diff --git a/api/src/main/java/org/openmrs/module/fhir2/providers/r4/MedicationFhirResourceProvider.java b/api/src/main/java/org/openmrs/module/fhir2/providers/r4/MedicationFhirResourceProvider.java
index 9298c20f6..18e79e85a 100644
--- a/api/src/main/java/org/openmrs/module/fhir2/providers/r4/MedicationFhirResourceProvider.java
+++ b/api/src/main/java/org/openmrs/module/fhir2/providers/r4/MedicationFhirResourceProvider.java
@@ -21,12 +21,15 @@
 import ca.uhn.fhir.rest.annotation.IdParam;
 import ca.uhn.fhir.rest.annotation.IncludeParam;
 import ca.uhn.fhir.rest.annotation.OptionalParam;
+import ca.uhn.fhir.rest.annotation.Patch;
 import ca.uhn.fhir.rest.annotation.Read;
 import ca.uhn.fhir.rest.annotation.ResourceParam;
 import ca.uhn.fhir.rest.annotation.Search;
 import ca.uhn.fhir.rest.annotation.Update;
 import ca.uhn.fhir.rest.api.MethodOutcome;
+import ca.uhn.fhir.rest.api.PatchTypeEnum;
 import ca.uhn.fhir.rest.api.server.IBundleProvider;
+import ca.uhn.fhir.rest.api.server.RequestDetails;
 import ca.uhn.fhir.rest.param.DateRangeParam;
 import ca.uhn.fhir.rest.param.TokenAndListParam;
 import ca.uhn.fhir.rest.server.IResourceProvider;
@@ -87,6 +90,18 @@ public MethodOutcome updateMedication(@IdParam IdType id, @ResourceParam Medicat
 		return FhirProviderUtils.buildUpdate(fhirMedicationService.update(id.getIdPart(), medication));
 	}
 	
+	@Patch
+	public MethodOutcome patchMedication(@IdParam IdType id, PatchTypeEnum patchType, @ResourceParam String body,
+	        RequestDetails requestDetails) {
+		if (id == null || id.getIdPart() == null) {
+			throw new InvalidRequestException("id must be specified to update Medication resource");
+		}
+		
+		Medication medication = fhirMedicationService.patch(id.getIdPart(), patchType, body, requestDetails);
+		
+		return FhirProviderUtils.buildPatch(medication);
+	}
+	
 	@Delete
 	@SuppressWarnings("unused")
 	public OperationOutcome deleteMedication(@IdParam @Nonnull IdType id) {
diff --git a/integration-tests/src/test/java/org/openmrs/module/fhir2/providers/r4/MedicationFhirResourceProviderIntegrationTest.java b/integration-tests/src/test/java/org/openmrs/module/fhir2/providers/r4/MedicationFhirResourceProviderIntegrationTest.java
index 7178a0802..e639b30a2 100644
--- a/integration-tests/src/test/java/org/openmrs/module/fhir2/providers/r4/MedicationFhirResourceProviderIntegrationTest.java
+++ b/integration-tests/src/test/java/org/openmrs/module/fhir2/providers/r4/MedicationFhirResourceProviderIntegrationTest.java
@@ -50,6 +50,10 @@ public class MedicationFhirResourceProviderIntegrationTest extends BaseFhirR4Int
 	
 	private static final String MEDICATION_DATA_XML = "org/openmrs/module/fhir2/api/dao/impl/FhirMedicationDaoImplTest_initial_data.xml";
 	
+	private static final String JSON_MERGE_PATCH_MEDICATION_PATH = "org/openmrs/module/fhir2/providers/Medication_patch.json";
+	
+	private static final String JSON_PATCH_MEDICATION_PATH = "org/openmrs/module/fhir2/providers/Medication_json_patch.json";
+	
 	private static final String JSON_CREATE_MEDICATION_DOCUMENT = "org/openmrs/module/fhir2/providers/MedicationWebTest_create.json";
 	
 	private static final String XML_CREATE_MEDICATION_DOCUMENT = "org/openmrs/module/fhir2/providers/MedicationWebTest_create.xml";
@@ -392,6 +396,54 @@ public void shouldReturnNotFoundWhenUpdatingNonExistentMedicationAsXML() throws
 		assertThat(operationOutcome.hasIssue(), is(true));
 	}
 	
