Find ion channels that relate to motor neurons AS01, AS02, DA01, DA02, DB01, DD01, SMDDL, SMDDR

[Interintel]

Define the specific types of Ion Channels and how they work within the cell.

Here's a powerpoint presentation that explains what ion channels are and some of the math behind simulating them.

Here's a book explaining what ion channels are, and how they relate to neurons.

This spreadsheet contains a very early documenting of ion channels in muscle cells, but begins to lay out the way in which we should start describing them.

Gene expression patterns that can be used to infer the location of ion channels are in another sheet in that same spreadsheet.

Here's a list of neurotransmitter receptors and what neurotransmitters they receive.

A wealth of neurotransmitter receptors are described on [https://docs.google.com/spreadsheet/ccc?key=0ArNOKkIblIRadE5lVkN4WGMzNUZLdVROUEZVTUlUVGc#gid=0](this spreadsheet), maintained by Z.F. Altun.

Textpresso for c elegans provides full text search of c. elegans journal articles and can be used to find papers that talk about specific ion channel types.

[slarson]

including @Crystinjoni on this.

[slarson]

Updated this with a bunch of links to resources

[slarson]

@Neurophile thought I'd add this comment here and make you a watcher on this. Cheers!

[slarson]

@ArjunSub check this out

[slarson]

@VahidGh has been helping out with this. The ion channels spreadsheet is moving again.

[slarson]

@Linuxese --thanks for agreeing to look into c. elegans RNASeq data. We also talked about looking into c. elegans ion channel mutants -- maybe we can try this as a next step. Could you update us here on any progress that you make?

[slarson]

@VahidGh is working on the following:

Right now, I'm working on studies related to ion channels underlying current in NMJ, studies are more related to body wall muscle than motor neurons.
In brief, important genes from the spread sheet are: egl-19, SHK-1, SLO-1, SHL-1, and CCA-1, and UNC-36 in muscle cells, and UNC-2, SLO-1, SLO-2, and SHK-1 for motor neurons.
(I'm working on a document with detailed info and refs)

[slarson]

Adding my update I typed up earlier:

As many channels as we can infer that are in the motor neurons (AS01, AS02, DA01, DA02, DB01, DD01, SMDDL, SMDDR), models for the synapses between these and our muscle cell, and the muscle cell itself. So @ahrasheed -- your efforts to get the motor neurons LEMS files generated then creates a rallying point for these ion channels to be attached. @VahidGh and @wilzh40 if we can start sorting the ion channel spreadsheet for those ion channels that either reference those neurons by name or has the word "motor" or possibly "ventral cord" or "dorsal cord" neurons since those neurons go through there, then we can start to build up a better list of ion channels to pursue. Make sense, all?