adipocyte (white/brown/beige) classification, definitions and axioms

[cmungall]

We have

• CL:0000136 ! fat cell
  • CL:0001070 ! beige adipocyte
  • CL:0000449 ! brown fat cell
  • CL:0000448 ! white fat cell

(ignore adipocytes defined by location)

This is correct, but could do with some work

• use consistent nomenclature as primary labels
• potentially introduce a grouping for 'thermogenic adipocyte' grouping brown and beige
• make text defs more consistent
• axiomatize where appropriate

beige is defined as A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor. which is our definition

brown is defined as A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation. which is from mesh

Both are OK but the style should be consistent, the dictionary-style mesh def should be replaced by a genus-differentia (presumably using Myf5 in the definition)

capable_of links can be added to these. However, CL capable-ofs should be at the level of cellular processes, and capable-ofs in Uberon (e.g. brown adipose tissue) should be at the level of physiological processes.

[cmungall]

Also if we want to be consistent with the terminology in one of the def xrefs (https://www.ncbi.nlm.nih.gov/pubmed/22796012) then we should avoid ambiguous 'brown' and instead have 'classic' (or 'inducible'?)