diff --git a/CHANGELOG.md b/CHANGELOG.md
index b4e5053138..5a8abe921a 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -64,7 +64,9 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#436](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/436))
 - `opentelemetry-instrumenation-flask` now supports trace response headers.
   ([#436](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/436))
-
+- `opentelemetry-instrumentation-grpc` Keep client interceptor in sync with grpc client interceptors.
+  ([#442](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/442))
+  
 ### Removed
 - Remove `http.status_text` from span attributes
   ([#406](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/406))
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/grpcext/_interceptor.py b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/grpcext/_interceptor.py
index 89889aceeb..53ee46a20d 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/grpcext/_interceptor.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/grpcext/_interceptor.py
@@ -13,9 +13,7 @@
 # limitations under the License.
 
 # pylint:disable=relative-beyond-top-level
-# pylint:disable=arguments-differ
 # pylint:disable=no-member
-# pylint:disable=signature-differs
 
 """Implementation of gRPC Python interceptors."""
 
@@ -48,9 +46,24 @@ def __init__(self, method, base_callable, interceptor):
         self._base_callable = base_callable
         self._interceptor = interceptor
 
-    def __call__(self, request, timeout=None, metadata=None, credentials=None):
+    def __call__(
+        self,
+        request,
+        timeout=None,
+        metadata=None,
+        credentials=None,
+        wait_for_ready=None,
+        compression=None,
+    ):
         def invoker(request, metadata):
-            return self._base_callable(request, timeout, metadata, credentials)
+            return self._base_callable(
+                request,
+                timeout,
+                metadata,
+                credentials,
+                wait_for_ready,
+                compression,
+            )
 
         client_info = _UnaryClientInfo(self._method, timeout)
         return self._interceptor.intercept_unary(
@@ -58,11 +71,22 @@ def invoker(request, metadata):
         )
 
     def with_call(
-        self, request, timeout=None, metadata=None, credentials=None
+        self,
+        request,
+        timeout=None,
+        metadata=None,
+        credentials=None,
+        wait_for_ready=None,
+        compression=None,
     ):
         def invoker(request, metadata):
             return self._base_callable.with_call(
-                request, timeout, metadata, credentials
+                request,
+                timeout,
+                metadata,
+                credentials,
+                wait_for_ready,
+                compression,
             )
 
         client_info = _UnaryClientInfo(self._method, timeout)
@@ -70,10 +94,23 @@ def invoker(request, metadata):
             request, metadata, client_info, invoker
         )
 
-    def future(self, request, timeout=None, metadata=None, credentials=None):
+    def future(
+        self,
+        request,
+        timeout=None,
+        metadata=None,
+        credentials=None,
+        wait_for_ready=None,
+        compression=None,
+    ):
         def invoker(request, metadata):
             return self._base_callable.future(
-                request, timeout, metadata, credentials
+                request,
+                timeout,
+                metadata,
+                credentials,
+                wait_for_ready,
+                compression,
             )
 
         client_info = _UnaryClientInfo(self._method, timeout)
@@ -88,9 +125,24 @@ def __init__(self, method, base_callable, interceptor):
         self._base_callable = base_callable
         self._interceptor = interceptor
 
-    def __call__(self, request, timeout=None, metadata=None, credentials=None):
+    def __call__(
+        self,
+        request,
+        timeout=None,
+        metadata=None,
+        credentials=None,
+        wait_for_ready=None,
+        compression=None,
+    ):
         def invoker(request, metadata):
-            return self._base_callable(request, timeout, metadata, credentials)
+            return self._base_callable(
+                request,
+                timeout,
+                metadata,
+                credentials,
+                wait_for_ready,
+                compression,
+            )
 
         client_info = _StreamClientInfo(self._method, False, True, timeout)
         return self._interceptor.intercept_stream(
@@ -105,11 +157,22 @@ def __init__(self, method, base_callable, interceptor):
         self._interceptor = interceptor
 
     def __call__(
-        self, request_iterator, timeout=None, metadata=None, credentials=None
+        self,
+        request_iterator,
+        timeout=None,
+        metadata=None,
+        credentials=None,
+        wait_for_ready=None,
+        compression=None,
     ):
         def invoker(request_iterator, metadata):
             return self._base_callable(
-                request_iterator, timeout, metadata, credentials
+                request_iterator,
+                timeout,
+                metadata,
+                credentials,
+                wait_for_ready,
+                compression,
             )
 