+	@Test
+	public void shouldPatchExistingMedicationUsingJsonMergePatch() throws Exception {
+		String jsonMedicationPatch;
+		try (InputStream is = this.getClass().getClassLoader().getResourceAsStream(JSON_MERGE_PATCH_MEDICATION_PATH)) {
+			Objects.requireNonNull(is);
+			jsonMedicationPatch = inputStreamToString(is, UTF_8);
+		}
+		
+		MockHttpServletResponse response = patch("/Medication/" + MEDICATION_UUID).jsonMergePatch(jsonMedicationPatch)
+				.accept(FhirMediaTypes.JSON).go();
+		
+		assertThat(response, isOk());
+		assertThat(response.getContentType(), is(FhirMediaTypes.JSON.toString()));
+		assertThat(response.getContentAsString(), notNullValue());
+		
+		Medication medication = readResponse(response);
+		
+		assertThat(medication, notNullValue());
+		assertThat(medication.getIdElement().getIdPart(), equalTo(MEDICATION_UUID));
+		assertThat(medication, validResource());
+		
+		assertThat(medication.getStatus(), is(Medication.MedicationStatus.ACTIVE));
+	}
+	
+	@Test
+	public void shouldPatchExistingMedicationUsingJsonPatch() throws Exception {
+		String jsonMedicationPatch;
+		try (InputStream is = this.getClass().getClassLoader().getResourceAsStream(JSON_PATCH_MEDICATION_PATH)) {
+			Objects.requireNonNull(is);
+			jsonMedicationPatch = inputStreamToString(is, UTF_8);
+		}
+		
+		MockHttpServletResponse response = patch("/Medication/" + MEDICATION_UUID).jsonPatch(jsonMedicationPatch)
+				.accept(FhirMediaTypes.JSON).go();
+		
+		assertThat(response, isOk());
+		assertThat(response.getContentType(), is(FhirMediaTypes.JSON.toString()));
+		assertThat(response.getContentAsString(), notNullValue());
+		
+		Medication medication = readResponse(response);
+		
+		assertThat(medication, notNullValue());
+		assertThat(medication.getIdElement().getIdPart(), equalTo(MEDICATION_UUID));
+		assertThat(medication, validResource());
+		
+		assertThat(medication.getStatus(), is(Medication.MedicationStatus.ACTIVE));
+	}
+	
 	@Test
 	public void shouldDeleteExistingMedication() throws Exception {
 		MockHttpServletResponse response = delete("/Medication/" + MEDICATION_UUID).accept(FhirMediaTypes.JSON).go();
diff --git a/test-data/src/main/resources/org/openmrs/module/fhir2/providers/Medication_json_patch.json b/test-data/src/main/resources/org/openmrs/module/fhir2/providers/Medication_json_patch.json
new file mode 100644
index 000000000..c0197f5a3
--- /dev/null
+++ b/test-data/src/main/resources/org/openmrs/module/fhir2/providers/Medication_json_patch.json
@@ -0,0 +1,7 @@
+[
+  {
+    "op": "replace",
+    "path": "/status",
+    "value": "inactive"
+  }
+]
diff --git a/test-data/src/main/resources/org/openmrs/module/fhir2/providers/Medication_patch.json b/test-data/src/main/resources/org/openmrs/module/fhir2/providers/Medication_patch.json
new file mode 100644
index 000000000..3eda9d21e
--- /dev/null
+++ b/test-data/src/main/resources/org/openmrs/module/fhir2/providers/Medication_patch.json
@@ -0,0 +1,3 @@
+{
+  "status": "inactive"
+}