diff --git a/receiver/prometheusreceiver/internal/metadata.go b/receiver/prometheusreceiver/internal/metadata.go
index 0898f252a76..739c60ff54a 100644
--- a/receiver/prometheusreceiver/internal/metadata.go
+++ b/receiver/prometheusreceiver/internal/metadata.go
@@ -55,18 +55,22 @@ func (s *metadataService) Get(job, instance string) (MetadataCache, error) {
 		return nil, errAlreadyStopped
 	}
 
-	targetGroup, ok := s.sm.TargetsAll()[job]
-	if !ok {
-		return nil, errors.New("unable to find a target group with job=" + job)
+	// Lookup against unaltered job label
+	if targetGroup, ok := s.sm.TargetsAll()[job]; ok {
+		for _, target := range targetGroup {
+			if target.Labels().Get(model.InstanceLabel) == instance {
+				return &mCache{target}, nil
+			}
+		}
 	}
-
-	// from the same targetGroup, instance is not going to be duplicated
-	for _, target := range targetGroup {
-		if target.Labels().Get(model.InstanceLabel) == instance {
-			return &mCache{target}, nil
+	// Fallback to lookup through all target groups for cases where job was relabeled
+	for _, targetGroup := range s.sm.TargetsAll() {
+		for _, target := range targetGroup {
+			if target.Labels().Get(model.InstanceLabel) == instance && target.Labels().Get(model.JobLabel) == job {
+				return &mCache{target}, nil
+			}
 		}
 	}
-
 	return nil, errors.New("unable to find a target with job=" + job + ", and instance=" + instance)
 }
 
diff --git a/receiver/prometheusreceiver/internal/transaction_test.go b/receiver/prometheusreceiver/internal/transaction_test.go
index 91979170b1b..31535e88ef1 100644
--- a/receiver/prometheusreceiver/internal/transaction_test.go
+++ b/receiver/prometheusreceiver/internal/transaction_test.go
@@ -54,6 +54,10 @@ func Test_transaction(t *testing.T) {
 			Name:  model.InstanceLabel,
 			Value: "localhost:8080",
 		},
+		labels.Label{
+			Name:  model.JobLabel,
+			Value: "testJobOverridden",
+		},
 	)
 
 	ms := &metadataService{
@@ -138,6 +142,43 @@ func Test_transaction(t *testing.T) {
 		// assert.Len(t, ocmds[0].Metrics, 1)
 	})
 
+	goodLabelsJobOverridden := labels.Labels([]labels.Label{{Name: "instance", Value: "localhost:8080"},
+		{Name: "job", Value: "testJobOverridden"},
+		{Name: "__name__", Value: "foo"}})
+	t.Run("Job label can be overridden", func(t *testing.T) {
+		sink := new(consumertest.MetricsSink)
+		tr := newTransaction(context.Background(), nil, true, "", rID, ms, sink, nil, testLogger)
+		if _, got := tr.Append(0, goodLabelsJobOverridden, time.Now().Unix()*1000, 1.0); got != nil {
+			t.Errorf("expecting error == nil from Add() but got: %v\n", got)
+		}
+		tr.metricBuilder.startTime = 1.0 // set to a non-zero value
+		if got := tr.Commit(); got != nil {
+			t.Errorf("expecting nil from Commit() but got err %v", got)
+		}
+		expectedNode, expectedResource := createNodeAndResource("testJobOverridden", "localhost:8080", "http")
+		mds := sink.AllMetrics()
+		if len(mds) != 1 {
+			t.Fatalf("wanted one batch, got %v\n", sink.AllMetrics())
+		}
+		var ocmds []*agentmetricspb.ExportMetricsServiceRequest
+		rms := mds[0].ResourceMetrics()
+		for i := 0; i < rms.Len(); i++ {
+			ocmd := &agentmetricspb.ExportMetricsServiceRequest{}
+			ocmd.Node, ocmd.Resource, ocmd.Metrics = internaldata.ResourceMetricsToOC(rms.At(i))
+			ocmds = append(ocmds, ocmd)
+		}
+		require.Len(t, ocmds, 1)
+		if !proto.Equal(ocmds[0].Node, expectedNode) {
+			t.Errorf("generated node %v and expected node %v is different\n", ocmds[0].Node, expectedNode)
+		}
+		if !proto.Equal(ocmds[0].Resource, expectedResource) {
+			t.Errorf("generated resource %v and expected resource %v is different\n", ocmds[0].Resource, expectedResource)
+		}
+
+		// TODO: re-enable this when handle unspecified OC type
+		// assert.Len(t, ocmds[0].Metrics, 1)
+	})
+
 	t.Run("Error when start time is zero", func(t *testing.T) {
 		sink := new(consumertest.MetricsSink)
 		tr := newTransaction(context.Background(), nil, true, "", rID, ms, sink, nil, testLogger)