diff --git a/src/app/config/config.ts b/src/app/config/config.ts
index 1e9b268c05..5344bc45a7 100644
--- a/src/app/config/config.ts
+++ b/src/app/config/config.ts
@@ -81,13 +81,17 @@ const s3BucketUrlVars = convict(s3BucketUrlSchema)
   .validate({ allowed: 'strict' })
   .getProperties()
 
+const hasR2Buckets = Object.values(s3BucketUrlVars).some((url) =>
+  /https:\/\/\w+.r2.cloudflarestorage.com/i.test(url),
+)
+
 const s3 = new aws.S3({
   region: basicVars.awsConfig.region,
   // Unset and use default if not in development mode
   // Endpoint and path style overrides are needed only in development mode for
   // localstack to work.
   endpoint: isDev ? s3BucketUrlVars.endPoint : undefined,
-  s3ForcePathStyle: isDev ? true : undefined,
+  s3ForcePathStyle: isDev || hasR2Buckets ? true : undefined,
 })
 
 // using aws-sdk v3 (FRM-993)
diff --git a/src/app/config/schema.ts b/src/app/config/schema.ts
index 5f8cde55c5..704a8b1917 100644
--- a/src/app/config/schema.ts
+++ b/src/app/config/schema.ts
@@ -59,8 +59,11 @@ const validateS3BucketUrl = (
   }
   // Region should be specified correctly in production
   const isRegionCorrect = new RegExp(`^https://s3.${region}.amazonaws.com`, 'i')
-  if (!isDev && !isRegionCorrect.test(val)) {
-    throw new Error(`region should be ${region}`)
+  const isR2 = new RegExp(`^https://\\w+.r2.cloudflarestorage.com`, 'i')
+  if (!isDev && !isRegionCorrect.test(val) && !isR2.test(val)) {
+    throw new Error(
+      `region should be ${region}, or url should be for Cloudflare R2`,
+    )
   }
   /* eslint-enable typesafe/no-throw-sync-func */
 }