CL:0000812
def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "immature T cell" RELATED []
synonym: "mature T cell" RELATED []
synonym: "T lymphocyte" EXACT []
synonym: "T-cell" EXACT []
synonym: "T-lymphocyte" EXACT []
xref: BTO:0000782
xref: CALOHA:TS-1001
xref: FMA:62870
xref: VHOG:0001479
is_a: CL:0000542 ! lymphocyte
[Term]
id: CL:0000085
name: germ line stem cell (sensu Vertebrata)
namespace: cell
is_a: CL:0000014 ! germ line stem cell
[Term]
id: CL:0000086
name: germ line stem cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004861
is_a: CL:0000014 ! germ line stem cell
[Term]
id: CL:0000087
name: male germ line stem cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004929
is_a: CL:0000016 ! male germ line stem cell
is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia)
[Term]
id: CL:0000088
name: female germ line stem cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00004873
is_a: CL:0000022 ! female germ line stem cell
is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia)
[Term]
id: CL:0000089
name: male germ line stem cell (sensu Vertebrata)
namespace: cell
synonym: "spermatogonial stem cell" EXACT [PMID:19948499]
is_a: CL:0000016 ! male germ line stem cell
is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata)
[Term]
id: CL:0000090
name: female germ line stem cell (sensu Vertebrata)
namespace: cell
is_a: CL:0000022 ! female germ line stem cell
is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata)
[Term]
id: CL:0000091
name: Kupffer cell
namespace: cell
def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0517223651, MESH:A11.329.372.588, PMID:15771589, PMID:17105582]
comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2.
synonym: "hepatic macrophage" EXACT []
synonym: "littoral cell of hepatic sinusoid" EXACT []
synonym: "liver macrophage" EXACT []
synonym: "macrophagocytus stellatus" EXACT []
synonym: "stellate cell of von Kupffer" EXACT []
synonym: "von Kupffer cell" EXACT []
xref: BTO:0000685
xref: FMA:14656
is_a: CL:0000864 ! tissue-resident macrophage
[Term]
id: CL:0000092
name: osteoclast
namespace: cell
def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158]
comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.
synonym: "chondroclast" RELATED []
xref: BTO:0000968
xref: CALOHA:TS-0721
xref: FMA:66781
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0001035 ! bone cell
[Term]
id: CL:0000093
name: obsolete osteochondroclast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using 'osteoclast ; CL:0000092' instead.
is_obsolete: true
[Term]
id: CL:0000094
name: granulocyte
namespace: cell
def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:A11.118.637.415, MESH:D006098]
synonym: "granular leucocyte" EXACT []
synonym: "granular leukocyte" EXACT []
synonym: "polymorphonuclear leukocyte" EXACT []
xref: BTO:0000539
xref: BTO:0001026
xref: CALOHA:TS-0422
xref: FMA:62854
is_a: CL:0000081 ! blood cell
is_a: CL:0000766 ! myeloid leukocyte
[Term]
id: CL:0000095
name: neuron associated cell
namespace: cell
is_a: CL:0002319 ! neural cell
[Term]
id: CL:0000096
name: mature neutrophil
namespace: cell
def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." [GOC:add, GOC:tfm, http://www.cap.org, MESH:A11.118.637.415.583, MESH:D009504, PMID:11138776, PMID:12560239, PMID:15514007, PMID:7880385]
comment: Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)).
synonym: "mature neutrocyte" EXACT []
synonym: "mature neutrophil leucocyte" EXACT []
synonym: "mature neutrophil leukocyte" EXACT []
synonym: "mature neutrophilic leucocyte" EXACT []
synonym: "mature neutrophilic leukocyte" EXACT []
synonym: "PMN" EXACT []
synonym: "poly" BROAD []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
synonym: "polymorphonuclear neutrophil" EXACT []
synonym: "polynuclear neutrophilic leucocyte" EXACT []
synonym: "polynuclear neutrophilic leukocyte" EXACT []
xref: BTO:0003473
is_a: CL:0000234 ! phagocyte
is_a: CL:0000775 ! neutrophil
is_a: CL:0002242 ! nucleate cell
[Term]
id: CL:0000097
name: mast cell
namespace: cell
def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A11.329.427, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811]
comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.
synonym: "histaminocyte" EXACT []
synonym: "labrocyte" EXACT [ISBN:0721601464]
synonym: "mastocyte" EXACT [ISBN:0721601464]
synonym: "tissue basophil" RELATED [ISBN:068340007X]
xref: BTO:0000830
xref: CALOHA:TS-0603
xref: FMA:66784
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0002274 ! histamine secreting cell
[Term]
id: CL:0000098
name: sensory epithelial cell
namespace: cell
def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544]
comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710).
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000197 ! receptor cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000099
name: interneuron
namespace: cell
def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:A08.663.358]
xref: BTO:0003811
xref: FBbt:00005125
xref: FMA:67313
xref: WBbt:0005113
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000100
name: motor neuron
namespace: cell
def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:A08.663.655.500, PMID:16875686]
synonym: "anterior horn cell" NARROW []
synonym: "motoneuron" EXACT []
xref: BTO:0000312
xref: FMA:83617
xref: WBbt:0005409
is_a: CL:0000527 ! efferent neuron
[Term]
id: CL:0000101
name: sensory neuron
namespace: cell
def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544]
xref: BTO:0001037
xref: FBbt:00005124
xref: FMA:84649
xref: WBbt:0005759
is_a: CL:0000526 ! afferent neuron
[Term]
id: CL:0000102
name: polymodal neuron
namespace: cell
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000103
name: bipolar neuron
namespace: cell
def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [GOC:tfm, ISBN:0444009442]
xref: FMA:67282
is_a: CL:0000099 ! interneuron
[Term]
id: CL:0000104
name: multipolar neuron
namespace: cell
def: "Neuron with an axon and two or more dendrites." [FMA:67287, GOC:tfm]
xref: FMA:67287
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000105
name: pseudounipolar neuron
namespace: cell
def: "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." [FMA:67305, GOC:tfm]
xref: FMA:67305
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000106
name: unipolar neuron
namespace: cell
def: "Neuron with one neurite that extends from the cell body." [FMA:67278, GOC:nv]
xref: FMA:67278
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000107
name: autonomic neuron
namespace: cell
def: "A neruon whose cell body is within an autonomic ganglion." [GOC:tfm]
xref: FMA:80121
is_a: CL:2000032 ! peripheral nervous system neuron
[Term]
id: CL:0000108
name: cholinergic neuron
namespace: cell
def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm]
xref: BTO:0004902
xref: FMA:84796
xref: WBbt:0006840
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000109
name: adrenergic neuron
namespace: cell
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000110
name: peptidergic neuron
namespace: cell
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000111
name: peripheral neuron
namespace: cell
def: "A neuron that is part of nerve found outside the central nervous system." [ISBN:0721662544]
xref: FMA:84664
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000112
name: columnar neuron
namespace: cell
synonym: "columnar neuron" RELATED []
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000113
name: mononuclear phagocyte
namespace: cell
def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149]
xref: BTO:0001433
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
[Term]
id: CL:0000114
name: surface ectodermal cell
namespace: cell
synonym: "cell of surface ectoderm" EXACT []
synonym: "surface ectoderm cell" EXACT []
xref: FMA:72552
is_a: CL:0000221 ! ectodermal cell
[Term]
id: CL:0000115
name: endothelial cell
namespace: cell
def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341]
comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].
synonym: "endotheliocyte" EXACT []
xref: BTO:0001176
xref: CALOHA:TS-0278
xref: FMA:66772
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
[Term]
id: CL:0000116
name: pioneer neuron
namespace: cell
def: "Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance." [GOC:cvs, GOC:tfm]
xref: FBbt:00005128
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000117
name: CNS neuron (sensu Vertebrata)
namespace: cell
is_a: CL:2000029 ! central nervous system neuron
[Term]
id: CL:0000118
name: basket cell
namespace: cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
[Term]
id: CL:0000119
name: cerebellar Golgi cell
namespace: cell
def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell enters ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." [] {comment="NIFSTD:sao1415726815"}
synonym: "cerebellar Golgi neuron" EXACT []
synonym: "cerebellum Golgi cell" EXACT []
synonym: "Golgi cell" EXACT []
synonym: "Golgi neuron" EXACT []
is_a: CL:0000402 ! CNS interneuron
is_a: CL:0011005 ! GABAergic interneuron
is_a: CL:1001611 ! cerebellar neuron
[Term]
id: CL:0000120
name: granule cell
namespace: cell
xref: BTO:0003393
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
[Term]
id: CL:0000121
name: Purkinje cell
namespace: cell
def: "The output neuron of the cerebellar cortex." [MESH:A08.186.211.132.810.428.200.212.600]
synonym: "cerebellar Purkinje cell" EXACT []
synonym: "cerebellum Purkinje cell" EXACT []
synonym: "Purkinje neuron" EXACT []
synonym: "Purkinje's cell" EXACT []
xref: BTO:0001011
xref: CALOHA:TS-0845
xref: FMA:67969
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
is_a: CL:0000527 ! efferent neuron
is_a: CL:1001611 ! cerebellar neuron
[Term]
id: CL:0000122
name: stellate neuron
namespace: cell
xref: BTO:0002316
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
[Term]
id: CL:0000123
name: neuron associated cell (sensu Vertebrata)
namespace: cell
is_a: CL:0000095 ! neuron associated cell
[Term]
id: CL:0000124
name: glial cell (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00005144
is_a: CL:0000125 ! glial cell
[Term]
id: CL:0000125
name: glial cell
namespace: cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:A08.637]
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
xref: CALOHA:TS-0415
xref: FMA:54536
is_a: CL:0000095 ! neuron associated cell
[Term]
id: CL:0000126
name: macroglial cell
namespace: cell
def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544]
synonym: "macrogliocyte" EXACT []
xref: BTO:0000771
xref: CALOHA:TS-2027
xref: FMA:54538
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
[Term]
id: CL:0000127
name: astrocyte
namespace: cell
def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:A08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978]
comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.
synonym: "astrocytic glia" EXACT []
xref: BTO:0000099
xref: CALOHA:TS-0060
xref: FMA:54537
is_a: CL:0000126 ! macroglial cell
[Term]
id: CL:0000128
name: oligodendrocyte
namespace: cell
def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:A08.637.600, MESH:D009836]
comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative.
synonym: "oligodendroglia" RELATED []
synonym: "OLs" EXACT [PMID:8734446]
xref: BTO:0000962
xref: CALOHA:TS-0709
xref: FMA:54540
is_a: CL:0000126 ! macroglial cell
[Term]
id: CL:0000129
name: microglial cell
namespace: cell
def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Microglia, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275]
comment: Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.
