diff --git a/ci-operator/config/openshift/release/openshift-release-main__nightly-5.0-upgrade-from-stable-4.22.yaml b/ci-operator/config/openshift/release/openshift-release-main__nightly-5.0-upgrade-from-stable-4.22.yaml
index 93b8d0ce7112b..eafaa64f62c8a 100644
--- a/ci-operator/config/openshift/release/openshift-release-main__nightly-5.0-upgrade-from-stable-4.22.yaml
+++ b/ci-operator/config/openshift/release/openshift-release-main__nightly-5.0-upgrade-from-stable-4.22.yaml
@@ -81,6 +81,31 @@ tests:
     env:
       TEST_TYPE: upgrade-conformance
     workflow: baremetalds-two-node-arbiter-upgrade
+- as: e2e-metal-ovn-two-node-arbiter-techpreview-upgrade-os-rhel10
+  capabilities:
+  - intranet
+  cron: '@weekly'
+  steps:
+    cluster_profile: equinix-edge-enablement
+    env:
+      DEVSCRIPTS_CONFIG: |
+        IP_STACK=v4
+        NUM_MASTERS=2
+        MASTER_DISK=100
+        MASTER_MEMORY=32768
+        NUM_ARBITERS=1
+        ARBITER_DISK=50
+        ARBITER_MEMORY=8192
+        ARBITER_VCPU=2
+        NUM_WORKERS=0
+        FEATURE_SET="TechPreviewNoUpgrade"
+      MCO_CONF_DAY2_OS_IMAGE_STREAM_DEFAULT: rhel-10
+      TEST_SUITE: ""
+      TEST_TYPE: upgrade
+    test:
+    - chain: baremetalds-ipi-test
+    - ref: mco-conf-day2-os-image-stream-default
+    workflow: baremetalds-two-node-arbiter-upgrade
 - as: e2e-metal-ovn-two-node-arbiter-upgrade-workers
   capabilities:
   - intranet
@@ -135,6 +160,21 @@ tests:
       enable:
       - observers-resource-watch
     workflow: openshift-upgrade-aws-single-node
+- as: e2e-aws-upgrade-ovn-single-node-techpreview-os-rhel10
+  interval: 168h
+  steps:
+    cluster_profile: openshift-org-aws
+    env:
+      FEATURE_SET: TechPreviewNoUpgrade
+      MCO_CONF_DAY2_OS_IMAGE_STREAM_DEFAULT: rhel-10
+      TEST_TYPE: upgrade
+    observers:
+      enable:
+      - observers-resource-watch
+    test:
+    - ref: single-node-e2e-test
+    - ref: mco-conf-day2-os-image-stream-default
+    workflow: openshift-upgrade-aws-single-node
 - as: e2e-metal-ovn-single-node-rt-upgrade
   interval: 168h
   steps:
diff --git a/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml b/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml
index 10c35ced6eabc..71bfc1079e0e2 100644
--- a/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml
+++ b/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml
@@ -292553,6 +292553,90 @@ periodics:
     - name: result-aggregator
       secret:
         secretName: result-aggregator
+- agent: kubernetes
+  cluster: build09
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+  extra_refs:
+  - base_ref: main
+    org: openshift
+    repo: release
+  interval: 168h
+  labels:
+    ci-operator.openshift.io/cloud: aws
+    ci-operator.openshift.io/cloud-cluster-profile: openshift-org-aws
+    ci-operator.openshift.io/variant: nightly-5.0-upgrade-from-stable-4.22
+    ci.openshift.io/generator: prowgen
+    ci.openshift.io/no-builds: "true"
+    job-release: "5.0"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  name: periodic-ci-openshift-release-main-nightly-5.0-upgrade-from-stable-4.22-e2e-aws-upgrade-ovn-single-node-techpreview-os-rhel10
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-aws-upgrade-ovn-single-node-techpreview-os-rhel10
+      - --variant=nightly-5.0-upgrade-from-stable-4.22
+      command:
+      - ci-operator
+      env:
+      - name: HTTP_SERVER_IP
+        valueFrom:
+          fieldRef:
+            fieldPath: status.podIP
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      ports:
+      - containerPort: 8080
+        name: http
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
 - agent: kubernetes
   cluster: build10
   cron: 0 12 1 1 *
@@ -292977,6 +293061,91 @@ periodics:
     - name: result-aggregator
       secret:
         secretName: result-aggregator
+- agent: kubernetes
+  cluster: build10
+  cron: '@weekly'
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+  extra_refs:
+  - base_ref: main
+    org: openshift
+    repo: release
+  labels:
+    capability/intranet: intranet
+    ci-operator.openshift.io/cloud: equinix-edge-enablement
+    ci-operator.openshift.io/cloud-cluster-profile: equinix-edge-enablement
+    ci-operator.openshift.io/variant: nightly-5.0-upgrade-from-stable-4.22
+    ci.openshift.io/generator: prowgen
+    ci.openshift.io/no-builds: "true"
+    job-release: "5.0"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  name: periodic-ci-openshift-release-main-nightly-5.0-upgrade-from-stable-4.22-e2e-metal-ovn-two-node-arbiter-techpreview-upgrade-os-rhel10
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-metal-ovn-two-node-arbiter-techpreview-upgrade-os-rhel10
+      - --variant=nightly-5.0-upgrade-from-stable-4.22
+      command:
+      - ci-operator
+      env:
+      - name: HTTP_SERVER_IP
+        valueFrom:
+          fieldRef:
+            fieldPath: status.podIP
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      ports:
+      - containerPort: 8080
+        name: http
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
 - agent: kubernetes
   cluster: build10
   cron: '@weekly'