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What is the relationship between the meninges and the brain? #1261
It seems that the most uncontroversial way to represent this is to have the meningeal cluster be surrounding yet spatially disjoint from the the brain itself.
(as an aside, this resolves an awkward modeling decision to place periosteal dura mater as outside the meningeal dura mater, to avoid making the brain and the skeletal system overlap)
we should first review some existing resources and see what statements they make
MP (cc @sbello) implicitly classifies brain meninges as part of the NS, but not the CNS (or brain).
The implicit suggestion is that
Zebrafish have a single meninx. The ZFA the text def states this surrounds the CNS, but places it as part-of the NS
MA has this as part_of the CNS (with subclasses that are part-of brain regions, such as the midbrain)
The meningeal cluster (ie mereological sum of each meninx) has no part-of axioms
When we examine the parts and look at their partonomy we see that they are part-of the "cerebral part of head" but not the NS itself.
FMA relates the innermost layer to the CNS using
I would advocate for consistency with FMA in this case (ie meninges surround and spatially disjoint from brain). However, note that this will lead to some odd axiomatization in the composite-metazoan and collected uberon releases; it will seem as if the relationships between meninges and CNS are species-specific when in fact it is really ontology-specific.
This is related to the discussion of whether lymphatics are present in the CNS
This was claimed in a Nature paper by Louveau et al (doi:10.1038/nature14432 http://www.nature.com/nature/journal/v523/n7560/full/nature14432.html), which claimed discovery of lymph vessels in the dura mater (and inferring from this presence in the CNS). Both the CNS inference and the claims to a new discovery are disputed by Bucchieri et al (doi:10.1111/joa.12381, http://onlinelibrary.wiley.com/doi/10.1111/joa.12381/epdf):