synonym: "brain macrophage" BROAD []
synonym: "brain-resident macrophage" EXACT []
synonym: "hortega cells" EXACT [http://www.copewithcytokines.de/]
synonym: "MF.microglia.CNS" RELATED []
synonym: "microglia" EXACT []
synonym: "microgliocyte" EXACT [http://www.copewithcytokines.de/]
xref: BTO:0000078
xref: BTO:0000962
xref: FMA:54539
xref: FMA:54540
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
is_a: CL:0000878 ! central nervous system macrophage
[Term]
id: CL:0000130
name: neuron associated cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000095 ! neuron associated cell
[Term]
id: CL:0000131
name: gut endothelial cell
namespace: cell
is_a: CL:0000115 ! endothelial cell
[Term]
id: CL:0000132
name: corneal endothelial cell
namespace: cell
def: "Cell of the single layer of large flattened cells covering the surface of the cornea." [GOC:tfm, MESH:A09.371.060.067.31]
xref: CALOHA:TS-0172
xref: FMA:70614
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000710 ! neurecto-epithelial cell
[Term]
id: CL:0000133
name: neurectodermal cell
namespace: cell
def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X]
synonym: "neurectoderm cell" EXACT []
is_a: CL:0000221 ! ectodermal cell
[Term]
id: CL:0000134
name: mesenchymal stem cell
namespace: cell
alt_id: CL:0002452
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814j, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
synonym: "BMSC" NARROW []
synonym: "bone marrow stromal cells" NARROW []
synonym: "CFU-F" RELATED []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
synonym: "mesenchymal progenitor cells" RELATED PLURAL [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED PLURAL []
synonym: "MSC" RELATED [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED PLURAL [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
xref: FMA:70546
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0000219 ! motile cell
is_a: CL:0002320 ! connective tissue cell
[Term]
id: CL:0000135
name: fibrocyte
namespace: cell
def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Fibrocyte, ISBN:0412046911, ISBN:0517223651, PMID:11641248, PMID:15010326, PMID:17607298, PMID:18222966, PMID:8790603, PMID:9551999]
comment: Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A.
xref: FMA:63879
is_a: CL:0000499 ! stromal cell
[Term]
id: CL:0000136
name: fat cell
namespace: cell
alt_id: CL:0000450
def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A11.329.114]
synonym: "adipocyte" EXACT []
synonym: "adipose cell" EXACT []
xref: BTO:0000443
xref: CALOHA:TS-0012
xref: FMA:63880
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0002320 ! connective tissue cell
[Term]
id: CL:0000137
name: osteocyte
namespace: cell
def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [GOC:tfm, MESH:A11.329.629.500]
comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118
synonym: "bone cell" BROAD []
xref: BTO:0002038
xref: CALOHA:TS-1167
xref: FMA:66779
xref: VSAO:0000124
is_a: CL:0001035 ! bone cell
[Term]
id: CL:0000138
name: chondrocyte
namespace: cell
def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:A11.329.171]
synonym: "cartilage cell" EXACT []
xref: BTO:0000249
xref: CALOHA:TS-0138
xref: FMA:66782
is_a: CL:0000153 ! GAG secreting cell
is_a: CL:0000667 ! collagen secreting cell
[Term]
id: CL:0000140
name: odontocyte
namespace: cell
def: "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." [GO_REF:0000034]
is_a: CL:0002320 ! connective tissue cell
[Term]
id: CL:0000141
name: cementocyte
namespace: cell
def: "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." [ISBN:0781733901]
comment: CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def).
xref: FMA:63003
is_a: CL:0000137 ! osteocyte
[Term]
id: CL:0000142
name: hyalocyte
namespace: cell
def: "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." [GOC:tfm, PMID:19073178]
synonym: "vitreous cell" RELATED []
xref: BTO:0004271
xref: FMA:70620
is_a: CL:0000499 ! stromal cell
[Term]
id: CL:0000143
name: guidepost cell
namespace: cell
is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia)
[Term]
id: CL:0000144
name: obsolete cell by function
namespace: cell
def: "OBSOLETE: A classification of cells by their primary end goal or behavior." [FB:ma]
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its function or behavior. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034
[Term]
id: CL:0000145
name: professional antigen presenting cell
namespace: cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
synonym: "APC" BROAD []
is_a: CL:0000473 ! defensive cell
[Term]
id: CL:0000146
name: simple columnar epithelial cell
namespace: cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
[Term]
id: CL:0000147
name: pigment cell
namespace: cell
def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm]
synonym: "chromatocyte" EXACT []
synonym: "chromatophore" EXACT []
xref: VHOG:0001678
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000148
name: melanocyte
namespace: cell
alt_id: CL:0000572
def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [SANBI:mhl]
synonym: "melanophore" NARROW []
xref: BTO:0000847
xref: CALOHA:TS-0613
xref: FMA:70545
xref: VHOG:0001679
is_a: CL:0000147 ! pigment cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000149
name: visual pigment cell
namespace: cell
synonym: "pigment cell" BROAD []
is_a: CL:0000147 ! pigment cell
[Term]
id: CL:0000150
name: glandular epithelial cell
namespace: cell
def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [GOC:tfm]
xref: CALOHA:TS-2085
xref: FMA:86494
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000151
name: secretory cell
namespace: cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000152
name: exocrine cell
namespace: cell
def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684]
xref: FMA:16014
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000153
name: GAG secreting cell
namespace: cell
def: "A cell that secretes glycosaminoglycans." [GOC:tfm]
synonym: "hyaluronic acid secreting cell" EXACT []
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0000447 ! carbohydrate secreting cell
[Term]
id: CL:0000154
name: protein secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000155
name: peptic cell
namespace: cell
def: "A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen." [GOC:tfm]
synonym: "chief cell of stomach" EXACT []
synonym: "gastric chief cell" EXACT []
synonym: "pepsinogen secreting cell" EXACT []
synonym: "zymogenic cell" EXACT []
xref: FMA:62902
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0002659 ! glandular cell of stomach
[Term]
id: CL:0000156
name: obsolete antibody secreting cell
namespace: cell
def: "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." []
comment: Consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true
[Term]
id: CL:0000157
name: surfactant secreting cell
namespace: cell
def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000158
name: Clara cell
namespace: cell
def: "Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium." [GOC:tfm, PMID:12107102, PMID:7905712]
synonym: "bronchiolar non-ciliated cell" EXACT []
synonym: "Clara cell of bronchiole" EXACT []
xref: BTO:0004811
xref: FMA:14119
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0002328 ! bronchial epithelial cell
[Term]
id: CL:0000159
name: seromucus secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000160
name: goblet cell
namespace: cell
def: "A cell of the epithelial lining that produce and secrete mucins." [MESH:A03.492.411.369.320]
synonym: "chalice cell" EXACT []
xref: BTO:0001540
xref: FMA:13148
xref: http://en.wikipedia.org/wiki/Goblet_cell
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000319 ! mucus secreting cell
[Term]
id: CL:0000161
name: acid secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000162
name: parietal cell
namespace: cell
def: "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl." [GOC:tfm, ISBN:0517223651]
synonym: "oxyntic cell" EXACT []
xref: BTO:0001780
xref: FMA:62901
is_a: CL:0000161 ! acid secreting cell
is_a: CL:0002659 ! glandular cell of stomach
[Term]
id: CL:0000163
name: endocrine cell
namespace: cell
def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:A06.407]
synonym: "endocrinocyte" EXACT []
xref: FMA:83809
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000164
name: enteroendocrine cell
namespace: cell
def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl]
xref: BTO:0003865
xref: FMA:62930
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000163 ! endocrine cell
[Term]
id: CL:0000165
name: neuroendocrine cell
namespace: cell
def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." [MESH:A06.688]
synonym: "neurosecretory cell" EXACT []
xref: BTO:0002691
xref: FMA:83810
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000710 ! neurecto-epithelial cell
[Term]
id: CL:0000166
name: chromaffin cell
namespace: cell
def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:A06.224.161]
synonym: "phaeochromocyte" EXACT []
xref: BTO:0000259
xref: FMA:69263
is_a: CL:0000568 ! amine precursor uptake and decarboxylation cell
[Term]
id: CL:0000167
name: peptide hormone secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000168
name: insulin secreting cell
namespace: cell
xref: BTO:0000783
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000169
name: type B pancreatic cell
namespace: cell
def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651]
comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression.
synonym: "B-cell of pancreatic islet" EXACT [FMA:70586]
synonym: "beta cell" BROAD [ZFA:0009102]
synonym: "beta cell islet" RELATED [MA:0002419]
synonym: "beta cell of pancreatic islet" EXACT [FMA:70586]
synonym: "insulin-secreting cell" EXACT [FMA:70586]
synonym: "pancreatic B cell" EXACT []
synonym: "pancreatic B-cell" EXACT [FMA:70586]
synonym: "pancreatic beta cell" EXACT [FMA:70586]
synonym: "pancreatic islet core" EXACT [MA:0002419]
synonym: "type B enteroendocrine cell" EXACT [FMA:70586]
xref: BTO:0000783
xref: EV:0200009
xref: FMA:70586
xref: MA:0002419
xref: ncithesaurus:Beta_Cell
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000168 ! insulin secreting cell
is_a: CL:0008024 ! pancreatic endocrine cell
[Term]
id: CL:0000170
name: glucagon secreting cell
namespace: cell
def: "A cell that secretes glucagon." [GOC:tfm]
synonym: "glucagon-secreting cell" EXACT []
xref: FMA:84045
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000171
name: pancreatic A cell
namespace: cell
def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544]
synonym: "alpha cell of iselt of Langerhans" EXACT []
synonym: "pancreatic alpha cell" EXACT []
xref: BTO:0000990
xref: FMA:70585
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0002067 ! type A enterocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
[Term]
id: CL:0000172
name: somatostatin secreting cell
namespace: cell
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000173
name: pancreatic D cell
namespace: cell
def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm]
synonym: "D-cell of pancreatic islet" EXACT []
synonym: "delta cell of islet" EXACT []
synonym: "delta cell of pancreatic islet" EXACT []
synonym: "pancreatic D-cell" EXACT []
synonym: "pancreatic delta cell" EXACT []
synonym: "somatostatin-secreting pancreatic cell" EXACT []
xref: BTO:0000803
xref: FMA:70587
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
[Term]
id: CL:0000174
name: steroid hormone secreting cell
namespace: cell
is_a: CL:0000163 ! endocrine cell
[Term]
id: CL:0000175
name: luteal cell
namespace: cell
def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [MESH:A05.360.319.114.630.278.400]
synonym: "lutein cell" EXACT []
xref: BTO:0003939
xref: FMA:18688
is_a: CL:0000179 ! progesterone secreting cell
is_a: CL:0002132 ! stromal cell of ovary
[Term]
id: CL:0000176
name: ecdysteroid secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
[Term]
id: CL:0000177
name: testosterone secreting cell
namespace: cell
is_a: CL:0000593 ! androgen secreting cell
[Term]
id: CL:0000178
name: Leydig cell
namespace: cell
def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:tfm, PMID:12050120]
comment: Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated
synonym: "interstitial cell" BROAD []
synonym: "interstitial cell of Leydig" EXACT []
xref: BTO:0000755
xref: CALOHA:TS-1150
xref: EMAPA:29655
xref: FMA:72297
is_a: CL:0000177 ! testosterone secreting cell
[Term]
id: CL:0000179
name: progesterone secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
[Term]
id: CL:0000180
name: estradiol secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
[Term]
id: CL:0000181
name: metabolising cell
namespace: cell
def: "A cell whose primary function is intermediary metabolism." [FB:ma]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000182
name: hepatocyte
namespace: cell
def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:A11.436.348, PMID:19717280]
comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive.