         client_info = _StreamClientInfo(self._method, True, False, timeout)
@@ -118,11 +181,22 @@ def invoker(request_iterator, metadata):
         )
 
     def with_call(
-        self, request_iterator, timeout=None, metadata=None, credentials=None
+        self,
+        request_iterator,
+        timeout=None,
+        metadata=None,
+        credentials=None,
+        wait_for_ready=None,
+        compression=None,
     ):
         def invoker(request_iterator, metadata):
             return self._base_callable.with_call(
-                request_iterator, timeout, metadata, credentials
+                request_iterator,
+                timeout,
+                metadata,
+                credentials,
+                wait_for_ready,
+                compression,
             )
 
         client_info = _StreamClientInfo(self._method, True, False, timeout)
@@ -131,11 +205,22 @@ def invoker(request_iterator, metadata):
         )
 
     def future(
-        self, request_iterator, timeout=None, metadata=None, credentials=None
+        self,
+        request_iterator,
+        timeout=None,
+        metadata=None,
+        credentials=None,
+        wait_for_ready=None,
+        compression=None,
     ):
         def invoker(request_iterator, metadata):
             return self._base_callable.future(
-                request_iterator, timeout, metadata, credentials
+                request_iterator,
+                timeout,
+                metadata,
+                credentials,
+                wait_for_ready,
+                compression,
             )
 
         client_info = _StreamClientInfo(self._method, True, False, timeout)
@@ -151,11 +236,22 @@ def __init__(self, method, base_callable, interceptor):
         self._interceptor = interceptor
 
     def __call__(
-        self, request_iterator, timeout=None, metadata=None, credentials=None
+        self,
+        request_iterator,
+        timeout=None,
+        metadata=None,
+        credentials=None,
+        wait_for_ready=None,
+        compression=None,
     ):
         def invoker(request_iterator, metadata):
             return self._base_callable(
-                request_iterator, timeout, metadata, credentials
+                request_iterator,
+                timeout,
+                metadata,
+                credentials,
+                wait_for_ready,
+                compression,
             )
 
         client_info = _StreamClientInfo(self._method, True, True, timeout)
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py
index f088f5cf8c..109a0d8563 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py
@@ -41,13 +41,57 @@
 from .protobuf.test_server_pb2 import Request
 
 
+# User defined interceptor. Is used in the tests along with the opentelemetry client interceptor.
+class Interceptor(
+    grpc.UnaryUnaryClientInterceptor,
+    grpc.UnaryStreamClientInterceptor,
+    grpc.StreamUnaryClientInterceptor,
+    grpc.StreamStreamClientInterceptor,
+):
+    def __init__(self):
+        pass
+
+    def intercept_unary_unary(
+        self, continuation, client_call_details, request
+    ):
+        return self._intercept_call(continuation, client_call_details, request)
+
+    def intercept_unary_stream(
+        self, continuation, client_call_details, request
+    ):
+        return self._intercept_call(continuation, client_call_details, request)
+
+    def intercept_stream_unary(
+        self, continuation, client_call_details, request_iterator
+    ):
+        return self._intercept_call(
+            continuation, client_call_details, request_iterator
+        )
+
+    def intercept_stream_stream(
+        self, continuation, client_call_details, request_iterator
+    ):
+        return self._intercept_call(
+            continuation, client_call_details, request_iterator
+        )
+
+    @staticmethod
+    def _intercept_call(
+        continuation, client_call_details, request_or_iterator
+    ):
+        return continuation(client_call_details, request_or_iterator)
+
+
 class TestClientProto(TestBase):
     def setUp(self):
         super().setUp()
         GrpcInstrumentorClient().instrument()
         self.server = create_test_server(25565)
         self.server.start()
+        # use a user defined interceptor along with the opentelemetry client interceptor
+        interceptors = [Interceptor()]
         self.channel = grpc.insecure_channel("localhost:25565")
+        self.channel = grpc.intercept_channel(self.channel, *interceptors)
         self._stub = test_server_pb2_grpc.GRPCTestServerStub(self.channel)
 
     def tearDown(self):