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Glymphatic system #1260

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sbello opened this Issue Sep 1, 2016 · 3 comments

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sbello commented Sep 1, 2016

Please consider adding a term for 'glymphatic system'. See:
https://www.urmc.rochester.edu/labs/Nedergaard-Lab/projects/glymphatic_system
http://www.ncbi.nlm.nih.gov/pubmed/25947369
for more information. We have a request to add abnormal glymphatic system terms to the MP and it would be helpful to have a term in UBERON to refer to.
Sue

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Very interesting. I'm choosing not to model this as part or subtype of the lymphatic system, but rather as an analog (for an interesting skeptical discussion of lymphatics in the CNS, see http://onlinelibrary.wiley.com/doi/10.1111/joa.12381/epdf)

we also need to figure how this relates to:

[Term]
id: UBERON:0035608
name: dura mater lymph vessel
def: "Any lymph vessel that is located in the dura mater of the brain." [doi:10.1038/nature14432, doi:10.1111/joa.12381]
comment: Structure notes: while Louveau et al (doi:10.1038/nature14432) state this is within the CNS (thus overturning dogma about the presence of lymphatics in the CNS), in this ontology the dura 
comment: Louveau et al (doi:10.1038/nature14432) claim the discovery of lymphatics in the cerebral dura mater, but this is disputed by Bucchieri et al (doi:10.1111/joa.12381) 
synonym: "dural lymph vessel" EXACT []
synonym: "dural lymph vasculature" RELATED []
intersection_of: UBERON:0001473 ! lymphatic vessel
intersection_of: located_in UBERON:0002363 ! dura mater
relationship: part_of UBERON:0010743 ! meningeal cluster

presumably this marks some kind of lymphatic-glymphatic boundary

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cmungall commented Sep 2, 2016

Very interesting. I'm choosing not to model this as part or subtype of the lymphatic system, but rather as an analog (for an interesting skeptical discussion of lymphatics in the CNS, see http://onlinelibrary.wiley.com/doi/10.1111/joa.12381/epdf)

we also need to figure how this relates to:

[Term]
id: UBERON:0035608
name: dura mater lymph vessel
def: "Any lymph vessel that is located in the dura mater of the brain." [doi:10.1038/nature14432, doi:10.1111/joa.12381]
comment: Structure notes: while Louveau et al (doi:10.1038/nature14432) state this is within the CNS (thus overturning dogma about the presence of lymphatics in the CNS), in this ontology the dura 
comment: Louveau et al (doi:10.1038/nature14432) claim the discovery of lymphatics in the cerebral dura mater, but this is disputed by Bucchieri et al (doi:10.1111/joa.12381) 
synonym: "dural lymph vessel" EXACT []
synonym: "dural lymph vasculature" RELATED []
intersection_of: UBERON:0001473 ! lymphatic vessel
intersection_of: located_in UBERON:0002363 ! dura mater
relationship: part_of UBERON:0010743 ! meningeal cluster

presumably this marks some kind of lymphatic-glymphatic boundary

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added

[Term]
id: UBERON:0036145
name: glymphatic system
def: "macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system." [doi:10.1007/s11064-015-1581-6, https://github.com/obophenotype/uberon/issues/1260, MGI:sbello]
comment: Function notes: hypothesized to be have roles such as waste clearance, distribution of compounds
is_a: UBERON:0000467 ! anatomical system
relationship: part_of UBERON:0001016 ! nervous system

leaving ticket open, as a reminder there is a lot to do in this area. See also perivascular spaces

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cmungall commented Sep 2, 2016

added

[Term]
id: UBERON:0036145
name: glymphatic system
def: "macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system." [doi:10.1007/s11064-015-1581-6, https://github.com/obophenotype/uberon/issues/1260, MGI:sbello]
comment: Function notes: hypothesized to be have roles such as waste clearance, distribution of compounds
is_a: UBERON:0000467 ! anatomical system
relationship: part_of UBERON:0001016 ! nervous system

leaving ticket open, as a reminder there is a lot to do in this area. See also perivascular spaces

cmungall added a commit that referenced this issue Sep 2, 2016

Added glymphatic system, see #1260
Added notes about modelinng of meninges, see #1261
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sbello Sep 2, 2016

I got the paper I included in the ticket by inter-library loan. Sending it
on as it may be useful to you as well.
Sue

On Fri, Sep 2, 2016 at 2:01 AM, Chris Mungall notifications@github.com
wrote:

added

[Term]
id: UBERON:0036145
name: glymphatic system
def: "macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system." [doi:10.1007/s11064-015-1581-6, https://github.com/obophenotype/uberon/issues/1260, MGI:sbello]
comment: Function notes: hypothesized to be have roles such as waste clearance, distribution of compounds
is_a: UBERON:0000467 ! anatomical system
relationship: part_of UBERON:0001016 ! nervous system

leaving ticket open, as a reminder there is a lot to do in this area. See
also perivascular spaces


You are receiving this because you authored the thread.
Reply to this email directly, view it on GitHub
#1260 (comment),
or mute the thread
https://github.com/notifications/unsubscribe-auth/AKeJ0XiPEEljib7_LCR0H2helGTzXoveks5ql7u6gaJpZM4JzIzM
.

sbello commented Sep 2, 2016

I got the paper I included in the ticket by inter-library loan. Sending it
on as it may be useful to you as well.
Sue

On Fri, Sep 2, 2016 at 2:01 AM, Chris Mungall notifications@github.com
wrote:

added

[Term]
id: UBERON:0036145
name: glymphatic system
def: "macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system." [doi:10.1007/s11064-015-1581-6, https://github.com/obophenotype/uberon/issues/1260, MGI:sbello]
comment: Function notes: hypothesized to be have roles such as waste clearance, distribution of compounds
is_a: UBERON:0000467 ! anatomical system
relationship: part_of UBERON:0001016 ! nervous system

leaving ticket open, as a reminder there is a lot to do in this area. See
also perivascular spaces


You are receiving this because you authored the thread.
Reply to this email directly, view it on GitHub
#1260 (comment),
or mute the thread
https://github.com/notifications/unsubscribe-auth/AKeJ0XiPEEljib7_LCR0H2helGTzXoveks5ql7u6gaJpZM4JzIzM
.

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