xref: BTO:0000575
xref: CALOHA:TS-0454
xref: FMA:14515
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000181 ! metabolising cell
is_a: CL:0000417 ! endopolyploid cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000183
name: contractile cell
namespace: cell
def: "A cell whose primary function is to shorten." [FB:ma]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000185
name: myoepithelial cell
namespace: cell
def: "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." [GOC:tfm, ISBN:0721662544]
synonym: "basket epithelial cell" EXACT []
synonym: "myoepitheliocyte" EXACT []
xref: BTO:0002309
xref: CALOHA:TS-2379
xref: FMA:67799
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0000183 ! contractile cell
is_a: CL:0002078 ! meso-epithelial cell
[Term]
id: CL:0000186
name: myofibroblast cell
namespace: cell
def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." [GOC:dsd, GOC:tfm, MESH:D058628, PMID:19800625, PMID:20630469]
comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha.
synonym: "MFB" EXACT [PMID:8731193]
is_a: CL:0000183 ! contractile cell
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000187
name: muscle cell
namespace: cell
def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:A11.620]
synonym: "muscle fiber" EXACT []
synonym: "myocyte" EXACT []
xref: BTO:0000888
xref: BTO:0000902
xref: CALOHA:TS-2032
xref: FBbt:00005074
xref: FMA:67328
xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000188
name: cell of skeletal muscle
namespace: cell
def: "A somatic cell located in skeletal muscle." [GOC:tfm]
xref: BTO:0004392
xref: CALOHA:TS-2158
xref: FMA:9727
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000189
name: slow muscle cell
namespace: cell
def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [GOC:tfm, ISBN:0323052908]
synonym: "slow muscle fiber" RELATED [ISBN:0815316208]
xref: FMA:84448
is_a: CL:0008002 ! skeletal muscle fiber
[Term]
id: CL:0000190
name: fast muscle cell
namespace: cell
def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron ." [GOC:tfm, ISBN:0323052908]
synonym: "glycolytic muscle fiber" EXACT []
is_a: CL:0008002 ! skeletal muscle fiber
[Term]
id: CL:0000192
name: smooth muscle cell
namespace: cell
alt_id: CL:0000191
def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:A11.620.520, MESH:D032389, PMID:9315361]
synonym: "myocytes, smooth muscle" EXACT [MESH:D032389]
synonym: "non-striated muscle cell" EXACT []
synonym: "SMCs" EXACT [PMID:9315361]
synonym: "smooth muscle fiber" EXACT []
xref: BTO:0004576
xref: CALOHA:TS-2159
xref: FMA:14072
is_a: CL:0008000 ! non-striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
[Term]
id: CL:0000193
name: cardiac muscle cell (sensu Arthopoda)
namespace: cell
alt_id: CL:0000466
def: "A striated muscle cell of an arthropod heart that participates in heart contraction." [MESH:A11.620.500]
is_a: CL:0000746 ! cardiac muscle cell
[Term]
id: CL:0000194
name: obsolete nodal cardiac cell
namespace: cell
comment: Consider CL:0002072.
is_obsolete: true
[Term]
id: CL:0000195
name: obsolete Purkinje fiber
namespace: cell
is_obsolete: true
[Term]
id: CL:0000196
name: flight muscle cell
namespace: cell
is_a: CL:0008003 ! somatic muscle myotube
[Term]
id: CL:0000197
name: receptor cell
namespace: cell
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000198
name: pain receptor cell
namespace: cell
def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:A08.800.550.700.650]
comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship
synonym: "nociceptor" EXACT []
synonym: "nocireceptor" EXACT []
is_a: CL:0000006 ! neuronal receptor cell
[Term]
id: CL:0000199
name: mechanoreceptor cell
namespace: cell
def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:A08.800.550.700.500]
synonym: "mechanoreceptor" RELATED [MP:0000972]
is_a: CL:0000101 ! sensory neuron
[Term]
id: CL:0000200
name: touch receptor cell
namespace: cell
is_a: CL:0000199 ! mechanoreceptor cell
[Term]
id: CL:0000202
name: auditory hair cell
namespace: cell
alt_id: CL:0000201
def: "A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:A08.663.650.250]
comment: In mammals these cells are located in the organ of Corti.
synonym: "auditory receptor cell" EXACT []
synonym: "cochlear hair cell" EXACT []
synonym: "inner ear hair cell" RELATED [GO:0060119]
synonym: "inner ear receptor cell" RELATED [GO:0060119]
xref: FMA:62364
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002374 ! ear hair cell
is_a: CL:0002491 ! auditory epithelial cell
[Term]
id: CL:0000203
name: gravity sensitive cell
namespace: cell
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000199 ! mechanoreceptor cell
[Term]
id: CL:0000204
name: acceleration receptive cell
namespace: cell
is_a: CL:0000006 ! neuronal receptor cell
[Term]
id: CL:0000205
name: thermoreceptor cell
namespace: cell
def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [GOC:tfm, MESH:A08.800.550.700.840, MP:0000971]
is_a: CL:0000006 ! neuronal receptor cell
[Term]
id: CL:0000206
name: chemoreceptor cell
namespace: cell
def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:A08.800.550.700.120]
is_a: CL:0000101 ! sensory neuron
[Term]
id: CL:0000207
name: olfactory receptor cell
namespace: cell
synonym: "odorant receptor cell" EXACT []
synonym: "olfactory receptor neuron" EXACT []
synonym: "olfactory sensory neuron" EXACT []
synonym: "Schultze's cell" EXACT []
xref: BTO:0004185
xref: FMA:67860
xref: Wikipedia:Olfactory_receptor_neuron
is_a: CL:0000206 ! chemoreceptor cell
[Term]
id: CL:0000208
name: pH receptor cell
namespace: cell
is_a: CL:0000206 ! chemoreceptor cell
[Term]
id: CL:0000209
name: taste receptor cell
namespace: cell
def: "A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste." [GOC:tfm, ISBN:0618947256]
synonym: "taste bud cell" EXACT []
xref: FMA:67910
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0000362 ! epidermal cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002076 ! endo-epithelial cell
[Term]
id: CL:0000210
name: photoreceptor cell
namespace: cell
def: "A cell specialized to detect and transduce light." [MESH:A08.663.650.650]
xref: BTO:0001060
xref: CALOHA:TS-0868
xref: FBbt:00004211
xref: FMA:86740
is_a: CL:0000006 ! neuronal receptor cell
[Term]
id: CL:0000211
name: electrically active cell
namespace: cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000212
name: absorptive cell
namespace: cell
def: "A cell that takes up and metabolizes substances." [CL:CVS]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000213
name: lining cell
namespace: cell
def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb]
synonym: "boundary cell" EXACT []
is_a: CL:0000215 ! barrier cell
[Term]
id: CL:0000214
name: synovial cell
namespace: cell
def: "A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid." [GOC:tfm, ISBN:0721662544, PMID:17942474]
synonym: "hyaluronic acid secreting cell" EXACT []
synonym: "synoviocyte" EXACT []
xref: BTO:0003652
xref: CALOHA:TS-0995
xref: FMA:66786
is_a: CL:0000153 ! GAG secreting cell
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
[Term]
id: CL:0000215
name: barrier cell
namespace: cell
def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000216
name: Sertoli cell
namespace: cell
def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:A05.360.444.849.789]
xref: BTO:0001238
xref: CALOHA:TS-0922
xref: FMA:72298
xref: VHOG:0001348
is_a: CL:0000511 ! androgen binding protein secreting cell
is_a: CL:0000630 ! supportive cell
is_a: CL:0002625 ! seminiferous tubule epithelial cell
[Term]
id: CL:0000217
name: insulating cell
namespace: cell
is_a: CL:0000215 ! barrier cell
[Term]
id: CL:0000218
name: myelinating Schwann cell
namespace: cell
def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:A08.637.800]
synonym: "neurilemmal cell" EXACT []
synonym: "peripheral neuroglial cell" BROAD []
synonym: "Schwann cell" BROAD []
xref: CALOHA:TS-0898
xref: FMA:62121
is_a: CL:0000217 ! insulating cell
is_a: CL:0000328 ! myelin accumulating cell
is_a: CL:0002573 ! Schwann cell
[Term]
id: CL:0000219
name: motile cell
namespace: cell
def: "A cell that moves by its own activities." [FB:ma]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000220
name: obsolete cell by lineage
namespace: cell
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell in a multicellular organiam, apart from a zygote, can potentially be classified by its lineage. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034
[Term]
id: CL:0000221
name: ectodermal cell
namespace: cell
def: "A cell of the outer of the three germ layers of the embryo." [MESH:A16.254.425.273]
synonym: "ectoderm cell" EXACT []
xref: FMA:72549
is_a: CL:0002321 ! embryonic cell
[Term]
id: CL:0000222
name: mesodermal cell
namespace: cell
def: "A cell of the middle germ layer of the embryo." [MESH:A16.254.425.660]
synonym: "mesoblast" EXACT []
synonym: "mesoderm cell" EXACT []
xref: FMA:72554
is_a: CL:0002321 ! embryonic cell
[Term]
id: CL:0000223
name: endodermal cell
namespace: cell
def: "A cell of the inner of the three germ layers of the embryo." [MESH:A16.254.425.407]
synonym: "endoderm cell" EXACT []
xref: FMA:72555
is_a: CL:0002321 ! embryonic cell
[Term]
id: CL:0000224
name: obsolete cell by nuclear number
namespace: cell
def: "OBSOLETE: A classification of cells by the number of their nuclei." [FB:ma, GOC:tfm]
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its nuclear number (note that this term was previously used as a parent class of enucleate cell). If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0001034
[Term]
id: CL:0000225
name: anucleate cell
namespace: cell
def: "A cell that lacks a nucleus." [FB:ma]
synonym: "non-nucleated cell" EXACT []
xref: FMA:68647
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000226
name: single nucleate cell
namespace: cell
def: "A cell with a single nucleus." [FB:ma, GOC:tfm]
is_a: CL:0002242 ! nucleate cell
[Term]
id: CL:0000227
name: binucleate cell
namespace: cell
is_a: CL:0000228 ! multinucleate cell
[Term]
id: CL:0000228
name: multinucleate cell
namespace: cell
def: "A cell with more than one nucleus." [FB:ma]
synonym: "syncitium" EXACT []
synonym: "syncytial cell" EXACT []
synonym: "syncytium" EXACT []
xref: AEO:0000203
xref: WBbt:0008074
is_a: CL:0002242 ! nucleate cell
[Term]
id: CL:0000229
name: obsolete lymphoblast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead.
is_obsolete: true
[Term]
id: CL:0000230
name: obsolete T lymphoblast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead.
is_obsolete: true
[Term]
id: CL:0000231
name: obsolete B lymphoblast
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true
[Term]
id: CL:0000232
name: erythrocyte
namespace: cell
def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:A11.118.290]
synonym: "RBC" EXACT []
synonym: "red blood cell" EXACT []
xref: BTO:0000424
xref: CALOHA:TS-0290
xref: FMA:81100
is_a: CL:0000081 ! blood cell
is_a: CL:0000329 ! oxygen accumulating cell
is_a: CL:0000764 ! erythroid lineage cell
[Term]
id: CL:0000233
name: platelet
namespace: cell
def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Platelet, MESH:A11.118.188, MESH:D001792, PMID:11110672, PMID:16987572, PMID:17204662, PMID:17479180, PMID:20414831]
comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF.
