Join GitHub today
GitHub is home to over 40 million developers working together to host and review code, manage projects, and build software together.Sign up
Redefine memory T cells in a functional manner #560
This is a followup to #110.
The suggest fix is to redefine memory T cell (CL:0000813) with the axiom has_completed 'memory T cell differentiation' (GO:0043379) instead of the marker axioms currently used. This functional approach will support non-human species better as well. Then all subtypes of memory T cells will receive the same axiom to allow for proper reasoning.
This involved a larger set of changes, including redefining 'memory T cell', 'CD4-positive memory T cell', and 'CD8-positive memory T cell' in a phenotypic and functional manner to be broadly applicable across species, and creating 'CD4-positive memory T cell, CD45RO-positive' 9CL;0001204) and 'CD8-positive memory T cell, CD45RO-positive' (CL:0001203) human specific terms with taxon restrictions. 'effector memory CD8-positive, alpha-beta T cell, terminally differentiated' was also provided a new definition as described previously with a human taxon restriction, and 'memory CCR4-positive regulatory T cell' also received a human taxon restriction based on its makers.