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NTR for saccus vasculosus and coronet cell #662

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michaelerice opened this Issue Mar 19, 2015 · 5 comments

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michaelerice commented Mar 19, 2015

Term: Saccus vasculosus
definition: a circumventricular organ of the hypothalamus of many jawed fishes, protruding from the caudal infundibular wall. It is a vascularized neuroepithelium that consists of coronet cells, cerebrospinal fluid-contacting neurons and supporting cells
PMID: 4115676, PMID: 23820554

Term: coronet cells
definition: the highly specialized cell type exclusive to and forming neuroepithelium of the Saccus vasculosus, covering the caudal diverticulum of the infundibular recess.
PMID: 17595538

cmungall added a commit that referenced this issue Mar 19, 2015

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cmungall commented Mar 19, 2015

Did I get the right GO curator code for you? GOC:mr AgBase Michael Rice

So the SV is a CVO, yet it's part of the hypothalamus, which is itself a CVO? Seems a little odd, but maybe OK. Also we currently classify CVOs are multi-tissue, but this is a neuroepithelium it seems.

I did a separate addition on CL, revision r491 CL:0010015, in next CL release. Currently coordinated CL and Uberon edits are a bit awkward sorry about that.

Btw, if you need the ID for the term, see the commit message above. But note it's currently only in the editors version. It will be incorporated in the next release. If you need it sooner (e.g. for annotation in Protein2GO) just let me know in the ticket, thanks!

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cmungall commented Mar 19, 2015

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michaelerice commented Mar 19, 2015

Chris,

that is the correct code for me, sorry I did not think to include it. I don't know how to explain it's classification as a CVO within a CVO but that seems to be the consensus in the publications. Thanks very much for handling the request.

Mike


Michael E. Rice AgBase biocurator
School of Animal and Comparative Biomedical Science
Thomas W. Keating Bioresearch Building
1657 E. Helen St.
Tucson, AZ 85721
The College of Agriculture and Life Sciences
The University of Arizona
520 955-2745
mrice@email.arizona.eduhttp://mrice@email.arizona.edu


From: Chris Mungall [notifications@github.com]
Sent: Thursday, March 19, 2015 3:03 PM
To: obophenotype/uberon
Cc: Rice, Michael E - (mrice)
Subject: Re: [uberon] NTR for saccus vasculosus and coronet cell (#662)

Did I get the right GO curator code for you? GOC:mr AgBase Michael Rice

So the SV is a CVO, yet it's part of the hypothalamus, which is itself a CVO? Seems a little odd, but maybe OK. Also we currently classify CVOs are multi-tissue, but this is a neuroepithelium it seems.

I did a separate addition on CL, r491. Currently coordinated CL and Uberon edits are a bit awkward sorry about that.


Reply to this email directly or view it on GitHubhttps://github.com//issues/662#issuecomment-83776136.

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cerivs commented Apr 15, 2015

Putting a little zebrafish info here for people with more brain anatomy @ybradford @mellybelly
Fish Physiology: Zebrafish https://books.google.com/books?isbn=0080961371
3.2

among the various differentiations of the ventricular epithelium, part of the hypothalamic ventricle protrudes ventrally to form the saccus vasculosis. Although its function remains hypothetical, it may contain sensory receptors for depth chemical detection. Other probable functions are osmoregulation ionic transport skeletal growth and tooth regeneration, although other homeostatic functions are not excluded. The saccus is innervated by the tractus sacci vasculosi, which terminates in the nucleus sacci vasculosi in the posterior tuberculum of the diencephalon.

3.7

... As in all other vertebrates the CSF is produced by the chorid plexus saccus vasculosus.
In some localized areas the ependymal lining of the ventricles is differentiated into specialized structures, the circumventricular organs, some of which secrete hormones and other neuroactive substances into the CSF. .... These circumventricular organs include the area postrema in the dorsal rhombecephalon, the subcommissural organ, the pineal at the dorsal midline of the diencephalon, the median eminence and the posterior pituitary and the dopaminergic paraventricular organ of the posterior tuberculum.

Of course there is disagreement in the field:

Neuroanatomy of the Zebrafish Brain: A Topological Atlas By Mario F. Wulliman, Barbara Rupp, Heinrich Reichert https://books.google.com/books?isbn=0080877982
The pituitary (Pit) is ventrally attached to the ventral and caudal hypothalamic zones. A saccus vasculosus seen in many other teleost caudal to the pituitary is absent in the zebrafish.

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cerivs commented Apr 17, 2015

Acta Zoologica (Stockholm), Vol 73, No.1 pp 67-77 1992. Says they don't have a SV. There s a structure in juvenile zfish (maybe not adults) shown in the microCT atlast picture from Keith Cheng that could be an SV or it could be something else (thanks to Zoltan Varga for the image, identification and markup).
[]

cmungall added a commit to obophenotype/cell-ontology that referenced this issue Jun 16, 2015

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