synonym: "anucleate thrombocyte" EXACT []
synonym: "blood platelet" EXACT []
synonym: "enucleate thrombocyte" EXACT []
xref: BTO:0000132
xref: CALOHA:TS-0803
xref: FMA:62851
is_a: CL:0000081 ! blood cell
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000763 ! myeloid cell
[Term]
id: CL:0000234
name: phagocyte
namespace: cell
def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464]
xref: BTO:0001044
xref: FMA:83806
is_a: CL:0000219 ! motile cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000473 ! defensive cell
[Term]
id: CL:0000235
name: macrophage
namespace: cell
def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437]
comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
synonym: "histiocyte" EXACT []
xref: BTO:0000801
xref: CALOHA:TS-0587
xref: FMA:63261
xref: FMA:83585
is_a: CL:0000234 ! phagocyte
is_a: CL:0000766 ! myeloid leukocyte
[Term]
id: CL:0000236
name: B cell
namespace: cell
def: "A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149]
synonym: "B lymphocyte" EXACT []
synonym: "B-cell" EXACT []
synonym: "B-lymphocyte" EXACT []
xref: BTO:0000776
xref: CALOHA:TS-0068
xref: FMA:62869
xref: VHOG:0001480
is_a: CL:0000945 ! lymphocyte of B lineage
[Term]
id: CL:0000237
name: keratinizing barrier epithelial cell
namespace: cell
is_a: CL:0000240 ! stratified squamous epithelial cell
is_a: CL:0000311 ! keratin accumulating cell
is_a: CL:0002077 ! ecto-epithelial cell
[Term]
id: CL:0000238
name: non keratinizing barrier epithelial cell
namespace: cell
is_a: CL:0000240 ! stratified squamous epithelial cell
[Term]
id: CL:0000239
name: brush border epithelial cell
namespace: cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
[Term]
id: CL:0000240
name: stratified squamous epithelial cell
namespace: cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000079 ! stratified epithelial cell
[Term]
id: CL:0000241
name: stratified cuboidal epithelial cell
namespace: cell
is_a: CL:0000079 ! stratified epithelial cell
[Term]
id: CL:0000242
name: Merkel cell
namespace: cell
def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." [MESH:A08.800.550.700.500.425]
synonym: "Merkel's cell" EXACT []
xref: FMA:70548
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0000312 ! keratinocyte
is_a: CL:0000710 ! neurecto-epithelial cell
[Term]
id: CL:0000243
name: glial cell (sensu Vertebrata)
namespace: cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." [MESH:A08.637]
is_a: CL:0000125 ! glial cell
[Term]
id: CL:0000244
name: transitional epithelial cell
namespace: cell
def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [GOC:tfm, ISBN:0721662544]
xref: FMA:66778
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000245
name: obsolete passage cell
namespace: cell
def: "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." [ISBN:0471245208]
comment: replaced_by: PO:0000353
is_obsolete: true
[Term]
id: CL:0000246
name: Mauthner neuron
namespace: cell
is_a: CL:0000099 ! interneuron
[Term]
id: CL:0000247
name: Rohon-Beard neuron
namespace: cell
def: "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." [VHOG:0001484]
synonym: "RB neuron" RELATED [VHOG:0001484]
synonym: "Rohon Beard cell" EXACT [VHOG:0001484]
synonym: "Rohon-Beard cell" EXACT []
xref: AAO:0010316
xref: EFO:0003711
xref: VHOG:0001484
is_a: CL:0000531 ! primary sensory neuron
[Term]
id: CL:0000248
name: obsolete microsporocyte
namespace: cell
def: "Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [ISBN:0471245208]
comment: replaced_by: PO:0020047
synonym: "pollen mother cell" EXACT []
synonym: "primary sporogenous cell" EXACT []
is_obsolete: true
[Term]
id: CL:0000249
name: hatching gland cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000250
name: obsolete megaspore
namespace: cell
def: "Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants." [ISBN:0471245208]
comment: replaced_by: PO:0020019
is_obsolete: true
[Term]
id: CL:0000251
name: extramedullary cell
namespace: cell
is_a: CL:0000101 ! sensory neuron
[Term]
id: CL:0000252
name: obsolete microspore
namespace: cell
def: "Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." [ISBN:0471245208]
comment: replaced_by: PO:0020048
is_obsolete: true
[Term]
id: CL:0000253
name: eurydendroid cell
namespace: cell
is_a: CL:0000527 ! efferent neuron
[Term]
id: CL:0000254
name: obsolete egg cell
namespace: cell
def: "Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants." [TAIR:lr]
comment: replaced_by: PO:0020094
synonym: "female gametophyte egg cell" EXACT []
is_obsolete: true
[Term]
id: CL:0000255
name: eukaryotic cell
namespace: cell
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000256
name: uric acid accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000257
name: Mycetozoan cell
namespace: cell
is_a: CL:0000255 ! eukaryotic cell
[Term]
id: CL:0000258
name: obsolete fiber tracheid
namespace: cell
def: "Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." [ISBN:0471245208]
comment: replaced_by: PO:0000355
is_obsolete: true
[Term]
id: CL:0000259
name: aggregate cell
namespace: cell
def: "Differentiating cell composing the aggregate that has acquired adhesive properties." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)
[Term]
id: CL:0000260
name: obsolete mucilage cell
namespace: cell
def: "Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." [ISBN:0471245208]
comment: replaced_by: PO:0000373
is_obsolete: true
[Term]
id: CL:0000261
name: anterior cell
namespace: cell
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)
[Term]
id: CL:0000262
name: obsolete guard mother cell
namespace: cell
def: "Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells." [ISBN:0471245208]
comment: replaced_by: PO:0000351
is_obsolete: true
[Term]
id: CL:0000263
name: vegetative cell (sensu Mycetozoa)
namespace: cell
def: "Unicellular haploid myxamoebae that feeds on bacteria and divides by binary fission." [DictyBase:DDB]
synonym: "amoeba" EXACT []
is_a: CL:0000257 ! Mycetozoan cell
[Term]
id: CL:0000264
name: obsolete phloem initial
namespace: cell
def: "Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." [ISBN:0471245208]
comment: replaced_by: PO:0000400
synonym: "phloem mother cell" EXACT []
is_obsolete: true
[Term]
id: CL:0000265
name: anterior like cell
namespace: cell
def: "Cell that has properties of anterior cells (for e.g., accumulate vital dyes in autophagic vesicles) but that is are scattered throughout the rear of the slug. Some but not all these cells express the ecmA gene and/or the ecmB gene. ALCs maintain an amoeboid appearance during culmination. ALCs that express the ecmO promoter have been called pstO/ALC." [DictyBase:DDB]
synonym: "ALC" EXACT []
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)
[Term]
id: CL:0000266
name: obsolete meristemoid
namespace: cell
def: "Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." [ISBN:0471245208]
comment: replaced_by: PO:0004011
is_obsolete: true
[Term]
id: CL:0000267
name: prespore cell
namespace: cell
def: "Cell that is undergoing differentiation to become a spore." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)
[Term]
id: CL:0000268
name: obsolete sieve element
namespace: cell
def: "Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." [ISBN:0471245208]
is_obsolete: true
[Term]
id: CL:0000269
name: prestalk cell
namespace: cell
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)
[Term]
id: CL:0000270
name: obsolete subsidiary cell
namespace: cell
def: "Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." [ISBN:047124520]
comment: replaced_by: PO:0000284
is_obsolete: true
[Term]
id: CL:0000271
name: prestalk A cell
namespace: cell
def: "Cell expressing the ecmA marker from a promoter region that is proximal to the ATG (ecmAO promoter). They are located at the anterior-most region of the slug. During culmination pstA cells differentiate into pstAB cells." [DictyBase:DDB]
synonym: "pstA" EXACT []
synonym: "pstAO" EXACT []
is_a: CL:0000269 ! prestalk cell
[Term]
id: CL:0000272
name: obsolete cambial initial
namespace: cell
def: "OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." [ISBN:0471245208]
comment: replaced_by PO:0000295
is_obsolete: true
[Term]
id: CL:0000273
name: prestalk AB cell
namespace: cell
def: "Cell that expresses both ecmA and ecmB either simultaneously or sequentially. During culmination pstA differentiate into pstAB cells." [DictyBase:DDB]
synonym: "pstAB" EXACT []
is_a: CL:0000269 ! prestalk cell
[Term]
id: CL:0000275
name: prestalk B cell
namespace: cell
def: "Cell expressing ecmB but not ecmA. Most pstB cells are located at the very rear of the slug (rearguard region). These cells form part of the basal disc of the fruiting body. If a migratory slug is formed, these cells are left behind." [DictyBase:DDB]
synonym: "pstB" EXACT []
is_a: CL:0000269 ! prestalk cell
[Term]
id: CL:0000276
name: obsolete sclerenchyma cell
namespace: cell
def: "Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." [ISBN:0471245208]
comment: replaced_by: PO:0000077
is_obsolete: true
[Term]
id: CL:0000277
name: obsolete prestalk I cell
namespace: cell
def: "OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." [DictyBase:DDB]
comment: This cell type does not exist in Dictyostelium. it has been long deleted in their anatomy ontology.
