Open Systems Pharmacology

Open Systems Pharmacology Website (www.open-systems-pharmacology.org)

SGS Exprimo and the FU Berlin will run a two-days hands-on PK-Sim® & MoBi® workshop on introducing PBPK for human dose projection and drug-drug interaction (DDI) prediction on 21st-22nd Feb 2019 at the Institute of Pharmacy, FU-Berlin, Germany.

MoBi® is a software tool for multiscale physiological modeling and simulation

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling

Documentation files for the Open Systems Pharmacology Suite

Installation Validation Tool for the Open Systems Pharmacology Suite

Core functionalities of the Open Systems Pharmacology Suite

Collection of Matlab® functions for the processing of PK-Sim® or MoBi® models

Collection of Matlab® core functions for the processing of PK-Sim® or MoBi® models

Concentration data from studies performed during proprietary drug development programs by Bayer

Open Systems Pharmacology - Live Documentation

List of dimensions supported by the Open Systems Pharmacology Suite

Creation and processing of a qualification plan

The physiologically-based whole-body model of the glucose-insulin-glucagon regulatory system

WIP: Protein Abundance Database

(Matlab) Reporting-Engine

Calculation engine for models built with PK-Sim® or MoBi®

Open Systems Pharmacology Suite Setup

Whole-body PBPK model of rifampicin as CYP3A4 and P-gp DDI perpetrator drug

Whole-body PBPK model of alfentanil as CYP3A4 DDI victim drug

Whole-body PBPK model of itraconazole as CYP3A4 and P-gp DDI perpetrator drug

Whole-body PBPK model of clarithromycin as CYP3A4 and P-gp DDI perpetrator drug

Whole-body PBPK model of midazolam as CYP3A4 DDI victim drug

Whole-body PBPK model of digoxin as P-gp DDI victim drug

Modeling of published clinical Rifampicin-Midazolam-DDI studies for model evaluation

Modeling of published clinical Rifampicin-Alfentanil-DDI studies for model evaluation

Modeling of published clinical Rifampicin-Digoxin-DDI studies for model evaluation