diff --git a/CHANGELOG.md b/CHANGELOG.md
index e5e2f7b1a..a6fd20527 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -19,6 +19,7 @@ OpenTelemetry Go Automatic Instrumentation adheres to [Semantic Versioning](http
 - Support Go `v1.22.3`. ([#824](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/824))
 - Support `google.golang.org/grpc` `1.65.0-dev`. ([#827](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/827))
 - Support `google.golang.org/grpc` `1.64.0`. ([#843](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/843))
+- `WithLoadedIndicator` `InstrumentationOption` to configure an Instrumentation to notify the caller once all the eBPF probes are loaded. ([#848](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/848))
 - Support `go.opentelemetry.io/otel@v1.27.0`. ([#850](https://github.com/open-telemetry/opentelemetry-go-instrumentation/pull/850))
 
 ### Fixed
diff --git a/cli/main.go b/cli/main.go
index ae96c978e..fc2e93905 100644
--- a/cli/main.go
+++ b/cli/main.go
@@ -93,7 +93,8 @@ func main() {
 
 	logger.Info("building OpenTelemetry Go instrumentation ...", "globalImpl", globalImpl)
 
-	instOptions := []auto.InstrumentationOption{auto.WithEnv()}
+	loadedIndicator := make(chan struct{})
+	instOptions := []auto.InstrumentationOption{auto.WithEnv(), auto.WithLoadedIndicator(loadedIndicator)}
 	if globalImpl {
 		instOptions = append(instOptions, auto.WithGlobal())
 	}
@@ -104,6 +105,15 @@ func main() {
 		return
 	}
 
+	go func() {
+		select {
+		case <-ctx.Done():
+			return
+		case <-loadedIndicator:
+			logger.Info("instrumentation loaded successfully")
+		}
+	}()
+
 	logger.Info("starting instrumentation...")
 	if err = inst.Run(ctx); err != nil && !errors.Is(err, process.ErrInterrupted) {
 		logger.Error(err, "instrumentation crashed")
diff --git a/instrumentation.go b/instrumentation.go
index fec19b4a9..d441c2b8b 100644
--- a/instrumentation.go
+++ b/instrumentation.go
@@ -120,7 +120,7 @@ func NewInstrumentation(ctx context.Context, opts ...InstrumentationOption) (*In
 		return nil, err
 	}
 
-	mngr, err := instrumentation.NewManager(logger, ctrl, c.globalImpl)
+	mngr, err := instrumentation.NewManager(logger, ctrl, c.globalImpl, c.loadIndicator)
 	if err != nil {
 		return nil, err
 	}
@@ -174,6 +174,7 @@ type instConfig struct {
 	serviceName        string
 	additionalResAttrs []attribute.KeyValue
 	globalImpl         bool
+	loadIndicator      chan struct{}
 }
 
 func newInstConfig(ctx context.Context, opts []InstrumentationOption) (instConfig, error) {
@@ -463,3 +464,14 @@ func WithResourceAttributes(attrs ...attribute.KeyValue) InstrumentationOption {
 		return c, nil
 	})
 }
+
+// WithLoadedIndicator returns an [InstrumentationOption] that will configure an
+// [Instrumentation] to close the provided indicator channel when the target
+// process has been instrumented (i.e. all probes have been loaded).
+// The provided indicator channel needs to be initialized by the caller.
+func WithLoadedIndicator(indicator chan struct{}) InstrumentationOption {
+	return fnOpt(func(_ context.Context, c instConfig) (instConfig, error) {
+		c.loadIndicator = indicator
+		return c, nil
+	})
+}
diff --git a/internal/pkg/instrumentation/manager.go b/internal/pkg/instrumentation/manager.go
index 33efd83c4..aae99dbc1 100644
--- a/internal/pkg/instrumentation/manager.go
+++ b/internal/pkg/instrumentation/manager.go
@@ -40,27 +40,29 @@ import (
 
 // Manager handles the management of [probe.Probe] instances.
 type Manager struct {
-	logger         logr.Logger
-	probes         map[probe.ID]probe.Probe
-	done           chan bool
-	incomingEvents chan *probe.Event
-	otelController *opentelemetry.Controller
-	globalImpl     bool
-	wg             sync.WaitGroup
-	closingErrors  chan error
+	logger          logr.Logger
+	probes          map[probe.ID]probe.Probe
+	done            chan bool
+	incomingEvents  chan *probe.Event
+	otelController  *opentelemetry.Controller
+	globalImpl      bool
+	wg              sync.WaitGroup
+	closingErrors   chan error
+	loadedIndicator chan struct{}
 }
 
 // NewManager returns a new [Manager].
-func NewManager(logger logr.Logger, otelController *opentelemetry.Controller, globalImpl bool) (*Manager, error) {
+func NewManager(logger logr.Logger, otelController *opentelemetry.Controller, globalImpl bool, loadIndicator chan struct{}) (*Manager, error) {
 	logger = logger.WithName("Manager")
 	m := &Manager{
-		logger:         logger,
-		probes:         make(map[probe.ID]probe.Probe),
-		done:           make(chan bool, 1),
-		incomingEvents: make(chan *probe.Event),
-		otelController: otelController,
-		globalImpl:     globalImpl,
-		closingErrors:  make(chan error, 1),
+		logger:          logger,
+		probes:          make(map[probe.ID]probe.Probe),
+		done:            make(chan bool, 1),
+		incomingEvents:  make(chan *probe.Event),
+		otelController:  otelController,
+		globalImpl:      globalImpl,
+		closingErrors:   make(chan error, 1),
+		loadedIndicator: loadIndicator,
 	}
 
 	err := m.registerProbes()
@@ -163,6 +165,10 @@ func (m *Manager) Run(ctx context.Context, target *process.TargetDetails) error
 		}(i)
 	}
 
+	if m.loadedIndicator != nil {
+		close(m.loadedIndicator)
+	}
+
 	for {
 		select {
 		case <-ctx.Done():
diff --git a/internal/pkg/instrumentation/manager_test.go b/internal/pkg/instrumentation/manager_test.go
index 21c9da328..dad760bf9 100644
--- a/internal/pkg/instrumentation/manager_test.go
+++ b/internal/pkg/instrumentation/manager_test.go
@@ -191,7 +191,7 @@ func fakeManager(t *testing.T) *Manager {
 	logger := stdr.New(log.New(os.Stderr, "", log.LstdFlags))
 	logger = logger.WithName("Instrumentation")
 
-	m, err := NewManager(logger, nil, true)
+	m, err := NewManager(logger, nil, true, nil)
 	assert.NoError(t, err)
 	assert.NotNil(t, m)