is_obsolete: true
replaced_by: DDANAT:0000406
[Term]
id: CL:0000278
name: obsolete central cell
namespace: cell
def: "Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." [TAIR:lr]
comment: replaced_by: PO:0020090
is_obsolete: true
[Term]
id: CL:0000279
name: prestalk 0 cell
namespace: cell
def: "Cell that express ecmA at a very low level. Located at the posterior half of the prestalk zone. Expresses ecmA from the distal region of its promoter (ecmO)." [DictyBase:DDB]
is_a: CL:0000269 ! prestalk cell
[Term]
id: CL:0000280
name: obsolete generative cell
namespace: cell
def: "Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization." [TAIR:lr]
comment: replaced_by: PO:0020097
is_obsolete: true
[Term]
id: CL:0000281
name: pstAB/ALC
namespace: cell
def: "Anterior-like cell expressing both ecmA and ecmB." [DictyBase:DDB]
is_a: CL:0000265 ! anterior like cell
[Term]
id: CL:0000282
name: obsolete trichome
namespace: cell
def: "Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." [ISBN:0471245208, PMID:10938806]
comment: replaced_by: PO:0000282
is_obsolete: true
[Term]
id: CL:0000283
name: pstO/ALC
namespace: cell
def: "Anterior-like cell that expresses the ecmO promoter and that can move to the position normally occupied by the pstO cells." [DictyBase:DDB]
is_a: CL:0000265 ! anterior like cell
[Term]
id: CL:0000284
name: obsolete companion cell
namespace: cell
def: "Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [ISBN:0879015322]
comment: replaced_by: PO:0000071
is_obsolete: true
[Term]
id: CL:0000285
name: stalk cell
namespace: cell
def: "Vacuolated cell located at the center of the stalk tube that has a cell wall composed of cellulose and that die upon terminal differentiation. Stalk cells provide structural support for the fruiting body." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)
[Term]
id: CL:0000286
name: hyphal cell
namespace: cell
def: "A cell of a filament of a fungal mycelium." [ISBN:08199377X]
is_a: CL:0000521 ! fungal cell
[Term]
id: CL:0000287
name: eye photoreceptor cell
namespace: cell
is_a: CL:0000210 ! photoreceptor cell
[Term]
id: CL:0000288
name: obsolete synergid
namespace: cell
def: "Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." [ISBN:047125208]
comment: replaced_by: PO:0000191
is_obsolete: true
[Term]
id: CL:0000289
name: chemotactic amoeboid cell (sensu Mycetozoa)
namespace: cell
def: "Starved cell that secretes and responds to chemoattractants (cAMP)." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)
is_a: CL:0000732 ! amoeboid cell
[Term]
id: CL:0000290
name: obsolete xylem fiber cell
namespace: cell
def: "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." [ISBN:0471245208]
comment: replaced_by: PO:0000274
is_obsolete: true
[Term]
id: CL:0000291
name: spore (sensu Mycetozoa)
namespace: cell
def: "Dormant cell protected by a tri-layer spore coat. The spore has an elliptical shape and is approximately 6-9 microns by 3 microns." [DDB_REF:5048, DictyBase:DDB, PMID:4338436]
xref: DDANAT:0000414
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)
[Term]
id: CL:0000292
name: obsolete guard cell
namespace: cell
def: "Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." [ISBN:0471245208]
comment: replaced_by: PO:0000293
synonym: "stomatal guard cell" EXACT []
is_obsolete: true
[Term]
id: CL:0000293
name: structural cell
namespace: cell
def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000294
name: obsolete sieve cell
namespace: cell
def: "Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." [ISBN:0471245208]
is_obsolete: true
[Term]
id: CL:0000295
name: somatotropin secreting cell
namespace: cell
alt_id: CL:0000471
def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [GOC:tfm, SANBI:mhl]
synonym: "growth hormone secreting cell" EXACT []
synonym: "somatotrophin secreting cell" EXACT []
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000296
name: obsolete vegetative cell
namespace: cell
def: "Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." [ISBN:0140514031, TAIR:lr]
comment: replaced_by: PO:0020099
is_obsolete: true
[Term]
id: CL:0000297
name: obsolete socket cell
namespace: cell
def: "Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome." [PMID:10938806]
comment: replaced_by: PO:0000115
is_obsolete: true
[Term]
id: CL:0000298
name: obsolete xylem element
namespace: cell
def: "Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem." [ISBN:0471245208]
comment: replaced_by: PO:0000273
is_obsolete: true
[Term]
id: CL:0000299
name: obsolete trichoblast
namespace: cell
def: "OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." [ISBN:0471245208]
comment: Obsoleted. Use trichoblast from the plant ontology (PO:0000262).
is_obsolete: true
[Term]
id: CL:0000300
name: gamete
namespace: cell
def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544]
synonym: "haploid germ cell" RELATED []
synonym: "haploid nucleated cell" EXACT []
xref: CALOHA:TS-0395
xref: FBbt:00005412
xref: FMA:18649
is_a: CL:0000413 ! haploid cell
is_a: CL:0000586 ! germ cell
[Term]
id: CL:0000301
name: pole cell
namespace: cell
xref: FBbt:00000092
is_a: CL:0000670 ! primordial germ cell
[Term]
id: CL:0000302
name: obsolete IgM B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true
[Term]
id: CL:0000303
name: obsolete IgG B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true
[Term]
id: CL:0000304
name: obsolete IgA B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true
[Term]
id: CL:0000305
name: obsolete IgE B cell
namespace: cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true
[Term]
id: CL:0000306
name: crystallin accumulating cell
namespace: cell
synonym: "lens cell" EXACT []
xref: FBbt:00004193
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000307
name: tracheal epithelial cell
namespace: cell
alt_id: CL:1000474
def: "An epithelial cell found in the trachea." [GOC:tfm]
comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'
synonym: "tracheocyte" EXACT []
xref: FMA:74793
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
[Term]
id: CL:0000308
name: metal ion accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000309
name: copper accumulating cell
namespace: cell
synonym: "cuprophilic cell" EXACT []
is_a: CL:0000308 ! metal ion accumulating cell
[Term]
id: CL:0000310
name: iron accumulating cell
namespace: cell
is_a: CL:0000308 ! metal ion accumulating cell
[Term]
id: CL:0000311
name: keratin accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000312
name: keratinocyte
namespace: cell
alt_id: CL:0002185
def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, http://en.wikipedia.org/wiki/Keratinocyte, MESH:A11.436.397, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116]
comment: Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.
synonym: "keratinized cell of epidermis" EXACT []
synonym: "malpighian cell" EXACT []
xref: BTO:0000667
xref: CALOHA:TS-0500
xref: FMA:62879
is_a: CL:0000237 ! keratinizing barrier epithelial cell
is_a: CL:0000362 ! epidermal cell
[Term]
id: CL:0000313
name: serous secreting cell
namespace: cell
def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544]
synonym: "serous cell" EXACT []
xref: BTO:0003687
xref: FMA:62511
is_a: CL:0000159 ! seromucus secreting cell
[Term]
id: CL:0000314
name: milk secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000315
name: tears secreting cell
namespace: cell
def: "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." [MESH:A12.200.882]
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000316
name: obsolete ray initial
namespace: cell
def: "Obsolete. Use PO:0000082 from Plant Ontology instead. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." [ISBN:0471245208]
comment: replaced_by: PO:0000082
is_obsolete: true
[Term]
id: CL:0000317
name: sebum secreting cell
namespace: cell
def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [MESH:A12.200.702]
synonym: "sebocyte" EXACT []
is_a: CL:0000152 ! exocrine cell
is_a: CL:2000021 ! sebaceous gland native cell
[Term]
id: CL:0000318
name: sweat secreting cell
namespace: cell
def: "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." [MESH:A12.200.849]
is_a: CL:0000150 ! glandular epithelial cell
[Term]
id: CL:0000319
name: mucus secreting cell
namespace: cell
synonym: "mucous cell" EXACT []
xref: BTO:0003689
is_a: CL:0000159 ! seromucus secreting cell
[Term]
id: CL:0000320
name: obsolete megasporocyte
namespace: cell
def: "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." [ISBN:0471245208]
comment: replaced_by: PO:0000431
synonym: "archesporial cell" EXACT []
synonym: "megaspore mother cell" EXACT []
is_obsolete: true
[Term]
id: CL:0000321
name: seminal fluid secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000322
name: pneumocyte
namespace: cell
def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [GOC:tfm, PMID:20054144]
synonym: "alveolar epithelial cell" EXACT []
synonym: "pneumonocyte" EXACT []
xref: BTO:0000395
xref: CALOHA:TS-2168
xref: FMA:62499
is_a: CL:0010003 ! epithelial cell of alveolus of lung
[Term]
id: CL:0000323
name: lysozyme secreting cell
namespace: cell
is_a: CL:0000154 ! protein secreting cell
[Term]
id: CL:0000324
name: metanephric mesenchyme stem cell
namespace: cell
is_a: CL:0000134 ! mesenchymal stem cell
[Term]
id: CL:0000325
name: stuff accumulating cell
namespace: cell
def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma]
subset: ubprop:upper_level
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000326
name: glycogen accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000327
name: extracellular matrix secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0000499 ! stromal cell
[Term]
id: CL:0000328
name: myelin accumulating cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell
[Term]
id: CL:0000329
name: oxygen accumulating cell
namespace: cell
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000330
name: obsolete collenchymal cell
namespace: cell
def: "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." [ISBN:0471245208]
comment: replaced_by: PO:0000075
is_obsolete: true
[Term]
id: CL:0000331
name: obsolete tracheid
namespace: cell
def: "Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." [ISBN:0471245208]
comment: replaced_by: PO:0000301
is_obsolete: true
[Term]
id: CL:0000332
name: obsolete atrichoblast
namespace: cell
def: "OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." [ISBN:0387987819]
comment: replaced_by: PO:0020090
synonym: "non-hair cell" RELATED []
is_obsolete: true
[Term]
id: CL:0000333
name: migratory neural crest cell
namespace: cell
def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [MESH:A16.254.600]
xref: FMA:86667
is_a: CL:0000219 ! motile cell
is_a: CL:0011012 ! neural crest cell
[Term]
id: CL:0000334
name: vegetative cell (sensu Fungi)
namespace: cell
synonym: "yeast-form" RELATED []
xref: BTO:0002307
xref: FAO:0000032
is_a: CL:0000521 ! fungal cell
[Term]
id: CL:0000335
name: mesenchyme condensation cell
namespace: cell
def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404]
is_a: CL:0008019 ! mesenchymal cell
[Term]
id: CL:0000336
name: adrenal medulla chromaffin cell
namespace: cell
alt_id: CL:1000422
def: "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." [GOC:tfm, http://www.britannica.com/EBchecked/topic/6405/adrenal-gland]
synonym: "medullary chromaffin cell of adrenal gland" EXACT [FMA:69262]
xref: FMA:69262
is_a: CL:0000457 ! biogenic amine secreting cell
is_a: CL:1000426 ! chromaffin cell of adrenal gland
[Term]
id: CL:0000337
name: neuroblast (sensu Vertebrata)
namespace: cell
def: "An embryonic cell that develops into a nerve cell or neuron." [FMA:70563]
is_a: CL:0000031 ! neuroblast
[Term]
id: CL:0000338
name: neuroblast (sensu Nematoda and Protostomia)
namespace: cell
synonym: "neuroblast" BROAD []
is_a: CL:0000031 ! neuroblast
[Term]
id: CL:0000339
name: glioblast (sensu Vertebrata)
namespace: cell
def: "An early neural cell developing from the early ependymal cell of the neural tube." [GOC:tfm, ISBN:0618947256]
synonym: "spongioblast" EXACT []
xref: FMA:70564
is_a: CL:0000030 ! glioblast
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
[Term]
id: CL:0000340
name: glioblast (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000030 ! glioblast
is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia)
[Term]
id: CL:0000341
name: pigment cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000147 ! pigment cell
[Term]
id: CL:0000342
name: pigment cell (sensu Vertebrata)
namespace: cell
def: "Any animal cell containing pigment granules." [GOC:tfm, ISBN:0721662544]
is_a: CL:0000147 ! pigment cell
[Term]
id: CL:0000343
name: visual pigment cell (sensu Vertebrata)
namespace: cell
def: "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." [GOC:tfm]
xref: FMA:63846
is_a: CL:0000149 ! visual pigment cell
is_a: CL:0000342 ! pigment cell (sensu Vertebrata)
[Term]
id: CL:0000344
name: obsolete non-visual cell (sensu Vertebrata)
namespace: cell
is_obsolete: true
[Term]
id: CL:0000345
name: dental papilla cell
namespace: cell
def: "A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." [GOC:tfm, ISBN:0721662544]
comment: Merge with odontoblast?
is_a: CL:0008019 ! mesenchymal cell
[Term]
id: CL:0000346
name: hair follicle dermal papilla cell
namespace: cell
def: "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." [GOC:tfm, PMID:9893172]
comment: Are these really all stem cells?
