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README.md

drugtarget

Drug efficacy targets, indications, and pharmacologic class

##Data tables

###Drug target table

Field Description
DRUG_ID unique identifier assigned to each active ingredient
CHEMBL_ID ChEMBL database assigned identifier
DRUG_NAME WHO INN name assigned to active ingredient, where available http://www.who.int/medicines/services/inn/en/
TARGET_NAME protein(s) name
TARGET_FAMILY high level target classification (GPCR, Enzyme, Ion Channel, Transporter, Nuclear Receptor, etc.)
UNIPROT Uniprot (http://www.uniprot.org/) accessions for protein targets, multicomponent targets and protein family targets list all Uniprot accessions
GENE gene symbol according to HUGO (http://www.genenames.org/)
ACTION_TYPE type of modulatory action exerted by drug on protein target
SOURCE source of mechanism of action annotation
REFERENCE reference for source URL or publication reference

###Drug indication table

Field Description
DRUG_ID unique identifier assigned to each active ingredient
DRUG_NAME WHO INN name assigned to active ingredient, where available http://www.who.int/medicines/services/inn/en/
INDICATION_FDB drug indication extracted from OMOP v4 http://archive-omop.fnih.org/CDMvocabV4
UMLS_CUI UMLS concept unique identifier http://www.nlm.nih.gov/research/umls/
SNOMEDCT_CUI SNOMED-CT concept unique identifier http://www.nlm.nih.gov/research/umls/Snomed/snomed_main.html
DOID Disease Ontology identifier http://disease-ontology.org/

###Pharmacologic class table

Field Description
DRUG_ID unique identifier assigned to each active ingredient
DRUG_NAME WHO INN name assigned to active ingredient, where available http://www.who.int/medicines/services/inn/en/
TYPE type according to source: FDA - Mechanism of Action (MOA), Physiologic Effect (PE), Chemical Structure (CS), and FDA Established Pharmacologic Class (EPC), MeSH - Pharmacological Action (PA), CHEBI - application (has role)
CLASS_SOURCE_ID class identifier provided by source
CLASS pharmacologic class
SOURCE source of classification: MeSH http://www.nlm.nih.gov/mesh/pa_abt.html, FDA http://www.fda.gov/ForIndustry/DataStandards/StructuredProductLabeling/ucm162549.htm, and CHEBI https://www.ebi.ac.uk/chebi/

###Drug identifiers table

Field Description
DRUG_ID unique identifier assigned to each active ingredient
DRUG_NAME WHO INN name assigned to active ingredient, where available http://www.who.int/medicines/services/inn/en/
ID_TYPE external resource
IDENTIFIER identifier in external resource

###Identifier type table

Field Description
ID_TYPE unique identifier type name in identifier table
DESCRIPTION description of external resource
URL external resource URL

###LINCS Mappings

Field Description
SMILES SMILES code for LINCS compounds
DRUG_ID unique identifier assigned to each active ingredient
SM_LINCS_ID LINCS compound id
DRUG_NAME WHO INN name assigned to active ingredient, where available http://www.who.int/medicines/services/inn/en/

###Updates (11/15/2016) Data in this repository can be also downloaded from DrugCentral. Data in this repository will not be updated, please refer to DrugCentral for updates and changes.

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