is_a: CL:0000134 ! mesenchymal stem cell
[Term]
id: CL:0000347
name: scleral cell
namespace: cell
def: "A cell of the sclera of the eye." [GOC:add]
is_a: CL:0000293 ! structural cell
[Term]
id: CL:0000348
name: choroidal cell of the eye
namespace: cell
def: "A cell of the choroid of the eye." [GOC:add]
is_a: CL:0000293 ! structural cell
[Term]
id: CL:0000349
name: extraembryonic cell
namespace: cell
is_a: CL:0000548 ! animal cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000350
name: amnioserosal cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000349 ! extraembryonic cell
[Term]
id: CL:0000351
name: trophoblast cell
namespace: cell
def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:A11.936]
synonym: "trophoblastic cell" EXACT []
xref: FMA:83028
is_a: CL:0000349 ! extraembryonic cell
[Term]
id: CL:0000352
name: epiblast cell
namespace: cell
def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256]
is_a: CL:0000052 ! totipotent stem cell
[Term]
id: CL:0000353
name: blastoderm cell
namespace: cell
def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:A11.104]
synonym: "blastomere" EXACT []
xref: BTO:0001473
xref: FMA:72551
is_a: CL:0000007 ! early embryonic cell
[Term]
id: CL:0000354
name: blastemal cell
namespace: cell
synonym: "blastema cell" EXACT []
xref: ncithesaurus:Blastemal_Cell
is_a: CL:0000048 ! multi fate stem cell
[Term]
id: CL:0000355
name: multi-potent skeletal muscle stem cell
namespace: cell
def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570]
comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo.
xref: FMA:86767
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0000188 ! cell of skeletal muscle
[Term]
id: CL:0000356
name: hair matrix stem cell
namespace: cell
is_a: CL:0000035 ! single fate stem cell
[Term]
id: CL:0000357
name: stratified epithelial stem cell
namespace: cell
is_a: CL:0000036 ! epithelial fate stem cell
[Term]
id: CL:0000358
name: sphincter associated smooth muscle cell
namespace: cell
def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm]
is_a: CL:0000192 ! smooth muscle cell
[Term]
id: CL:0000359
name: vascular associated smooth muscle cell
namespace: cell
def: "A smooth muscle cell assocatiated with the vasculature." [GOC:dsd, GOC:tfm]
synonym: "vascular smooth muscle cell" EXACT []
synonym: "VSMC" EXACT []
is_a: CL:0000192 ! smooth muscle cell
[Term]
id: CL:0000360
name: morula cell
namespace: cell
def: "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." [MESH:A16.254.270.550]
is_a: CL:0000007 ! early embryonic cell
[Term]
id: CL:0000361
name: gastrula cell
namespace: cell
def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." [MESH:A16.254.412]
is_a: CL:0000007 ! early embryonic cell
[Term]
id: CL:0000362
name: epidermal cell
namespace: cell
alt_id: CL:1000396
def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma]
synonym: "cell of epidermis" EXACT [FMA:62411]
synonym: "epithelial cell of skin" NARROW [FMA:62411]
xref: BTO:0001470
xref: CALOHA:TS-0283
xref: FMA:62411
is_a: CL:0002159 ! general ecto-epithelial cell
[Term]
id: CL:0000363
name: obsolete axial cell
namespace: cell
def: "Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." [ISBN:0471245208]
comment: replaced_by: PO:0000081
is_obsolete: true
[Term]
id: CL:0000364
name: obsolete ray cell
namespace: cell
def: "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." [ISBN:0471245208]
is_obsolete: true
[Term]
id: CL:0000365
name: zygote
namespace: cell
def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208]
xref: BTO:0000854
xref: EHDAA2:0004546
xref: FMA:72395
is_a: CL:0000007 ! early embryonic cell
[Term]
id: CL:0000366
name: obsolete sperm cell (sensu Viridiplantae)
namespace: cell
def: "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." [ISBN:0471245208]
comment: replaced_by: PO:0000084
synonym: "gametophyte sperm cell" RELATED []
synonym: "male gametophyte sperm cell" RELATED []
synonym: "pollen germ cell " RELATED []
is_obsolete: true
[Term]
id: CL:0000367
name: sheath cell (sensu Nematoda)
namespace: cell
synonym: "glial cell (sensu Nematoda)" RELATED []
is_a: CL:0000619 ! support cell (sensu Nematoda)
[Term]
id: CL:0000368
name: obsolete myrosin cell
namespace: cell
def: "Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." [ISBN:0471245208]
comment: replaced_by: PO:0000352
is_obsolete: true
[Term]
id: CL:0000370
name: obsolete transfer cell
namespace: cell
def: "Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." [ISBN:0471245208]
comment: replaced_by: PO:0000078
synonym: "intermediary cell" RELATED []
is_obsolete: true
[Term]
id: CL:0000371
name: protoplast
namespace: cell
def: "The cell protoplasm after removal of the cell wall." [ISBN:08199377X]
is_a: CL:0000578 ! experimentally modified cell in vitro
[Term]
id: CL:0000372
name: tormogen cell
namespace: cell
def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell." [ISBN:978-0801481253]
synonym: "socket cell" BROAD [ISBN:978-0801481253]
xref: FBbt:00005171
is_a: CL:0000463 ! epidermal cell (sensu arthropoda)
[Term]
id: CL:0000373
name: histoblast
namespace: cell
xref: FBbt:00001789
is_a: CL:0000146 ! simple columnar epithelial cell
[Term]
id: CL:0000374
name: trichogen cell
namespace: cell
def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell." [ISBN:978-0801481253]
synonym: "hair cell" BROAD []
xref: BTO:0004744
xref: FBbt:00005169
is_a: CL:0000463 ! epidermal cell (sensu arthropoda)
[Term]
id: CL:0000375
name: obsolete osteoprogenitor cell
namespace: cell
xref: BTO:0002051
is_obsolete: true
replaced_by: CL:0007010
[Term]
id: CL:0000376
name: humidity receptor cell
namespace: cell
is_a: CL:0000006 ! neuronal receptor cell
[Term]
id: CL:0000377
name: tracheoblast
namespace: cell
is_a: CL:0000069 ! branched duct epithelial cell
[Term]
id: CL:0000378
name: support cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000630 ! supportive cell
[Term]
id: CL:0000379
name: sensory processing neuron
namespace: cell
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000380
name: thecogen cell
namespace: cell
def: "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." [Fbbt:00005173]
synonym: "fly sheath cell" EXACT []
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)
[Term]
id: CL:0000381
name: neurosecretory neuron
namespace: cell
xref: FBbt:00005130
is_a: CL:0000151 ! secretory cell
is_a: CL:0000527 ! efferent neuron
[Term]
id: CL:0000382
name: scolopale cell
namespace: cell
xref: FBbt:00005219
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)
[Term]
id: CL:0000383
name: nephrogenic mesenchyme stem cell
namespace: cell
is_a: CL:0000134 ! mesenchymal stem cell
[Term]
id: CL:0000384
name: ligament cell
namespace: cell
is_a: CL:0000630 ! supportive cell
[Term]
id: CL:0000385
name: prohemocyte (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00005062
is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia)
[Term]
id: CL:0000386
name: attachment cell
namespace: cell
is_a: CL:0000630 ! supportive cell
[Term]
id: CL:0000387
name: hemocyte (sensu Nematoda and Protostomia)
namespace: cell
xref: FBbt:00005063
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
[Term]
id: CL:0000388
name: tendon cell
namespace: cell
def: "An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance." [GOC:NV, GOC:tfm, PMID:957445]
synonym: "muscle attachment cell" EXACT []
synonym: "tenocyte" RELATED []
is_a: CL:0000135 ! fibrocyte
is_a: CL:0000386 ! attachment cell
[Term]
id: CL:0000389
name: socket cell (sensu Nematoda)
namespace: cell
is_a: CL:0000619 ! support cell (sensu Nematoda)
is_a: CL:0000658 ! cuticle secreting cell
is_a: CL:0000710 ! neurecto-epithelial cell
[Term]
id: CL:0000390
name: blood cell (sensu Nematoda and Protostomia)
namespace: cell
is_a: CL:0000081 ! blood cell
[Term]
id: CL:0000391
name: podocyte (sensu Diptera)
namespace: cell
def: "An insect immune cell that develops from plasmatocyte." [PMID:12930778]
xref: FBbt:00001688
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)
[Term]
id: CL:0000392
name: crystal cell
namespace: cell
xref: FMA:63847
is_a: CL:0000391 ! podocyte (sensu Diptera)
[Term]
id: CL:0000393
name: electrically responsive cell
namespace: cell
def: "A cell whose function is determined by its response to an electric signal." [FB:ma]
is_a: CL:0000211 ! electrically active cell
[Term]
id: CL:0000394
name: plasmatocyte
namespace: cell
xref: FBbt:00001685
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)
[Term]
id: CL:0000395
name: procrystal cell
namespace: cell
xref: FBbt:00001689
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)
[Term]
id: CL:0000396
name: lamellocyte
namespace: cell
xref: FBbt:00001687
is_a: CL:0000394 ! plasmatocyte
[Term]
id: CL:0000397
name: ganglion interneuron
namespace: cell
is_a: CL:0000099 ! interneuron
[Term]
id: CL:0000398
name: polygonal cell
namespace: cell
xref: FBbt:00001691
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)
[Term]
id: CL:0000399
name: obsolete phloem element
namespace: cell
def: "Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion." [GOC:tfm]
is_obsolete: true
[Term]
id: CL:0000400
name: obsolete pavement cell
namespace: cell
def: "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." [ISBN:087694289]
comment: replaced_by: PO:0000332
is_obsolete: true
[Term]
id: CL:0000401
name: macrophage (sensu Diptera)
namespace: cell
xref: FBbt:00001686
is_a: CL:0000394 ! plasmatocyte
[Term]
id: CL:0000402
name: CNS interneuron
namespace: cell
is_a: CL:0000099 ! interneuron
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
[Term]
id: CL:0000404
name: electrically signaling cell
namespace: cell
def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma]
is_a: CL:0000211 ! electrically active cell
[Term]
id: CL:0000405
name: neuroepidermoblast
namespace: cell
xref: FBbt:00005148
is_a: CL:0000338 ! neuroblast (sensu Nematoda and Protostomia)
[Term]
id: CL:0000406
name: CNS short range interneuron
namespace: cell
is_a: CL:0000402 ! CNS interneuron
[Term]
id: CL:0000407
name: scolopidial ligament cell
namespace: cell
xref: FBbt:00005221
is_a: CL:0000384 ! ligament cell
[Term]
id: CL:0000408
name: male gamete
namespace: cell
xref: BTO:0001277
xref: CALOHA:TS-0949
is_a: CL:0000015 ! male germ cell
is_a: CL:0000300 ! gamete
[Term]
id: CL:0000409
name: scolopidial sheath cell
namespace: cell
xref: FBbt:00005219
is_a: CL:0000618 ! sheath cell
[Term]
id: CL:0000410
name: CNS long range interneuron
namespace: cell
is_a: CL:0000402 ! CNS interneuron
[Term]
id: CL:0000411
name: flatworm hypodermal cell
namespace: cell
def: "An epithelial cell of the hypodermis of flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm]
xref: WBbt:0007846
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000412
name: polyploid cell
namespace: cell
def: "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." [FB:ma]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000413
name: haploid cell
namespace: cell
def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000414
name: obsolete cell by ploidy
namespace: cell
def: "OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma, GOC:tfm]
comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell with chromosomes can be classified by its ploidy. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), eukaryotic cell (CL:0000255) or cell in vitro (CL:0001034) as appropriate.
is_obsolete: true
consider: CL:0000000
consider: CL:0000003
consider: CL:0000255
consider: CL:0001034
[Term]
id: CL:0000415
name: diploid cell
namespace: cell
def: "A cell whose nucleus has two haploid genomes." [FB:ma]
xref: FMA:72300
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000416
name: polytene cell
namespace: cell
is_a: CL:0000412 ! polyploid cell
[Term]
id: CL:0000417
name: endopolyploid cell
namespace: cell
is_a: CL:0000412 ! polyploid cell
[Term]
id: CL:0000418
name: arcade cell
namespace: cell
def: "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." [GOC:tfm, http://www.wormatlas.org/ver1/handbook/hypodermis/hypsupportother.htm#arcadecells]
xref: WBbt:0005793
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000419
name: seam cell
namespace: cell
def: "An epithelial fate stem cell found in flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/seam%20cells/mainframe.htm]
xref: BTO:0003039
is_a: CL:0000036 ! epithelial fate stem cell
[Term]
id: CL:0000420
name: syncytial epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000421
name: coelomocyte
namespace: cell
def: "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." [GOC:tfm, ISBN:0721662544]
xref: BTO:0002856
xref: WBbt:0005751
is_a: CL:0000080 ! circulating cell
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
[Term]
id: CL:0000422
name: mitogenic signaling cell
namespace: cell
def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." [FB:ma]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000423
name: tip cell
namespace: cell
is_a: CL:0000422 ! mitogenic signaling cell
[Term]
id: CL:0000424
name: excretory cell
namespace: cell
def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [GOC:tfm, PMID:19783135]
xref: WBbt:0005812
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000425
name: pore cell
namespace: cell
def: "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." [JB:jb]
is_a: CL:0000658 ! cuticle secreting cell
[Term]
id: CL:0000426
name: scaffold cell
namespace: cell
is_a: CL:0000445 ! apoptosis fated cell
[Term]
id: CL:0000427
name: GLR cell
namespace: cell
def: "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." [GOC:tfm, http://wormatlas.psc.edu/hermaphrodite/muscleGLR/mainframe.htm]
is_a: CL:0002320 ! connective tissue cell
[Term]
id: CL:0000428
name: yolk cell
namespace: cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000349 ! extraembryonic cell
[Term]
id: CL:0000429
name: imaginal disc cell
namespace: cell
is_a: CL:0000146 ! simple columnar epithelial cell
[Term]
id: CL:0000430
name: xanthophore cell
namespace: cell
def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [SANBI:mhl]
synonym: "xanthophore" RELATED []
is_a: CL:0000147 ! pigment cell
[Term]
id: CL:0000431
name: iridophore
namespace: cell
def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [SANBI:mhl]
synonym: "guanophore" RELATED []
is_a: CL:0000147 ! pigment cell
[Term]
id: CL:0000432
name: reticular cell
namespace: cell
def: "Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum." [GOC:tfm, http://en.wikipedia.org/wiki/Reticular_cell, ISBN:0517223651]
synonym: "reticulum cell" EXACT []
xref: FMA:62877
is_a: CL:0000057 ! fibroblast
[Term]
id: CL:0000433
name: obsolete functional megaspore
namespace: cell
def: "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." [TAIR:lr]
comment: replaced_by: PO:0000244
is_obsolete: true
[Term]
id: CL:0000434
name: eccrine cell
namespace: cell
def: "A secretory cell that discharges its product without loss of cytoplasm." [ISBN:0198547684]
is_a: CL:0000150 ! glandular epithelial cell
[Term]
id: CL:0000435
name: alkali secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000436
name: vaginal lubricant secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000437
name: gonadtroph
namespace: cell
def: "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." [GOC:tfm, http://en.wikipedia.org/wiki/Gonadotroph, ISBN:0517223651]
synonym: "delta basophil" EXACT []
synonym: "follicle stimulating hormone secreting cell" EXACT []
synonym: "gonadotrope" EXACT []
synonym: "gonadotrope cell" EXACT []
synonym: "gonadotroph" EXACT []
synonym: "gonadotropic cell" EXACT []
synonym: "pituitary delta cell" EXACT []
xref: BTO:0002482
xref: FMA:83100
is_a: CL:0000438 ! luteinizing hormone secreting cell
is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis
[Term]
id: CL:0000438
name: luteinizing hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm]
is_a: CL:0000163 ! endocrine cell
[Term]
id: CL:0000439
name: prolactin secreting cell
namespace: cell
def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl]
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000440
name: melanocyte stimulating hormone secreting cell
namespace: cell
def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl]
synonym: "melanotrope" EXACT []
synonym: "melanotroph" EXACT []
xref: BTO:0002277
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000441
name: follicle stem cell
namespace: cell
xref: FBbt:00004903
is_a: CL:0000036 ! epithelial fate stem cell
[Term]
id: CL:0000442
name: follicular dendritic cell
namespace: cell
def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." [ISBN:127520252]
comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451.
xref: BTO:0004267
xref: FMA:83037
is_a: CL:0000473 ! defensive cell
[Term]
id: CL:0000443
name: calcitonin secreting cell
namespace: cell
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000444
name: obliquely striated muscle cell
namespace: cell
def: "A muscle cell in which the fibers are organised into sarcomeres but in which adjacent myofibrils are offset from each other, producing an oblique banding pattern." [GOC:DOS, PMID:8720463]
comment: Examples include the somatic muscles of nemotodes and cephalopods.
is_a: CL:0000737 ! striated muscle cell
[Term]
id: CL:0000445
name: apoptosis fated cell
namespace: cell
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000446
name: chief cell of parathyroid gland
namespace: cell
def: "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." [FMA:69078, GOC:tfm, ISBN:0517223651]
synonym: "parathyroid chief cell" EXACT []
synonym: "parathyroid gland chief cell" EXACT []
synonym: "parathyroid hormone secreting cell" EXACT []
synonym: "principal cell of parathyroid gland" EXACT []
xref: BTO:0004712
xref: CALOHA:TS-2140
xref: FMA:69078
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0002260 ! epithelial cell of parathyroid gland
[Term]
id: CL:0000447
name: carbohydrate secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000448
name: white fat cell
namespace: cell
def: "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [GOC:tfm, MESH:A11.329.114.500]
synonym: "white adipocyte" RELATED []
synonym: "white adipose cell" EXACT []
synonym: "white fat cell" EXACT []
xref: CALOHA:TS-1119
xref: FMA:83434
is_a: CL:0000136 ! fat cell
[Term]
id: CL:0000449
name: brown fat cell
namespace: cell
def: "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:A10.165.114.322]
synonym: "brown adipocyte" EXACT []
synonym: "brown adipose cell" EXACT []
xref: CALOHA:TS-0099
xref: FMA:83435
is_a: CL:0000136 ! fat cell
[Term]
id: CL:0000451
name: dendritic cell
namespace: cell
def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149]
synonym: "interdigitating cell" RELATED []
synonym: "veiled cell" RELATED []
xref: BTO:0002042
xref: CALOHA:TS-0194
xref: FMA:83036
is_a: CL:0000738 ! leukocyte
[Term]
id: CL:0000452
name: thyroid hormone secreting cell
namespace: cell
is_a: CL:0000163 ! endocrine cell
[Term]
id: CL:0000453
name: Langerhans cell
namespace: cell
def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMCID:PMC2346585, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.
synonym: "Langerhans' cell" EXACT []
synonym: "LC" EXACT []
xref: BTO:0000705
xref: CALOHA:TS-2375
xref: FMA:63072
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 ! conventional dendritic cell
[Term]
id: CL:0000454
name: epinephrine secreting cell
namespace: cell
def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." [GOC:tfm, PMID:12438093]
synonym: "adrenaline secreting cell" EXACT [GO:0048242]
synonym: "epinephrin secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
[Term]
id: CL:0000455
name: obsolete starch sheath cell
namespace: cell
def: "Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch." [ISBN:044174520]
comment: replaced_by: PO:0004531
is_obsolete: true
[Term]
id: CL:0000456
name: mineralocorticoid secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
[Term]
id: CL:0000457
name: biogenic amine secreting cell
namespace: cell
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000458
name: serotonin secreting cell
namespace: cell
def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576]
synonym: "5-HT secreting cell" EXACT []
synonym: "5-Hydroxytryptamine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
[Term]
id: CL:0000459
name: noradrenergic cell
namespace: cell
def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X]
synonym: "noradrenaline secreting cell" EXACT []
synonym: "norepinephrin secreting cell" EXACT []
synonym: "norepinephrine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
[Term]
id: CL:0000460
name: glucocorticoid secreting cell
namespace: cell
is_a: CL:0000174 ! steroid hormone secreting cell
[Term]
id: CL:0000462
name: adepithelial cell
namespace: cell
xref: FBbt:00003219
is_a: CL:0000680 ! muscle precursor cell
[Term]
id: CL:0000463
name: epidermal cell (sensu arthropoda)
namespace: cell
def: "An epidermal cell that secretes chitinous cuticle from its apical side." [FlyBase:ds, ISBN:ISBN\:978-0801481253]
comment: While insect epidermis is generally columnar/cuboidal, there are certainly well studied cases where it is not (e.g.- Rhodnius prolixus when starved). So it would be safer to add this as a differentium for particular species where this is known. -DSJ.
is_a: CL:0000362 ! epidermal cell
is_a: CL:0000710 ! neurecto-epithelial cell
[Term]
id: CL:0000464
name: epidermoblast
namespace: cell
def: "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." [GOC:tfm, PMID:7576311]
xref: FBbt:00004994
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000710 ! neurecto-epithelial cell
[Term]
id: CL:0000465
name: cardioblast (sensu Arthropoda)
namespace: cell
xref: FBbt:00001666
is_a: CL:0010021 ! cardiac myoblast
[Term]
id: CL:0000467
name: adrenocorticotropic hormone secreting cell
namespace: cell
alt_id: CL:0000640
def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [GOC:tfm, SANBI:mhl]
synonym: "ACTH secreting cell" EXACT [GO:0051458]
synonym: "adrenocorticotrophic hormone secreting cell" EXACT []
synonym: "corticotrophin hormone secreting cell" EXACT []
synonym: "corticotropin hormone secreting cell" EXACT []
synonym: "corticotropin secreting cell" EXACT [GO:0051458]
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000468
name: neuroglioblast
namespace: cell
xref: FBbt:00005147
is_a: CL:0000047 ! neuronal stem cell
is_a: CL:0000055 ! non-terminally differentiated cell
[Term]
id: CL:0000469
name: ganglion mother cell
namespace: cell
xref: FBbt:00005149
is_a: CL:0000468 ! neuroglioblast
[Term]
id: CL:0000470
name: digestive enzyme secreting cell
namespace: cell
is_a: CL:0000154 ! protein secreting cell
[Term]
id: CL:0000472
name: obsolete chlorenchyma cell
namespace: cell
def: "Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." [ISBN:0471245208]
comment: replaced_by: PO:0000076
is_obsolete: true
[Term]
id: CL:0000473
name: defensive cell
namespace: cell
def: "A cell whose primary function is to protect the organism." [JB:jb]
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000474
name: pericardial nephrocyte
namespace: cell
def: "an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." [FBbt:00003184, GO:0061320, GOC:tfm, PMID:19783135]
synonym: "pericardial cell" NARROW [FBbt:00005058, GO:0061320]
xref: FBbt:00005058
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
is_a: CL:0002520 ! nephrocyte
[Term]
id: CL:0000475
name: obsolete degenerate megaspore
namespace: cell
def: "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." [TAIR:lr]
comment: replaced_by: PO:0000245
is_obsolete: true
[Term]
id: CL:0000476
name: thyrotroph
namespace: cell
def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." [ISBN:0517223651, SANBI:mhl]
synonym: "beta-basophil" EXACT []
synonym: "thyroid stimulating hormone secreting cell" EXACT []
synonym: "thyrotrope" EXACT []
xref: FMA:83099
is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis
[Term]
id: CL:0000477
name: follicle cell
namespace: cell
comment: Editors note: check this. Currently used in goxp
synonym: "ovarian follicle cell" EXACT [GO:0007297]
xref: FBbt:00004904
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
[Term]
id: CL:0000478
name: oxytocin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes oxytocin stimulating hormone" [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000479
name: vasopressin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000480
name: secretin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes secretin stimulating hormone" [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000481
name: cholecystokin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000482
name: juvenile hormone secreting cell
namespace: cell
def: "An endocrine cell that secretes juvenile hormone." [GO:tfm]
is_a: CL:0000163 ! endocrine cell
[Term]
id: CL:0000483
name: bombesin stimulating hormone secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000484
name: connective tissue type mast cell
namespace: cell
def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [GOC:add, GOC:dsd, GOC:tfm, PMID:19923473, PMID:9354811]
comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype.
synonym: "MC(TC)" EXACT []
synonym: "MCTC" EXACT []
synonym: "TC mast cells" EXACT []
is_a: CL:0000097 ! mast cell
is_a: CL:0002320 ! connective tissue cell
[Term]
id: CL:0000485
name: mucosal type mast cell
namespace: cell
def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." [GOC:add, GOC:dsd, PMID:19923473, PMID:9354811]
comment: They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype.
synonym: "MC(T)" EXACT []
synonym: "MCT" EXACT []
synonym: "T mast cells" EXACT []
is_a: CL:0000097 ! mast cell
[Term]
id: CL:0000486
name: garland cell
namespace: cell
def: "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." [fbbt:00005059, GOC:tfm, PMID:19783135]
synonym: "garland nephrocyte" BROAD [GO:0061321]
xref: BTO:0004596
xref: FBbt:00005059
is_a: CL:0000227 ! binucleate cell
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
is_a: CL:0002520 ! nephrocyte
[Term]
id: CL:0000487
name: oenocyte
namespace: cell
def: "A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments." [GOC:bf, PMID:11171397]
xref: FBbt:00004995
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000488
name: visible light photoreceptor cell
namespace: cell
def: "A photoreceptor cell that detects visible light." [GOC:tfm]
is_a: CL:0000210 ! photoreceptor cell
[Term]
id: CL:0000489
name: scotopic photoreceptor cell
namespace: cell
is_a: CL:0000210 ! photoreceptor cell
[Term]
id: CL:0000490
name: photopic photoreceptor cell
namespace: cell
is_a: CL:0000488 ! visible light photoreceptor cell
[Term]
id: CL:0000491
name: obsolete cytotoxic T cell
namespace: cell
def: "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." []
comment: This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation.
is_obsolete: true
[Term]
id: CL:0000492
name: CD4-positive helper T cell
namespace: cell
def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149, MESH:A11.118.637.555.567.569.200.400]
synonym: "CD4-positive helper T lymphocyte" EXACT []
synonym: "CD4-positive helper T-cell" EXACT []
synonym: "CD4-positive helper T-lymphocyte" EXACT []
synonym: "CD4-positive T-helper cell" EXACT []
xref: CALOHA:TS-1146
xref: FMA:70572
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000912 ! helper T cell
[Term]
id: CL:0000493
name: obsolete regulatory T cell
namespace: cell
def: "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." []
comment: This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead.
is_obsolete: true
[Term]
id: CL:0000494
name: UV sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that detects ultraviolet light." [GOC:tfm]
is_a: CL:0000210 ! photoreceptor cell
[Term]
id: CL:0000495
name: blue sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that is sensitive to blue light." [GO:tfm]
is_a: CL:0000490 ! photopic photoreceptor cell
[Term]
id: CL:0000496
name: green sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that is sensitive to green light." [GO:tfm]
is_a: CL:0000490 ! photopic photoreceptor cell
[Term]
id: CL:0000497
name: red sensitive photoreceptor cell
namespace: cell
def: "A photoreceptor cell that is sensitive to red light." [GO:tfm]
is_a: CL:0000490 ! photopic photoreceptor cell
[Term]
id: CL:0000498
name: inhibitory interneuron
namespace: cell
def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [GOC:tfm, http://en.wikipedia.org/wiki/Interneuron]
xref: FMA:84776
is_a: CL:0000099 ! interneuron
[Term]
id: CL:0000499
name: stromal cell
namespace: cell
def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:A11.329.830]
xref: BTO:0002064
xref: FMA:83624
is_a: CL:0002320 ! connective tissue cell
[Term]
id: CL:0000500
name: follicular epithelial cell
namespace: cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000501
name: granulosa cell
namespace: cell
def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:A05.360.319.114.630.535.200]
synonym: "granulosa cell of ovary" EXACT []
xref: BTO:0000542
xref: CALOHA:TS-0729
xref: FMA:18718
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0002174 ! follicular cell of ovary
[Term]
id: CL:0000502
name: type D enteroendocrine cell
namespace: cell
def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:A03.492.766.440.175]
synonym: "D cell" EXACT []
xref: FMA:62935
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000172 ! somatostatin secreting cell
[Term]
id: CL:0000503
name: theca cell
namespace: cell
def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." [MESH:A05.360.319.114.630.535.400]
xref: BTO:0002850
xref: FMA:18690
is_a: CL:0000499 ! stromal cell
is_a: CL:0000593 ! androgen secreting cell
[Term]
id: CL:0000504
name: enterochromaffin-like cell
namespace: cell
def: "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." [GOC:tfm, MESH:A06.224.365]
comment: Consider enterochromaffin cell (CL:0002065). For several years this cell type was "enterochromaffin cell" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell.
synonym: "ECL" EXACT []
xref: BTO:0002692
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0002274 ! histamine secreting cell
[Term]
id: CL:0000505
name: substance P secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes substance P." [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000506
name: enkephalin secreting cell
namespace: cell
def: "An endorphine cell that secretes enkephalin." [GO:tfm]
is_a: CL:0000507 ! endorphin secreting cell
[Term]
id: CL:0000507
name: endorphin secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000508
name: type G enteroendocrine cell
namespace: cell
def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:A03.492.766.440.300]
synonym: "G cell " EXACT []
xref: BTO:0004108
xref: FMA:67609
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000506 ! enkephalin secreting cell
is_a: CL:0000509 ! gastrin secreting cell
is_a: CL:0002180 ! mucous cell of stomach
[Term]
id: CL:0000509
name: gastrin secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell
[Term]
id: CL:0000510
name: paneth cell
namespace: cell
def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." [GOC:tfm, ISBN:0517223651, MESH:A03.492.411.369.700]
xref: BTO:0000993
xref: FMA:62897
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000323 ! lysozyme secreting cell
is_a: CL:0002563 ! intestinal epithelial cell
[Term]
id: CL:0000511
name: androgen binding protein secreting cell
namespace: cell
def: "A peptide hormone secreting cell that secretes androgen binding protein." [GO:tfm]
is_a: CL:0000154 ! protein secreting cell
[Term]
id: CL:0000512
name: paracrine cell
namespace: cell
def: "A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it." [GOC:tfm, ISBN:0198529171]
is_a: CL:0000151 ! secretory cell
[Term]
id: CL:0000513
name: cardiac muscle myoblast
namespace: cell
alt_id: CL:0000714
def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:A11.635.470]
xref: FMA:84797
is_a: CL:0002494 ! cardiocyte
is_a: CL:0010021 ! cardiac myoblast
[Term]
id: CL:0000514
name: smooth muscle myoblast
namespace: cell
def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:A11.635.510, MESH:D032390]
synonym: "myoblast, smooth muscle" EXACT [MESH:D032390]
synonym: "satellite cell" RELATED []
xref: FMA:84798
is_a: CL:0000056 ! myoblast
[Term]
id: CL:0000515
name: skeletal muscle myoblast
namespace: cell
def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl]
synonym: "skeletal myoblast" EXACT []
xref: FMA:84799
is_a: CL:0000056 ! myoblast
[Term]
id: CL:0000516
name: perineuronal satellite cell
namespace: cell
def: "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." [GOC:tfm, MESH:A08.340.685]
synonym: "perineural satellite cell" EXACT []
synonym: "perineuronal satellite oligodendroglial cell" EXACT []
synonym: "satellite oligodendrocyte" EXACT []
xref: FMA:54550
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
[Term]
id: CL:0000517
name: macrophage derived foam cell
namespace: cell
def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:20213546]
is_a: CL:0000891 ! foam cell
[Term]
id: CL:0000518
name: phagocyte (sensu Vertebrata)
namespace: cell
def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm]
is_a: CL:0000234 ! phagocyte
[Term]
id: CL:0000519
name: phagocyte (sensu Nematoda and Protostomia)
namespace: cell
def: "A phagocyte from organisms in the Nematoda or Protostomia clades." [GOC:tfm]
is_a: CL:0000234 ! phagocyte
[Term]
id: CL:0000520
name: prokaryotic cell
namespace: cell
is_a: CL:0000003 ! native cell
[Term]
id: CL:0000521
name: fungal cell
namespace: cell
is_a: CL:0000255 ! eukaryotic cell
[Term]
id: CL:0000522
name: obsolete spore
namespace: cell
def: "OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms." [ISBN:08199377X]
is_obsolete: true
[Term]
id: CL:0000523
name: mononuclear cytotrophoblast cell
namespace: cell
def: "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." [GOC:tfm, ISBN:0323052908]
synonym: "Langhans' cell" EXACT []
xref: FMA:83042
is_a: CL:0000351 ! trophoblast cell
[Term]
id: CL:0000524
name: spheroplast
namespace: cell
def: "A cell, usually of bacteria or yeast, which has partially lost its cell wall." [MESH:A11.868]
synonym: "sphaeroplast" EXACT []
is_a: CL:0000371 ! protoplast
[Term]
id: CL:0000525
name: syncytiotrophoblast cell
namespace: cell
def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908]
synonym: "plasmidotrophoblast" EXACT []
synonym: "syncytial trophoblast" EXACT []
synonym: "syntrophoblast" EXACT []
xref: FMA:83043
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000351 ! trophoblast cell
[Term]
id: CL:0000526
name: afferent neuron
namespace: cell
def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:A08.663.650]
synonym: "input neuron" EXACT []
xref: FMA:87653
is_a: CL:0000540 ! neuron
[Term]
id: CL:0000527
name: efferent neuron
namespace: cell
def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A08.663.655]
synonym: "output neuron" EXACT []